Review
Nutrition & Dietetics
Chao-Yi Wu, Huang-Yu Yang, Shue-Fen Luo, Jing-Long Huang, Jenn-Haung Lai
Summary: Vitamin D plays an important role in bone health and immune regulation. Juvenile idiopathic arthritis is a chronic inflammatory joint disease, and vitamin D may have potential effects on its manifestations and outcomes.
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Debora Mariarita d'Angelo, Giulia Di Donato, Luciana Breda, Francesco Chiarelli
Summary: Juvenile Idiopathic Arthritis is a common chronic disease in children, often leading to growth and puberty disorders that can cause short stature or limb asymmetry. Various factors, including chronic inflammation, medication, undernutrition, and delayed puberty, can contribute to these disorders, highlighting the importance of early assessment and intervention.
PEDIATRIC RHEUMATOLOGY
(2021)
Article
Oncology
Hui Yang, Chun Lan, Jing Xie, Chunzheng Xun, Mengqing Wang, Kuan Rong, Jianjun Kuang
Summary: This study aimed to investigate the effects of methotrexate combined with tocilizumab on growth and bone metabolism in children with juvenile idiopathic arthritis (JIA). The results showed that compared to methotrexate alone, methotrexate combined with tocilizumab significantly improved efficacy, with no significant increase in adverse reactions. A multivariate logistic regression analysis identified longer disease duration, disease type, and use of methotrexate alone as independent risk factors affecting treatment efficacy.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Iwona Sudol-Szopinska, Nele Herregods, Andrea S. Doria, Mihra S. Taljanovic, Piotr Gietka, Nikolay Tzaribachev, Andrea Sabine Klauser
Summary: Over the past decade, imaging techniques for inflammatory arthritis in juvenile arthropathies have significantly improved, allowing for more accurate assessment and diagnosis. Ultrasound and magnetic resonance imaging have seen advancements in resolution, sensitivity, and diagnostic possibilities.
Review
Nutrition & Dietetics
Renata Puppin Zandonadi
Summary: Nutrition plays a crucial role in the treatment, health, and life of patients with juvenile idiopathic arthritis (JIA). Suboptimal nutrition can adversely affect the long-term outcome of JIA patients, while correct nutritional status helps with recovery and inflammation reduction.
Article
Pediatrics
Damjana Kljucevsek, Vesna Potocnik Tumpaj, Ana Gazikalovic
Summary: The role of conventional radiography in the diagnosis, monitoring, and prognosis of juvenile idiopathic arthritis (JIA) has changed with the increasing use of ultrasound, magnetic resonance imaging, and biological drugs. Conventional radiography is not important in the diagnosis of JIA, but it is useful for detecting and monitoring growth disorders, chronic structural changes, and differential diagnosis of conditions that mimic JIA. The development of degenerative joint changes is considered a poor predictive factor, but more studies are needed to define the predictive value of radiographic changes.
PEDIATRIC RADIOLOGY
(2023)
Article
Medicine, General & Internal
Monika Ostrowska, Piotr Gietka, Malgorzata Manczak, Emil Michalski, Iwona Sudol-Szopinska
Summary: The study aimed to differentiate between hip arthritis in JIA and hip arthralgia of unknown etiology using MRI. MRI is effective in distinguishing between the two conditions, with good specificity in confirming a diagnosis of JIA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Saverio La Bella, Marta Rinaldi, Armando Di Ludovico, Giulia Di Donato, Giulio Di Donato, Vincenzo Salpietro, Francesco Chiarelli, Luciana Breda
Summary: This review evaluates the current understanding of the pathogenesis of JIA subtypes by examining the most relevant and up-to-date evidence. Despite significant improvements over the past decade, the exact cause and molecular mechanisms of JIA remain unclear. Complex interactions between genetic background and environmental factors, as well as the involvement of HLA haplotypes and non-HLA genes, contribute to the abnormal activation of immune cells and the inflammatory process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pediatrics
Emil Carlsson, Michael W. Beresford, Athimalaipet Ramanan, Andrew D. Dick, Christian M. Hedrich
Summary: Early treatment and frequent screening are crucial for controlling JIA-associated uveitis, which poses a significant risk for serious complications. The identification of specific risk factors for JIA-associated uveitis is a key focus of research as our understanding of pathogenic drivers is still incomplete. Genomic, transcriptomic, and proteomic factors have been identified as potential risk factors, and therapeutic strategies are being discussed.
Article
Medicine, General & Internal
Alberto Martini, Daniel J. Lovell, Salvatore Albania, Hermine Brunner, Kimme L. Hyrich, Susan D. Thompson, Nicolino Ruperto
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory rheumatic condition of childhood, classified into seven categories. The pathogenesis of JIA involves autoimmune and autoinflammatory mechanisms, and the availability of new drugs has significantly improved treatment options.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Rheumatology
Johannes C. Nossent, Erin Kelty, Helen Keen, David Preen, Charles Inderjeeth
Summary: Systemic juvenile idiopathic arthritis (S-JIA) is a rare, potentially life-threatening autoinflammatory condition in children. A study investigated the epidemiological characteristics and long-term outcomes of S-JIA in the Australasian region. The annual incidence of S-JIA was 0.61/100,000, with a stable prevalence rate of 7.15/100,000. Disease flares occurred in 24% of patients during a median follow-up of 8 years, with higher rates in boys than girls. No deaths were reported, but there were substantial rates of readmission and emergency department visits for other illnesses.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Xinyi Meng, Xiaoyuan Hou, Ping Wang, Joseph T. Glessner, Hui-Qi Qu, Michael E. March, Sipeng Zhang, Xiaohui Qi, Chonggui Zhu, Kenny Nguyen, Xinyi Gao, Xiaoge Li, Yichuan Liu, Wentao Zhou, Shuyue Zhang, Junyi Li, Yan Sun, Jie Yang, Patrick M. A. Sleiman, Qianghua Xia, Hakon Hakonarson, Jin Li
Summary: This study identified rare coding variants in JIA patients using RNA-seq data, including some reported causal variants. These variants were partially replicated in polyarticular patients and shared common variants with genes associated with autoimmune diseases. Genes related to immune pathways were enriched for rare coding variants and differentially expressed genes.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Neurosciences
Leandra Woolnough, Ariel Pomputius, Heather K. Vincent
Summary: The systematic review highlighted significant changes in gait among children with JIA, such as slower walking speed, shortened step length, and decreased range of joint motion. Exercise and pharmaceutical interventions have the potential to ameliorate these changes.
Article
Rheumatology
Gustaf Bruze, Johan Askling, AnnaCarin Horne, Martin Neovius
Summary: This study compared the trajectories of marriage and parenthood in individuals with JIA and the general population. The results showed that there was no significant difference between JIA patients and the general population in terms of the timing of first marriage and parenthood, suggesting that adolescents with JIA follow a similar path into family life as their community peers. However, a subgroup of patients with systemic onset JIA had a lower rate of becoming parents for the first time compared to the general population.