Article
Gastroenterology & Hepatology
Jia-Chen E. Hu, Franziska Weiss, Christian Bojarski, Federica Branchi, Joerg-Dieter Schulzke, Michael Fromm, Susanne M. Krug
Summary: In remission of UC, tricellulin expression level and intestinal barrier functions were restored to normal after being impaired in active UC. This indicates a re-sealing of the impaired tricellular paracellular pathway and reduced uptake of antigens back to normal rates in remission of UC.
BMC GASTROENTEROLOGY
(2021)
Article
Pharmacology & Pharmacy
Helena Hader, Nina A. Hering, Joerg-Dieter Schulzke, Roland Buecker, Rita Rosenthal
Summary: The study demonstrates the antagonizing effects of myrrh against IL-13-induced barrier impairment in a human intestinal cell model. This suggests the potential use of myrrh as a treatment option for inflammatory bowel disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rina Fujiwara-Tani, Shiori Mori, Ruiko Ogata, Rika Sasaki, Ayaka Ikemoto, Shingo Kishi, Masuo Kondoh, Hiroki Kuniyasu
Summary: CLDN4 is a crucial component of tight junctions in epithelial cells and is overexpressed in many epithelial malignancies. Changes in CLDN4 expression are associated with epigenetic factors, inflammation, and growth factor signaling. CLDN4 plays a role in maintaining the tumor microenvironment and acts as a barrier to anticancer drug entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Carlos Ayala-Torres, Susanne M. Krug, Rita Rosenthal, Michael Fromm
Summary: Water transport in epithelia is regulated by tight junction proteins, with modulation of these proteins affecting ion and macromolecule permeability in tight and intermediate-tight epithelial cell lines. However, transepithelial water permeability is only affected in tight cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Lucas Heils, Martina Schneemann, Ralf Gerhard, Joerg-Dieter Schulzke, Roland Buecker
Summary: The study investigated the impact of Clostridioides difficile binary toxin (CDT) on the intestinal epithelial barrier and found that sublethal concentrations of CDT induced barrier dysfunction with increased permeability and redistribution of tight junction proteins. This suggests that CDT may contribute to diarrhea by compromising the intestinal barrier function.
Article
Multidisciplinary Sciences
Akira C. Saito, Chisato Endo, Yugo Fukazawa, Tomohito Higashi, Hideki Chiba
Summary: MarvelD3 does not affect the morphology of TJ strands and barrier function in MDCK II cells. The carboxy-terminal cytoplasmic tail of tricellulin is dispensable for barrier improvement.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Health Care Sciences & Services
Darren Cowzer, Mohammed Zameer, Michael Conroy, Walter Kolch, Austin G. Duffy
Summary: This article reviews therapeutic innovations targeting RAS signaling in pancreatic cancer from a clinical perspective. Despite the strong resistance of pancreatic cancer to treatment, new approaches such as inhibiting mutated KRAS, KRAS activators, and effectors show promise in breaking this therapeutic deadlock.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Emily Truong, Stephen Pandol, Christie Jeon
Summary: This review examines the role of pancreatic steatosis in the development of pancreatic cancer through epidemiological studies and experimental animal models. It highlights the prevalence of pancreatic steatosis and its association with pancreatic cancer. The review also explores the cellular mechanisms underlying pancreatic steatosis and its impact on the tumor microenvironment, as well as the effects of bariatric surgery. Additionally, it identifies gaps in current knowledge and proposes future research directions for understanding the mechanisms of other obesity-associated cancers.
Article
Medicine, General & Internal
Tawfik Khoury, Wisam Sbeit
Summary: This study found a significant association between fatty pancreas and pancreatic cancer. Fatty pancreas may be an important risk factor for pancreatic cancer. A follow-up plan should be considered for individuals with fatty pancreas.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Yuma Cho, Daichi Haraguchi, Kenta Shigetomi, Kenji Matsuzawa, Seiichi Uchida, Junichi Ikenouchi
Summary: This study revealed the role of tricellulin in regulating actomyosin organization at tricellular junctions, contributing to the formation of the epithelial barrier. Additionally, alpha-catenin was identified as a novel binding partner of tricellulin, bridging tricellulin attachment to actin cables and closing the gap at tricellular junctions.
