Article
Cell Biology
Ruping Pan, Yong Chen
Summary: Obesity and metabolic disorders are prevalent and fatal human health issues, where sex and age play a role. Adipose tissues are crucial for energy balance in humans, with overlooked sex differences in their metabolism regulation. Visceral fat distribution and its impact on metabolic disorders are also discussed in this review.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria E. Casado, Sandra Canelles, Eduardo Arilla-Ferreiro, Laura M. M. Frago, Vicente Barrios
Summary: Leptin can regulate lipid metabolism and reduce adipose tissue stores by inhibiting food intake and altering adipocyte sensitivity to insulin. This study investigated the effects of chronic central leptin administration on lipid metabolism and inflammatory- and insulin-signaling pathways in epididymal adipose tissue. Changes were observed in the expression of key enzymes involved in lipid metabolism, as well as insulin-signaling targets and inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ana B. Emiliano, Natalie R. Lopatinsky, Marko Kraljevic, Sei Higuchi, Ying He, Rebecca A. Haeusler, Gary J. Schwartz
Summary: Sleeve gastrectomy or intermittent fasting with calorie restriction produces better metabolic outcomes in females than in males. Intermittent fasting with calorie restriction increases brown adipose tissue sympathetic innervation density and improves glucose tolerance in females, irrespective of weight loss.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang
Summary: Increasing evidence suggests that the intrauterine environment affects fetal hypothalamic energy intake, and maternal inulin intervention can modify offspring lipid metabolism through gene methylation in the hypothalamus feeding circuit.
Review
Biology
Antoni Olona, Subhankar Mukhopadhyay, Charlotte Hateley, Fernando O. Martinez, Siamon Gordon, Jacques Behmoaras
Summary: The paper discusses the relationship between multinucleated osteoclasts and fusion in adipoclasts within obese individuals, suggesting that they may have specialized catabolic functions similar to osteoclasts.
Article
Endocrinology & Metabolism
C. Brent Wakefield, Vanessa R. Lee, Danielle Johnston, Parastoo Boroumand, Nicolas J. Pillon, Samar Sayedyahossein, Brooke L. O'Donnell, Justin Tang, Rafael E. Sanchez-Pupo, Kevin J. Barr, Robert Gros, Lauren Flynn, Nica M. Borradaile, Amira Klip, Frank Beier, Silvia Penuela
Summary: PANX3 expression in male adult mouse adipose tissue may regulate adipocyte numbers, influencing fat accumulation and inflammation. Male KO mice fed a chow diet had lower body weight and lower fat mass, reduced to the same extent as WT mice with forced exercise, suggesting a potential role of PANX3 in regulating body weight. Additionally, KO mice exhibited a more anti-inflammatory phenotype on a high-fat diet compared to WT mice, with significantly lower expression of multiple pro-inflammatory genes in white adipose tissue.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Cell Biology
Yunpo Zhao, Emilia Johansson, Jianli Duan, Zhe Han, Mattias Alenius
Summary: This study investigates the interaction between taste perception and macronutrients. It reveals that fat overconsumption reduces fatty acid taste and increases sweet perception, while sugar intake enhances fatty acid perception and suppresses sweet taste. The study further uncovers the signaling pathways involved in regulating taste perception in response to sugar and fat.
Article
Genetics & Heredity
Janine Molder, Esther Guiu-Jurado, Yusef Moulla, Christine Stroh, Arne Dietrich, Michael R. Schoen, Daniel Gaertner, Tobias Lohmann, Miriam Dressler, Michael Stumvoll, Peter Kovacs, Matthias Blueher, Nora Kloeting
Summary: This study aimed to investigate the influence of SNP rs10487505 on leptin mRNA expression and obesity-related parameters. The researchers found that rs10487505 is associated with lower leptin levels in women and a lower mean BMI in women carrying the C allele. However, no association was found between rs10487505 and leptin mRNA expression in adipose tissue.
Article
Medicine, Research & Experimental
Alan C. Rupp, Abigail J. Tomlinson, Alison H. Affinati, Warren T. Yacawych, Allison M. Duensing, Cadence True, Sarah R. Lindsley, Melissa A. Kirigiti, Alexander MacKenzie, Joseph Polex-Wolf, Chien Li, Lotte Bjerre Knudsen, Randy J. Seeley, David P. Olson, Paul Kievit, Martin G. Myers Jr
Summary: The study found that the adipose-derived hormone leptin controls food intake and body weight by acting on a specific group of GABAergic hypothalamic neurons through its receptor LepRb. This group of neurons shows conservation across species.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Vicente Barrios, Ana Campillo-Calatayud, Santiago Guerra-Cantera, Sandra Canelles, Alvaro Martin-Rivada, Laura M. Frago, Julie A. Chowen, Jesus Argente
Summary: Leptin modulates insulin signaling through Akt pathway in a tissue-specific manner, with changes in inflammatory environment affecting cytokine synthesis. Chronic central leptin infusion in rats led to increased phosphorylation of JNK and NFkB in inguinal fat, with a pro-inflammatory profile, while liver showed reduced activation of JNK and NFkB with an anti-inflammatory pattern.
