Article
Materials Science, Multidisciplinary
Abdul Rahim Ferhan, Youngkyu Hwang, Mohammed Shahrudin Bin Ibrahim, Shikhar Anand, Ahram Kim, Joshua A. Jackman, Nam-Joon Cho
Summary: This study presents the development of plasmonic gold nanorod arrays with ultrahigh surface sensitivity for detecting biomacromolecular interactions, demonstrating superior biosensing performance. By rationally tuning nanorod dimensions, the highest reported degree of surface sensitivity compared to various plasmonic nanostructures was achieved. The measurement capabilities developed in this study have broad applicability to a wide range of biosensing applications.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Analytical
James Ethan Batey, Meek Yang, Hannah Giang, Bin Dong
Summary: In this study, an ultrahigh-throughput spectroscopy and microscopy imaging system was developed to characterize AuNPs at the single-particle level using phasor analysis. The developed method allows quantification of spectra and spatial information of a large number of AuNPs with high temporal resolution and localization precision. Compared to conventional optical grating method, the phasor approach enables high-throughput analysis of single-particle SPR properties in high particle density, demonstrating up to 10-fold greater efficiency.
ANALYTICAL CHEMISTRY
(2023)
Article
Optics
Jiayi Wu, Nanshou Wu, Peijun Tang, Jiayi Lin, Yi Lian, Zhilie Tang
Summary: In this Letter, a pulse photothermal optical coherence tomography (P-PTOCT) technique is proposed to solve the separation problem of photothermal phase and Doppler phase, which is difficult to solve in traditional PTOCT. This technique can obtain blood flow distribution, light absorption distribution, and concentration images simultaneously, providing a technical reference for potential clinical research on hemodynamics of cerebral ischemia.
Article
Nanoscience & Nanotechnology
Ling Tong, Jun Yuan, Zhiwei Zhang, Jau Tang, Zhiwei Wang
Summary: This study presents a centred dark-field imaging approach based on ultrafast transmission electron microscopy to directly observe the picosecond-scale evolution of intrananoparticle vibration with high spatial resolution and detection sensitivity.
NATURE NANOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Lin Li, Fenglian Qi, Jiong Guo, Jing Fan, Wenxiang Zheng, Murtaza Ghulam, Weizhi Wang, Zihui Meng, Lili Qiu
Summary: In this study, Fe2O3@Au hexagonal nanodisks with tunable near-infrared (NIR) absorptions were successfully prepared. The localized surface plasmon resonance (LSPR) peaks of Au nanodisks were accurately tuned in the NIR therapeutic window. The Fe2O3@Au nanodisks showed low cytotoxicity and high photothermal therapy (PTT) performance.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Inorganic & Nuclear
Tian Tian, Zefen Li, Naizheng Wang, Sangen Zhao, Jiayue Xu, Zheshuai Lin, Dajiang Mei
Summary: The study successfully synthesized a sulfide compound with a two-dimensional layered structure and large birefringence through structural transformation, providing important guidance for the synthesis of birefringent materials.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mirko Maturi, Paolo Armanetti, Luca Menichetti, Mauro Comes Franchini
Summary: Gold nanorods (GNRs) are suitable contrast agents in photoacoustics (PA) that provide tunable absorption contrast and detectable PA signals from highly localized and targeted areas. Multivariate analysis is essential for recovering relative magnitude spectra and distribution maps of image constituents in biological samples with tunable absorption properties of GNRs.
Article
Engineering, Environmental
Defan Yao, Yanshu Wang, Rongfeng Zou, Kexin Bian, Shuguang Yuan, Bingbo Zhang, Dengbin Wang
Summary: Researchers have successfully developed a toolbox of wavelength-adjustable butterfly molecules and gold nanorods-based peptide nanoassemblies for targeted optical imaging and phototherapy of TNBC, which can significantly reduce background fluorescence and phototoxicity in adjacent healthy tissues. This novel strategy offers potential for specific phototheranostics of TNBC.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Anatomy & Morphology
Guanhua Lu, Ziyu Han, Min Hu
Summary: This article introduces a high-sensitivity optical imaging technology to achieve early tumor diagnosis by detecting tumor angiogenesis. Liver and pancreatic tumor models were established in nude mice, and the changes in blood vessels were verified by immunostaining. The results show that optical imaging methods can effectively monitor the characteristics of angiogenesis in tumors at different stages and under different blood supply conditions, which is of great significance for early tumor diagnosis.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Materials Science, Biomaterials
Xiaokang Jin, Chengfeng Xu, Jinhua Hu, Shuting Yao, Zhiwen Hu, Bing Wang
Summary: The study introduced a versatile nanoplatform using antimonene nanosheets coated with biodegradable chitosan, loaded with small molecule photosensitizer IR820 and gold nanoparticles. This system demonstrated excellent photothermal and photodynamic properties, satisfactory degradability, photoacoustic imaging ability, good biocompatibility, and effective intracellular synergistic treatment triggered by near infrared light.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Sujin Jiracheewanun, Michael B. Cortie, Dakrong Pissuwan
Summary: In this study, the generation and transfer of heat when laser irradiation is applied to water containing gold nanorods coated with different polyelectrolytes were investigated. Experimental measurements were compared to a finite element model. It was observed that high fluences are required to produce biologically relevant temperature changes due to significant lateral heat transfer from the well sides. A 650 mW continuous-wave laser with a wavelength similar to the gold nanorods' longitudinal plasmon resonance peak can deliver heat with an overall efficiency of up to 3%, which is double the efficiency without the nanorods. An increase in temperature of up to 15 degrees C, suitable for inducing cell death by hyperthermia, can be achieved. The nature of the polymer coating on the gold nanorods has only a small effect.
