Article
Chemistry, Multidisciplinary
Jing-Shi Lei, Yi Zheng, Yu-Feng Meng, Fei Wang, Yan-Hui-Zhi Feng, Hai-Cheng Wang, Li-Bo Mao, Shu-Hong Yu, Zuo-Lin Wang
Summary: This study developed a biomimetic strategy by using drug proteins to stabilize amorphous carbonated calcium phosphate (ACCP) carriers, which showed high loading capacity and long-term release for drug protein-based therapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Kohei Abe, Susumu Inasawa
Summary: The study revealed that at low ion concentrations, oil droplets were tightly packed, deformed into polygonal shapes, and coalesced into smaller droplets, displaying liquid-like oil-water interfaces. Conversely, at high ion concentrations, oil droplets readily coalesced into larger ellipsoidal shapes, indicating solid-like oil-water interfaces.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Chemistry, Multidisciplinary
Zhefei Yang, Deborah Snyder, Ashlin Sathyan, Anna Balazs, Todd Emrick
Summary: This article reviews the latest advances in smart emulsion droplets, with a focus on the applications of organic, polymer, and/or particle surfactants in inter-droplet communication, controlled delivery, autonomous motion, and tunable emulsion inversion. The authors emphasize the importance of reactive and functional surfactants and the interplay between materials science and biology.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Sten ten Klooster, Machi Takeuchi, Karin Schroen, Remco Tuinier, Rick Joosten, Heiner Friedrich, Claire Berton-Carabin
Summary: This study characterized the coexisting colloidal structures at the nanoscale in model emulsions and found the importance of tiny droplets for the oxidative stability of oil-in-water emulsions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Chuanzi Liu, Zhichao Hao, Tao Yang, Fushi Wang, Feng Sun, Wei Teng
Summary: The study developed a Si/Ca(Sr)-NCF mat with acid resistant and biomimetic mineralizational nanoparticles, demonstrating its potential for dentine remineralization with antibacterial and cytocompatible properties.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Applied
Shengnan Li, Panpan Li, Jing Wang, Yanju Lu, Yuxiang Chen, Zhendong Zhao, Jianxin Jiang, Xian Cheng, Liangwu Bi
Summary: This study prepared low oil emulsion gels stabilized by camellia saponin (CS) and different concentrations of carrageenan (KC), and investigated their particle size, microstructure, rheology, and stability. The results showed that the addition of KC decreased the average particle size of emulsion droplets and resulted in the formation of spindle-shaped oil droplets, leading to good solid-like properties and excellent stability of the samples. These co-stabilized emulsion gels with CS and KC have great potential for solid fat replacement in low-saturated and trans-fat-free foods.
FOOD HYDROCOLLOIDS
(2024)
Article
Food Science & Technology
Sewuese S. Okubanjo, Aiqian Ye, Peter J. Wilde, Harjinder Singh, Simon M. Loveday
Summary: The study compared the performance of an antioxidant when incorporated either in shell droplets or in the core lipid of droplet-stabilized emulsions (DSEs), finding that incorporating it into shell droplets may be more effective. DSEs with trimyristin processed below the shell lipid melting temperature showed the greatest oxidation resistance.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Magdalena A. Czekalska, Anne M. J. Jacobs, Zenon Toprakcioglu, Lingling Kong, Kevin N. Baumann, Hongze Gang, Greta Zubaite, Ruqiang Ye, Bozhong Mu, Aviad Levin, Wilhelm T. S. Huck, Tuomas P. J. Knowles
Summary: This article introduces a robust method for dynamically controlling the generation of Multisomes with controllable sizes and high monodispersity from lipid-based double emulsions. The microfluidic approach involves using three different phases to form a water/oil/water (W/O/W) double emulsion stabilized by lipid layers. By applying a glycerol concentration gradient between the inner core and outer phase to drive directed osmosis, small aqueous daughter droplets can be formed at the interface of the inner aqueous core. By adjusting the glycerol concentration in the outer aqueous phase and varying the osmotic gradient, key structural parameters such as the size of the internal droplets can be specifically controlled. Finally, it is demonstrated that this method can be used to generate Multisomes encapsulating small-molecule cargo, with potential applications in synthetic biology, drug delivery, and as carriers for active materials in the food and cosmetics industries.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Multidisciplinary Sciences
