Article
Cell & Tissue Engineering
Naoki Ishiuchi, Ayumu Nakashima, Satoshi Maeda, Yoshie Miura, Kisho Miyasako, Kensuke Sasaki, Toshio Uchiki, Ayano Sasaki, Shogo Nagamatsu, Naoki Nakao, Masataka Nagao, Takao Masaki
Summary: Fibrosis is a common histological feature in chronic organ injury, leading to organ failure. Adipose-derived mesenchymal stem cells (ASCs) have been studied as a therapeutic tool to prevent organ failure. This study compared the therapeutic effects of ASCs from superficial and deep layers and found that both types of ASCs are equally effective and safe for treating organ injury.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Veterinary Sciences
Faezeh Rezaei, Samira Khasaf, Samaneh Ghasemi, Abbas Parham, Pezhman Mirshokraei
Summary: This study evaluates the impact of different conditions on MSCs derived from adipose tissue and finds suitable transportation methods to minimize changes in MSCs.
BMC VETERINARY RESEARCH
(2022)
Article
Cell Biology
Maria Serena Piccinno, Tiziana Petrachi, Marco Pignatti, Alba Murgia, Giulia Grisendi, Olivia Candini, Elisa Resca, Valentina Bergamini, Francesco Ganzerli, Alberto Portone, Ilenia Mastrolia, Chiara Chiavelli, Ilaria Castelli, Daniela Bernabei, Mara Tagliazucchi, Elisa Bonetti, Francesca Lolli, Giorgio De Santis, Massimo Dominici, Elena Veronesi
Summary: This study investigates the use of adipose-derived mesenchymal stromal/stem cells (AD-MSCs) in autologous fat transfer (AFT) for tissue reconstruction. The results show that AD-MSCs can improve graft persistence and reduce tissue resorption after AFT. The implanted AD-MSCs can persist and differentiate into mature adipocytes, leading to better outcomes in terms of graft weight and reduced cyst formation. This suggests a long-term protective and anti-inflammatory/proangiogenic role of AD-MSCs in autologous AFT tissue resorption.
Article
Medicine, Research & Experimental
Ahmed Abdelbaset-Ismail, Abeer Tharwat, Ahmed E. Ahmed, Tarek Khamis, Ibrahim H. Abd El-Rahim, Sadeq K. Alhag, Mohamed F. Dowidar
Summary: This study found that rat adipose-derived mesenchymal stem cells (rAD-MSCs) could alleviate diclofenac sodium (DIC)-induced acute liver injury by being transplanted into the injured liver. This treatment method significantly improved survival rate, body weight, and liver function indicators, while reducing inflammation and cell damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Veterinary Sciences
Usman Rashid, Arfan Yousaf, Muhammad Yaqoob, Evelyn Saba, Muhammad Moaeen-ud-Din, Shahid Waseem, Sandra K. Becker, Gerhard Sponder, Jorg R. Aschenbach, Mansur Abdullah Sandhu
Summary: In this study, we found that canine MSCs derived from infrapatellar fat pad (IPFP) have the highest proliferation rate, while those from omental (OM) adipose tissue have higher cell metabolism. MSCs from all sources showed positive expression of CD73, CD90, CD105, and low expression of CD45. The differentiation potential of canine MSCs isolated from different adipose tissue sources was assessed, with OM-derived MSCs showing better differentiation potential towards adipo- and osteogenic lineages.
BMC VETERINARY RESEARCH
(2021)
Review
Medicine, General & Internal
Robert Ossendorff, Alessandra Menon, Frank A. Schildberg, Pietro S. Randelli, Sebastian Scheidt, Christof Burger, Dieter C. Wirtz, Davide Cucchi
Summary: The global distribution and quality of studies using adipose tissue derivates in orthopedics were assessed through a systematic review. Among the 82 included studies, 70% focused on knee disorders, mainly osteoarthritis. Approximately 26% of the studies investigated expanded adipose-derived stem/stromal cells (ADSCs), with 72% of these using stromal vascular fraction (SVF). The overall quality of the studies varied, with a higher score found in studies involving expanded ADSCs compared to SVF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Megan Stefkovich, Sarah Traynor, Lan Cheng, David Merrick, Patrick Seale
Summary: The study demonstrates that Dpp4+ interstitial progenitor cells play a crucial role in adipogenesis, especially in the expansion of visceral adipose tissue under HFD stimulation.
