期刊
HORMONE RESEARCH
卷 72, 期 -, 页码 41-45出版社
KARGER
DOI: 10.1159/000243778
关键词
Noonan syndrome; Growth hormone treatment; Disproportional growth
Growth hormone treatment in Noonan syndrome increases growth velocity significantly during the first 2 years of treatment and, to some extent, until puberty. This increase is more pronounced if treatment is started at an early age. Treatment before the age of 5 years is not recommended due to an increased risk of malignancies. In contrast to other growth hormone-treated patients, a slight but significant further increase in height gain can be expected during pubertal growth (at least in boys). Final height improvement varies between 1 and 2 SDS in different studies. Cardiac function does not seem to be impaired during treatment. No significant adverse events have been reported. Copyright (C) 2009 S. Karger AG, Basel
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