Article
Oncology
Xiaocui Zhong, Rui Ran, Shanhu Gao, Manlin Shi, Xian Shi, Fei Long, Yanqiu Zhou, Yang Yang, Xianglan Tang, Anping Lin, Wuyang He, Tinghe Yu, Ting-Li Han
Summary: This study investigates the metabolic characteristics of ovarian cancer (OC) and non-malignant diseases by analyzing biological samples from patients. The results show significant differences in metabolites between OC and non-malignant groups in ovarian tissue, plasma, and urine, but not in hair samples. Elevated glycolysis and TCA cycle intermediates are observed in OC tissue, indicating altered energy metabolism. The study also identifies specific metabolic changes in different biospecimens and finds potential biomarkers for distinguishing OC from control or benign ovarian tumor groups through machine learning modeling.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Xin Kang, Yanli Liu, Yi Gong, Lin Huang, Hongliang Liu, Minhan Hu, Ruitian Huang, Feihong Chen, Sijie Chen, Feiyu Zhang, Yujie Ning, Cheng Li, Rong Zhou, Hongmou Zhao, Xi Wang, Xiong Guo
Summary: This study aimed to detect the status of selenium and zinc in the urine of children from endemic areas of Kashin-Beck disease (KBD) over three consecutive years. The results showed that the selenium levels in children from KBD endemic areas were lower than normal, indicating the need for constant monitoring and adjustment of selenium supplementation.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Ana Maletic, Ivo Dumic-Cule, Petar Brlek, Rado Zic, Dragan Primorac
Summary: The study tested the efficacy of a new PRP application protocol that only requires two treatments, using a combination of a PRP collecting device and a conventional kit. The treatment showed significant effectiveness in the vertex region after six months, with increases in hair count, thickness, and follicular units.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Anon Paichitrojjana, Anand Paichitrojjana
Summary: Platelet rich plasma (PRP) is a plasma with higher concentrations of platelets than normal blood, initially used for treating thrombocytopenia but now widely used in the medical field for wound healing and tissue regeneration. Studies have shown its effectiveness in treating hair loss, although the exact mechanism of action is still not fully understood.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Daria Apostolo, Davide D'Onghia, Stelvio Tonello, Rosalba Minisini, Alessio Baricich, Carla Gramaglia, Filippo Patrucco, Patrizia Zeppegno, Antonio Acquaviva, Piero Emilio Balbo, Luigi Mario Castello, Giuseppe Cappellano, Annalisa Chiocchetti, Chiara Gerevini, Mara Giordano, Fatiha Laaguid, Marcello Manfredi, Davide Raineri, Cristina Rigamonti, Roberta Rolla, Valentina Romano, Marco Confalonieri, Paola Savoia, Elisa Zavattaro, Mario Pirisi, Barbara Ruaro, Pier Paolo Sainaghi, Mattia Bellan
Summary: Post-acute conditions are common after COVID-19, and the underlying mechanisms are not yet fully understood. This study suggests that Gas6 and its soluble receptors, sAxl and sMer, may be implicated in these conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Jungyoon Ohn, Ho-Young Son, Da-Ae Yu, Min Su Kim, Sijin Kwon, Won-Seok Park, Jong-Il Kim, Ohsang Kwon
Summary: This study investigated the clinical features and genetic characteristics of early onset Female Pattern Hair Loss (eFPHL), finding associations with androgen-related features and identifying significant SNPs. Further large-scale studies are required to validate these findings and gain deeper insights into the underlying pathophysiology of eFPHL.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Rocio Barragan, Cristina Sanchez-Gonzalez, Pilar Aranda, Jose Sorli, Eva M. Asensio, Olga Portoles, Carolina Ortega-Azorin, Laura V. Villamil, Oscar Coltell, Juan Llopis, Lorenzo Rivas-Garcia, Dolores Corella
Summary: This study aimed to investigate the association between trace elements and cardiovascular risk factors in a Mediterranean population. The results showed that higher plasma levels of trace elements (primarily Se, Cu, and Zn) were directly associated with elevated plasma lipids, while the mixture effect in urine was primarily associated with plasma glucose.
Article
Nutrition & Dietetics
Yaqin Tu, Guorun Fan, Nan Wu, Hao Wu, Hongjun Xiao
Summary: This study found a significant association between blood levels of cadmium and selenium with hearing loss, especially in adults aged 35-52. Among different genders, the hearing loss in men showed a dose-dependent relationship with blood selenium levels, while in women, only cadmium levels were associated with speech and high-frequency hearing loss.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Chemistry, Medicinal
Periyanaina Kesika, Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Muruganantham Bharathi, Chaiyavat Chaiyasut
Summary: Hair health is important for personal distress and psychological well-being. Various factors such as genetics, disease, lifestyle, and chemical exposure can affect hair health. Treatment options for hair problems include pharmacological and cosmeceutical procedures, with a growing interest in natural compounds-based remedies. Scientific studies have shown the potential of phytochemicals in managing hair loss and promoting hair growth. However, further research is needed to validate these findings and bring effective treatments to market.
