Article
Cell Biology
Jose Erik Alvarez-Contino, Estela Diaz-Sanchez, Marina Mirchandani-Duque, Jose Andres Sanchez-Perez, Miguel A. Barbancho, Alexander Lopez-Salas, Natalia Garcia-Casares, Kjell Fuxe, Dasiel O. Borroto-Escuela, Manuel Narvaez
Summary: This study found that intranasal infusion of GALR2 and Y1R agonists promotes neuroblast proliferation and induces the expression of the neurotrophic factor BDNF in the ventral hippocampus, resulting in antidepressant effects. These effects may be mediated by increased formation of Y1R-GALR2 heteroreceptor complexes. These findings may provide a new approach for the development of novel therapies for major depressive disorder.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Integrative & Complementary Medicine
Pit Shan Chong, Chi Him Poon, Jaydeep Roy, Ka Chun Tsui, Sze Yuen Lew, Michael Weng Lok Phang, Rachael Julia Yuenyinn Tan, Poh Guat Cheng, Man-Lung Fung, Kah Hui Wong, Lee Wei Lim
Summary: Hericium erinaceus exerts antidepressant effects by promoting neurogenesis and reducing neuroinflammation through enhancing the BDNF-TrkB-CREB signaling pathway. The neurogenesis blocker temozolomide completely eliminates the antidepressant-like effects of HE, and HE induces anti-neuroinflammatory effects by decreasing astrocyte activation in the hippocampus.
Article
Neurosciences
Ye Li, Cuiqin Fan, Rui Gao, Tian Lan, Wenjing Wang, Shu Yan Yu
Summary: The study reveals that altered levels of miR-211-5p in the hippocampal DG area have a significant impact on neurogenesis, apoptosis, and depression-like behaviors in rats. Specifically, up-regulation of miR-211-5p can alleviate depression-like behaviors, reduce neuronal apoptosis, and promote neuronal regeneration; while down-regulation of miR-211-5p can induce depression-like behaviors, increase neuronal apoptosis, and decrease neuronal regeneration.
Article
Pharmacology & Pharmacy
Frank Adu-Nti, Xu Gao, Jia-Min Wu, Jing Li, Javed Iqbal, Riaz Ahmad, Xin-Ming Ma
Summary: This study found that Osthole (OST) can improve ovariectomy-induced cognitive impairment, alleviate anxiety and depression-like behaviors, and reverse alterations in hippocampal protein levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Edith Araceli Cabrera-Munoz, Gerardo Bernabe Ramirez-Rodriguez, Lizeth Diaz-Yanez, Veronica Reyes-Galindo, David Meneses-San Juan, Nelly Maritza Vega-Rivera
Summary: Melatonin, synthesized by the pineal gland, has neuroprotective and neurodevelopmental effects. It acts as an antidepressant by regulating the generation of new neurons. In this study, melatonin was shown to prevent the harmful effects of temozolomide, a chemotherapeutic drug, on depression-like behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Eydie L. Moses-Kolko, Layla Banihashemi, Alison E. Hipwell
Summary: The study found that hippocampal gray matter volume was inversely associated with positive maternal caregiving, while similar findings in the vmPFC did not remain significant after correction for multiple comparisons. ELS, particularly physical assault, was associated with reduced GM volumes, but was unrelated to observed maternal caregiving.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Il Bin Kim, Seon-Cheol Park
Summary: Depression is characterized by impairments in adult neurogenesis, particularly in the hippocampus. Disruption of hippocampal neurogenesis in depression may be a consequence of neural circuitry impairments, with the entorhinal cortex playing a regulatory role. However, the exact mechanisms by which disruption of neural circuitry leads to neurogenesis impairments in depression, specifically regarding the regulatory role of the entorhinal cortex, remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Ebrahim Samodien, Nireshni Chellan
Summary: Obesity and anxiety are public health problems with no effective cure, and are related to each other with unclear mechanisms. The hypothalamus and hippocampus play vital roles in neurogenesis and understanding these disorders. Interventional therapies can affect neurogenesis in these areas, potentially offering therapeutic benefits for obesity and anxiety.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Binglu Ye, Yawei Yuan, Rui Liu, Haitao Zhou, Yujie Li, Zhihao Sheng, Tianyu Li, Bing Zhang, Zhendong Xu, Yang Li, Zhiqiang Liu
Summary: Hormonal fluctuations during the postpartum period can induce depressive-like behaviors and disrupt neurotransmission. The blunted Wnt signaling pathway is implicated in the deficits of synaptic transmission and behaviors. Restoring Wnt signaling can alleviate anhedonia symptoms and rebalance the excitation/inhibition ratio in the brain.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gerardo Bernabe Ramirez-Rodriguez, Nelly Maritza Vega-Rivera, David Meneses-San Juan, Leonardo Ortiz-Lopez, Erika Montserrat Estrada-Camarena, Monica Flores-Ramos
Summary: The study found that fluoxetine, environmental enrichment, and their combination had significant effects on depressive-associated behavior, with fluoxetine reversing anhedonia and the environmental enrichment improving the coat deterioration and anhedonia. Additionally, the combination of fluoxetine and environmental enrichment showed more significant effects than fluoxetine alone on certain events of the neurogenic process, indicating that environmental enrichment enhances the benefits of pharmacological treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Desiree R. Seib, Oren Princz-Lebel, Erin R. Chahley, Stan B. Floresco, Jason S. Snyder
Summary: A fundamental trait of depression is low motivation. This study used a rat model to investigate the role of adult hippocampal neurogenesis in motivation and found that reducing neurogenesis decreased response vigor to obtain rewards, providing further insights into how neurogenesis shapes depression.
