Article
Pharmacology & Pharmacy
Y. Ding, Y. Liu, Y. Qu, M. Lin, F. Dong, Y. Li, L. Cao, S. Lin
Summary: Combination therapy with vildagliptin and metformin can significantly reduce blood glucose and body weight in patients with type 2 diabetes mellitus, but it increases the risk of dizziness and does not increase the risk of other adverse events.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Yuxin Huang, Xudan Lou, Cuiping Jiang, Xueying Ji, Xiaoming Tao, Jiao Sun, Zhijun Bao
Summary: Gastrointestinal discomfort is a common adverse event in metformin treatment for type 2 diabetes. This study found that metformin promotes the secretion of intestinal hormones such as GLP-1 by increasing the abundance of SCFA-producing bacteria. This not only plays an anti-diabetic role but may also cause gastrointestinal adverse events.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sahar Hossam Elhini, Amal K. Hussien, Ahmed Abd Elsamie Omran, Asmaa A. Elsayed, Haitham Saeed
Summary: The study showed that sitagliptin, vildagliptin, and metformin are all equally effective and safe in treating type 2 diabetes mellitus. Vildagliptin demonstrated slightly better results in lowering blood sugar levels compared to sitagliptin.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Oncology
Li Zhong, Qing Wu, Fuchun Chen, Junjin Liu, Xianhe Xie
Summary: This study demonstrates that irAEs triggered by ICIs, especially in the skin, endocrine organs, or gastrointestinal tract, can predict significant survival benefits for patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Viswanathan Mohan, Abdul Zargar, Manoj Chawla, Ameya Joshi, Usha Ayyagari, Bipin Sethi, Kumar Gaurav, Usha Rani H. Patted, Seema Vikas Bhagat, Amey Ishwara Mane
Summary: This study aims to compare the real-world efficacy of a combination of metformin and vildagliptin with metformin alone in Indian T2DM patients. The results showed a more significant reduction in HbA1c levels and a lower percentage of patients requiring additional oral antidiabetic drugs in the combination therapy group.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Immunology
Kazuyuki Hamada, Junya Isobe, Kouya Hattori, Masahiro Hosonuma, Yuta Baba, Masakazu Murayama, Yoichiro Narikawa, Hitoshi Toyoda, Eiji Funayama, Kohei Tajima, Midori Shida, Yuya Hirasawa, Toshiaki Tsurui, Hirotsugu Ariizumi, Tomoyuki Ishiguro, Risako Suzuki, Ryotaro Ohkuma, Yutaro Kubota, Takehiko Sambe, Mayumi Tsuji, Satoshi Wada, Yuji Kiuchi, Shinichi Kobayashi, Atsuo Kuramasu, Atsushi Horiike, Yun-Gi Kim, Takuya Tsunoda, Kiyoshi Yoshimura
Summary: Immune checkpoint inhibitors have revolutionized cancer treatment, and the gut microbiota plays a crucial role in the cancer microenvironment and treatment response. This study investigates the gut microbiota of Japanese cancer patients and identifies bacteria associated with the efficacy of immunotherapy and immune-related adverse events.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Arminas Jasionis, Gabija Jasionyte, Ruta Mameniskiene
Summary: A Lithuanian version of the Liverpool Adverse Events Profile (LT-LAEP) was developed and validated to assess the adverse effects of antiseizure medicine (ASM). The study found that higher scores on the LT-LAEP were predicted by female sex, higher seizure frequency, and anxiety and depression levels, rather than total drug load.
EPILEPSY & BEHAVIOR
(2021)
Article
Infectious Diseases
Yuta Mori, Yutaka Ito, Norihisa Takeda, Kensuke Fukumitsu, Satoshi Fukuda, Yoshihiro Kanemitsu, Takehiro Uemura, Tomoko Tajiri, Hirotsugu Ohkubo, Ken Maeno, Tetsuya Oguri, Akio Niimi
Summary: This retrospective study analyzed the medical records of 96 patients with MAC pulmonary disease and found no significant differences in tolerability, adverse events, and treatment efficacy between elderly and nonelderly patients.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Carlos M. Ardila, Gustavo A. Jimenez-Arbelaez, Annie Marcela Vivares-Builes
Summary: Fentanyl is effective for perioperative pain management in dentistry, but there are other alternatives with better or comparable outcomes. Common adverse events associated with fentanyl use include nausea, vomiting, drowsiness, delirium, and respiratory depression.
Review
Biochemistry & Molecular Biology
Katrin Giglhuber, Achim Berthele
Summary: This review summarizes the safety issues of drugs used in the treatment of Neuromyelitis Optica Spectrum Disorders (NMOSD), including azathioprine, mycophenolate mofetil, rituximab, tocilizumab, eculizumab, satralizumab, and inebilizumab. Understanding the safety concerns of different drugs can help guide treatment choices for individual patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Omar Fahmy, Osama A. A. Ahmed, Mohd Ghani Khairul-Asri, Nabil A. Alhakamy, Waleed S. Alharbi, Usama A. Fahmy, Mohamed A. El-Moselhy, Claudia G. Fresta, Giuseppe Caruso, Filippo Caraci
Summary: The combination of durvalumab and tremelimumab has a higher risk of treatment discontinuation, mortality, fever, diarrhea, rash, pruritis, and reduced appetite compared to durvalumab monotherapy. This information is crucial for patients enrolled in clinical trials involving this combined therapy.
Article
Immunology
Wenru Qin, Linlin Yang, Bingjie Fan, Bing Zou, Yanan Duan, Butuo Li, Linlin Wang
Summary: This study explores the association between immune-related adverse events (irAEs) caused by PD-1 inhibitors and treatment outcomes in esophageal cancer (EC) patients. The results show that patients with irAEs have significantly better objective response rate, disease control rate, progression-free survival, and overall survival compared to those without irAEs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Srikanth Dumpati, Shehzad A. Naroo, Sunil Shah, Debarun Dutta
Summary: This study assessed the antimicrobial activity of a UVC device against microorganisms related to contact lens adverse events. The results showed that UVC exposure had a high antimicrobial efficacy and could be used for lens disinfection.
Article
Cell Biology
Xi Jia, Tianyu Zhai, Chunjie Qu, Jianjun Ye, Jing Zhao, Xuerong Liu, Jin-an Zhang, Qiaohui Qian
Summary: The study showed that metformin has a therapeutic effect on Hashimoto's thyroiditis by reducing antibodies and lymphocyte infiltration, and suppressing the differentiation of inflammatory cells. In addition, metformin exerts its therapeutic effects by regulating immune pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Molly Morton, Ioana Marcu, Monica Levine, Casey Cosgrove, Floor Backes, David O'Malley, Laura Chambers
Summary: Immunotherapy has revolutionized the treatment of gynecologic malignancies, particularly in advanced and recurrent endometrial cancer. The RUBY and NRG-GY018 studies have shown significant survival improvements with immunotherapy combined with chemotherapy. Repeated exposure to immunotherapy after initial treatment also demonstrated positive outcomes in a retrospective series of endometrial and cervical cancer patients.
OBSTETRICS AND GYNECOLOGY
(2023)