期刊
HORMONE RESEARCH IN PAEDIATRICS
卷 82, 期 5, 页码 303-309出版社
KARGER
DOI: 10.1159/000366079
关键词
Placenta; Fetal growth; Mitochondrial DNA; Superoxide dismutase activity; Small for gestational age
资金
- Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III
- Fondo Europeo de Desarrollo Regional (FEDER), Madrid, Spain [PI11/0443]
- Research Foundation Sant Joan de Deu [AFR 00020]
- Clinical Research Council of the University Hospital Leuven
Background: Prenatal growth restraint is associated with increased oxidative stress - as judged by mitochondrial dysfunction - in pregnancies complicated by preeclampsia or diabetes, but it is uncertain whether this is also the case in uncomplicated pregnancies. We assessed the link between fetal growth restraint and placental mitochondrial dysfunction, as reflected by changes in mitochondrial DNA (mtDNA) content and superoxide dismutase (SOD) activity. Methods: After uncomplicated pregnancies, placentas (n = 48) were collected at term delivery of singleton infants who were appropriate for gestational age (AGA) or small for gestational age (SGA) (n = 24 in each subgroup). Placental mtDNA content was assessed by real-time PCR, placental SOD activity by colorimetry, and citrate synthase activity - to determine mitochondrial mass - by the spectrophotometric method. Results: Placentas of SGA infants had a lower mtDNA content (p = 0.015) and a higher SOD activity (p = 0.001) than those of AGA controls. These differences were maintained after normalization of the mtDNA content by citrate synthase activity. In placentas of SGA infants, there was a negative association between mtDNA content and SOD activity (r = -0.58, p = 0.008). Conclusions: Fetal growth restraint is accompanied by adaptive changes in the mitochondrial function of the placenta, also in uncomplicated pregnancies. (C) 2014 S. Karger AG, Basel
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