MOLECULAR METABOLISM
(2021)
Article
Environmental Sciences
Meriem Koual, Celine Tomkiewicz, Ida Chiara Guerrera, David Sherr, Robert Barouki, Xavier Coumoul
Summary: The study aimed to investigate the interaction between breast cancer cells and organic pollutants in their microenvironment on tumor invasiveness. The results showed that coexposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and preadipocytes can modify BC cell properties, induce the expression of the cancer stem cell marker ALDH1A3, and lead to the appearance of giant cancer cells with cell-in-cell structures in vivo, which are associated with malignant metastatic progression.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Orthopedics
Xing Guo, Denghua Huang, Dan Li, Longfei Zou, Hui Lv, Yuanhui Wang, Meiyun Tan
Summary: This study found that hypoxia preconditioning attenuates the proliferation and migration ability of ADSCs, but has positive impact on tenogenic differentiation through HIF-1 alpha signaling pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Review
Hematology
Yukako Ono-Uruga, Yasuo Ikeda, Yumiko Matsubara
Summary: The review focuses on the application of ex vivo technologies in MK development using human adipose tissue-derived mesenchymal stem/stromal cell line (ASCL), aiming to address the clinical shortage of platelets. Manufacturing platelets from adipose tissue-derived mesenchymal stem/stromal cells (ASCs) without the need for donors may lead to sufficient platelet production within 12 days.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cell Biology
Furkan Yigitbilek, Sabena M. Conley, Hui Tang, Ishran M. Saadiq, Kyra L. Jordan, Lilach O. Lerman, Timucin Taner
Summary: MSCs from liver and adipose tissue showed similar proliferation and migration properties, but had differences in immunomodulatory and pro-angiogenic abilities. Selecting cell-based therapy according to the specific characteristics of different cell sources may be important for treating certain diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Romina Marcoccia, Salvatore Nesci, Barbara Merlo, Giulia Ballotta, Cristina Algieri, Alessandra Pagliarani, Eleonora Iacono
Summary: This study compared the characteristics of canine adipose tissue and umbilical cord matrix MSCs, finding no significant differences in cell proliferation, migration, spheroid formation ability, and differentiation potential. ATP production pathways were also evaluated, with mitochondrial respiration being the main pathway for both types of MSCs. Mitochondrial respiration and ATP turnover were higher in UC-MSCs compared to AT-MSCs, but both had 100% coupling efficiency, indicating a potential for differentiation.
Article
Agriculture, Dairy & Animal Science
Manuela Heimann, Mohamed I. Elashry, Michele C. Klymiuk, Asmaa Eldaey, Sabine Wenisch, Stefan Arnhold
Summary: The investigation of mesenchymal stem cells has become an interesting scientific field in regenerative medicine and organ transplantation. This study focused on establishing an adipogenic differentiation protocol suitable for different mammalian species, and found that using rosiglitazone instead of traditional protocols significantly improves cell viability and adipogenic differentiation capacity. The study also revealed differences between species in terms of fat formation and fat-regulating gene expression. This information is essential for selecting a stem cell specification program and improving clinical targeting of obesity and metabolic disorders in veterinary medicine.
