Review
Chemistry, Multidisciplinary
Abdul Rahim Ferhan, Soohyun Park, Hyeonjin Park, Hyunhyuk Tae, Joshua A. Jackman, Nam-Joon Cho
Summary: This article focuses on the development of next-generation lipid-based nanoparticles from a nanoarchitectonics perspective, analyzing the design, nucleic acid encapsulation methods, scalable production, and application prospects. It also compares and contrasts different nanoarchitectures, such as traditional lipid nanoparticles, lipoplexes, and bicelles, and evaluates the current development status and possible future directions in overcoming clinical translation challenges and exploring new application opportunities.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
A. R. Ortiz Moreno, R. Li, K. Wu, R. Schirhagl
Summary: Lipid peroxidation is a process where reactive oxygen species attack lipids within cell membranes, leading to toxic and carcinogenic products. Understanding this process at nanoscale resolution is important and challenging due to the short lifespan and reactivity of the radical intermediates involved. In this study, lipid peroxidation of three artificial lipid bilayers on a diamond substrate was investigated using a diamond quantum sensing method called T-1-relaxometry, allowing for in situ measurements and imaging of radical intermediates.
Article
Engineering, Biomedical
Rebecca L. Goldman, Namratha Turuvekere Vittala Murthy, Trent P. Northen, Anuranjani Balakrishnan, Sudha Chivukula, Hillary Danz, Timothy Tibbitts, Anusha Dias, Jorel Vargas, Dustin Cooper, Hardip Gopani, Angela Beaulieu, Kirill V. Kalnin, Timothy Plitnik, Saswata Karmakar, Ramesh Dasari, Ryan Landis, Shrirang Karve
Summary: Lipid nanoparticles (LNPs) incorporating ionizable lipids have shown great promise as delivery vehicles for mRNA and vaccines. In this study, a novel family of ionizable lipids with unique tails and degradable moieties was synthesized. The structure of the lipids and the physical characteristics of LNPs were found to affect protein production in vivo. LNPs formulated with mRNA encoding an influenza HA antigen successfully generated functional HA inhibition antibody titers in non-human primates, demonstrating their potential as a vaccine.
Review
Chemistry, Multidisciplinary
Rumiana Tenchov, Robert Bird, Allison E. Curtze, Qiongqiong Zhou
Summary: Lipid nanoparticles (LNPs) have become promising vehicles in the pharmaceutical industry for delivering various therapeutics, particularly highlighted in the COVID-19 mRNA vaccines. LNPs exhibit versatility and physical stability, allowing for targeted delivery of therapeutic drugs to specific locations within the body. Liposomes, an early version of LNPs, have already been widely applied in medical practice.
Review
Biochemistry & Molecular Biology
Durgaramani Sivadasan, Kalaivanan Ramakrishnan, Janani Mahendran, Hariprasad Ranganathan, Arjunan Karuppaiah, Habibur Rahman
Summary: Recent advancements in drug delivery technologies have led to the emergence of nanotechnology as a potential tool in cancer therapeutics. Solid lipid nanoparticles (SLNs) have shown great potential for drug delivery, clinical medicine, and overcoming challenges in cancer therapy. Further research is needed to better understand the biological responses of SLNs and develop therapeutics with reduced side effects. This review focuses on the development, mechanisms, and applications of SLNs in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Gonna Somu Naidu, Seok-Beom Yong, Srinivas Ramishetti, Riccardo Rampado, Preeti Sharma, Assaf Ezra, Meir Goldsmith, Inbal Hazan-Halevy, Sushmita Chatterjee, Anjaiah Aitha, Dan Peer
Summary: Ionizable lipid-based nanoparticles (LNPs) were synthesized by modifying hydrophobic tail chains and linkers, and stable LNPs were formed with the help of other lipids and a microfluidic mixing approach. Using various mRNA and animal models, specific lipids for efficient cell-type specific mRNA delivery were identified. In vitro assays showed that a combination of branched ester tail chains and hydroxylamine linker negatively affects mRNA delivery efficiency. In vivo studies identified superior liver-trophic and cell type-specific lipid nanoparticles. Comparisons with SM-102-based LNPs showed cell-specific mRNA delivery efficiency and toxicity. This study suggests that tail and linker combination can drive novel functionality of LNPs in vivo.