JOURNAL OF CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lokender Kumar, Sanjay Kumar, Kumar Sandeep, Sanjay Kumar Singh Patel
Summary: Cancer poses a significant challenge for effective treatment due to its complex mechanism, different stages of progression, and lack of screening and identification procedures. Pancreatic cancer, with a low survival rate of around 5 years, is ranked seventh globally among mortality-associated cancers. Therefore, it is crucial to develop diagnostic procedures for early detection, understand pancreatic cancer mechanisms, and explore therapeutic strategies. This review highlights recent developments in pancreatic cancer progression, mechanisms, and therapeutic approaches, including molecular techniques and biomedicines for effective cancer treatment.
Article
Biochemistry & Molecular Biology
Jorge Yassen Diaz-Blancas, Ismael Dominguez-Rosado, Carlos Chan-Nunez, Jorge Melendez-Zajgla, Vilma Maldonado
Summary: This study analyzed the effects of platelets on pancreatic cancer cells and found that platelets can increase the proliferation and migration capacity of cancer cells, enhance clonogenicity, and induce higher expression of stem cell markers. Differential expression of microRNAs in platelets from pancreatic cancer patients and healthy subjects was also discovered, with clear differences between the two groups. Furthermore, differences between blood-derived and pancreatic juice-derived platelets in the cancer patients suggest the presence of distinct platelet subpopulations, warranting further analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Junjie Huang, Veeleah Lok, Chun Ho Ngai, Lin Zhang, Jinqiu Yuan, Xiang Qian Lao, Kelvin Ng, Charing Chong, Zhi-Jie Zheng, Martin C. S. Wong
Summary: Through data analysis of 48 countries, increasing trends in pancreatic cancer incidence and mortality were observed, especially among women and populations over the age of 50, as well as among younger individuals. More preventive efforts are recommended for these populations.
Article
Surgery
Bradley N. Reames, Alex B. Blair, Robert W. Krell, Vincent P. Groot, Georgios Gemenetzis, James C. Padussis, Sarah P. Thayer, Massimo Falconi, Christopher L. Wolfgang, Matthew J. Weiss, Chandrakanth Are, Jin He
Summary: There is substantial variation in management preferences, perceived contraindications to surgery, and the propensity to consider exploration in LAPC among an international cohort of pancreas surgeons. These results emphasize the importance of a robust and nuanced multidisciplinary discussion for each patient, and suggest an evolving concept of resectability.
Review
Cell Biology
Joan Casamitjana, Elisa Espinet, Meritxell Rovira
Summary: Ex vivo organoid cultures have gained attention as a model for studying regenerative medicine and diseases in the pancreas. Pancreatic organoids can be generated for diabetes research and studying pancreatic ductal adenocarcinoma, serving as a translational bridge between in vitro and in vivo models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Tibor Szarvas, Michele J. Hoffmann, Csilla Olah, Eszter Szekely, Andras Kiss, Jochen Hess, Stephan Tschirdewahn, Boris Hadaschik, Vera Grotheer, Peter Nyirady, Anita Csizmarik, Melinda Varadi, Henning Reis
Summary: Chemotherapy resistance is a major issue in bladder cancer treatment. MMP-7 tissue and serum levels are associated with poor prognosis in patients undergoing platinum-based chemotherapy. Analysis of MMP-7 may help in optimizing therapeutic decisions for bladder cancer patients.
Article
Oncology
Andrea Reszegi, Katalin Karaszi, Gabor Toth, Kristof Rada, Lorand Vancza, Lilla Turiak, Zsuzsa Schaff, Andras Kiss, Laszlo Szilak, Gabor Szabo, Gabor Petovari, Anna Sebestyen, Katalin Dezso, Eszter Regos, Peter Tatrai, Kornelia Baghy, Ilona Kovalszky
Summary: Syndecan-1 plays a dual role in tumor development, either promoting or inhibiting tumors depending on the cancer type. In the context of liver cancer, transgenic expression of human syndecan-1 delayed tumor formation by downregulating lipid metabolism, inhibiting mTOR and beta-catenin pathways, and activating Foxo1 and p53 transcription factors. This oncoprotective effect was mediated by a beneficial modulation of lipid metabolism and molecular signaling pathways involved in cell cycle regulation and intermediary metabolism.
