Review
Biochemistry & Molecular Biology
Yuhan Zhu, Lin Chen, Binyu Song, Zhiwei Cui, Guo Chen, Zhou Yu, Baoqiang Song
Summary: The article describes the expression changes and fibrosis-promoting effects of insulin-like growth factor 2 (IGF-2) in different tissues during fibrosis process.
Article
Oncology
Seyda Berk, Joseph A. M. J. L. Janssen, Peter M. van Koetsveld, Fadime Dogan, Naci Degerli, Servet Ozcan, Fahrettin Kelestimur, Leo J. Hofland
Summary: The effects of glucose, insulin, and IGF on the growth of colon cancer cells vary between early and late stages. Glucose plays a more significant role in stimulating proliferation in early stage cells, while growth factor-mediated stimulation becomes more pronounced in late stage cells. Strict glucose control may be crucial in controlling tumor growth in early stages, while inhibiting the endocrine actions of IGFs and insulin is more important in late stages of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biology
Ji-Sun Lee, Claire E. Tocheny, Leslie M. Shaw
Summary: This review provides an overview of the role of the IGF signaling pathway in breast cancer and discusses its potential as a therapeutic target. Dysregulation of IGF pathway components contributes to breast cancer risk and progression, and the pathway has also been implicated in resistance to current therapies. Unfortunately, targeting IGF signaling for breast cancer treatment has been unsuccessful so far due to adverse effects on normal glucose metabolism. However, recent discoveries offer hope for continued efforts in this area.
Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Article
Multidisciplinary Sciences
Michele Andreucci, Damiano Cosimo Rigiracciolo, Umberto Marcello Bracale, Nicola Ielapi, Michele Provenzano, Diletta D'Iuorno, Ashour Michael, Pasquale Mastroroberto, Giuseppe Filiberto Serraino, Marcello Maggiolini, Raffaele Serra
Summary: This study examined the expression of AR, IGF-IR, and IR in the arterial vessel walls of PAD patients and found that the expression levels of these receptors gradually decreased as the severity of the disease increased.
Review
Biochemistry & Molecular Biology
Tomoko Okuyama, Mayu Kyohara, Yasuo Terauchi, Jun Shirakawa
Summary: IGFs mainly mediate long-term actions in cell fates, while insulin predominantly exerts its role on metabolic activities. The interactions between insulin receptor signaling and IGF-I receptor signaling in metabolism and cell fates are complicated, and the function of IGF-I in respective tissues remains insufficiently understood. Clarifying the precise roles of IGF-I signaling on metabolism separate from those of insulin signaling is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Fa Zhang, Emrah Altindis, C. Ronald Kahn, Richard D. DiMarchi, Vasily Gelfanov
Summary: The study identified viral insulin-like peptides with unique biological functions, including one that acts as a potent and full antagonist of the IGF-1R. The results revealed the importance of the internal structure of VILPs in regulating their biological activities and discovered a set of potentially medicinally important antagonists.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
S. Chandhini, Bushra Trumboo, Seena Jose, Tincy Varghese, M. Rajesh, V. J. Rejish Kumar
Summary: The insulin-like growth factor signalling system plays a crucial role in the growth and development of fishes and shellfishes, serving as important biomarkers for assessing growth and nutritional status in aquaculture.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Kazuki Kurihara, Hajime Moteki, Mitsutoshi Kimura, Masahiko Ogihara
Summary: The mechanism of GH-induced hepatocyte DNA synthesis and proliferation is mainly mediated through the JAK2/PLC pathway leading to autocrine secretion of IGF-I, which then activates the IGF-I receptor tyrosine kinase signaling pathway. Blocking antibodies to IGF-I, but not transforming growth factor alpha, inhibit GH-induced hepatocyte DNA synthesis and proliferation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Michael W. Lero, Leslie M. Shaw
Summary: This review underscores the significance of the IR/IGF-1R signaling pathway in cancer and its potential as a therapeutic target. Understanding the pathway's role in normal mammary gland function provides insight into its aberrations in breast cancer. However, efforts to target this pathway for cancer treatment are hindered by a lack of biomarkers and adverse effects on normal metabolism.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Wentao Zhong, Xueqing Wang, Yufei Wang, Guoqian Sun, Jia Zhang, Zhuo Li
Summary: Obesity is a global epidemic and a risk factor for endocrine-related cancers. It affects insulin, IGF-1, sex hormones, IGFBPs, and adipokines, with IGF-1 playing a crucial role in obesity-related endocrine cancers. This review discusses the impact of obesity on prostate, breast, and pancreatic cancers, focusing on the mechanism of IGF-1 and its interaction with estrogen and adipokines. Additionally, the current status of IGF-1R inhibitors in clinical practice and their potential combination with other anticancer drugs are briefly introduced.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Leonie Rieger, Rosemary O'Connor
Summary: The internalization and localization of the IGF-1 receptor play crucial roles in cell signaling and biological processes, with different cell types and cell adhesion receptors regulating this process. Further study on how IGF-1R intracellular trafficking and compartmentalized signaling is controlled, particularly in cancer, is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Hiroki Nishi, Kaito Uchida, Maki Saito, Daisuke Yamanaka, Haruka Nagata, Hinako Tomoshige, Ichiro Miyata, Koichi Ito, Yuka Toyoshima, Shin-Ichiro Takahashi, Fumihiko Hakuno, Asako Takenaka
Summary: This study evaluates the contribution of protein nutrition and the GH/IGF-I system to body growth regulation. The results show that a reduction in serum EAA concentration hinders Igf1 transcription and decreases serum IGF-I levels. Restoring serum IGF-I levels through recombinant IGF-I infusion rescues body growth, indicating the importance of EAAs for animal growth.
