Article
Endocrinology & Metabolism
Ling Hou, Ke Huang, Chunxiu Gong, Feihong Luo, Haiyan Wei, Liyang Liang, Hongwei Du, Jianping Zhang, Yan Zhong, Ruimin Chen, Xinran Chen, Jiayan Pan, Xianjiang Jin, Ting Zeng, Wei Liao, Deyun Liu, Dan Lan, Shunye Zhu, Zhiya Dong, Huamei Ma, Yu Yang, Feng Xiong, Ping Lu, Shengquan Cheng, Xuefan Gu, Runming Jin, Yu Liu, Jinzhun Wu, Xu Xu, Linqi Chen, Qin Dong, Hui Pan, Zhe Su, Lijun Liu, Xiaoming Luo, Shining Ni, Zhihong Chen, Yuhua Hu, Chunlin Wang, Jing Liu, Li Liu, Biao Lu, Xinli Wang, Yunfeng Wang, Fan Yang, Manyan Zhang, Lizhi Cao, GeLi Liu, Hui Yao, Yaqin Zhan, Mingjuan Dai, Guimei Li, Li Li, Yanjie Liu, Kan Wang, Yanfeng Xiao, Xingxing Zhang, Junhua Dong, Zaiyan Gu, Lirong Ying, Feng Huang, Yanling Liu, Zheng Liu, Jin Ye, Dongmei Zhao, Xu Hu, Zhihong Jiang, Kan Ye, Hong Zhu, Shaoke Chen, Xiaobo Chen, Naijun Wan, Zhuangjian Xu, Qingjin Yin, Hongxiao Zhang, Xiaodong Huang, Jianying Yin, Huifeng Zhang, Pin Li, Ping Yin, Junfen Fu, XiaoPing Luo
Summary: This study examined the effectiveness and safety of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric growth hormone deficiency (GHD). The results showed that PEG-rhGH had favorable outcomes and was safe for treating children with GHD. The high-dose subgroup had better treatment outcomes compared to the low-dose subgroup, and a weekly dose of 0.2 mg/kg might have additional benefits.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Physiology
Jonathan A. Young, Shouan Zhu, Edward O. List, Silvana Duran-Ortiz, Yosri Slama, Darlene E. Berryman
Summary: Growth hormone has anabolic effects on muscle and bone, and also has metabolic effects in various tissues. It is closely associated with aging, with levels declining as individuals age. Although clinical data is inconclusive, animal models are essential in understanding the molecular mechanisms of growth hormone action.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Lars Savendahl, Tadej Battelino, Michael Hojby Rasmussen, Meryl Brod, Sebastian Rohrich, Paul Saenger, Reiko Horikawa
Summary: This study aimed to assess the efficacy and safety of somapacitan in treating growth hormone deficiency (GHD) in children, as well as the burden of treatment. The results showed that weekly injections of somapacitan could reduce the burden for patients and their parents/guardians compared to daily GH injections.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Rohan K. Henry, Bradley S. Miller
Summary: This article provides a practical approach to the management of pediatric growth hormone deficiency through 4 case-based presentations. Pediatric GHD has diverse etiology and clinical presentation, and timely intervention can improve growth and metabolic outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Editorial Material
Endocrinology & Metabolism
Gudmundur Johannsson, John J. Kopchick
Summary: This thematic review provides short reviews on growth hormone deficiency and insensitivity in children and adults, covering from basic science to clinical significance.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Kazuki Kurihara, Hajime Moteki, Mitsutoshi Kimura, Masahiko Ogihara
Summary: The mechanism of GH-induced hepatocyte DNA synthesis and proliferation is mainly mediated through the JAK2/PLC pathway leading to autocrine secretion of IGF-I, which then activates the IGF-I receptor tyrosine kinase signaling pathway. Blocking antibodies to IGF-I, but not transforming growth factor alpha, inhibit GH-induced hepatocyte DNA synthesis and proliferation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Olga Gimenez-Palop, Laia Casamitjana, Raquel Corripio, Susanna Esteba-Castillo, Rocio Pareja, Nestor Albinana, Mercedes Rigla, Assumpta Caixas
Summary: In patients with Prader-Willi syndrome and obesity, plasma kisspeptin levels were higher compared to healthy subjects before treatment. After 12-month GH therapy, lean body mass increased, total fat mass decreased, and plasma kisspeptin levels decreased to normal levels, indicating improvements in body composition.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Concetta Mastromauro, Cosimo Giannini, Francesco Chiarelli
Summary: Linear growth during childhood is the result of various factors, with the growth hormone-insulin-like growth factor axis playing a crucial role. Growth hormone insensitivity (GHI) is a significant disorder characterized by low IGF-1 levels, normal or elevated GH levels, and lack of IGF-1 response after GH administration. Recombinant IGF-1 preparations can be used for treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Li Yang, Qi Sun, Yanping Wang, Zhulong Chan
Summary: Melatonin acts as a plant growth regulator in a concentration-dependent manner, inhibiting primary root growth but promoting lateral root development. After melatonin treatment, genes involved in JA, BR, and CK biosynthesis were inhibited, while those in ET, SL, and GA biosynthetic pathways were activated. This study identified the networks modulated by melatonin in regulating root growth.