Article
Behavioral Sciences
Elena Hernandez-Hernandez, Sandra Ledesma-Corvi, Fernando Yanez-Gomez, Celia Garau, Laura Galvez-Melero, Andrea Bagan, Carmen Escolano, M. Julia Garcia-Fuster
Summary: In this study, the researchers investigated the potential effects of two I2 drugs, CR4056 and B06, on male and female rats exposed to early-life stress. They found that CR4056 showed antidepressant-like effects in both male and female rats, but its efficacy in females was dependent on prior early-life stress exposure. In contrast, B06 had no antidepressant-like effects in either male or female rats. The study also identified some molecular differences underlying the therapeutic response of CR4056 between sexes.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Review
Biochemistry & Molecular Biology
Il Bin Kim, Seon-Cheol Park
Summary: Depression affects both neural circuitry and neurogenesis, with defects in hippocampal activity and volume associated with depression-related behaviors. However, the mechanisms by which defective neural circuitry induces neurogenesis defects in depression remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Shan Xu, Xiaofeng Zhao, Zhaoqiong Zhu, Miao He, Xue Zheng, Xiaoxi Zhang
Summary: Studies have suggested that dexmedetomidine (DEX) may have potential antidepressant effects, but there is a lack of research on its effects in depression caused by chronic pain. This study found that DEX dose-dependently alleviated depression induced by chronic pain by promoting neurogenesis in the dentate gyrus (DG) region of the hippocampus.
Review
Biochemistry & Molecular Biology
Gabriel Berdugo-Vega, Shonali Dhingra, Federico Calegari
Summary: This article reviews a wealth of research in cellular, anatomical, behavioral, and computational studies on the mammalian hippocampus, aiming to understand the fundamental mechanisms underlying cognition. Despite accumulating knowledge on how the hippocampus processes and stores information for learning and memory, our understanding of hippocampal cognitive function remains incomplete. The article discusses the structural separability of the two blades of the dentate gyrus in the hippocampus and proposes a model that suggests differences in connectivity and adult neurogenesis in the two blades may contribute to subtly different cognitive functions.
Review
Neurosciences
Shunya Yagi, Liisa A. M. Galea
NEUROPSYCHOPHARMACOLOGY
(2019)
Review
Endocrinology & Metabolism
Paula Duarte-Guterman, Benedetta Leuner, Liisa A. M. Galea
FRONTIERS IN NEUROENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Wansu Qiu, Travis E. Hodges, Emily L. Clark, Samantha A. Blankers, Liisa A. M. Galea
FRONTIERS IN NEUROENDOCRINOLOGY
(2020)
Article
Behavioral Sciences
Dannia Islas-Preciado, Steven R. Wainwright, Julia Sniegocki, Stephanie E. Lieblich, Shunya Yagi, Stan B. Floresco, Liisa A. M. Galea
HORMONES AND BEHAVIOR
(2020)
Article
Psychology, Clinical
Kelly J. Murphy, Travis E. Hodges, Paul A. S. Sheppard, Angela K. Troyer, Elizabeth Hampson, Liisa A. M. Galea
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2020)
Article
Endocrinology & Metabolism
Wansu Qiu, Kimberly A. Go, Yvonne Lamers, Liisa A. M. Galea
Summary: Perinatal depression affects 15% of mothers, with SSRIs as the first-line treatment but not always effective. Inflammation and tryptophan-kynurenine metabolic pathway (TKP) are associated with SSRI efficacy, with higher neurotoxic pathway metabolite concentrations linked to depression onset. The study in a rodent model of de novo postpartum depression found maternal postpartum CORT increased neurotoxic metabolites and SSRI treatment had limited influence on TKP metabolites.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Gina S. Ogilvie, Shanlea Gordon, Laurie W. Smith, Arianne Albert, C. Sarai Racey, Amy Booth, Anna Gottschlich, David Goldfarb, Melanie C. M. Murray, Liisa A. M. Galea, Angela Kaida, Lori A. Brotto, Manish Sadarangani
Summary: The study found that 79.8% of respondents intended to receive a COVID-19 vaccine. Factors such as vaccine attitudes, direct social norms, and influencers like family physicians and Provincial Health Officers were associated with intention to vaccinate. However, certain populations, such as females, those with lower education levels, minority groups, Indigenous people, and non-health care workers, reported lower intention to receive the vaccine.