Rikhia Ghosh, Vahid Satarifard, Reinhard Lipowsky
Summary: During endocytosis, cellular membranes engulf nanoparticles and form a closed membrane neck that undergoes fission. This process has been studied extensively for solid nanoparticles and recently observed for liquid and condensate droplets. Molecular dynamics simulations show that both partial and complete engulfment result in two different endocytic pathways, with the shape of the membrane neck playing a crucial role.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Zhe Liu, Aimin Shi, Chao Wu, Xue Hei, Shanshan Li, Hongzhi Liu, Bo Jiao, Benu Adhikari, Qiang Wang
Summary: Shellac nanoparticles (SNPs) produced through the anti-solvent method were used to stabilize Pickering emulsions with different structures. The SNPs showed high hydrophobicity and successfully formed oil-in-water, bi-continuous, and water-in-oil Pickering emulsions. Additionally, the SNPs could be used as templates to prepare porous materials with good water and oil absorption properties.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Sara Baldassari, Alice Balboni, Giuliana Drava, Daniela Donghia, Paolo Canepa, Giorgia Ailuno, Gabriele Caviglioli
Summary: The majority of anticancer agents currently used are derived from plants, which are rich in natural compounds that exhibit antitumor activity. However, many of these molecules suffer from poor pharmacokinetics and limited specificity, which can be overcome by incorporating them into nanovehicles. Cell-derived nanovesicles have shown promise in targeted drug delivery, but their large-scale production and application in clinics are challenging. Bioinspired vesicles that combine cell-derived and artificial membranes have been developed as an alternative, showing flexibility and efficient drug delivery. This review highlights the recent advances in using these vesicles for targeted delivery of anticancer compounds from plants, focusing on vehicle manufacturing, characterization, and effectiveness evaluation through in vitro and in vivo assays. The outlook for these vesicles is promising in terms of efficient drug loading and selective targeting of tumor cells, suggesting future exciting developments.
Article
Chemistry, Applied
Zhisheng Pei, Huibo Wang, Guanghua Xia, Yaqin Hu, Changfeng Xue, Shanshan Lu, Chuan Li, Xuanri Shen
Summary: Surimi products rich in lipids were prepared using myofibril protein emulsion gel as carriers, resulting in stable embedding of oil droplets and prevention of water and oil leakage. The emulsion gel exhibited a hybrid network structure composed of cross-linked myofibril protein polymers and protein-stabilized emulsion droplets, with a high elastic modulus. Adding myofibril protein emulsion gel significantly reduced the gel strength of surimi products.
Article
Chemistry, Multidisciplinary
Qingchuan Li, Qingchun Song, Wei Guo, Yang Cao, Xinyu Cui, Dairong Chen, Ho Cheung Shum
Summary: In this study, a synthetic droplet called segregative-associative (SA) droplets is developed to mimic membraneless organelles (MLOs) in cells. These SA droplets exhibit complex phase behaviors similar to MLOs and can cluster lipid vesicles like synapsin condensates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Maria Reverte-Lopez, Svetozar Gavrilovic, Adrian Merino-Salomon, Hiromune Eto, Ana Yaguee Relimpio, German Rivas, Petra Schwille
Summary: The bottom-up reconstitution of proteins can uncover hidden functions of proteins and in this study, it was shown that the bacterial Min proteins can transport diffusible cargo molecules directionally on membranes. The MinDE protein system was used to design 3D systems with surface patterning, demonstrating the ability to uniformly pattern bioactive molecules. Additionally, the MinDE system can form stationary patterns inside lipid vesicles, allowing for the targeting and clustering of higher-order protein structures. Min proteins are valuable tools for functionalizing artificial biosystems.
Article
Chemistry, Applied
Yang Ni, Qianhui Gu, Jinwei Li, Liuping Fan
Summary: The study found that nanocellulose-stabilized emulsions form a gel structure in the gastric environment, leading to oil droplet aggregation but not coalescence, which reduces lipid digestion. The length of cellulose nanoparticles affects the strength of this emulsion structure.