Review
Medicine, General & Internal
Nicole Natarelli, Nimrit Gahoonia, Raja K. Sivamani
Summary: The hair cycle consists of four main phases: anagen, catagen, telogen, and exogen. Anagen is a phase characterized by hair shaft production, while catagen and telogen describe regression and resting phases of the hair follicle, ultimately resulting in hair shedding. Various factors can promote the transition from anagen to telogen, such as inflammation, hormones, stress, nutritional deficiency, poor sleep quality, and certain medications that inhibit cell division. On the other hand, increased blood flow, direct stimulation of the hair follicle, and growth factors promote the transition from telogen to anagen and subsequent hair growth. This review comprehensively discusses the hair cycle, the balance between anagen and telogen, factors affecting the transition between these phases, and the clinical usefulness of laboratory testing and evaluations. Overall, a holistic approach is necessary to address hair loss due to the multiple factors impacting the hair cycle.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychology, Biological
Sonia Valdivieso Barba, Clemens Kirschbaum, Wei Gao
Summary: The endocannabinoid system may not accurately reflect the levels of peripheral circulating endocannabinoids or N-Acylethanolamine. However, hair N-Acylethanolamine levels may be useful in studying certain psychological phenotypes such as stress.
BIOLOGICAL PSYCHOLOGY
(2023)
Article
Surgery
Abigail Meyers, Alison Jin, Grzegorz J. Kwiecien, James Gatherwright, Shilpi Khetarpal, James E. Zins
Summary: This study demonstrates that platelet-rich plasma (PRP) treatment can improve the quality of life for patients with hair loss, as assessed by the HAIRDEX 48 scale. Statistical analysis showed significant improvements in symptoms, functioning, emotions, stigmatization, and self-confidence domains after PRP treatment.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Yuehui Jia, Ruixiang Wang, Guijin Li, Chen Feng, Lei Qi, Yuanyuan Wang, Shengqi Su, Yuanjie Zou, Xu Liu, Yanan Wang, Yiyi Zhang, Linlin Du, Huixin Sun, Shuxiu Hao, Jie Hou, Hongqi Feng, Qi Li, Tong Wang
Summary: This research aimed to provide evidence for the prevention, control, and elimination of Keshan disease (KD) by assessing the selenium nutrition levels of residents. The study found that the hair selenium levels of inhabitants in KD endemic areas were significantly lower compared to non-endemic areas, and a higher proportion of residents in KD endemic areas were selenium-deficient or marginally deficient. Provinces such as Shannxi, Heilongjiang, and Gansu should be given high priority in KD prevention and control.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yaqing Liu, Zongzhang Wang, Yiru Wang, Yushuo Feng, Mengjiao Xu, Xiaoqian Ma, Qianqian Shi, Huaping Deng, Fangfang Ren, Yong Chen, Hongmin Chen
Summary: A Ca-DEX biomineralization-inducing nut (CaCO3-DEX) with controlled release properties is proposed to mitigate the toxic side effects of long-term administration of DEX in rheumatoid arthritis (RA) treatment, especially the damage to cartilage and bone. CaCO3-DEX releases the drug and Ca2+ preferentially in an inflammatory environment, significantly reduces the secretion of pro-inflammatory factors, inhibits ROS production, and demonstrates superior pro-biomineralization and osteogenic differentiation potential. In a mouse model, CaCO3-DEX significantly reduces the clinical score of arthritis, improves edema and bone erosion, and reduces inflammatory factors at the injury areas, providing favorable protection to cartilage and bone.
Article
Public, Environmental & Occupational Health
Nurfatehar Ramly, Husna Maizura Ahmad Mahir, Wan Nurul Farah Wan Azmi, Zailina Hashim, Jamal Hisham Hashim, Rafiza Shaharudin
Summary: A comparative cross-sectional study was conducted in two villages in Malaysia to assess the prevalence of arsenicosis and determine the arsenic concentrations in drinking water and hair. The results showed that 41% of water samples from one village exceeded the safe level of arsenic, while none of the samples from the other village did. Additionally, 13.5% of the respondents had arsenic levels above the safe limit in their hair. Factors such as living in the high arsenic village, being female, increasing age, and smoking were significantly associated with higher arsenic levels in hair. Immediate mitigation actions are needed to reduce the risk of arsenicosis in the exposed village.
FRONTIERS IN PUBLIC HEALTH
(2023)
