Article
Oncology
Simone Augustinus, Pascale J. M. V. Schafrat, Boris V. A. Janssen, Bert A. Bonsing, Lodewijk A. A. R. Brosens, Olivier R. Busch, Stijn Crobach, Michail H. Doukas, Casper H. van Eijck, Lydia G. M. van der Geest, Bas Groot Koerkamp, Ignace H. J. T. de Hingh, G. Mihaela C. Raicu, Hjalmar C. van Santvoort, Marie-Louise van Velthuysen, Joanne G. Verheij, Marc G. Besselink, Arantza Farina Sarasqueta
Summary: This nationwide retrospective cohort study found that the rate of R0 resection after pancreatoduodenectomy for pancreatic cancer decreased over time, mainly due to more complete pathology reporting. R0 resection remained associated with overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Christof Kaltenmeier, Ibrahim Nassour, Richard S. Hoehn, Sidrah Khan, Alison Althans, David A. Geller, Alessandro Paniccia, Amer Zureikat, Samer Tohme
Summary: The study examined predictors and impact of resection margins on survival in patients with resected pancreatic cancer. Positive margins were associated with poorer survival outcomes compared to negative margins, regardless of stage and receipt of adjuvant therapy. Factors like neoadjuvant treatment and treatment at Academic/Research Programs significantly predict the likelihood of achieving negative margins.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Mihir M. Shah, Jashodeep Datta, Nipun B. Merchant, David A. Kooby
Summary: The important goal of cancer surgery is to achieve negative surgical margins and completely remove all disease. However, extending resection to ensure clear margins may not improve patient outcome, as an initial positive margin may indicate more aggressive underlying tumor biology. Careful consideration is needed in the management of initial positive margins in pancreatic neoplasms to determine if more aggressive approaches are necessary.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Giulio Belfiori, Guido Fiorentini, Domenico Tamburrino, Stefano Partelli, Michele Pagnanelli, Giulia Gasparini, Renato Castoldi, Gianpaolo Balzano, Corrado Rubini, Giuseppe Zamboni, Stefano Crippa, Massimo Falconi
Summary: The study evaluated the impact of venous vascular resection for pancreatic ductal adenocarcinoma on postoperative and long-term outcomes. Venous vascular resection was associated with increased morbidity, R1 resections, and perineural invasion. Patients who underwent venous vascular resection had lower disease-free and disease-specific survival rates.
Review
Surgery
Jie Wu, Yuqian Hu, Liwei Xu
Summary: This study found that positive circumferential resection margin is associated with worse prognosis in esophageal cancer through systematic review and meta-analysis.
UPDATES IN SURGERY
(2022)
Article
Surgery
Sivesh K. Kamarajah, Christopher J. Sonnenday, Clifford S. Cho, Timothy L. Frankel, Filip Bednar, Theodore S. Lawrence, Hari Nathan
Summary: Adjuvant radiotherapy after R0 resection of PDAC is associated with improved survival, particularly in patients with node-positive disease. This survival benefit was shown to be restricted to patients with N1 and N2 disease. Adjuvant RT should be considered in node-positive PDAC patients after R0 resection.
Article
Oncology
L. A. Daamen, I. W. J. M. van Goor, T. J. Schouten, G. Dorland, S. R. van Roessel, M. G. Besselink, B. A. Bonsing, K. Bosscha, L. A. A. Brosens, O. R. Busch, R. M. van Dam, A. Farina Sarasqueta, S. Festen, B. Groot Koerkamp, E. van der Harst, I. H. J. T. de Hingh, M. P. W. Intven, G. Kazemier, V. E. de Meijer, V. B. Nieuwenhuijs, G. M. Raicu, D. Roos, J. M. J. Schreinemakers, M. W. J. Stommel, M. F. van Velthuysen, J. Verheij, H. M. Verkooijen, H. C. van Santvoort, I. Q. Molenaar
Summary: This study aimed to assess the prognostic value of different definitions for resection margin status on disease-free survival (DFS) and overall survival (OS) in pancreatic ductal adenocarcinoma (PDAC). R1 (direct) margin involvement was associated with worse OS, and preoperative predictors of R1 (direct) included age, male sex, performance score 2-4, and venous or arterial tumor involvement.