FOOD HYDROCOLLOIDS
(2021)
Article
Biochemistry & Molecular Biology
Begona Monterroso, Silvia Zorrilla, Marta Sobrinos-Sanguino, Miguel A. Robles-Ramos, Marina Lopez-Alvarez, William Margolin, Christine D. Keating, German Rivas
Article
Multidisciplinary Sciences
Raghav R. Poudyal, Rebecca M. Guth-Metzler, Andrew J. Veenis, Erica A. Frankel, Christine D. Keating, Philip C. Bevilacqua
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Fatma Pir Cakmak, Alex T. Grigas, Christine D. Keating
Article
Biochemistry & Molecular Biology
Gregory A. Mountain, Christine D. Keating
Article
Chemistry, Physical
Andrew T. Rowland, David N. Cacace, Nuerxida Pulati, Morgan L. Gulley, Christine D. Keating
CHEMISTRY OF MATERIALS
(2019)
Article
Chemistry, Physical
Omid Jahanmahin, David J. Kirby, Benjamin D. Smith, Christopher A. Albright, Zachary A. Gobert, Christine D. Keating, Kristen A. Fichthorn
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Article
Chemistry, Physical
Nicole R. Famularo, Rachel S. Hendley, Sarah J. Boehm, Xuexue Guo, Theresa S. Mayer, Michael A. Bevan, Christine D. Keating
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Article
Chemistry, Multidisciplinary
Jennifer R. Miller, Cheng-Yu Wang, Christine D. Keating, Zhiwen Liu
Article
Chemistry, Physical
Nicole R. Famularo, Lei Kang, Zehua Li, Tian Zhao, Kenneth L. Knappenberger, Christine D. Keating, Douglas H. Werner
JOURNAL OF CHEMICAL PHYSICS
(2020)
Article
Multidisciplinary Sciences
Fatma Pir Cakmak, Saehyun Choi, McCauley O. Meyer, Philip C. Bevilacqua, Christine D. Keating
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Charles D. Crowe, Albanie K. Hendrickson-Stives, Stephanie L. Kuhn, Jennifer B. Jackson, Christine D. Keating
Summary: The affordable 3D printed setup is a reliable tool for measuring the contact angle of water on various surfaces, using smart devices as the imaging basis. It provides proper backlighting, stable camera holder, and adjustable platform for samples, resulting in better quality images and improved data acquisition compared to handheld devices. Its success in teaching about water/surface interactions on different surfaces makes it a versatile tool for educators to explore various learning objectives.
JOURNAL OF CHEMICAL EDUCATION
(2021)
Article
Chemistry, Multidisciplinary
Fatma Pir Cakmak, Allyson M. Marianelli, Christine D. Keating
Summary: Formation of coacervate-supported phospholipid membranes by hydrating a dried lipid film in the presence of coacervate droplets leads to the presence of continuous lipid bilayers around many droplets. Different coating types on coacervate droplets result in membrane diversity within the same population, showcasing various functionalities.
Article
Chemistry, Multidisciplinary
Saehyun Choi, McCauley O. Meyer, Philip C. Bevilacqua, Christine D. Keating
Summary: Research has found significant differences in interactions between RNA and adjacent phases of decapeptide-based multiphase model membraneless organelles. Single- and double-stranded RNAs preferentially accumulate in different phases within the same droplet. This discovery is important for understanding and designing functional artificial membraneless organelles.
Article
Chemistry, Physical
Andrew T. Rowland, Christine D. Keating
Summary: Changing the aqueous two-phase system can impact droplet uniformity and solute partitioning, while comparing liposomes formed by extrusion with those formed by vortexing reveals similar effectiveness in creating functional microreactors. This study expands the compositions possible for liposome-stabilized, all-aqueous emulsion droplet bioreactors, providing cost and time-saving alternatives for production.
Article
Multidisciplinary Sciences
Hadi M. Fares, Alexander E. Marras, Jeffrey M. Ting, Matthew Tirrell, Christine D. Keating
NATURE COMMUNICATIONS
(2020)