Article
Genetics & Heredity
Linn Amanda Syding, Agnieszka Kubik-Zahorodna, David Pajuelo Reguera, Petr Nickl, Bohdana Hruskova, Michaela Kralikova, Jana Kopkanova, Vendula Novosadova, Petr Kasparek, Jan Prochazka, Jan Rozman, Rostislav Turecek, Radislav Sedlacek
Summary: Stress responses can lead to pathological conditions if there is prolonged secretion of glucocorticoids or inappropriate behavioral responses. In this study, we found that Gabra5 deficiency, which is linked to anxiety disorders, is associated with decreased anxiety and stress response. However, this phenotype was not observed in traditional anxiety behavior tests.
Article
Psychology, Biological
Julliet Araujo de Souza, Matilde Cesiana da Silva, Jose Candido de Souza Ferraz Junior, Felipe Leitao de Souza, Sandra Lopes de Souza
Summary: Maternal care in early life is crucial for the growth and development of offspring. This study compared the effects of maternal separation during the light and dark phases of the circadian cycle on the behavior and physiology of adult male rats. The results showed that light-phase stress had a greater impact on emotional behavior during the first two weeks of life, while dark-phase stress had a greater impact on the functioning of the Hypothalamus-Pituitary-Adrenal axis. The study provides empirical support for the effects of early-life stress on offspring.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Neurosciences
Maria Willadsen, Rainer K. W. Schwarting, Markus Woehr
Summary: Rats communicate through ultrasonic vocalizations and acute treatment with the SSRI escitalopram (ESC) increases anxiety-related behavior and affects ultrasonic communication.
Article
Neurosciences
Fatemeh Babaei, Mohammadreza Mirzababaei, Ghazaleh Mohammadi, Leila Dargahi, Marjan Nassiri-Asl
Summary: Anxiety is the brain's response to dangerous or stressful situations. Exposure to stressors can cause gut microbiota dysbiosis and activate the hypothalamic-pituitary-adrenal (HPA) axis, leading to the secretion of glucocorticoids associated with anxiety. Recent studies have reported that probiotics can attenuate anxiety-like behaviors by modulation of the gut microbiome composition. The present study aimed to investigate the effects of Saccharomyces boulardii (Sb) administration on anxiety-like behaviors induced by lipopolysaccharide (LPS) in rats. The results revealed that S. boulardii could attenuate LPS-induced anxiety-like behaviors, probably through modulation of the HPA axis and the gut microbiome. Oral administration of S. boulardii significantly attenuated the elevated levels of cortisol and corticosterone in the LPS-induced model, and also alleviated the decremental effect of LPS on the serum serotonin and BDNF levels.
NEUROSCIENCE LETTERS
(2022)
Article
Pharmacology & Pharmacy
Mohamed Z. Elhussiny, Haruka Nishimura, Phuong Tran, Shogo Haraguchi, Elizabeth R. Gilbert, Mark A. Cline, Takashi Bungo, Mitsuhiro Furuse, Vishwajit S. Chowdhury
Summary: The objective of this study was to investigate the mechanism of brain monoamine metabolism in taurine-induced hypothermia and appetite suppression. Central taurine activates dopamine-beta-hydroxylase and tryptophan hydroxylase to produce norepinephrine and 5-HT, which then induces hypothermia and anorexia, respectively.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Psychology, Biological
Sarah Fourman, Dana Buesing, Sean Girvin, Houda Nashawi, Yvonne M. Ulrich-Lai
Summary: The study suggests that palatable foods can reduce stress responses regardless of their sugar or carbohydrate content. Male rats showed reduced stress responses and improved behavior after limited intake of cheese, indicating that the rewarding nature of delicious foods contributes to stress relief.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
K. Hohlbaum, R. Merle, S. Frahm, A. Rex, R. Palme, C. Thoene-Reineke, K. Ullmann
Summary: In laboratory animal facilities, it is common to house female mice in groups, but some experimental conditions require individual housing. This study introduced a separated pair housing system and examined its effects on the well-being of adult female mice. The results showed that the separated pair housing system improved nesting and burrowing behavior, but decreased locomotor activity.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Mega O. Oyovwi, Eze K. Nwangwa, Benneth Ben-Azu, Tesi P. Edesiri, Victor Emojevwe, John C. Igweh
Summary: This study demonstrates that taurine and COQ-10 can prevent and reverse the effects of chlorpromazine on reproductive, thyroid hormones, dopamine levels, corticosterone release, neurodegenerations, and cataleptic behavior in rats.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Neurosciences
C. A. Favoretto, N. B. Bertagna, T. Righi, B. T. Rodolpho, A. Anjos-Santos, F. B. R. Silva, P. C. Bianchi, F. C. Cruz
Summary: The study evaluated the effects of chronic maternal separation (MS) on ethanol intake and striatal Fos expression induced by ethanol consumption. It also analyzed the impacts of MS on anxiety- and depressive-like behaviors, as well as locomotor and plasma corticosterone responses to ethanol treatment in adolescent mice. The results showed that MS transiently increased ethanol intake, but did not affect Fos expression, behavioral parameters, locomotor activity, or plasma corticosterone response.
