Article
Cell Biology
Marco Gelpi, Flora Mikaeloff, Andreas D. Knudsen, Rui Benfeitas, Shuba Krishnan, Sara Svenssson Akusjarvi, Julie Hogh, Daniel D. Murray, Henrik Ullum, Ujjwal Neogi, Susanne D. Nielsen
Summary: This study investigated metabolic alterations in well-treated PLWH with MetS and identified potential mechanisms and biomarkers associated with MetS through advanced statistical and machine learning algorithms, indicating clinical significance in altered glutamate metabolism.
Article
Multidisciplinary Sciences
Arguine Ivonne Urraza-Robledo, Marta Giralt, Faviel Francisco Gonzalez-Galarza, Francesc Villarroya, Alberto Alejandro Miranda Perez, Pablo Ruiz Flores, Maria Elena Gutierrez Perez, Pere Domingo, Francisco Carlos Lopez-Marquez
Summary: The study revealed that insulin resistance and FGF21 elevations were observed in overweight-obese individuals living with HIV, suggesting a compensation mechanism. In contrast, in the control group, FGF21 correlations appeared to be mainly related to weight and waist circumference.
Article
Infectious Diseases
Yuanyuan Qin, Yihong Zhou, Songtao Liu, Yanqiu Lu, Min Liu, Jing Yuan, Jingmin Nie, Jing Ouyang, Hao Wu, Yingmei Qin, Zhongsheng Jiang, Guoqiang Zhou, Qun Tian, Ke Lan, Yang Zhou, Xinping Yang, Kaiyin He, Jun Liu, Vijay Harypursat, Yaokai Chen
Summary: This study aimed to evaluate the optimal timing of antiretroviral therapy (ART) initiation for HIV-positive patients with talaromycosis. The results showed that patients who initiated ART early had lower mortality rates and lower rates of AIDS-defining events or death compared to those who deferred ART initiation.
JOURNAL OF INFECTION
(2022)
Article
Microbiology
Tonatiuh Abimael Baltazar-Diaz, Fernando Amador-Lara, Jaime F. Andrade-Villanueva, Luz Alicia Gonzalez-Hernandez, Rodolfo Ismael Cabrera-Silva, Karina Sanchez-Reyes, Monserrat Alvarez-Zavala, Aldo Valenzuela-Ramirez, Susana Del Toro-Arreola, Miriam Ruth Bueno-Topete
Summary: Antiretroviral therapies are associated with weight gain and metabolic syndrome in HIV-infected patients. This study evaluated the association between gut microbiota and different treatment regimens in HIV-infected patients with metabolic syndrome. The results revealed that both INSTI-based and PI-based regimens were associated with decreased gut microbiota diversity compared to healthy controls. Additionally, the specific bacterial genera were differentially abundant in the two treatment groups with metabolic syndrome.
Article
Nutrition & Dietetics
Nigusie Shifera, Tewodros Yosef, Mengistu Mekonen
Summary: This study in public hospitals in Southwest Ethiopia found a high prevalence of undernutrition among HAART users, with 29.3% being undernourished, and 10% being overweight or obese. Factors such as food insecurity, history of diarrhea, low CD4 cell count, and substance use were identified as independent factors associated with undernutrition.
FRONTIERS IN NUTRITION
(2022)
Article
Infectious Diseases
Dandan Niu, Ticheng Xiao, Yuanyi Chen, Houlin Tang, Fangfang Chen, Chang Cai, Qianqian Qin, Decai Zhao, Yichen Jin, Shi Wang, Yushan Hou, Zhen Lu, Luoyao Yang, Hong Liu, Dongqin Xie, Huachun Zou, Fan Lyu
Summary: This study investigated the mortality rates among people living with HIV (PLHIV) initiating HAART in Luzhou, China from 2006 to 2020. The results showed a decrease in excess mortality rates over time, but the mortality rate among PLHIV was still higher than the general population. Male gender, low CD4 counts, advanced WHO clinical stages, delayed initiation of HAART, unchanged initial treatment regimens, and virological failure were associated with an increased risk of excess deaths.
BMC INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Nilaramba Adhikari, Ratna Bahadur Bhattarai, Rajendra Basnet, Lok Raj Joshi, Bhim Singh Tinkari, Anil Thapa, Basant Joshi
Summary: This study in Nepal found a 9.9% prevalence of tuberculosis among people living with HIV, with higher risk observed among male individuals, those from the Dalit ethnic group, those at WHO stage 3 and 4 of HIV, and those with a family history of TB. Targeted interventions are needed to prevent TB among PLHIVs in Nepal, as well as integrated TB and HIV diagnosis and treatment services for co-infected individuals.