Review
Urology & Nephrology
Maximilian Pallauf, Thomas Herrmann, David Oswald, Peter Torzsok, Susanne Deininger, Lukas Lusuardi
Summary: Endoscopic surgery for benign prostatic enlargement has become a preferred treatment option for patients on antithrombotic medication or undergoing same-day surgery. Advancements in surgical techniques have improved patient outcomes, making surgical treatment an appealing choice for sexually active men.
CURRENT OPINION IN UROLOGY
(2021)
Article
Emergency Medicine
Christian Deininger, Thomas Freude, Florian Wichlas, Lukas Konstantin Kriechbaumer, Sebastian Hubertus Markus Deininger, Peter Toerzsoek, Lukas Lusuardi, Maximilian Pallauf, Amelie Deluca, Susanne Deininger
Summary: The study analyzed blunt renal trauma cases treated in a Level 1 Trauma Center in Austria, finding that sports-associated blunt renal trauma is more likely to occur isolated and has a lower risk of severe outcomes compared to other trauma mechanisms. Non-operative management was successfully performed in over 90% of cases.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Review
Oncology
Susanne Deininger, Peter Toerzsoek, Michael Mitterberger, Maximilian Pallauf, David Oswald, Christian Deininger, Lukas Lusuardi
Summary: In non-muscle-invasive bladder cancer, immune-modulating therapies and oncolytic virus instillations show good efficacy without significant systemic adverse events. Recombinant BCG and recombinant pox-viral vector vaccines need further investigation, and interleukin mediating therapies are currently being studied.
Article
Oncology
Susanne Deininger, Lukas Lusuardi, Maximilian Pallauf, Stefan Hecht, Rosemarie Forstner, Matthias Meissnitzer, Florian A. Distler, Eva Erne, Sebastian Graf, Sebastian Lenart, Juliane Putz, Christian Deininger, Peter Toerzsoek
Summary: This study compared the diagnostic accuracy of MRI and standard ultrasound in testicular tumors, showing that MRI has good sensitivity and specificity for estimating testicular tumors, with benign lesions significantly smaller than malignant ones.
Article
Medicine, General & Internal
Peter Toerzsoek, Christopher Steiner, Maximilian Pallauf, Michael Abenhardt, Ljiljana Milinovic, Bethseba Plank, Alena Rueckl, Manuela Sieberer, Lukas Lusuardi, Susanne Deininger
Summary: This study investigates the long-term effects of surgery for testicular torsion (TT) on endocrine and exocrine testicular function, oxidative stress in semen, and erectile function. The results show that TT does not significantly affect these functions in the long term. Preservation of the testis is associated with a higher round cell count and follicle stimulating hormone (FSH) compared to orchiectomy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
David Oswald, Maximilian Pallauf, Susanne Deininger, Peter Torzsok, Manuela Sieberer, Christian Eiben
Summary: This study analyzed the effectiveness of neoadjuvant chemotherapy and immunotherapy in patients with upper tract urothelial carcinoma. The results showed that neoadjuvant chemotherapy significantly improved pathological downstaging and complete response rates, as well as overall survival and progression-free survival. However, there were no comparative studies on immunotherapy in this setting.
Article
Infectious Diseases
Susanne Deininger, Therese Gruendler, Sebastian Hubertus Markus Deininger, Karina Luetcke, Harry Luetcke, James Agbesi, Williams Ladzaka, Eric Gyamfi, Florian Wichlas, Valeska Hofmann, Eva Erne, Peter Toerzsoek, Lukas Lusuardi, Jan Marco Kern, Christian Deininger
Summary: Little is known about the antimicrobial resistance (AMR) status of uropathogens in Western Africa. This study retrospectively evaluated the urine cultures of patients in a rural hospital in Ghana and found alarmingly high AMR rates among uropathogens, including resistance to reserve antibiotics. Similar resistance profiles may be present in West African patients living in high-income countries.
