4.1 Article

Delayed diagnosis of HIV infection and late initiation of antiretroviral therapy in the Swiss HIV Cohort Study

期刊

HIV MEDICINE
卷 9, 期 6, 页码 397-405

出版社

WILEY
DOI: 10.1111/j.1468-1293.2008.00566.x

关键词

cohort study; late ART initiation; late HIV diagnosis; late presentation

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Objectives To investigate delayed HIV diagnosis and late initiation of antiretroviral therapy (ART) in the Swiss HIV Cohort Study. Methods Two sub-populations were included: 1915 patients with HIV diagnosis from 1998 to 2007 and within 3 months of cohort registration (group A), and 1730 treatment-naive patients with CD4 >= 200 cells/mu L before their second cohort visit (group B). In group A, predictors for low initial CD4 cell counts were examined with a median regression. In group B, we studied predictors for CD4 < 200 cells/mu L without ART despite cohort follow-up. Results Median initial CD4 cell count in group A was 331 cells/mu L; 31% and 10% were < 200 and < 50 cells/mu L, respectively. Risk factors for low CD4 count were age and non-White race. Homosexual transmission, intravenous drug use and living alone were protective. In group B, 30% initiated ART with CD4 >= 200 cells/mu L; 18% and 2% dropped to CD4 < 200 and < 50 cells/mu L without ART, respectively. Sub-Saharan origin was associated with lower probability of CD4 < 200 cells/mu L without ART during follow-up. Median CD4 count at ART initiation was 207 and 253 cells/mu L in groups A and B, respectively. Conclusions CD4 < 200 cells/mu L and, particularly, CD4 < 50 cells/mu L before starting ART are predominantly caused by late presentation. Earlier HIV diagnosis is paramount.

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