Article
Oncology
Zhuoya Yu, Mengfei Ding, Yiqing Cai, Tiange Lu, Xiaomin Chen, Xiangxiang Zhou, Xin Wang
Summary: Recent studies have shown that epigenetic alterations, particularly histone acetylation, play a significant role in the pathogenesis of lymphoma. A HAscore model has been developed to analyze histone acetylation patterns in DLBCL, revealing that patients with a low HAscore have distinct tumor immune microenvironments and poorer prognoses. KAT2A has been identified as a potential biomarker related to immune infiltration and malignant pathways in DLBCL.
Article
Obstetrics & Gynecology
Ferran Barrachina, Alberto de la Iglesia, Meritxell Jodar, Ada Soler-Ventura, Carme Mallofre, Leonardo Rodriguez-Carunchio, Afsaneh Goudarzi, Juan Manuel Corral, Josep Lluis Ballesca, Judit Castillo, Rafael Oliva
Summary: In this study, the researchers investigated the alteration of histone H4 acetylation (H4ac) in the seminiferous tubules of testicular tumour patients. They found a considerable dysregulation of H4ac in the unaffected cells of the seminiferous tubules adjacent to the tumours, suggesting a potential paracrine effect of the neoplasia. This epigenetic alteration could have implications for the molecular changes in male germ cells in testicular tumour patients.
HUMAN REPRODUCTION
(2022)
Article
Neurosciences
Bryan McClarty, Guadalupe Rodriguez, Hongxin Dong
Summary: The study showed that the HDAC inhibitor CI-994 at different doses could reduce motor and memory side effects induced by haloperidol in aged mice. A dose of 20 mg/kg was effective in improving motor coordination and mitigating memory impairment in aged mice. Biochemical analyses indicated an increase in histone acetylation and expression of the dopamine 2 receptor gene in aged mice after administration of CI-994 at 20 mg/kg.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Immunology
Yue Zhu, Di Fu, Qing Shi, Ziyang Shi, Lei Dong, Hongmei Yi, Zhenhua Liu, Yan Feng, Qian Liu, Hai Fang, Shu Cheng, Li Wang, Qiang Tian, Pengpeng Xu, Weili Zhao
Summary: The prognosis of diffuse large B-cell lymphoma (DLBCL) is worse in older patients, who present with advanced disease stage, specific genetic mutations, and immune system dysfunction. Understanding the molecular features and tumor microenvironment alterations in older DLBCL patients may provide insights for targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Shunfeng Hu, Tiange Lu, Juanjuan Shang, Yiqing Cai, Mengfei Ding, Xiangxiang Zhou, Xin Wang
Summary: This study found that DLBCL patients have high concentration of serum PGD2 and low expression of PGD2 receptor CRTH2, which are associated with clinical features and prognosis. Moreover, high-concentration PGD2 can inhibit DLBCL progression by regulating cell proliferation, apoptosis, cell cycle, and invasion, as well as induce DNA damage and enhance the cytotoxicity of anti-tumor drugs. Additionally, HDAC inhibitors and CRTH2 inhibitors can modulate PGD2 production and enhance their anti-tumor effects. Overall, PGD2 and CRTH2 may serve as prognostic biomarkers and therapeutic targets in DLBCL.
CELL DEATH DISCOVERY
(2023)
Article
Medicine, Research & Experimental
Zhihui Song, Lili Yang, Wei Hu, Jianping Yi, Fumin Feng, Lingyan Zhu
Summary: Histone modification is closely associated with diseases, especially during pregnancy. This study investigated the associations among histone acetylation, matrix metalloproteinases (MMPs), and premature rupture of membranes (PROM). The results showed that MMP2 and MMP9 activities differed in PPROM and TPROM, and HDAC inhibitors reduced cell invasion and migration ability, as well as MMP2 and MMP9 expression levels in vitro.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Anagh Ray, Preeti Khan, Ronita Nag Chaudhuri
Summary: The study highlights the importance of lysine acetylation in maintaining chromatin structure and function, specifically focusing on the role of H4K16 acetylation in regulating the expression of constitutive genes. Deacetylation of H4K16 is associated with hypoacetylation of H4K12 and H3K9, along with hyperacetylation of H3K56, creating a chromatin landscape conducive for transcription of constitutive genes.