Article
Biochemistry & Molecular Biology
Cadenas-Martin Marta, Moratilla Adrian, Fernandez-Delgado Jorge, Arnalich-Montiel Francisco, Maria P. De Miguel
Summary: Corneal disease affects millions worldwide and standard treatment involves transplantation, but there is a shortage. Lamellar endothelial keratoplasty and directed differentiation of adult stem cells show promise in addressing the issue. Efforts are ongoing to find new sources of corneal endothelial cells for transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Stefano Cianfarani, Valentina Pampanini
Summary: The COVID-19 pandemic poses challenges to global health, with efforts from the scientific community shedding light on the pathogenetic mechanisms of SARS-CoV-2 infection and potential therapeutic strategies. However, the impact of social isolation and pandemic-related anxiety on mental and physical health remains poorly investigated.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Review
Endocrinology & Metabolism
Fabrizio Barbetti, Novella Rapini, Riccardo Schiaffini, Carla Bizzarri, Stefano Cianfarani
Summary: Monogenic diabetes is a form of diabetes caused by a mutation in a single gene, with over 40 loci associated with isolated or syndromic monogenic diabetes. While genetic testing is mandatory for cases with diabetes onset in the first 6 months of life, decision-making for childhood or adolescent diabetes can be challenging. Technical improvements in DNA sequencing allow for rapid analysis of all genes involved in monogenic diabetes, but the analysis of genetic data requires close cooperation between geneticists and diabetologists.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Margaret C. S. Boguszewski, Cesar L. Boguszewski, Wassim Chemaitilly, Laurie E. Cohen, Judith Gebauer, Claire Higham, Andrew R. Hoffman, Michel Polak, Kevin C. J. Yuen, Nathalie Alos, Zoltan Antal, Martin Bidlingmaier, Beverley M. K. Biller, George Brabant, Catherine S. Y. Choong, Stefano Cianfarani, Peter E. Clayton, Regis Coutant, Adriane A. Cardoso-Demartini, Alberto Fernandez, Adda Grimberg, Kolbeinn Gudmundsson, Jaime Guevara-Aguirre, Ken K. Y. Ho, Reiko Horikawa, Andrea M. Isidori, Jens Otto Lunde Jorgensen, Peter Kamenicky, Niki Karavitaki, John J. Kopchick, Maya Lodish, Xiaoping Luo, Ann McCormack, Lillian Meacham, Shlomo Melmed, Sogol Mostoufi Moab, Hermann L. Muller, Sebastian J. C. M. M. Neggers, Manoel H. Aguiar Oliveira, Keiichi Ozono, Patricia A. Pennisi, Vera Popovic, Sally Radovick, Lars Savendahl, Philippe Touraine, Hanneke M. van Santen, Gudmundur Johannsson
Summary: Growth hormone replacement therapy is not associated with primary tumor or cancer recurrence. The risk of secondary neoplasia from GH replacement is minimal compared to other factors. GH replacement may be considered in adult cancer survivors in remission after careful risk/benefit analysis.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Anita C. S. Hokken-Koelega, Manouk van der Steen, Margaret C. S. Boguszewski, Stefano Cianfarani, Jovanna Dahlgren, Reiko Horikawa, Veronica Mericq, Robert Rapaport, Abdullah Alherbish, Debora Braslavsky, Evangelia Charmandari, Steven D. Chernausek, Wayne S. Cutfield, Andrew Dauber, Asma Deeb, Wesley J. Goedegebuure, Paul L. Hofman, Elvira Isganatis, Alexander A. Jorge, Christina Kanaka-Gantenbein, Kenichi Kashimada, Vaman Khadilkar, Xiao-Ping Luo, Sarah Mathai, Yuya Nakano, Mabel Yau
Summary: This International Consensus Guideline, developed by experts from 10 pediatric endocrine societies worldwide, provides new insights into the causes and consequences of short stature after SGA birth. It also offers recommendations for accurate diagnosis, early follow-up, and appropriate treatment options. The guideline emphasizes the importance of genetic testing and counseling, as well as promoting a healthy lifestyle for young adults born SGA.