NEUROSCIENCE LETTERS
(2023)
Article
Behavioral Sciences
Luana A. Chagas, Tatiane H. Batista, Ana Claudia A. F. Ribeiro, Mariela S. Ferrari, Jadina S. Vieira, Viviana C. T. Rojas, Bruna Kalil-Cutti, Lucila L. K. Elias, Alexandre Giusti-Paiva, Fabiana C. Vilela
Summary: This study found that gestational PTSD affected maternal behavior, led to anxiety-like symptoms, increased corticosterone levels, and increased GR expression in the offspring's hippocampus.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Ahmad Sarikhani, Shadi Vosoughi Zadeh, Saeed Tahmasebi, Bahareh Khalajabadi Farahani, Maryam Heydari Nik, Hamid Reza Mohajerani
Summary: The effects of maternal probiotics during pregnancy and consumption by offspring in the post-weaning period on anxiety behavior were examined. The results showed that probiotics could protect against foot shock stress-induced anxiety and regulate the expression of anxiety-related genes. Probiotics also had an impact on sex hormones.
NUTRITIONAL NEUROSCIENCE
(2023)
Review
Cell Biology
Fei Huang, Xiaojun Wu
Summary: Researches show that gut microbiota play a crucial role in neurotransmitter modulation in the brain, which is closely related to the pathophysiology of anxiety and depression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alaa M. Hammad, Ala A. Alhusban, Lujain F. Alzaghari, Fawaz Alasmari, Youssef Sari
Summary: Cigarette smoke withdrawal can cause anxiety-like behavior and modulate neurotransmitter-related proteins in the brain. The concentrations of neurotransmitters in the amygdala and hippocampus were examined after cigarette smoke exposure with and without aspirin treatment. The results showed that cigarette smoke withdrawal induced anxiety behaviors and increased tissue content of dopamine, serotonin, glutamate, glutamine, and GABA, while aspirin treatment reduced anxiety and reversed the effects of cigarette smoke exposure on neurotransmitter levels.
Article
Multidisciplinary Sciences
Min-Kyung Joo, Yoon-Jung Shin, Dong-Hyun Kim
Summary: Antibiotics, particularly cefaclor, may cause anxiety and depression through gut dysbiosis and altered central serotonin expression. Targeting antibiotics-resistant pathogenic bacteria could be a promising therapeutic strategy for anxiety and depression.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Ferda Hosgorler, Erhan Caner Akkaya, Rabia Ilgin, Basar Koc, Servet Kizildag, Hikmet Gumus, Nazan Uysal
Summary: The aim of the study was to investigate the differences in empathy-like behavior between old and adult rats, and the effects of neurochemicals and emotional situations on this behavior. The study found that empathy-like behavior deteriorated in old rats, and anxiety signs were more pronounced. Midazolam may improve this behavior by reducing anxiety.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Surgery
Renee Michele Girbig, Jasmin Baier, Rupert Palme, Rene Tolba, Anne Rix, Fabian Kiessling
Summary: This study aimed to investigate the possible effects of ultrasound imaging on the welfare of healthy mice and explore the potential influence of ultrasound and molecular ultrasound on the well-being and therapy response in breast cancer-bearing mice. The results showed that repeated ultrasound examinations had no detectable impact on the welfare of healthy and tumor-bearing mice. However, the combination of ultrasound and isoflurane anesthesia may attenuate immunological processes in tumor-bearing animals and affect responses to antitumor therapy.