Article
Multidisciplinary Sciences
Xiaoyun Wu, Jiansheng Lai, Yeyu Chen, Ya Liu, Mingjiang Song, Feiyang Li, Pengcheng Li, Qingzhi Li, Quan Gong
Summary: By analyzing different-sized Acipenser dabryanus, we found that there was no significant difference in the length-weight relationship (LWR) b value between large and small A. dabryanus. However, the levels of serum growth hormone (gh) and insulin-like growth factor 1 (igf1) were significantly lower in the large A. dabryanus compared to the small. Additionally, the activity levels of Total superoxide dismutase (T-sod) and catalase (cat) showed opposite results to gh and igf1.
Article
Endocrinology & Metabolism
Kaiyu Guan, Chunyan Shan, Anqi Guo, Xiang Gao, Xi Li
Summary: This study investigates the cellular and molecular mechanisms of ghrelin in regulating ADHD-like behaviors by studying the ghrelin mutant zebrafish. The study found that gh1 mRNA and genes related to the gh signaling pathway were significantly reduced at the transcriptional expression levels. The downregulation of gh signaling pathway-related genes in ghrelin mutant zebrafish larvae and adult zebrafish brain was confirmed by qPCR. Additionally, the ghrelin mutant zebrafish displayed hyperactive and hyperreactive phenotypes, and treatment with recombinant human growth hormone partially rescued these behaviors.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Manisha Dixit, Sher Bahadur Poudel, Shoshana Yakar
Summary: Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) play crucial roles in regulating body growth and skeletal acquisition, with their activity declining with age and leading to detrimental effects on the musculoskeletal system.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Cesar Luiz Boguszewski
Summary: Complications associated with active Cushing's disease may persist even after successful therapeutic remission, and the presence of growth hormone deficiency (GHD) after disease remission (GHD-CR) can worsen systemic complications caused by hypercortisolism. GHD-CR is more prevalent in women and is associated with younger age at onset of pituitary disease and diagnosis of GHD-CR, as well as higher rates of diabetes, hypertension, low bone mass, fractures, and poor quality of life.
Review
Endocrinology & Metabolism
Mabel Yau, Robert Rapaport
Summary: The evaluation of children with short stature involves long-term monitoring to establish growth patterns and rule out chronic medical conditions. Growth hormone stimulation testing is essential for diagnosing growth hormone deficiency, although its results are influenced by various factors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Coline Puvilland, Carine Villanueva, Anaelle Hemmendinger, Laure Kornreich, Iva Gueorguieva, Melodie-Anne Karnoub, Pierre Aurelien Beuriat, Pierre Leblond
Summary: Growth hormone replacement therapy does not increase the risk of relapse in children with midline low-grade gliomas, and it is safe to use growth hormone in this population.