Review
Endocrinology & Metabolism
Stefano Cianfarani, Tadej Battelino
Summary: Novel and innovative therapeutic options are now available or will soon become available for children and adolescents with endocrine disorders and diabetes. While some of these treatments have shown effectiveness and safety in adults, their use and long-term effects in children are still limited and raise caution.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Alessia Aureli, Rosanna Recupero, Michela Mariani, Melania Manco, Francesco Carlomagno, Sarah Bocchini, Mirella Nicodemo, Maria Rosaria Marchili, Stefano Cianfarani, Marco Cappa, Danilo Fintini
Summary: This study reveals the association between vitamin B12 levels and body mass index, visceral adiposity, and metabolic health in children, adolescents, and young adults.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Endocrinology & Metabolism
Novella Rapini, Patrizia I. Patera, Riccardo Schiaffini, Paolo Ciampalini, Valentina Pampanini, Matteoli M. Cristina, Annalisa Deodati, Giorgia Bracaglia, Ottavia Porzio, Rosario Ruta, Antonio Novelli, Mafalda Mucciolo, Stefano Cianfarani, Fabrizio Barbetti
ACTA DIABETOLOGICA
(2023)
Article
Endocrinology & Metabolism
Novella Rapini, Patrizia Patera, Riccardo Schiaffini, Paolo Ciampalini, Valentina Pampanini, Matteoli M. Cristina, Annalisa Deodati, Giorgia Bracaglia, Ottavia Porzio, Rosario Ruta, Antonio Novelli, Mafalda Mucciolo, Stefano Cianfarani, Fabrizio Barbetti
Summary: In the pediatric diabetes clinic, establishing a monogenic diabetes clinic has been found to improve diagnostic pipelines and provide tailored care for patients with monogenic diabetes, which accounts for 6% of cases.
ACTA DIABETOLOGICA
(2023)
Review
Biochemistry & Molecular Biology
Federica Del Chierico, Novella Rapini, Annalisa Deodati, Maria Cristina Matteoli, Stefano Cianfarani, Lorenza Putignani
Summary: This review summarizes the associations between gut microbiota and Type 1 Diabetes (T1D), suggesting that dysbiosis in the gut microbiota may influence the onset and progression of T1D, and microbiota-based therapies show promise in slowing down disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Endocrinology & Metabolism
Annalisa Deodati, Novella Rapini, Valentina Pampanini, Paolo Ciampalini, Maria Cristina Matteoli, Ippolita Patriza Patera, Riccardo Schiaffini, Stefano Cianfarani
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Alessandra Fierabracci, Marco Cappa, Andrea Pietrobattista, Maria Felicia Faienza, Donatella Capalbo, Mariella Valenzise, Vito Lampasona, Olivia Pagliarosi, Elena Carbone, Maria Carolina Salerno, Corrado Betterle
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Federica Del Chierico, Giorgia Conta, Maria Cristina Matteoli, Alessandra Fierabracci, Sofia Reddel, Gabriele Macari, Simone Gardini, Valerio Guarrasi, Stefano Levi Mortera, Valeria Marzano, Pamela Vernocchi, Fabio Sciubba, Federico Marini, Annalisa Deodati, Novella Rapini, Stefano Cianfarani, Alfredo Miccheli, Lorenza Putignani
Summary: Specific gut microbiota profiles were identified in T1D patients and their relatives, which differed from healthy subjects. These specific microbial and metabolic profiles may be associated with the progression and severity of T1D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Milena Pizzoferro, Gabriele Masselli, Arianna Maiorana, Emanuele Casciani, Saadi Sollaku, Carlo Dionisi-Vici, Marco Spada, Claudio Altini, Maria Felicia Villani, Vittoria Rufini, Gianfranco Gualdi, Maria Carmen Garganese
Summary: Congenital hyperinsulinism (HI) is a life-threatening condition that requires accurate diagnosis and treatment. Integrated PET/CT scan is a crucial imaging technique that can help differentiate between different forms of HI and guide surgical treatment.
AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Pediatrics
Lucia Santoro, Dorina Pjetraj, Virtut Velmishi, Carmen Campana, Carlo Catassi, Carlo Dionisi-Vici, Arianna Maiorana
Summary: This case report describes a new phenotype of glycogen storage disease type XII in a 14-year-old boy, who presented with seizures and rhabdomyolysis. In addition to antiepileptic treatment, a new therapeutic approach based on ketogenic diet was proposed and well tolerated by the patient.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Riccardo Schiaffini, Andrea Campana, Annalisa Deodati, Emanuela Peschiaroli, Maria Francesca Lanzillotta, Alessandra Fierabracci
Summary: This study reported a case of a child diagnosed with Type 1 diabetes during a paucisymptomatic COVID-19 infection, with well-controlled metabolic status throughout. The study speculated that SARS-CoV-2 infection may have acted as a precipitating factor in the disease, but the fundamental triggering event of the autoimmune disease may have occurred even before the infection.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