Article
Multidisciplinary Sciences
Kristina Wright, Ka Ming Nip, Ji Eun Kim, Kimberly M. Cheng, Inanc Birol
Summary: This study analyzed the differentially expressed genes related to fat metabolism in emus, focusing on the seasonal and sex-dependent variations. Several genes were found to be involved in fat changes, and their functional investigations supported their influence on fat gain and loss in emus. These findings provide important insights into understanding fat production in emus.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Eva Hassler, Gunter Almer, Gernot Reishofer, Hannes Deutschmann, Wilfried Renner, Markus Herrmann, Stefan Leber, Alexander Staszewski, Felix Gunzer, Harald Mangge
Summary: This study investigates the association between osteocalcin levels and the distribution of subcutaneous and intermuscular adipose tissue of the mid-thigh, as well as the impact of different training methods on osteocalcin levels. The results show a negative correlation between osteocalcin and the distribution of adipose tissue, as well as muscle area, in the mid-thigh. Additionally, osteocalcin is negatively related to serum insulin. These findings provide further insights into the role of osteocalcin in glucose metabolism.
Article
Biochemistry & Molecular Biology
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, Maria Collantes, Philipp Kaldis, Jose Alfredo Martinez, Gema Medina-Gomez, Maria Jesus Moreno-Aliaga, Xavier Escote
Summary: The aim of this study was to investigate the effect of p27 deletion on the activity of brown adipose tissue and the susceptibility to develop obesity and glucose homeostasis disturbances in mice. The results showed that p27 knockout mice were more prone to obesity and insulin resistance. The study suggested that p27 may play a role in brown adipose tissue activation and the development of obesity and insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L. Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E. Dupont-Versteegden, Philip A. Kern
Summary: Treatment with pioglitazone or the combination of pioglitazone and mirabegron increased beige adipose tissue protein marker expression and improved insulin sensitivity and glucose homeostasis, but neither treatment induced BAT in these obese subjects. Monotherapy with mirabegron was found to be the most effective at inducing beige adipose tissue.
Review
Biochemistry & Molecular Biology
Iker Gomez-Garcia, Jenifer Trepiana, Alfredo Fernandez-Quintela, Marta Giralt, Maria P. Portillo
Summary: This narrative review examines the sex differences in the effects of cold exposure, feeding pattern, and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. The findings suggest that females tend to activate thermogenesis earlier in response to cold exposure and exhibit greater sensitivity to overfeeding or energy restriction. Sexual development leads to increased BAT activity, especially in boys, while aging results in a decline in thermogenic capacity, particularly in men. Additionally, females are more susceptible to WAT browning. Further studies are needed to provide valuable information for personalized approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Gastroenterology & Hepatology
Marita Grimanesa Trelles Guzman, Maria Teresa Novell Duran, M. Luisa Heredia Centeno, Monica Florido Garcia, Maria del Carmen Sanchez-Contador Escudero, Eduardo Yun Iyo Miyashiro, Silvia Patricia Ortega Moya, Elisa Miro Viamonte, Guillem Artigues Vives, Joan Gelabert Zornoza, Paul David Garcia Cortez, Juan Antonio Lucero Pizones, Carolina Rodriguez Hidalgo, Alicia Ruiz Rubi, Maria del Pilar Roca Salom, Jorge Sastre-Serrae, Jose Reyes Moreno
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Article
Food Science & Technology
Margalida Torrens-Mas, Marina Alorda-Clara, Maria Martinez-Vigara, Pilar Roca, Jorge Sastre-Serra, Jordi Oliver, Daniel Gabriel Pons
Summary: The study found that low doses of XN treatment did not significantly affect cell viability, but led to a general decrease in pro-inflammatory, antioxidant and mitochondrial biogenesis gene expression. Additionally, glucose and oxidative metabolism enzymes were also reduced.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Review
Oncology
Marina Alorda-Clara, Margalida Torrens-Mas, Pere Miquel Morla-Barcelo, Toni Martinez-Bernabe, Jorge Sastre-Serra, Pilar Roca, Daniel Gabriel Pons, Jordi Oliver, Jose Reyes
Summary: Colorectal cancer (CRC) is a highly diagnosed cancer with significant mortality rates, and early detection is crucial for improving patient survival. Current CRC screening programs involve stool tests and colonoscopies, but the use of new biomarkers could enhance screening effectiveness. Omics technologies offer promise in detecting novel biomarkers for CRC across different sample types.
Article
Oncology
Anna Torrent, Joana Amengual, Catalina Maria Sampol, Mario Ruiz, Jorge Rioja, Gabriel Matheu, Pilar Roca, Octavi Cordoba
Summary: This study demonstrates that the use of dual tracer and dual injection site during the learning curve can improve the detection rate of Sentinel lymph nodes (SLN) in early-stage endometrial cancer patients and the detection rate of para-aortic SLNs.