Article
Nutrition & Dietetics
Peter Toerzsoek, Jasper Van Goubergen, Martin Pichler, Renate Pichler, Frederic R. Santer
Summary: Isochromosome 12p is common in invasive testicular cancers and increased gene copy number on this chromosome is related to tumor development. Genes involved in Vitamin D metabolism are clustered in chromosome 12. The mRNA expression of Vitamin D receptor (VDR) and enzymes involved in Vitamin D metabolism can distinguish between different types of testicular tumors. Disturbance in Vitamin D metabolism through iChr12p formation may influence testicular carcinogenesis. Further research is needed to understand the relationship between Vitamin D deficiency, iChr12p formation, and testicular cancer.
Article
Multidisciplinary Sciences
Peter Torzsok, David Oswald, Klaus-Peter Dieckmann, Markus Angerer, Lukas Christian Scherer, Piotr Tymoszuk, Yannic Kunz, Germar-Michael Pinggera, Lukas Lusuardi, Wolfgang Horninger, Renate Pichler
Summary: This study investigated the preoperative sexual hormone homeostasis in patients with testicular germ cell tumors (TGCT) and identified different hormonal clusters. TGCT may directly influence the systemic hormone balance through in-situ synthesis of sex hormones.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Susanne Deininger, Peter Toerzsoek, Lukas Lusuardi, Sebastian Hubertus Markus Deininger, Thomas Freude, Florian Wichlas, Christian Deininger
Summary: This study reports three cases of traumatic renal arteriovenous fistulas following blunt renal laceration. Renal arteriovenous fistula is a rare but severe complication associated with higher-grade renal trauma. Coil embolization can help preserve kidney function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Peter Torzsok, David Oswald, Christopher Steiner, Michael Abenhardt, Christian Ramesmayer, Ljiljana Milinovic, Bethseba Plank, Zoe Tischleritsch, Lukas Lusuardi, Susanne Deininger
Summary: This study evaluated the effects of COVID-19 infection on male fertility and sexual function. The results showed that COVID-19 infection does not appear to negatively impact sperm quality and oxidative stress in the intermediate term.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Klaus-Peter Dieckmann, Tomas Pokrivcak, Lajos Geczi, David Niehaus, Inken Dralle-Filiz, Cord Matthies, Tamas Dienes, Stefanie Zschaebitz, Pia Paffenholz, Tanja Gschliesser, Renate Pichler, Michal Mego, Pia Bader, Friedemann Zengerling, Julia Heinzelbecker, Philipp Krausewitz, Susanne Krege, Gaetano Aurilio, Cem Aksoy, Marcus Hentrich, Christoph Seidel, Peter Toerzsoek, Tim Nestler, Matthaeus Majewski, Andreas Hiester, Tomas Buchler, Sonia Vallet, Hana Studentova, Sandra Schoenburg, Dora Niedersuess-Beke, Julia Ring, Emanuela Trenti, Axel Heidenreich, Christian Wuelfing, Hendrik Isbarn, Uwe Pichlmeier, Martin Pichler
Summary: The 1xBEP regimen is a safe treatment for patients with CS1 NSGCT, with a low relapse rate and a high cure rate for relapses.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Andrology
Kilian Vomstein, Elisabeth Reiser, Germar Pinggera, Peter Toerzsoek, Susanne Deininger, Thomas Kriesche, Wolfgang Biasio, Lukas Lusuardi, Bettina Toth
Summary: This study aimed to compare sperm quality in different cancer types and benign diseases before gonadotoxic treatment, with patients with testicular malignancy showing the lowest sperm counts. The usage rate of cryopreserved sperm for assisted reproductive treatment was found to be low, highlighting the need for further patient interviews and sperm analyses to optimize fertility preservation strategies.
ASIAN JOURNAL OF ANDROLOGY
(2021)