Article
Oncology
B. Brac, C. Dufour, H. Behal, M. Vanderbeken, J. Labreuche, E. Leteurtre, C. Mariette, C. Eveno, G. Piessen, F. Renaud
Summary: This study found that the CAP definition was more accurate in predicting prognosis and recurrence, and identified a new cutoff value for CRM based on histologic type.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Qiao Ke, Zhiting Guo, Jian He, Zisen Lai, Fuli Xin, Yongyi Zeng, Lei Wang, Jingfeng Liu
Summary: The width of resection margin (RM) does not appear to have a significant impact on the prognosis of patients with solitary hepatocellular carcinoma (HCC) undergoing anatomical resection (AR). However, in certain selected patients, a wider RM may confer benefits.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Review
Oncology
Maia Blomhoff Holm, Caroline Sophie Verbeke
Summary: Pancreatic cancer has a poor prognosis, and surgical resection is the only curative treatment option. However, there is limited data on the prognostic impact of the resection margin status in distal pancreatectomy specimens, and the existing studies show divergent results due to small sample sizes and heterogeneity in pathology examination practices.
Article
Oncology
Takanori Konishi, Shigetsugu Takano, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Isamu Hosokawa, Takashi Mishima, Masayuki Ohtsuka
Summary: Extrapancreatic nerve plexus (PL) invasion is a common pathological feature of aggressive pancreatic ductal adenocarcinoma (PDAC) and is associated with extensive venous invasion and a high percentage of lymph node metastases. The resection margin status does not seem to have an impact on the survival of PDAC patients with PL invasion.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Chaobin He, Shuxin Sun, Xin Huang, Yu Zhang, Xiaojun Lin, Shengping Li
Summary: The study compared the long-term survival of LAPC patients after neoadjuvant chemotherapy followed by conversional resection and IRE. Patients in the resection and IRE groups had similar median OS time, which was significantly longer than that of the chemotherapy group. Combining chemotherapy with resection or IRE was identified as significant prognostic factors for OS and PFS in LAPC patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Mohadeseh Fathi, Tianyue Zhai, Mohammad Taheri, Peixin Dong
Summary: Pancreatic cancer is a deadly neoplasm with poor prognosis, and recent research has highlighted the impact of lncRNAs on its progression. Some lncRNAs are oncogenic while others act as tumor suppressors in pancreatic cancer. Dysregulated expression of specific lncRNAs may serve as prognostic markers in patients with this aggressive cancer.
Review
Oncology
S. G. Brouwer de Koning, A. W. M. A. Schaeffers, W. Schats, M. W. M. van den Brekel, T. J. M. Ruers, M. B. Karakullukcu
Summary: One of the main challenges in oral cancer surgery is obtaining adequate resection margins, especially the deep margin. A systematic review of current technologies shows promising methods for assessing the deep resection margin, with techniques like fluorescence and optical imaging showing potential for future use in larger trials.
Article
Oncology
Zhaoyang Yang, Hua Lin, Zhen Wang, Lulu Rong, Xuchen Zhang, Lin Wang, Jianjun Qin, Xuemin Xue, Yin Li, Liyan Xue
Summary: This study evaluated the long-term prognostic significance of circumferential resection margin (CRM) status in esophageal squamous cell carcinoma (ESCC) using different CRM criteria. The results showed that CRM status, based on different criteria, was an independent prognostic factor. However, the prognostic value of CRM status was limited to patients without or with less lymph node metastasis. The study recommended the use of the 1 mm-three-tier criteria for more predictive value in clinical practice.
Article
Gastroenterology & Hepatology
Sandra van Brunschot, Robbert A. Hollemans, Olaf J. Bakker, Marc G. Besselink, Todd H. Baron, Hans G. Beger, Marja A. Boermeester, Thomas L. Bollen, Marco J. Bruno, Ross Carter, Jeremy J. French, Djalma Coelho, Bjoern Dahl, Marcel G. Dijkgraaf, Nilesh Doctor, Peter J. Fagenholz, Gyula Farkas, Carlos Fernandez del Castillo, Paul Fockens, Martin L. Freeman, Timothy B. Gardner, Harry van Goor, Hein G. Gooszen, Gerjon Hannink, Rajiv Lochan, Colin J. McKay, John P. Neoptolemos, Atilla Olah, Rowan W. Parks, Miroslav P. Peev, Michael Raraty, Bettina Rau, Thomas Rosch, Maroeska Rovers, Hans Seifert, Ajith K. Siriwardena, Karen D. Horvath, Hjalmar C. van Santvoort
Article
Oncology
Andrea S. Bauer, Petr V. Nazarov, Nathalia A. Giese, Stefania Beghelli, Anette Heller, William Greenhalf, Eithne Costello, Arnaud Muller, Melanie Bier, Oliver Strobel, Thilo Hackert, Laurent Vallar, Aldo Scarpa, Markus W. Buechler, John P. Neoptolemos, Stephanie Kreis, Joerg D. Hoheisel