Article
Biology
Reyniel Hernandez-Lopez, Margalida Torrens-Mas, Daniel G. Pons, Maria M. Company, Esther Falco, Teresa Fernandez, Javier M. Ibarra de la Rosa, Pilar Roca, Jordi Oliver, Jorge Sastre-Serra
Summary: Metastasis is a crucial factor in the mortality of colorectal cancer (CRC) patients. This study explores the changes in mitochondrial function associated with the metastatic stage of CRC and investigates whether they could be utilized as therapeutic targets. The findings indicate notable differences in mitochondrial functionality between tumor tissue and normal adjacent tissue in metastatic CRC patients. These alterations contribute to the promotion and maintenance of the metastatic phenotype, highlighting the impairment of mitochondrial function in tumor tissue during the metastatic stage.
Article
Biochemistry & Molecular Biology
Marina Alorda-Clara, Margalida Torrens-Mas, Pere Miquel Morla-Barcelo, Pilar Roca, Jorge Sastre-Serra, Daniel Gabriel Pons, Jordi Oliver
Summary: Genistein may increase oxidative stress and inflammation in colon cancer cells, ultimately decreasing cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Margalida Torrens-Mas, Cayetano Navas-Enamorado, Devin Wahl, Andres Sanchez-Polo, Anna Picca, Jordi Oliver, Pilar Roca, Marta Gonzalez-Freire
Summary: “Calorie restriction (CR) is the only nutritional strategy proven to extend lifespan, prevent age-related diseases, and delay functional decline. The effects of CR when started early in life are not well understood. This study found that young female rats treated with CR showed similar expression patterns of key genes/pathways associated with healthy aging compared to old animals treated with CR, while in male rats these effects were reduced.”
Article
Oncology
Marina Alorda-Clara, Margalida Torrens-Mas, Reyniel Hernandez-Lopez, Javier M. Ibarra de la Rosa, Esther Falco, Teresa Fernandez, Maria Margarita Company, Jorge Sastre-Serra, Jordi Oliver, Daniel Gabriel Pons, Pilar Roca
Summary: Non-tumor adjacent tissue has an important role in the development and inflammatory process of colorectal cancer. This study analyzed the expression of inflammatory, epithelial-mesenchymal transition (EMT), and metastasis-related proteins in tumor and non-tumor adjacent tissues from colorectal cancer patients. The results showed that tumor tissue had increased levels of metastasis and EMT-related proteins compared to non-tumor adjacent tissue, particularly in stage II. Tumor tissue from stage II also had increased levels of inflammatory-related proteins, which was also observed in non-tumor adjacent tissue from stage II. Additionally, higher expression levels of Vimentin and VEGF-B were associated with lower relapse-free survival in stage II patients. These findings suggest that these proteins could be potential biomarkers for early diagnosis of colorectal cancer.
Article
Biochemistry & Molecular Biology
Toni Martinez-Bernabe, Jordi Oliver, Jorge Sastre-Serra, Daniel Gabriel Pons
Summary: This study analyzed the effect of oxaliplatin on tumor spheres formation efficiency, cell viability, cancer stem cells, and inflammation in primary- and metastatic-derived colorectal tumor spheres. The results showed that primary-derived spheres responded to oxaliplatin by modulating cancer stem cells and stemness properties, while metastatic-derived spheres exhibited an inflammatory response. In addition, the expression of inflammatory markers after oxaliplatin treatment correlated with poor prognosis and a metastatic phenotype. These findings highlight the importance of drug testing and personalized medicine in early-stage colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marina Alorda-Clara, Jose Reyes, Marita Grimanesa Trelles-Guzman, Monica Florido, Pilar Roca, Daniel Gabriel Pons, Jordi Oliver
Summary: Colorectal cancer is the third most common cancer worldwide, and the lack of early and specific biomarkers leads to late-stage detection. Tumors release extracellular vesicles (EVs) that have various functions and can be used as a source of biomarkers. Bowel lavage fluid (BLF) obtained during colonoscopy is an underutilized sample that represents EVs from tumor cells and has the potential to be a useful research tool. In this study, EVs from BLF were isolated and characterized, confirming their suitability for CRC study and potential as biomarkers for diagnosis and monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ecology
Facundo Luna, Jorge Sastre-Serra, Jordi Oliver, C. Daniel Antenucci
Summary: In mammals, the integrated requirements of all activities must conform to a sustained rate of metabolism for the pup's development and adult life. Partitioning available energy according to short-term priorities allows animals to optimize long-term reproductive success. In this study, the development of thermogenic capacity in altricial rodent pups, specifically Ctenomys talarum, was evaluated. The results showed that non-shivering thermogenesis was absent in the pups until day 60, despite the presence of molecular markers for thermogenesis in brown adipose tissue deposits. However, the total thermogenic capacity became fixed at an early age, indicating an improvement in shivering thermogenesis efficiency after day 10.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Pharmacology & Pharmacy
Silvia P. Ortega-Moya, Ileana Martinez-Cabrera, Marita Telles Guzman, Eduardo Iyo Miyashiro, Jose Reyes Moreno
Summary: This study evaluated the reliability, reproducibility, and effectiveness of simethicone pre-treatment before endoscopic exploration. The results showed that using simethicone as a pre-preparation drink improved image quality and reduced operation time.
JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
(2022)