EUROPEAN SURGICAL RESEARCH
(2023)
Article
Surgery
Anna Maria Kuemmecke, Leonie Zieglowski, Lisa Ernst, Rupert Palme, Rene H. Tolba
Summary: This study investigated sex differences in rats following partial hepatectomy. The results suggest that males and females respond similarly, indicating the importance of examining both sexes in translational research. However, further investigation is needed to explore a broader spectrum of measures.
EUROPEAN SURGICAL RESEARCH
(2023)
Article
Biodiversity Conservation
Kwaslema Malle Hariohay, Louis Hunninck, Peter S. Ranke, Robert D. Fyumagwa, Rupert Palme, Eivin Roskaft
Summary: Understanding the drivers of animal population decline requires considering the combined effects of human activities, environmental changes, and social contexts. Hunting increases stress levels in animals, while forage availability and temperature variability decrease stress levels. Group size affects stress levels differently for different species. Therefore, the management of protected areas and monitoring of hunting quotas are important for maintaining stable animal populations.
CONSERVATION PHYSIOLOGY
(2023)
Article
Zoology
Olivier Kaisin, Felipe Bufalo, Rodrigo Amaral, Rupert Palme, Pascal Poncin, Fany Brotcorne, Laurence Culot
Summary: By using non-invasive methods, the study explored the relationship between glucocorticoid levels and behavior in black lion tamarins. The results showed that fecal glucocorticoid metabolite levels varied according to changes in activity and resting time on a long-term scale, and were influenced by interspecific competition on a short-term scale. These findings provide insights into the physiological stress responses of wild species to environmental and social pressures.
AMERICAN JOURNAL OF PRIMATOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
C. Toinon, S. Waiblinger, R. Palme, J. -L. Rault
Summary: Early maternal deprivation has long-term effects on the social behavior and stress-coping strategy of goat kids. In this study, we investigated the effects of early maternal deprivation on 18-month-old goats, and found differences in their social behaviors and responses to stressors between goats raised with their dams and those artificially reared.
Editorial Material
Biochemistry & Molecular Biology
Flavia Santamaria, Rupert Palme, Rolf Schlagloth
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lydia Smith Osborne, Anh Duorg, Alexis Resendez, Rupert Palme, Jonathan P. Fadok
Summary: Social species form dominance hierarchies to ensure survival and promote reproductive success. Female hierarchies are thought to be less despotic and rank is conferred by intrinsic traits. Both social buffering and elevated social status confer resilience to chronic stress. In this study, we investigate how female social hierarchies and individual traits influence stress resilience. The results show that stable female hierarchies emerge rapidly and individual traits are characteristic of rank. Female rank is associated with behavior, stress status, and neurobiology. Hierarchies exert context-specific influence upon stress outcomes.
Article
Ecology
Phoebe D. Edwards, Rupert Palme, Rudy Boonstra
Summary: Chronic stress is hypothesized to play a role in population cycles. Our study found that high density does not directly impair the stress axis in meadow voles, but high density populations have elevated glucocorticoid levels early in the breeding season and decreased levels towards late summer.
Article
Ecology
Lucas D. Lalande, Emmanuelle Gilot-Fromont, Jeffrey Carbillet, Francois Debias, Jeanne Duhayer, Jean-Michel Gaillard, Jean-Francois Lemaitre, Rupert Palme, Sylvia Pardonnet, Maryline Pellerin, Benjamin Rey, Pauline Vuarin
Summary: Environmental fluctuations affect the secretion of glucocorticoids (GCs) in animals, which are used as an indicator of individual stress levels. This study found that a higher baseline level of GCs is negatively correlated with body mass, regardless of the environmental context, but might vary according to an individual's life history stage.