Article
Multidisciplinary Sciences
Fernando Real, Aiwei Zhu, Boxin Huang, Ania Belmellat, Alexis Sennepin, Thomas Vogl, Celine Ransy, Marc Revol, Riccardo Arrigucci, Anne Lombes, Johannes Roth, Maria Laura Gennaro, Frederic Bouillaud, Sarra Cristofari, Morgane Bomsel
Summary: This study found that tissue-resident macrophages contain active HIV-1 virus and can produce and release the virus upon stimulation with the endogenous factor S100A8. These findings have important implications for future HIV eradication strategies.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Maria P. Yavropoulou, Artemis Kolynou, Polyzois Makras, Maria Pikilidou, Sideris Nanoudis, Lemonia Skoura, Olga Tsachouridou, Georgios Ntritsos, Alexandros Tzallas, Dimitrios G. Tsalikakis, Olga Tsave, Simeon Metallidis, Dimitrios Chatzidimitriou
Summary: The study examined the serum expression of miRNAs linked to bone metabolism in individuals with HIV-associated bone loss. It found that miRNA-21-5p and miRNA-23a-3p were significantly decreased while miRNA-24-2-5p was significantly increased in HIV+ individuals with osteoporosis compared to those with normal bone mass. These findings suggest a common pattern of altered circulating miRNAs related to bone metabolism in HIV+ individuals with osteoporosis.
Article
Ophthalmology
Qun Liu, Zhi-Yi Xu, Xiao-Li Wang, Xiao-Mei Huang, Wen-Lin Zheng, Mei-Jun Li, Fan Xiao, Pei-Wen Ouyang, Xiao-Hua Yang, Yu-Hong Cui, Hong-Wei Pan
Summary: Comparing the ocular microbiota between HIV-infected individuals and healthy individuals revealed compositional and structural differences, indicating that HIV infection or its treatment may contribute to ocular surface dysbiosis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Yi-Hsuan Chen, Chi-Tai Fang, Ming-Chieh Shih, Kuan-Yin Lin, Shu-Sen Chang, Zong-Tai Wu, Yu-Yao Lee, Chang-Hsun Chen
Summary: The study found that routine HIV testing was associated with lower rates of late diagnosis, HIV-related mortality, and all-cause mortality compared to nonroutine testing based on individual risk assessment.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Immunology
Peilin Cao, Yifan Zhang, Guangyan Dong, Hongkun Wu, Yuxiang Yang, Yi Liu
Summary: The purpose of this study was to assess the clinical oral status and investigate the effect of highly active antiretroviral therapy (HAART) on oral flora diversity in HIV-infected/AIDS patients. The study found that demographic indicators such as age, sex, marital status, income level, smoking, and oral health behaviors had an impact on periodontal and dental health indicators in HIV-infected/AIDS patients. Most of these patients had oral manifestations such as candidiasis, salivary gland disease, AIDS-associated periodontitis, and oral ulcers. HAART may play a crucial role in maintaining the salivary microecological balance in AIDS patients, and early initiation of HAART could be important in preventing oral lesions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Rebecka Papaioannu Borjesson, Laura Galli, Camilla Muccini, Andrea Poli, Tommaso Clemente, Martina Bottanelli, Nicola Gianotti, Silvia Nozza, Antonella Castagna, Vincenzo Spagnuolo
Summary: This study analyzed the impact of the COVID-19 pandemic on the prevalence and incidence of metabolic syndrome in people living with HIV. The results showed an increase in both the prevalence and incidence of metabolic syndrome during the pandemic period.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Refeletswe Lebelonyane, Pamela Bachanas, Lisa Block, Faith Ussery, Mary Grace Alwano, Tafireyi Marukutira, Shenaaz El Halabi, Michelle Roland, William Abrams, Gene Ussery, James A. Miller, Shahin Lockman, Tendani Gaolathe, Molly Pretorius Holme, Shannon Hader, Lisa A. Mills, Kathleen Wirth, Naomi Bock, Janet Moore
Summary: Through the Botswana Combination Prevention Project, increases in knowledge of HIV-positive status and ART coverage were achieved towards the 95-95 targets. The increases in HIV testing and ART use among men and youth were essential in reaching these targets.