Article
Immunology
Dulanjalee Kariyawasam, Marianne Peries, Frantz Foissac, Sabrina Eymard-Duvernay, Thorkild Tylleskar, Mandisa Singata-Madliki, Chipepo Kankasa, Nicolas Meda, James Tumwine, Mwiya Mwiya, Ingunn Engebretsen, Christa E. Flueck, Michaela F. Hartmann, Stefan A. Wudy, Deborah Hirt, Jean Marc Treluyer, Jean-Pierre Moles, Stephane Blanche, Philippe Van de Perre, Michel Polak, Nicolas Nagot
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Endocrinology & Metabolism
Saskia van der Straaten, Alexander Springer, Aleksandra Zecic, Doris Hebenstreit, Ursula Tonnhofer, Aneta Gawlik, Malgorzata Baumert, Kamila Szeliga, Sara Debulpaep, An Desloovere, Lloyd Tack, Koen Smets, Malgorzata Wasniewska, Domenico Corica, Mariarosa Calafiore, Marie Lindhardt Ljubicic, Alexander Siegfried Busch, Anders Juul, Anna Nordenstrom, Jon Sigurdsson, Christa E. Fluck, Tanja Haamberg, Stefanie Graf, Sabine E. Hannema, Katja P. Wolffenbuttel, Olaf Hiort, S. Faisal Ahmed, Martine Cools
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Review
Biochemistry & Molecular Biology
Nuria Camats, Christa E. Fluck, Laura Audi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Endocrinology & Metabolism
Shaheena Parween, Monica Fernandez-Cancio, Sara Benito-Sanz, Nuria Camats, Maria Natalia Rojas Velazquez, Juan-Pedro Lopez-Siguero, Sameer S. Udhane, Norio Kagawa, Christa E. Flueck, Laura Audi, Amit Pandey
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Marco Janner, Grit Sommer, Michael Groessl, Christa E. Fluck
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Editorial Material
Biochemistry & Molecular Biology
Laura Audi, Silvano Bertelloni, Christa E. Fluck
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Rona Karahoda, Sampada Kallol, Michael Groessl, Edgar Ontsouka, Pascale Anderle, Christa Fluck, Frantisek Staud, Christiane Albrecht
Summary: This study investigates the gestational age-dependent changes in the gene expression of key steroidogenic enzymes in human placentas, as well as explores the role of trophoblast cells in steroid biosynthesis and metabolism. The research provides insights into the cellular origin of steroidogenesis in the human placenta and highlights the functional activity of steroidogenic enzymes in primary human trophoblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Chrysanthi Kouri, Grit Sommer, Christa E. Fluck
Summary: This paper discusses the possible oligogenic inheritance in individuals with differences of sex development (DSD), indicating that variations in common DSD genes may be associated with other related genes, implying a role of oligogenic inheritance in DSD.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Editorial Material
Endocrinology & Metabolism
Tulay Guran, Christa E. Fluck
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Tobias Troger, Grit Sommer, Mariarosaria Lang-Muritano, Daniel Konrad, Beatrice Kuhlmann, Urs Zumsteg, Christa E. Fluck
Summary: This study analyzed the impact of growth during adrenarche on the final height of adequately treated classic CAH patients. The results showed that patients with accelerating bone age during adrenarche were taller than the normal population, but their predicted adult height was lower compared to nonaccelerating patients. However, when reassessed during puberty, both groups showed similar (predicted) final height.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Michelle J. J. Dennig, Grit Sommer, Tanja Zingg, Christa E. E. Flueck, Claudia Boettcher
Summary: This study evaluated metabolic control in children and adolescents with type 1 diabetes and found that many patients failed to reach treatment goals. Factors such as insulin pump use, parents coming from Western European countries, and shorter duration of diabetes were associated with better metabolic control. Age, diabetes technology use, and native language influenced the frequency of healthcare contacts.
JOURNAL OF DIABETES RESEARCH
(2022)
Article
Endocrinology & Metabolism
Christa E. Flueck, Tanja Kuiri-Hanninen, Sanna Silvennoinen, Ulla Sankilampi, Michael Groessl
Summary: Fetal adrenal involution occurs around term-equivalent age in preterm infants and is not triggered by premature birth. Testosterone levels are higher in preterm infants at birth and decline slower until term compared to full-term babies. Premature infants have lower levels of dihydrotestosterone and lower activity in the classic androgen biosynthesis pathway, but no difference was found in the activity of the alternate backdoor pathway.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Emanuele Pignatti, Therina du Toit, Christa E. Flueck
Summary: The adrenal cortex undergoes multiple structural and functional rearrangements to meet the systemic needs for steroids during different stages of life. Its proper subdivision into distinct functional zones from embryonic stages to adulthood depends on a fine-tuned gene network. The steroidogenic activity of the fetal adrenal plays a crucial role in maintaining normal fetal development and growth.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Endocrinology & Metabolism
Benjamin P. Magyar, Maristella Santi, Grit Sommer, Jean-Marc Nuoffer, Alexander Leichtle, Michael Groessl, Christa E. Fluck
Summary: Significant changes in steroid metabolism occurred after 48 hours of fasting in healthy women. In contrast to metabolic changes seen at baseline in PCOS women compared to healthy women, and after starving of steroidogenic cells, no androgen excess was observed after short-term fasting in healthy young women.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Article
Endocrinology & Metabolism
Valiyaparambil Pavithran Praveen, Asmahane Ladjouze, Kay-Sara Sauter, Annie Pulickal, Efstathios Katharopoulos, Mafalda Trippel, Aurel Perren, Amit Pandey, Christa E. Flueck
JOURNAL OF THE ENDOCRINE SOCIETY
(2020)