Article
Endocrinology & Metabolism
P. A. Sheppard, T. A. Puri, L. A. Galea
NEUROENDOCRINOLOGY
(2022)
Editorial Material
Neurosciences
Jennifer E. Richard, Liisa A. M. Galea
BIOLOGICAL PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Amy M. Inkster, Paula Duarte-Guterman, Arianne Y. Albert, Cindy K. Barha, Liisa A. M. Galea, Wendy P. Robinson
Summary: Sex, cognitive impairment diagnosis, and APOE ε4 allele load are not associated with epigenetic age acceleration in Alzheimer's disease, but females exhibit more accelerated epigenetic aging in the transition from normal cognition to cognitive impairment using the Skin & Blood clock.
NEUROBIOLOGY OF AGING
(2022)
Article
Multidisciplinary Sciences
Rebecca K. Rechlin, Tallinn F. L. Splinter, Travis E. Hodges, Arianne Y. Albert, Liisa A. M. Galea
Summary: Sex differences exist in many neurological and psychiatric diseases, but research has not adequately addressed this issue. It is necessary to incorporate sex into study design and analysis, but progress in this area has been insufficient.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Shunya Yagi, Amanda Lee, Nadine Truter, Liisa A. M. Galea
Summary: From the results of the study, it can be seen that females showed significant sex differences compared to males in context discrimination. Although fear memory was similar between the two sexes, there were differences in activation patterns in different neural regions, with females showing more negative correlations and activation. These findings highlight the importance of studying sex differences in fear memory and the contribution of adult neurogenesis to the neuronal network.
BIOLOGY OF SEX DIFFERENCES
(2022)
Review
Neurosciences
Tanvi A. Puri, Jennifer E. Richard, Liisa A. M. Galea
Summary: Growing attention is given to the inclusion of females in neuroscience studies and studying sex as a biological variable. However, there is limited research on how female-specific factors like menopause and pregnancy affect the brain. This review focuses on pregnancy as a unique female experience that can impact neuroplasticity, neuroinflammation, and cognition, highlighting studies in humans and rodents.
TRENDS IN NEUROSCIENCES
(2023)
Article
Endocrinology & Metabolism
Tori N. Stranges, Amanda B. Namchuk, Tallinn F. L. Splinter, Katherine N. Moore, Liisa A. M. Galea
Summary: Sex and gender play a significant role in health outcomes, yet the health of women and 2S/LGBTQ+ individuals is often compromised. The CIHR implemented a framework to incorporate sex and gender analysis into grant proposals, but only a small percentage of funded grants mentioned sex or gender. There is a need for greater emphasis on sex, gender, and health equity populations in research.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Endocrinology & Metabolism
Paula Duarte-Guterman, Stephanie E. Lieblich, Steven R. Wainwright, Carmen Chow, Jessica A. Chaiton, Neil V. Watson, Liisa A. M. Galea
Article
Behavioral Sciences
Farrah N. Madison, Verner P. Bingman, Tom Smulders, Christine R. Lattin
Summary: Although research on the avian hippocampus has been limited, it is crucial for understanding its evolution and changes over time. The avian hippocampus plays important roles in spatial cognition as well as regulating anxiety, approach-avoidance behavior, and stress responses. Future research should focus on elucidating the cellular and molecular mechanisms, including endocrinology, to resolve outstanding questions about avian hippocampal function and organization.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Judith A. H. Smit, Riet Vooijs, Peter Lindenburg, Alexander T. Baugh, Wouter Halfwerk
Summary: This study investigates the effects of urbanization on hormone levels in tungara frogs and found that urban frogs and forest frogs have different endocrine phenotypes. Exposure to urban noise and light pollution led to an increase in testosterone and a decrease in corticosterone in urban frogs, while forest frogs showed no endocrine response to sensory pollutants. These results suggest that urbanization can modulate hormone levels and influence behavior in frogs.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Hannah D. Fulenwider, Yangmiao Zhang, Andrey E. Ryabinin
Summary: Social hierarchies have significant effects on overall health of individuals in animal groups, particularly the lowest-ranking individuals. Tube test can be used to determine social rank in male and female mice, and the complex interactions between social rank, sex, environment, and testing length influence peptide levels.
HORMONES AND BEHAVIOR
(2024)