Review
Pharmacology & Pharmacy
Erin M. B. Scholz, Angela D. M. Kashuba
Summary: Finding a cure for HIV is still a top priority despite advances in treatment, as chronic HIV infection is linked to an increased risk of comorbidities and the importance of adhering to daily antiretroviral therapy. Viral recrudescence from cellular reservoirs in lymphoid tissues is central to the pathology of HIV, and understanding ARV concentrations and distribution in lymph nodes may explain their maintenance as HIV reservoirs and viral rebound upon treatment interruption.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Urology & Nephrology
Esben Iversen, Thomas Kallemose, Mads Hornum, Anne Kathrine Bengaard, Jan Olof Nehlin, Line Jee Hartmann Rasmussen, Haakon Sandholdt, Juliette Tavenier, Bo Feldt-Rasmussen, Ove Andersen, Jesper Eugen-Olsen, Morten Baltzer Houlind
Summary: The study shows that elevated suPAR levels during hospitalization are associated with a decline in eGFR after discharge. Measurement of suPAR may be useful for early detection of kidney disease.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Chemistry, Medicinal
Tanja Stenholdt Andersen, Mia Nimb Gemmer, Hayley Rose Constance Sejberg, Lillian Morch Jorgensen, Thomas Kallemose, Ove Andersen, Esben Iversen, Morten Baltzer Houlind
Summary: Medication reconciliation is crucial for preventing medication errors, but physicians often fail to update the shared electronic prescribing system. This study examined the occurrence of discrepancies, factors associated with discrepancies, and the availability of clinical pharmacists during pharmacy working hours. The findings highlight the frequent discrepancies between the system and patients' actual medication use upon admission to the emergency department.
Article
Health Care Sciences & Services
Nina Thorny Stefansdottir, Per Nilsen, Mette Bendtz Lindstroem, Ove Andersen, Byron J. Powell, Tine Tjornhoj-Thomsen, Jeanette Wassar Kirk
Summary: This study examines the reactions of managers and key employees at a university hospital in Denmark to the planned change to a new Emergency Department (ED), as well as their perceptions of the change involved in its implementation. The findings highlight that the implementation processes in healthcare are not straightforward and that success is not solely determined by the content of the change, but also by how it is perceived by those responsible for the process and their context. Managers need to recognize the need for fluid implementation plans and management skills.
BMC HEALTH SERVICES RESEARCH
(2022)
Letter
Endocrinology & Metabolism
Mads N. Thomsen, Arne Astrup, Jens J. Holst, Sten Madsbad, Faidon Magkos, Steen B. Haugaard, Thure Krarup
Article
Nursing
Anna Zisberg, Jakub Lickiewicz, Amos Rogozinski, Sabine Hahn, Cedric Mabire, Jenny Gentizon, Iwona Malinowska-Lipien, Hulya Bilgin, Zeliha Tulek, Mette Merete Pedersen, Ove Andersen, Hanna Mayer, Birgit Schonfelder, Katrin Gillis, Mattia J. Gilmartin, Allison Squires
Summary: Hospitalization can pose risks for older adults, and most hospitals in Europe are not adequately prepared to meet the unique needs of this population. Assessing the current approaches to care for older adults is an important first step in improving the quality of care. The Geriatric Institutional Assessment Profile could be a valuable tool for this purpose.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Letter
Urology & Nephrology
Esben Iversen, Anne Kathrine Bengaard, Aino Andersen, Thomas Kallemose, Morten Damgaard, Mads Hornum, Bo Feldt-Rasmussen, Ove Andersen, Morten Baltzer Houlind
KIDNEY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Marie Reeberg Sass, Tobias Sogaard Juul, Robert Skov, Kasper Iversen, Lene Holm Harritshoj, Erik Sorensen, Sisse Rye Ostrowski, Ove Andersen, Claus Thorn Ekstrom, Henrik Ullum, Jimmi Nielsen, Ida Hageman, Anders Fink-Jensen
Summary: This study aimed to investigate whether patients with schizophrenia, schizoaffective disorder, and bipolar disorder are at increased risk of COVID-19 infection. The results showed no significant difference in SARS-CoV-2 risk between SMI patients and blood donors in the Capital Region of Denmark, but the infection rate among SMI patients was significantly lower than among blood donors. This is important for understanding the risk of SMI patients in the COVID-19 pandemic.
Article
Environmental Sciences
Pia Keinicke Fabricius, Anissa Aharaz, Nina Thorny Stefansdottir, Morten Baltzer Houlind, Karina Dahl Steffensen, Ove Andersen, Jeanette Wassar Kirk
Summary: Shared decision making about medication with older poly-medicated patients in the Emergency Department is not well-implemented and may lead to inequality in health. Patients' preferences and needs are not being effectively addressed, which puts those with low health literacy at risk. Healthcare professionals should systematically investigate patients' preferences, discuss side effects, and consider reducing harmful medication.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Baker Nawfal Jawad, Janne Petersen, Ove Andersen, Mette Merete Pedersen
Summary: Inactivity is common among older patients during hospitalization, but their daily activity patterns change after discharge, with increased physical activity and an additional peak in the afternoon. This emphasizes the importance of promoting physical activity during hospitalization for older patients.