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Svetlana Sharifulina
Summary: HDAC and HAT play crucial roles in regulating cell functions through acetylating/deacetylating histones and non-histone proteins, impacting cell survival, death, and other processes. The effects of stroke on non-histone protein acetylation/deacetylation in brain cells are still poorly understood, but HDAC inhibitors have shown promise in protecting the brain from ischemic damage. The roles of different HDAC isoforms in brain cell survival and death after stroke remain controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Rihan Hai, Liuer He, Guang Shu, Gang Yin
Summary: Epigenetic dysregulation, specifically through histone post-translational modifications, plays a crucial role in tumour pathogenesis. Histone deacetylases and histone acetyltransferases are pivotal epigenetic modulators that regulate the transcription of oncogenes and tumour suppressor genes, influencing a host of pathological processes in cancer development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Neurosciences
Heena Khan, Palak Tiwari, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Sirtuins, as a class III of histone deacetylases dependent on nicotinamide adenine dinucleotide, play a significant role in influencing the progression of neurodegenerative disorders by switching between deacetylation and acetylation processes. Pharmacological modulation of sirtuin activity has shown promising effects on various neurodegenerative disorders, and sirtuins may serve as a potential therapeutic target for the treatment of these diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Priscilla Van den Ackerveken, Alison Lobbens, Dorian Pamart, Aristotelis Kotronoulas, Guillaume Rommelaere, Mark Eccleston, Marielle Herzog
Summary: This study found that the levels of H3.1-nucleosomes are elevated in the plasma samples of patients with non-Hodgkin lymphoma (NHL) compared to healthy donors. The study also identified eight histone post-translational modifications (PTMs) that were present at higher levels in NHL patients' plasma. These findings suggest that H3.1-nucleosomes and histone PTMs may serve as useful biomarkers for diagnosing and monitoring non-Hodgkin lymphoma.
SCIENTIFIC REPORTS
(2023)
Review
Genetics & Heredity
Shuang Li, Xu He, Yuan Gao, Chenguang Zhou, Vincent L. Chiang, Wei Li
Summary: The article summarizes the changes in histone acetylation in plant response to drought stress, and reviews the functions of histone acetyltransferases and histone deacetylases in drought response and resistance.
Article
Cell Biology
Jin Yang, Francis Grafton, Sara Ranjbarvaziri, Ana Budan, Farshad Farshidfar, Marie Cho, Emma Xu, Jaclyn Ho, Mahnaz Maddah, Kevin E. Loewke, Julio Medina, David Sperandio, Snahel Patel, Tim Hoey, Mohammad A. Mandegar
Summary: This study developed an in vitro model of dilated cardiomyopathy (DCM) using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and identified cardioprotective drugs by inhibiting histone deacetylase 6 (HDAC6). The findings were validated in a mouse model, and the effects of these drugs on mitochondrial function were further investigated.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Penglin Pan, Gengdu Qin, Bo Wang, Haixin Yu, Jie Chen, Jiaying Liu, Kaijian Bing, Jian Shen, Dianyun Ren, Yuhan Zhao, Wentao Xia, Hui Li, Heshui Wu, Yingke Zhou
Summary: HDAC5 loss is associated with unfavorable prognosis in pancreatic cancer by regulating the expression of cPLA2 and arachidonic acid (AA). Deacetylation of GATA1 by HDAC5 represses cPLA2 expression. Dietary management along with cPLA2-targeted therapy can be an effective strategy for treating HDAC5-deficient pancreatic cancer.
Article
Biotechnology & Applied Microbiology
Nando D. Das, Jen-Chien Chang, Chung-Chau Hon, S. Thomas Kelly, Shinsuke Ito, Marina Lizio, Bogumil Kaczkowski, Hisami Watanabe, Keisuke Katsushima, Atsushi Natsume, Haruhiko Koseki, Yutaka Kondo, Aki Minoda, Takashi Umehara
Summary: This study found that H4K5acK8ac and H3K27ac signals have some overlap in binding to the super-enhancer transcription factor BRD4 at higher levels, but they also have distinct specificities, especially in glioblastoma stem-like cell lines. Deletion of H4K5acK8ac-preferred super-enhancers associated with MYCN and NFIC resulted in a reduction in stem-like properties.