INTERNATIONAL JOURNAL OF CANCER
(2018)
Review
Oncology
Oliver Strobel, John Neoptolemos, Dirk Jaeger, Markus W. Buechler
NATURE REVIEWS CLINICAL ONCOLOGY
(2019)
Article
Surgery
Paula Ghaneh, Jorg Kleeff, Christopher M. Halloran, Michael Raraty, Richard Jackson, James Melling, Owain Jones, Daniel H. Palmer, Trevor F. Cox, Chloe J. Smith, Derek A. O'Reilly, Jakob R. Izbicki, Andrew G. Scarfe, Juan W. Valle, Alexander C. McDonald, Ross Carter, Niall C. Tebbutt, David Goldstein, Robert Padbury, Jennifer Shannon, Christos Dervenis, Bengt Glimelius, Mark Deakin, Alan Anthoney, Markus M. Lerch, Julia Mayerle, Attila Olah, Charlotte L. Rawcliffe, Fiona Campbell, Oliver Strobel, Markus W. Buechler, John P. Neoptolemos
Article
Surgery
A. R. G. Sheel, R. D. Baron, L. D. Dickerson, P. Ghaneh, F. Campbell, M. G. T. Raraty, V Yip, C. M. Halloran, J. P. Neoptolemos
LANGENBECKS ARCHIVES OF SURGERY
(2019)
Article
Gastroenterology & Hepatology
Aimilia Exarchakou, Georgia Papacleovoulou, Brian Rous, Winnie Magadi, Bernard Rachet, John P. Neoptolemos, Michel P. Coleman
Review
Surgery
Max Heckler, Thilo Hackert, Kai Hu, Cristopher M. Halloran, Markus W. Buechler, John P. Neoptolemos
Summary: Acute pancreatitis is a sudden inflammatory attack of the pancreas, with a mortality rate of 15-20% in severe cases. Early and accurate diagnosis is crucial for initiating appropriate treatment and improving survival rates. Intensive monitoring and management is necessary for severe cases, with a focus on preventing multi-organ failure and implementing effective treatments for local complications.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Cell Biology
L. Xia, Z. Xu, X. Zhou, F. Bergmann, N. Grabe, M. W. Buechler, J. P. Neoptolemos, T. Hackert, G. Kroemer, F. Fortunato
CELL DEATH & DISEASE
(2020)
Article
Surgery
Ryan D. Baron, Andrea R. G. Sheel, Ammad Farooq, Joerg Kleeff, Pietro Contin, Christopher M. Halloran, John P. Neoptolemos
Summary: The Livocado procedure is a safe and successful option for patients with chronic pancreatitis complicated by vascular involvement. Post-operative pain scores significantly improved, with two-thirds of patients being completely pain-free at 12 months, and employment rehabilitation rates also increased significantly.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Review
Gastroenterology & Hepatology
Patrick Michl, Matthias Lohr, John P. Neoptolemos, Gabriele Capurso, Vinciane Rebours, Nuria Malats, Mathilde Ollivier, Luigi Ricciardiello
Summary: Pancreatic ductal adenocarcinoma is a deadly cancer with scarce research funding in Europe, calling for public-private partnerships to support research and improve treatment methods.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Editorial Material
Oncology
Christoph Springfeld, John P. Neoptolemos
Summary: Pancreatic ductal adenocarcinoma (PDAC) patients typically have poor prognosis, and even after curative resection, most patients experience disease relapse and ultimately die. However, adjuvant chemotherapy has significantly improved outcomes for patients eligible for surgery. The PREOPANC trial provides evidence supporting neoadjuvant therapy for patients with borderline resectable PDACs, but not for those with resectable tumors.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Letter
Oncology
M. W. Buechler, J. P. Neoptolemos
ANNALS OF ONCOLOGY
(2023)
Review
Oncology
Christoph Springfeld, Cristina R. Ferrone, Matthew H. G. Katz, Philip A. Philip, Theodore S. Hong, Thilo Hackert, Markus W. Buechler, John Neoptolemos
Summary: This article discusses the treatment strategies for pancreatic ductal adenocarcinoma (PDAC), including surgical resection and systemic chemotherapy. Neoadjuvant chemotherapy may improve the survival outcomes of patients with borderline-resectable PDAC. For patients with unresectable PDAC, undergoing chemotherapy may lead to surgical resection and improved survival outcomes.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Letter
Oncology
Christoph Springfeld, Markus W. Buchler, John P. Neoptolemos
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Cell Biology
Peter Bailey, Xu Zhou, Jingyu An, Teresa Peccerella, Kai Hu, Christoph Springfeld, Markus Buechler, John P. Neoptolemos
Summary: Pancreatic cancer is a highly lethal cancer, especially in Europe and North America. Combination therapies have improved survival in the short and medium term. Early diagnosis and aggressive treatment have the best chance for long-term survival. Metastatic pancreatic cancer is difficult to treat and often only palliative options are available.