Article
Psychology, Multidisciplinary
Jamie Raines, Luke Holmes, Tuesday M. Watts-Overall, Erlend Slettevold, Dragos C. Gruia, Sheina Orbell, Gerulf Rieger
Summary: Most men exhibit genital sexual arousal towards one preferred gender, while most women show arousal towards both genders. Transgender individuals show patterns of sexual arousal that are both male-typical and female-typical, suggesting that gender identity and biological sex may influence sexual arousal patterns.
PSYCHOLOGICAL SCIENCE
(2021)
Article
Neurosciences
Christoph Abe, Alexander Lebedev, Ruyue Zhang, Lina Jonsson, Sarah E. Bergen, Martin Ingvar, Mikael Landen, Qazi Rahman
Summary: This study utilized a large-scale neuroimaging-genetics dataset to investigate the neurobiological basis of sexual orientation through comparing brain covariance patterns between males and females. The findings revealed significant shifts in brain patterns among non-heterosexual females, as well as specific brain region differences related to sexual orientation.
HUMAN BRAIN MAPPING
(2021)
Article
Psychology, Clinical
J. Michael Bailey, Ray Blanchard, Kevin J. Hsu, William Revelle
Summary: Men's sexual interest in adults and children is influenced by the targets' sexual maturity and biological sex, which are predictive of sexual offending. Men's preferences for prepubescent children compared to adults of their preferred sex are significant.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychology, Biological
Lambert C. Heatlie, Lanna J. Petterson, Paul L. Vasey
Summary: Research shows that Canadian men are more sexually attracted and aroused to gynandromorphs with breasts, followed by gynandromorphs without breasts and cisgender males. However, there is no significant difference in sexual arousal between gynandromorphs without breasts and cisgender males.
BIOLOGICAL PSYCHOLOGY
(2023)
Article
Behavioral Sciences
Sophie Rosa van 't Hof, Nicoletta Cera
Summary: Most neuroimaging studies on sexual behavior focus on men, but future research should consider factors specific to women such as menstrual cycle and sexual orientation, as well as use more representative sexual stimuli. This review provides useful guidelines for more inclusive research on sexual arousal and may lead to more accurate neurobiological models.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Oncology
Ryan C. Perez, DaeHee Kim, Aaron W. P. Maxwell, Juan C. Camacho
Summary: The association between hypoxia, cancer aggressiveness, and decreased therapeutic response is well-established. This review aims to summarize the molecular pathways associated with tumor hypoxia and the use of PET and MRI techniques for imaging hypoxia in cancer. It also discusses future directions and challenges in this field.
Article
Clinical Neurology
Weixing Liu, Gui Chen, Junyang Xie, Tianhao Liang, Chunyi Zhang, Xiao Liao, Wenjing Liao, Lijuan Song, Xiaowen Zhang
Summary: A new coordinate system named W-X was developed and evaluated for MRI studies of the vestibular system. The results showed that it can accurately measure the orientations of the semicircular canals.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychology, Clinical
Luke Holmes, Tuesday M. Watts-Overall, Erlend Slettevold, Dragos C. Gruia, Jamie Raines, Gerulf Rieger
Summary: Research suggests that homosexual women tend to show more arousal towards their preferred sex, similar to a male pattern, compared to heterosexual women. While homosexual women exhibited more male-typical sexual responses, their digit ratios did not necessarily reflect this masculine pattern, indicating that factors other than digit ratios contribute to the link between sexual orientation and sexual responses. Homosexual women also displayed more masculinity than heterosexual women, but this masculinity was not directly related to their male-typical sexual arousal, suggesting that different factors may influence sexual and behavioral traits in women during different stages of gestation.
ARCHIVES OF SEXUAL BEHAVIOR
(2021)
Article
Psychology, Clinical
Lambert C. Heatlie, Lanna J. Petterson, Paul L. Vasey
Summary: Gynandromorphophilia refers to sexual attraction and arousal to feminine males, who may or may not have breasts, and retain their penises. This study examined Canadian cisgender gynephilic men's visual attention and subjective ratings of sexual arousal when presented with nude images of different gender expressions. The results suggest that female sex-based traits play a more primary role in gynephilic men's sexual arousal than feminine gender-based traits.
ARCHIVES OF SEXUAL BEHAVIOR
(2023)
Article
Biochemical Research Methods
Marius E. Mayerhoefer, Lale Umutlu, Heiko Schoeder
Summary: Lymphomas are ideal targets for radiomics due to their distinct characteristics, and functional imaging tests play a crucial role in diagnosing and predicting treatment outcomes for lymphoma. However, more data is needed to support the application of radiomics in lymphoma due to differences in lymphoma subtypes and increasing treatment options.