Article
Nanoscience & Nanotechnology
Nicolo Paracini, Philipp Gutfreund, Rebecca Welbourn, Juan Francisco Gonzalez-Martinez, Kexin Zhu, Yansong Miao, Nageshwar Yepuri, Tamim A. . Darwish, Christopher Garvey, Sarah Waldie, Johan Larsson, Max Wolff, Marite Cardenas
Summary: Arrays of nanoparticle-supported lipid bilayers (nanoSLB) are lipid-coated nanopatterned interfaces that provide a platform to study curved model biological membranes using surface-sensitive techniques. We investigated the structure of lipid bilayers formed on nanoparticle arrays through vesicle fusion using scattering techniques and direct imaging. The presence of both flat and curved supported lipid bilayers on the same substrate, combined with the accuracy of grazing incidence neutron scattering, offers a promising approach to studying curvature-dependent membrane phenomena.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
James M. Kelvin, Madison L. Chimenti, Dan Y. Zhang, Evelyn K. Williams, Samuel G. Moore, Gabrielle M. Humber, Travon A. Baxter, Lacey A. Birnbaum, Min Qui, Henry Zecca, Aashis Thapa, Juhi Jain, Nathan T. Jui, Xiaodong Wang, Haian Fu, Yuhong Du, Melissa L. Kemp, Wilbur A. Lam, Douglas K. Graham, Deborah Deryckere, Erik C. Dreaden
Summary: Advances in multiagent chemotherapy have improved survival rates for ALL patients, but there is still a subset of non-responders or relapsing patients with low long-term survival rates. By conducting high-throughput combination drug screens, we found that MRX-2843 and vincristine synergistically inhibited the growth of B-ALL and T-ALL cell lines. Nanoparticle formulations of these drugs improved their anti-leukemia activity and reduced disease burden in an animal model of T-ALL.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Salar Khaledian, Danial Kahrizi, Sajad Moradi, Fleming Martinez
Summary: This study successfully designed lipid nanocarriers for loading poorly water-soluble anticancer drugs, which demonstrated sustained release patterns and suitable cytotoxicity against acute myeloid leukemia cells through chitosan/tragacanth encapsulated natural lipid SLNs.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Engineering, Biomedical
Yuandong Xu, Yuexiao Hu, Heng Xia, Shiqiang Zhang, Hanqi Lei, Binyuan Yan, Ze Xiu Xiao, Jinjin Chen, Jun Pang, Gao-Feng Zha
Summary: This study explores the use of a novel library of 248 ionizable lipids, including 1,2-diesters, as a platform for mRNA vaccines. The top-performing lipids and formulations show faster liver clearance, increased stability, and higher safety compared to DLin-MC3-DMA. Furthermore, the lipids demonstrate superior intramuscular mRNA delivery and effective anticancer activity in different tumor models expressing specific antigens.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Wenrui Wang, Mengyang Zhou, Yang Xu, Wei Peng, Shiwen Zhang, Rongjie Li, Han Zhang, Hui Zhang, Shumin Cheng, Youjing Wang, Xinyu Wei, Chengxu Yue, Qingling Yang, Changjie Chen
Summary: The study successfully formulated TPGS-Res-SLNs nanoparticles to improve therapeutic efficacy against breast cancer, showing significant anti-tumor activity and promotion of cell apoptosis. It also exhibited significant inhibition of cancer cell invasion and migration. In vivo experiments showed that TPGS-Res-SLNs had higher efficacy in promoting tumor cell apoptosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Environmental
Lichun Guo, Cui Yang, Ruijin Yang, Wei Zhao
Summary: The study utilized immune response to induce antibodies (IgY) against alpha-amylase, which were then developed into long-term inhibitor against glycemic variability. This research opens new possibilities for healthcare in metabolic diseases such as diabetes, obesity, and cardiovascular diseases.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Nagi M. El-Shafai, Shaymaa Shawky, Ibrahim M. El-Mehasseb, Maged A. El-Kemary
Summary: The research focused on the application of sandwich nanohybrid of nano-PVA and nano-chitosan in water treatment and drug adsorption, revealing their potential effects through tests on photocatalytic activity and release efficiency. Additionally, studies on cytotoxicity and antioxidant properties were conducted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Yamin Li, Zhongfeng Ye, Hanyi Yang, Qiaobing Xu
Summary: Lipid nanoparticle (LNP) -based drug delivery systems hold great potential in clinical applications and can encapsulate and transport various bioactive substances. To ensure the safe and efficient delivery of cargo molecules, careful design of each LNP carrier system is necessary. Our research group has developed novel LNP delivery systems through combinatorial library synthesis and in vitro and in vivo screening, and evaluated and optimized their drug delivery effects.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Jinjin Chen, Min Qiu, Feihe Ma, Liu Yang, Zachary Glass, Qiaobing Xu
Summary: PROTAC technology allows targeted protein degradation, but faces limitations due to high molecular weight and polar surface area. Pre-fusion of PROTACs with E3Ps simplifies the system to enhance degradation efficiency. Pre-fusion strategy could also be generalized to other degraders for improved protein degradation.
JOURNAL OF CONTROLLED RELEASE
(2021)