Article
Agriculture, Dairy & Animal Science
Marisol Parada Sarmiento, Lydia Lanzoni, Leandro Sabei, Matteo Chincarini, Rupert Palme, Adroaldo Jose Zanella, Giorgio Vignola
Summary: This study demonstrates that lameness in pregnant sows can lead to decreased placental efficiency in inactivating stress hormones, potentially impacting the welfare of the offspring. Therefore, greater attention should be paid to the lameness of sows as it may affect the welfare of both the sow and her offspring.
Article
Agriculture, Dairy & Animal Science
Sara Corsetti, Eugenia Natoli, Rupert Palme, Emanuela Viggiano
Summary: Shelters are stressful environments for domestic dogs. Evaluating dogs' welfare is crucial to improve their life condition and to promote a better management of shelters. This research aimed to analyse the physiological and behavioural responses of dogs in different environmental conditions. The presence of conspecifics is the best way to reduce stress in shelter dogs. This research could provide some useful guidelines for managing shelters and improving dogs' life condition.
Article
Zoology
Jeffrey Carbillet, Rupert Palme, Marie-Line Maublanc, Nicolas Cebe, Emmanuelle Gilot-Fromont, Helene Verheyden, Benjamin Rey
Summary: The use of fecal corticosteroid metabolites (FCMs) is suitable for assessing adrenocortical activity in wildlife. However, sample preservation and storage can affect FCM stability and result interpretations. It is generally acceptable to temporarily store samples at low above-zero temperature before freezing them. This study found that storing feces at +4 degrees C for 24 h and 48 h before freezing resulted in a decrease in FCM levels over time.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Dorota Kidawa, Katarzyna Wojczulanis-Jakubas, Dariusz Jakubas, Rupert Palme, Mateusz Barcikowski
Summary: This study found individual differences in chick calls of little auks and a high acceptance rate of cross-fostered chicks by parents. This suggests the potential usage of vocal recognition in offspring identification by seabirds, although parents may disregard individual characteristics enabling chick discrimination.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Anna Staffeld, Sadaf Gill, Annelie Zimmermann, Natalie Boege, Katharina Schuster, Stephan Lang, Markus Kipp, Rupert Palme, Linda Frintrop
Summary: This study aimed to establish a murine AN model and found that only when the weight reduction reached 25%, the AN-related symptoms could be observed. These findings provide new targets for the study of the pathophysiology and treatment interventions of AN.
Article
Biology
Martina Stocker, Eoin P. O'Sullivan, Rupert Palme, Eva Millesi, Ruth Sonnweber
Summary: Glucocorticoids (GCs) are mammalian steroid hormones that play important roles in various physiological processes. Measuring GC levels, especially in saliva samples, can provide valuable information for conservation and welfare assessment in animal populations. This study validated the method of measuring salivary GC levels using high-pressure liquid chromatography and enzyme immunoassay in squirrel monkeys and brown capuchin monkeys. Our findings support the reliability of salivary cortisol measurements and their potential use in research and welfare assessment for these non-human primates.
Article
Behavioral Sciences
Farrah N. Madison, Verner P. Bingman, Tom Smulders, Christine R. Lattin
Summary: Although research on the avian hippocampus has been limited, it is crucial for understanding its evolution and changes over time. The avian hippocampus plays important roles in spatial cognition as well as regulating anxiety, approach-avoidance behavior, and stress responses. Future research should focus on elucidating the cellular and molecular mechanisms, including endocrinology, to resolve outstanding questions about avian hippocampal function and organization.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Judith A. H. Smit, Riet Vooijs, Peter Lindenburg, Alexander T. Baugh, Wouter Halfwerk
Summary: This study investigates the effects of urbanization on hormone levels in tungara frogs and found that urban frogs and forest frogs have different endocrine phenotypes. Exposure to urban noise and light pollution led to an increase in testosterone and a decrease in corticosterone in urban frogs, while forest frogs showed no endocrine response to sensory pollutants. These results suggest that urbanization can modulate hormone levels and influence behavior in frogs.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Hannah D. Fulenwider, Yangmiao Zhang, Andrey E. Ryabinin
Summary: Social hierarchies have significant effects on overall health of individuals in animal groups, particularly the lowest-ranking individuals. Tube test can be used to determine social rank in male and female mice, and the complex interactions between social rank, sex, environment, and testing length influence peptide levels.
HORMONES AND BEHAVIOR
(2024)
