期刊
HORMONES AND BEHAVIOR
卷 64, 期 1, 页码 95-102出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2013.05.005
关键词
NPY Y1 receptor; NF-kappa B; NPY; MC4R; Hypothalamus
资金
- National Science Council in Taiwan, ROC [NSC-101-2320-B-040-002-MY3]
Neuropeptide Y (NPY) and nuclear factor-kappa B (NF-kappa B) are involved in regulating anorexia elicited by phenylpropanolamine (PPA), a sympathomimetic drug. This study explored whether NPY Y1 receptor (Y1R) is involved in this process, and a potential role for the proopiomelanocortin system was identified. Rats were given PPA once a day for 4 days. Changes in the hypothalamic expression of the NPY, Y1R, NF-kappa B, and melanocortin receptor 4 (MC4R) levels were assessed and compared. The results indicated that food intake and NPY expression decreased, with the largest reductions observed on Day 2 (approximately 50% and 45%, respectively), whereas NF-kappa B, MC4R, and Y1R increased, achieving maximums on Day 2 (160%, 200%, and 280%, respectively). To determine the role of Y1R, rats were pretreated with Y1R antisense or a Y1R antagonist via intracerebroventricular injection 1 h before the daily PPA dose. Y1R knockdown and inhibition reduced PPA anorexia and partially restored the normal expression of NPY, MC4R, and NF-kappa B. The data suggest that hypothalamic Y1R participates in the appetite-suppression from PPA by regulating MC4R and NF-kappa B. The results of this study increase our understanding of the molecular mechanisms in PPA-induced anorexia. (C) 2013 Elsevier Inc. All rights reserved.
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