Article
Biochemical Research Methods
Yanjie Wang, Muhannad N. Fadhel, Eno Hysi, Maurice Pastenak, Krishnan Sathiyamoorthy, Michael C. Kolios
Summary: This study reports on the development and application of theragnostic agents targeting HER2 receptors in breast tumors, demonstrating the potential of PLGA-GNRs as theragnostic agents for anti-HER2 breast cancer therapy through in vitro and in vivo studies.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Chemistry, Multidisciplinary
Jin Wang, Yinhang Jia, Qiyue Wang, Zeyu Liang, Guangxu Han, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai, Daishun Ling
Summary: The article introduces a T-1-T-2 dual-mode contrast agent designed for ultrahigh-field MRI, which not only improves resolution and signal-to-noise ratio, but also effectively displays microvasculature structures with high sensitivity and accuracy in detecting tumor vascular permeability.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Tianye Yang, Hui Ren, Wei Zhang, Li Rong, Duo Zhang
Summary: This article focuses on photothermal therapy (PTT) of tumors using gold nanomaterials. It proposes a method of surface coating gold nanomaterials with natural polyphenols with antitumor activity to address the issues faced in related research. The results showed that this method effectively induced apoptosis of tumor cells and achieved synergistic therapy through the photothermal conversion effect of the gold nanomaterials under near-infrared (NIR) laser.
Article
Chemistry, Analytical
Suyan Wang, Qinlu Lin, Seth Leon Filbrun, Rongju Zhou, Qingxiao An, Yueqin Yin, Weizhen Xu, Dong Xu, Cai Liu
Summary: The proposed method utilizes additives to alter chemical equilibriums and enhance sensitivity in detecting nitrite, demonstrating a linear relationship between Delta lambda and nitrite concentration. This approach outperformed the conventional Griess assay and other GNM-based methods, showing potential for application in food sample testing.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Physics, Applied
Yonatan Winetraub, Elliott D. SoRelle, Orly Liba, Adam de la Zerda
APPLIED PHYSICS LETTERS
(2016)
Article
Biochemical Research Methods
Debasish Sen, Elliott D. SoRelle, Orly Liba, Roopa Dalal, Yannis M. Paulus, Tae-Wan Kim, Darius M. Moshfeghi, Adam de la Zerda
JOURNAL OF BIOMEDICAL OPTICS
(2016)
Article
Biology
Elliott D. SoRelle, Orly Liba, Jos L. Campbell, Roopa Dalal, Cristina L. Zavaleta, Adam de la Zerda
Article
Computer Science, Interdisciplinary Applications
Yilei Li, Yonatan Winetraub, Orly Liba, Adam de la Zerda, Steven Chu
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2019)
Article
Chemistry, Physical
Orly Liba, David Kauzlaric, Zeev R. Abrams, Yael Hanein, Andreas Greiner, Jan G. Korvink
MOLECULAR SIMULATION
(2008)
Article
Multidisciplinary Sciences
Orly Liba, Elliott D. SoRelle, Debasish Sen, Adam de la Zerda
SCIENTIFIC REPORTS
(2016)
Article
Chemistry, Multidisciplinary
Rebecca Dutta, Orly Liba, Elliott D. SoRelle, Yonatan Winetraub, Vishnu C. Ramani, Stefanie S. Jeffrey, George W. Sledge, Adam de la Zerda
Article
Chemistry, Multidisciplinary
Elliott Daniel SoRelle, Derek William Yecies, Orly Liba, Frederick Christian Bennett, Claus Moritz Graef, Rebecca Dutta, Siddhartha Mitra, Lydia-Marie Joubert, Samuel Cheshier, Gerald A. Grant, Adam de la Zerda
Proceedings Paper
Engineering, Biomedical
Elliott SoRelle, Orly Liba, Zeshan Hussain, Milan Gambhir, Adam de la Zerda
COLLOIDAL NANOPARTICLES FOR BIOMEDICAL APPLICATIONS X
(2015)