Review
Public, Environmental & Occupational Health
Charlotte Thor Petersen, Kristoffer Jarlov Jensen, Mary Rosenzweig, Benedikte Irene von Osmanski, Mikkel Zollner Ankarfeldt, Janne Petersen
Summary: This study conducted a systematic mapping review of pharmacoepidemiological studies based on Danish registries published from 2018 to 2019. The results showed that most studies investigated traditional clinical outcomes and used data from the Danish Health Data Authority and Statistics Denmark registries as the primary data sources.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Education & Educational Research
Jeanette Wassar Kirk, Nina Porny Stefansdottir, Byron J. Powell, Mette Bendtz Lindstroem, Ove Andersen, Tine Tjornhoj-Thomsen, Per Nilsen
Summary: This study explored the use of oilcloth sessions as a strategy in implementing new emergency departments in Denmark, based on the experiences of healthcare professionals, managers, and other key employees. The study emphasized the importance of ensuring alignment in implementation strategies, which is often overlooked in the literature and in practice. The findings showed the complexity of challenges faced in using oilcloth sessions, and highlighted the need for alignment among various components in implementation strategies.
BMC MEDICAL EDUCATION
(2022)
Article
Cardiac & Cardiovascular Systems
Shengyuan Luo, Alexi Vasbinder, Jeanne M. Du-Fay-de-Lavallaz, Joanne Michelle D. Gomez, Tisha Suboc, Elizabeth Anderson, Annika Tekumulla, Husam Shadid, Hanna Berlin, Michael Pan, Tariq U. Azam, Ibrahim Khaleel, Kishan Padalia, Chelsea Meloche, Patrick O'Hayer, Tonimarie Catalan, Pennelope Blakely, Christopher Launius, Kingsley-Michael Amadi, Rodica Pop-Busui, Sven H. Loosen, Athanasios Chalkias, Frank Tacke, Evangelos J. Giamarellos-Bourboulis, Izzet Altintas, Jesper Eugen-Olsen, Kim A. Williams, Annabelle Santos Volgman, Jochen Reiser, Salim S. Hayek
Summary: Higher levels of soluble urokinase plasminogen activator receptor (suPAR) were found to be independently associated with an increased risk of venous thromboembolism (VTE) in COVID-19 hospitalized patients, regardless of D-dimer levels. Combining suPAR and D-dimer can help identify patients at low risk of developing VTE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Philip Weber, Mads N. N. Thomsen, Mads Juul Skytte, Amirsalar Samkani, Martin Hansen Carl, Arne Astrup, Jan Frystyk, Jens J. J. Holst, Bolette Hartmann, Sten Madsbad, Faidon Magkos, Thure Krarup, Steen B. B. Haugaard
Summary: In a real-life setting, the benefits of a fully provided, hypocaloric, carbohydrate-reduced high-protein diet were not maintained when individuals with type 2 diabetes switched to self-prepared diets aiming for the same nutritional goals for 6 months.
Article
Medical Informatics
Pernille B. Nielsen, Caroline S. Langkjaer, Martin Schultz, Anne Marie Kodal, Niels Egholm Pedersen, John Asger Petersen, Theis Lange, Michael Dan Arvig, Christian S. Meyhoff, Morten H. Bestle, Bibi Holge-Hazelton, Gitte Bunkenborg, Anne Lippert, Ove Andersen, Lars Simon Rasmussen, Kasper Karmark Iversen
Summary: This study aimed to investigate whether the combination of clinical assessment and Early Warning Scores (EWSs) would reduce the number of routine measurements without increasing mortality. Comparing the Individual EWS (I-EWS) with the National Early Warning Score (NEWS), it was found that I-EWS, which included clinical assessment, was not inferior to NEWS in terms of all-cause mortality at 30 days, and the number of routine measurements was minimally reduced.
LANCET DIGITAL HEALTH
(2022)
Article
Infectious Diseases
Kasper Iversen, Jonas Henrik Kristensen, Rasmus Bo Hasselbalch, Mia Pries-Heje, Pernille Brok Nielsen, Andreas Dehlbaek Knudsen, Kamille Fogh, Jakob Boesgaard Norsk, Ove Andersen, Thea Kohler Fischer, Claus Antonio Juul Jensen, Christian Torp-Pedersen, Jorgen Rungby, Sisse Bolm Ditlev, Ida Hageman, Rasmus Mogelvang, Mikkel Gybel-Brask, Ram B. Dessau, Erik Sorensen, Lene Harritshoj, Fredrik Folke, Curt Sten, Maria Elizabeth Engel Moller, Thomas Benfield, Henrik Ullum, Charlotte Svaerke Jorgensen, Christian Erikstrup, Sisse R. Ostrowski, Susanne Dam Nielsen, Henning Bundgaard
Summary: Healthcare workers remained at an increased risk of SARS-CoV-2 infection during the 6-month period, while seropositivity against SARS-CoV-2 persisted for at least 6 months in the majority of healthcare workers and was associated with a significantly lower risk of reinfection.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