Article
Engineering, Multidisciplinary
Amir Mohammad Ghani Dehkordi, Alireza Kashaninia, Fardad Farokhi, Nader Jafarnia Dabanloo
Summary: This study presents a five-step algorithm to determine functional brain connections in Alzheimer's disease using Molecular Dynamics method in functional MRI images. The results indicate a significant decrease in memory connections over time in Alzheimer's patients.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2023)
Article
Neurosciences
Hui Wang, Jianxia Xu, Miao Yu, Gaiyan Zhou, Jingru Ren, Yajie Wang, Huifen Zheng, Yu Sun, Jun Wu, Weiguo Liu
Summary: This study aimed to explore the potential clinical utility of functional and structural magnetic resonance imaging (MRI) in the diagnosis of depression in Parkinson's disease (DPD). The results showed that both the ReHo value of the left dorsolateral superior frontal gyrus and the DC value of the left inferior temporal gyrus were equally well suited for the diagnosis and differential diagnosis of DPD, with a combination of them being slightly preferable. The multimodal MRI technique represents a promising approach for the classification of subjects with PD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Psychology, Clinical
Janice Attard-Johnson, Martin R. Vasilev, Caoilte O. Ciardha, Markus Bindemann, Kelly M. Babchishin
Summary: Pupillary responses can be used as an objective measure of sexual interest, showing clear associations with sexual orientation in men but smaller effects in women.
Bisexual men and lesbian women demonstrated unique pupillary responses to stimuli, with bisexual men showing greater dilation to male stimuli and lesbian women displaying greater dilation to male stimuli.
Methodological factors and the limited number of studies remain as significant influences on the research outcomes of pupillary measurement of sexual interest.
ARCHIVES OF SEXUAL BEHAVIOR
(2021)
Article
Clinical Neurology
Andra Braban, Robert Leech, Kevin Murphy, Fatemeh Geranmayeh
Summary: This study investigates the relationship between hemodynamic lag and cerebrovascular reactivity (CVR) following stroke using functional magnetic resonance imaging (fMRI). The findings suggest that the hemodynamic responses derived from fMRI can be affected by vascular insult, resulting in reduced magnitude and temporal delays in the response. However, the contribution of altered CVR to hemodynamic lag is negligible, and other factors, such as intrinsic neural network dynamics, may play a larger role.
Article
Neurosciences
Jianing Hao, Xintao Hu, Liting Wang, Lei Guo, Junwei Han
Summary: The study suggests that the human cerebellum is involved in a wide range of cognitive tasks beyond traditional motor control and can be divided into distinct functional subregions. By utilizing a naturalistic paradigm of fMRI, the research successfully identified different subregions of the cerebellum, providing an alternative template for exploring neural activities in naturalistic environments.
FRONTIERS IN NEUROSCIENCE
(2021)
Letter
Cardiac & Cardiovascular Systems
Elke R. Gizewski, Hannes Deutschmann, Michael Knoflach, Lukas Mayer-Suess, Thomas Gattringer
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Neurosciences
Noora Tuovinen, Nursen Yalcin-Siedentopf, Anna-Sophia Welte, Christian M. Siedentopf, Ruth Steiger, Elke R. Gizewski, Alex Hofer
Summary: The study investigated the relationship between personality traits, behavioral measures, and metabolite ratios, finding gender differences in metabolite correlates and personality traits.
Article
Biochemistry & Molecular Biology
Stephanie Mangesius, Lukas Haider, Lukas Lenhart, Ruth Steiger, Ferran Prados Carrasco, Christoph Scherfler, Elke R. Gizewski
Summary: Brain volumetric software is widely used in clinical practice, but the agreement across different software applications is limited. This study found moderate to low agreement among different applications in categorizing hippocampal volumes. Despite the quantitative differences, the volumetric measures derived from different software still differed significantly from the mean value.
