Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Bhavesh Premdjee, Asser S. Andersen, Mark Larance, Kilian W. Conde-Frieboes, Richard J. Payne
Summary: The text discusses the successful assembly of a 31.5 kDa phosphorylated IGFBP-2 protein using two ligation manifolds, incorporating phosphoserine post-translational modification and nine disulfide bonds.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kuan-Yu Chen, Shin-Yu Lin, Chien-Nan Lee, Hung-Tsung Wu, Ching-Hua Kuo, Han-Chun Kuo, Chia-Chi Chuang, Chun-Heng Kuo, Szu-Chi Chen, Kang-Chih Fan, Ming-Wei Lin, Chi-Tai Fang, Hung-Yuan Li
Summary: This study investigated the relationship between maternal lipids during pregnancy and placental growth factors on excess fetal growth, finding that certain free fatty acids can induce placental IGF-1 secretion, potentially linking maternal plasma lipids and large-for-gestational-age (LGA) neonates.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Kuan-Yu Chen, Shin-Yu Lin, Chien-Nan Lee, Hung-Tsung Wu, Ching-Hua Kuo, Han-Chun Kuo, Chia-Chi Chuang, Chun-Heng Kuo, Szu-Chi Chen, Kang-Chih Fan, Ming-Wei Lin, Chi-Tai Fang, Hung-Yuan Li
Summary: It was found in the study that maternal lipids during pregnancy and placental growth factors are closely associated with excess fetal growth, suggesting a potential link between certain free fatty acids and induction of placental IGF-1 secretion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Mao-Xiong Wu, Shao-Hua Wang, Yong Xie, Zhi-Teng Chen, Qi Guo, Wo-Liang Yuan, Chang Guan, Cheng-Zhang Xu, Yu-Na Huang, Jing-Feng Wang, Hai-Feng Zhang, Yang-Xin Chen
Summary: IL-33 alleviates diabetic cardiomyopathy by alleviating ER stress and promoting autophagy, with IGFBP3 playing an essential role in the process.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shiva Nasr, Athar Nakisa, Setareh Jandaghian, Monireh Kouhi, Erfan Sadeghi, Jaleh Varshosaz
Summary: This systematic review found that flavonoid supplements do not have a significant effect on IGF-1 and IGFBP-3. However, a high soy diet has beneficial effects on components of the IGF system, which may be useful in breast cancer.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Charmaine J. Green, Miriam Span, Monique H. Rayhanna, Marisa Perera, Margot L. Day
Summary: The viability of embryos cultured in vitro is poor compared to those that develop in vivo. This study investigated the role of autocrine and exogenous IGFBP3 in mouse preimplantation embryos. Addition of exogenous IGFBP3 to embryo culture media increased the rate of development, and the effect was mediated by IGF1 and EGF receptors. Acute exposure to IGFBP3 activated the PI3-kinase/Akt pathway to promote cell proliferation and survival. Therefore, addition of IGFBP3 to IVF culture media should be considered.
Review
Medicine, Research & Experimental
Shujian Zhang, Xue Luan, Huiwen Li, Zhengyong Jin
Summary: Bronchopulmonary dysplasia (BPD) is a common respiratory disorder among preterm infants, and there are currently no specific drugs or efficient measures available for prevention or treatment. However, insulin-like growth factor-1 (IGF-1) may serve as a new target for treating BPD.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Carlos Fernandez-Pereira, Maria Aranzazu Penedo, Tania Rivera-Baltanas, Rafael Fernandez-Martinez, Saida Ortolano, Jose Manuel Olivares, Roberto Carlos Agis-Balboa
Summary: This study aimed to evaluate whether the alterations in insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) in schizophrenia patients are related to the psychiatric disorder itself or are a result of antipsychotic treatment. The results showed that drug-naive first episode patients had lower levels of IGF-2 compared to controls, but no significant change in IGFBP-7 levels. However, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment in these patients. Chronic patients, on the other hand, had higher levels of both proteins compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Haijian Sun, Shuang Wang, Zheng Yang, Lijie Tian, Xiaoxia Li, Jie Zhou, Baoli Wang
Summary: In this study, the researchers found that CHRDL1 acts as an antagonist of BMPs by binding to them and blocking their interaction with BMP receptors. They revealed that CHRDL1 suppresses osteoblast differentiation while promoting adipocyte differentiation. Mechanistic exploration showed that CHRDL1 stabilizes IGFBP3 and differentially modulates AKT/mTORC1 signaling, thereby regulating the differentiation of osteoblasts and adipocytes.
Review
Medicine, Research & Experimental
Fei Song, Xiao-Xia Zhou, Yu Hu, Gang Li, Yan Wang
Summary: The IGF system plays multiple roles in disease development by regulating cell proliferation and differentiation. IGFBPs can bind to IGFs and perform different functions, possibly having broader functions through IGF-independent mechanisms.
ADVANCES IN THERAPY
(2021)
Article
Oncology
Huong Thuy Le, Ho Jin Lee, Jaebeom Cho, Hye-Young Min, Ji-Sun Lee, Su-Jae Lee, Ho-Young Lee
Summary: The study demonstrates the anti-metastatic effects of IGFBP-3 in inhibiting migration and invasion of NSCLC and HNSCC cells, as well as the development of metastasized tumors in vivo. Mechanistically, IGFBP-3 disrupts the protein stability of vimentin via direct binding, providing a molecular explanation for its IGF-independent anti-metastatic and anti-tumor activities.
Article
Agriculture, Dairy & Animal Science
Mengying Dou, Md. Abul Kalam Azad, Yating Cheng, Sujuan Ding, Yang Liu, Bo Song, Xiangfeng Kong
Summary: Animal growth after weaning is influenced by various factors, including breed, nutrition, growth hormones, physiological stage, and environment. This study investigated the insulin-like growth factor (IGF) system components in different pig breeds during weaning and found that expressions of IGF system components were affected by weaning stress and differed among the breeds.