Article
Gastroenterology & Hepatology
Ruta Sahasrabudhe, Paul Lott, Mabel Bohorquez, Ted Toal, Ana P. Estrada, John J. Suarez, Alejandro Brea-Fernandez, Jose Cameselle-Teijeiro, Carla Pinto, Irma Ramos, Alejandra Mantilla, Rodrigo Prieto, Alejandro Corvalan, Enrique Norero, Carolina Alvarez, Teresa Tapia, Pilar Carvallo, Luz M. Gonzalez, Alicia Cock-Rada, Angela Solano, Florencia Neffa, Adriana Della Valle, Chris Yau, Gabriela Soares, Alexander Borowsky, Nan Hu, Li-Ji He, Xiao-You Han, Philip R. Taylor, Alisa M. Goldstein, Javier Torres, Magdalena Echeverry, Clara Ruiz-Ponte, Manuel R. Teixeira, Luis G. Carvajal-Carmona
Article
Multidisciplinary Sciences
Andres Julian Gutierrez-Escobar, Gina Mendez-Callejas, Orlando Acevedo, Maria Mercedes Bravo
Article
Plant Sciences
Esperanza Trujillo, Ricardo Sanchez, Maria Mercedes Bravo
ACTA BIOLOGICA COLOMBIANA
(2018)
Article
Plant Sciences
Sandra Susana Novoa Herran, Mariela Castelblanco, Myriam Sanchez-Gomez, Adriana Umana Perez
ACTA BIOLOGICA COLOMBIANA
(2019)
Article
Microbiology
Cosmeri Rizzato, Javier Torres, Elena Kasamatsu, Margarita Camorlinga-Ponce, Maria Mercedes Bravo, Federico Canzian, Ikuko Kato
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Andres J. Gutierrez-Escobar, Maria M. Bravo, Orlando Acevedo, Steffen Backert
Article
Immunology
Monica Losada-Barragan, Adriana Umana-Perez, Jonathan Duraes, Sergio Cuervo-Escobar, Andres Rodriguez-Vega, Flavia L. Ribeiro-Gomes, Luiz R. Berbert, Fernanda Morgado, Renato Porrozzi, Daniella Areas Mendes-da-Cruz, Priscila Aquino, Paulo C. Carvalho, Wilson Savino, Myriam Sanchez-Gomez, Gabriel Padron, Patricia Cuervo
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Biochemical Research Methods
Monica Losada-Barragan, Adriana Umana-Perez, Andres Rodriguez-Vega, Sergio Cuervo-Escobar, Renata Azevedo, Fernanda N. Morgado, Vinicius de Frias Carvalho, Priscila Aquino, Paulo C. Carvalho, Renato Porrozzi, Myriam Sanchez-Gomez, Gabriel Padron, Patricia Cuervo
JOURNAL OF PROTEOMICS
(2019)
Article
Oncology
Lourdes Flores-Luna, Maria Mercedes Bravo, Elena Kasamatsu, Eduardo Cesar Lazcano Ponce, Teresa Martinez, Javier Torres, Margarita Camorlinga-Ponce, Ikuko Kato
CANCER EPIDEMIOLOGY
(2020)
Article
Oncology
Federico Canzian, Cosmeri Rizzato, Ofure Obazee, Angelika Stein, Lourdes Flores-Luna, Margarita Camorlinga-Ponce, Alfonso Mendez-Tenorio, Jorge Vivas, Esperanza Trujillo, Hyejong Jang, Wei Chen, Elena Kasamatsu, Maria Mercedes Bravo, Javier Torres, Nubia Munoz, Ikuko Kato
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Multidisciplinary Sciences
Cosmeri Rizzato, Javier Torres, Ofure Obazee, Margarita Camorlinga-Ponce, Esperanza Trujillo, Angelika Stein, Alfonso Mendez-Tenorio, Maria Mercedes Bravo, Federico Canzian, Ikuko Kato
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Alix A. Guevara-Tique, Roberto C. Torres, Maria M. Bravo, Luis G. Carvajal Carmona, Maria M. Echeverry de Polanco, Mabel E. Bohorquez, Javier Torres
Summary: H. pylori in Colombia has evolved into subpopulations with self identity ancestry, demonstrating advanced adaptation to mixed Colombian groups. Recombination plays a more important role than punctual mutations in the genome diversity of H. pylori.
Article
Oncology
Paula Daniela Morales-Suarez, Wendy Johana Montero-Ovalle, Paula Juliana Pardo-Sanabria, Juan Camilo Cuestas-Castaneda, Yenifer Yamile Segura-Moreno, Marcela Nunez-Lemus, Maria Carolina Sanabria-Salas, Rodolfo Varela-Ramirez, Martha Lucia Serrano
Summary: Prostate cancer is the most common cancer in men in Colombia, posing a significant public health issue. A study was conducted to enhance students' understanding of biology concepts and cancer perceptions through the social appropriation of knowledge strategy. The intervention resulted in improved comprehension and awareness of the subject matter, highlighting the importance of linking school and scientific knowledge to real-world problems.
JOURNAL OF CANCER EDUCATION
(2023)
Review
Oncology
Wendy Montero-Ovallea, Maria Carolina Sanabria-Salasa, Martha Lucia Serranoa
Summary: SPOP, as a component of ubiquitin ligase E3 cullin-3 RING-box1 complex, is involved in ubiquitination and proteasomal degradation of biomolecules, and its alterations are associated with the development of various types of cancer.
REVISTA COLOMBIANA DE CANCEROLOGIA
(2021)
Article
Oncology
Hector Javier Ardila, Maria Carolina Sanabria-Salas, Ximena Meneses, Rafael Rios, Antonio Huertas-Salgado, Martha Lucia Serrano
MOLECULAR AND CLINICAL ONCOLOGY
(2019)