Article
Oncology
Martha Nowosielski, Georg Goebel, Sarah Iglseder, Ruth Steiger, Lukas Ritter, Daniel Stampfl, Johanna Heugenhauser, Johannes Kerschbaumer, Elke R. Gizewski, Christian F. Freyschlag, Guenther Stockhammer, Christoph Scherfler
Summary: In this retrospective study, a quantitative textural analysis of apparent diffusion coefficient (ADC) images derived from diffusion weighted MRI (DW-MRI) of single brain metastases (BM) patients from different primary tumors was performed to test whether these imaging parameters may improve established clinical risk models. The results showed that textural analysis of ADC maps in patients with single brain metastases improved established clinical risk models, which may aid in understanding the pathogenesis of BM and selecting patients for new treatment options.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Neuroimaging
Hanna Styczen, Volker Maus, Lukas Goertz, Martin Koehrmann, Christoph Kleinschnitz, Sebastian Fischer, Markus Moehlenbruch, Iris Muehlen, Bernd Kallmuenzer, Franziska Dorn, Asadeh Lakghomi, Matthias Gawlitza, Daniel Kaiser, Joachim Klisch, Donald Lobsien, Stefan Rohde, Gisa Ellrichmann, Daniel Behme, Maximilian Thormann, Fabian Flottmann, Laurens Winkelmeier, Elke R. Gizewski, Lukas Mayer-Suess, Tobias Boeckh-Behrens, Isabelle Riederer, Randolf Klingebiel, Bjoern Berger, Martin Schlunz-Hendann, Dominik Grieb, Ali Khanafer, Richard du Mesnil de Rochemont, Christophe Arendt, Jens Altenbernd, Jan-Ulrich Schlump, Adrian Ringelstein, Vivian Jean Marcel Sanio, Christian Loehr, Agnes Maria Dahlke, Carolin Brockmann, Sebastian Reder, Ulrich Sure, Yan Li, Ruben Muehl-Benninghaus, Thomas Rodt, Kai Kallenberg, Alexandru Durutya, Mohamed Elsharkawy, Paul Stracke, Mathias Gerhard Schumann, Alexander Bock, Omid Nikoubashman, Martin Wiesmann, Hans Henkes, Pascal J. Mosimann, Rene Chapot, Michael Forsting, Cornelius Deuschl
Summary: There is limited data on the frequency and outcome of mechanical thrombectomy (MT) for large vessel occlusion (LVO) in COVID-19 patients. Our multicenter study found that most cases of LVO treated with MT in COVID-19 patients were due to cardioembolic events. While successful reperfusion was achieved in the majority of cases, there was a significant rate of procedure-related complications and poor clinical outcomes, with a high mortality rate.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vincent Beliveau, Christoph Birkl, Ambra Stefani, Elke R. Gizewski, Christoph Scherfler
Summary: The purpose of this study was to accurately predict susceptibility from homodyne-filtered phase images using convolutional neural networks. The results showed that the U-Net model provided more accurate voxel-wise predictions of susceptibility, while the HFP-QSMGAN model had stronger correlations with TGV-QSM in terms of regional estimates of susceptibility.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Clinical Neurology
Andrea Quattrone, Maria G. Bianco, Angelo Antonini, David E. Vaillancourt, Klaus Seppi, Roberto Ceravolo, Antonio P. Strafella, Gioacchino Tedeschi, Alessandro Tessitore, Roberto Cilia, Maurizio Morelli, Salvatore Nigro, Basilio Vescio, Pier Paolo Arcuri, Rosa De Micco, Mario Cirillo, Luca Weis, Eleonora Fiorenzato, Roberta Biundo, Roxana G. Burciu, Florian Krismer, Nikolaus R. McFarland, Christoph Mueller, Elke R. Gizewski, Mirco Cosottini, Eleonora Del Prete, Sonia Mazzucchi, Aldo Quattrone
Summary: This study developed an automated Magnetic Resonance Parkinsonism Index 2.0 (MRPI 2.0) algorithm to differentiate progressive supranuclear palsy-parkinsonism (PSP-P) from Parkinson's disease (PD) and validated its diagnostic performance in two large independent cohorts. The automated MRPI 2.0 showed excellent performance in distinguishing PSP-P from PD and control subjects in both cohorts, suggesting its generalizability. The use of the automated MRPI 2.0 algorithm could standardize measures in patients with PSP-P across centers and have a positive impact on multicenter studies and clinical trials.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Stephanie Alice Treichl, Wing Mann Ho, Ruth Steiger, Astrid Ellen Grams, Andreas Rietzler, Markus Luger, Elke Ruth Gizewski, Claudius Thome, Ondra Petr
Summary: This pilot study evaluated the feasibility and diagnostic potential of early 31P-MRS in patients with aneurysmal subarachnoid hemorrhage (aSAH). The results showed that 31P-MRS can detect significant changes in cerebral energy metabolism in different cerebrovascular territories, providing valuable information for understanding early brain injury.
FRONTIERS IN NEUROLOGY
(2022)
Review
Oncology
Malik Galijasevic, Ruth Steiger, Stephanie Mangesius, Julian Mangesius, Johannes Kerschbaumer, Christian Franz Freyschlag, Nadja Gruber, Tanja Janjic, Elke Ruth Gizewski, Astrid Ellen Grams
Summary: This review provides an insight into the use of magnetic resonance spectroscopy (MRS) in the diagnosis and follow-up of gliomas. It covers both proton and phosphorous MRS techniques in clinical and scientific practice, including preoperative grade prediction and post-treatment follow-up. The review also discusses the current research utility and possible future strategies of proton and phosphorous MRS in glioma research.
Article
Computer Science, Artificial Intelligence
Nadja Gruber, Malik Galijasevic, Milovan Regodic, Astrid Ellen Grams, Christian Siedentopf, Ruth Steiger, Marlene Hammerl, Markus Haltmeier, Elke Ruth Gizewski, Tanja Janjic
Summary: Segmentation of specific brain tissue from MRI volumes is crucial for brain disease diagnosis and monitoring. This paper presents an efficient deep learning approach using CNNs and multi-view segmentation models to improve segmentation performance. The proposed method is evaluated using expert rating and standard evaluation metrics, showing its competitive accuracy and clinical applicability.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2022)
Review
Oncology
Julian Mangesius, Stephanie Mangesius, Matthias Demetz, Christian Uprimny, Gianpaolo Di Santo, Malik Galijasevic, Danijela Minasch, Elke R. Gizewski, Ute Ganswindt, Irene Virgolini, Claudius Thome, Christian F. Freyschlag, Johannes Kerschbaumer
Summary: Radiation necrosis is a common problem in neuro-oncology, and interdisciplinary collaboration is necessary for image interpretation and patient management. This article provides an institutional guideline for using current imaging tools to differentiate radiation necrosis from tumor recurrence, and discusses therapeutic possibilities and future developments.
Article
Oncology
Valentin Karl Ladenhauf, Malik Galijasevic, Johannes Kerschbaumer, Christian Franz Freyschlag, Martha Nowosielski, Anna Maria Birkl-Toeglhofer, Johannes Haybaeck, Elke Ruth Gizewski, Stephanie Mangesius, Astrid Ellen Grams
Summary: MGMT-methylated glioblastomas have lower ADC values compared to glioblastomas without MGMT methylation in peritumoral white matter. There were no differences in enhancing tumor areas. These findings could improve predictions of MGMT status in glioblastomas.
Article
Oncology
Sarah Iglseder, Anna Iglseder, Vincent Beliveau, Johanna Heugenhauser, Elke R. Gizewski, Johannes Kerschbaumer, Guenther Stockhammer, Christian Uprimny, Irene Virgolini, Jozsef Dudas, Meinhard Nevinny-Stickel, Martha Nowosielski, Christoph Scherfler
Summary: This retrospective study aimed to analyze the correlation between somatostatin receptor subtypes (SSTR 1-5) and maximum standardized uptake value (SUVmax) in meningioma patients using Gallium-68 DOTA-D-Phe1-Tyr3-octreotide Positron Emission Tomography ([68Ga]Ga-DOTATOC PET). The study also developed a radiomic model based on apparent diffusion coefficient (ADC) maps derived from diffusion weighted magnetic resonance images (DWI MRI) to reproduce SUVmax. Results showed that SSTR subtypes 2A, 2B, and 5 correlated significantly with SUVmax in meningioma patients.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Medicine, General & Internal
Martin Bendszus, Jens Fiehler, Fabien Subtil, Susanne Bonekamp, Anne Hege Aamodt, Blanca Fuentes, Elke R. Gizewski, Michael D. Hill, Antonin Krajina, Laurent Pierot, Claus Z. Simonsen, Kamil Zelenak, Rolf A. Blauenfeldt, Bastian Cheng, Angelique Denis, Hannes Deutschmann, Franziska Dorn, Fabian Flottmann, Susanne Gellissen, Johannes C. Gerber, Mayank Goyal, Jozef Haring, Christian Herweh, Silke Hopf-Jensen, Vi Tuan Hua, Maerit Jensen, Andreas Kastrup, Christiane Fee Keil, Andrej Klepanec, Egon Kurca, Ronni Mikkelsen, Markus Moehlenbruch, Stefan Mueller-Huelsbeck, Nico Muennich, Paolo Pagano, Panagiotis Papanagiotou, Gabor C. Petzold, Mirko Pham, Volker Puetz, Jan Raupach, Gernot Reimann, Peter Arthur Ringleb, Maximilian Schell, Eckhard Schlemm, Silvia Schoenenberger, Bjorn Tennoe, Christian Ulfert, Katerina Valis, Eva Vitkova, Dominik F. Vollherbst, Wolfgang Wick, Goetz Thomalla
Summary: Endovascular thrombectomy is associated with improved functional outcome and lower mortality in patients with acute ischemic stroke from large vessel occlusion using non-contrast CT as the primary imaging modality for patient selection.
Article
Pediatrics
Maria Sappler, Nina Volleritsch, Marlene Hammerl, Yasmin Pellkofer, Elke Griesmaier, Elke Ruth Gizewski, Susanne Kaser, Ursula Kiechl-Kohlendorfer, Vera Neubauer
Summary: This study found that there was no impairment of brain development in GDM-exposed preterm infants compared to matched controls, but there were differences in white matter microstructure in specific regions indicating an enhanced maturation. However, neurodevelopmental outcome did not differ between the groups.