Letter
Dermatology
Pia Rude Nielsen, Jens Ole Eriksen, Lise Maria Lindahl, Ulrike Wehkamp, Michael Bzorek, Gitte Andersen, Anders Woetmann, Lars Iversen, Niels Odum, Thomas Litman, Lise Mette Rahbek Gjerdrum
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Cell Biology
Magnus S. Agren, Lana Chafranska, Jens Ole Eriksen, Julie Lyng Forman, Morten J. Bjerrum, Peter Schjerling, Heidi F. Larsen, Elena Cottarelli, Lars N. Jorgensen, Lise Mette Rahbek Gjerdrum
Summary: Reepithelialization is crucial for wound healing, and studies have shown that zinc treatment can enhance the expression of MMP-1 and MT to promote epidermal healing. Quantitative immunohistochemistry can aid in identifying proteins involved in reepithelialization process.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2021)
Letter
Oncology
S. Cordua, L. Kjaer, V. Skov, N. Pallisgaard, M. Kefala, L. M. R. Gjerdrum, H. C. Hasselbalch, C. Ellervik
Article
Oncology
Jacob Handlos Grauslund, Morten Orebo Holmstrom, Nicolai Gronne Jorgensen, Uffe Klausen, Stine Emilie Weis-Banke, Daniel El Fassi, Claudia Schollkopf, Mette Borg Clausen, Lise Mette Rahbek Gjerdrum, Marie Fredslund Breinholt, Julie Westerlin Kjeldsen, Morten Hansen, Steffen Koschmieder, Nicolas Chatain, Guy Wayne Novotny, Jesper Petersen, Lasse Kjaer, Vibe Skov, Ozcan Met, Inge Marie Svane, Hans Carl Hasselbalch, Mads Hald Andersen
Summary: In a phase I clinical vaccination trial of CALRLong36 peptide vaccines for CALR-mutant MPN patients, the vaccines were found to be safe and tolerable, and were able to induce T-cell responses. However, the vaccines did not lead to clinical responses, but the study indicates that vaccines targeting mutant CALR may have potential in enhancing anti-tumor immune responses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Rasmus Krarup Sigaard, Kasper Wennervaldt, Lars Munksgaard, Lise Mette Rahbek Gjerdrum, Preben Homoe
Summary: This prospective study found a sensitivity of 66% for diagnosing lymphoma with a core needle biopsy. The core needle biopsy method was correct in all non-lymphoma cases, retaining a specificity of 100%. However, in 18% of cases, the core needle biopsy method gave an incorrect lymphoma subtype.
Article
Dermatology
Andreas Willerslev-Olsen, Lise Mette Rahbek Gjerdrum, Lise M. Lindahl, Terkild B. Buus, Emil M. H. Pallesen, Maria Gluud, Michael Bzorek, Boye S. Nielsen, Maria R. Kamstrup, Anne Hald Rittig, Charlotte M. Bonefeld, Thorbjorn Krejsgaard, Carsten Geisler, Sergei B. Koralov, Thomas Litman, Jurgen C. Becker, Anders Woetmann, Lars Iversen, Niels Odum
Summary: Staphylococcal enterotoxins induce the expression of oncogenic miR-155 in malignant T cells, promoting disease activity in cutaneous T-cell lymphoma. Antibiotics inhibit this process, but the specific mechanism is not fully understood.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Letter
Hematology
Agoston Gyula Szabo, Jonathan Thorsen, Katrine Fladeland Iversen, Mette Boegh Levring, Birgitte Preiss, Carsten Helleberg, Marie Fredslund Breinholt, Emil Hermansen, Lise Mette Rahbek Gjerdrum, Soren Thorgaard Bonlokke, Katrine Nielsen, Eigil Kjeldsen, Elena Manuela Teodorescu, Marveh Dokhi, Eva Kurt, Casper Norgaard Strandholdt, Mette Klarskov Andersen, Annette Juul Vangsted
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Letter
Immunology
Jannik Helweg-Larsen, Morten Rasmussen, Hanne Vibeke Marquart, Daniel Kondziella
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Andreas Mund, Fabian Coscia, Andras Kriston, Reka Hollandi, Ferenc Kovacs, Andreas-David Brunner, Ede Migh, Lisa Schweizer, Alberto Santos, Michael Bzorek, Soraya Naimy, Lise Mette Rahbek-Gjerdrum, Beatrice Dyring-Andersen, Jutta Bulkescher, Claudia Lukas, Mark Adam Eckert, Ernst Lengyel, Christian Gnann, Emma Lundberg, Peter Horvath, Matthias Mann
Summary: Deep Visual Proteomics combines machine learning, automated image analysis and single-cell proteomics to link protein abundance to complex cellular or subcellular phenotypes while preserving spatial context. It successfully identifies distinct cell states with proteomic profiles and reveals spatial proteome changes in cancer progression.
NATURE BIOTECHNOLOGY
(2022)
Article
Hematology
Maria Gluud, Emil M. H. Pallesen, Terkild B. Buus, Lise Mette Rahbek Gjerdrum, Lise M. Lindahl, Maria R. Kamstrup, Michael Bzorek, Maria Danielsen, Rikke Bech, Madalena N. Monteiro, Edda Blumel, Andreas Willerslev-Olsen, Anders Lykkebo-Valloe, Chella Krishna Vadivel, Thorbjorn Krejsgaard, Charlotte Menne Bonefeld, Carsten Geisler, Juergen C. Becker, Sergei B. Koralov, Lars Iversen, Thomas Litman, Anders Woetmann, Niels Odum
Summary: Cutaneous T-cell lymphoma (CTCL) is a devastating lymphoid malignancy characterized by the accumulation of malignant T cells in the dermis and epidermis. Skin lesions cause serious symptoms and increase the risk of bacterial infection. The study found that malignant T cells secrete cytokines that downregulate the expression of filaggrin and filaggrin-2, leading to compromised skin barrier. Treatment with JAK inhibitors can reverse this effect and increase filaggrin expression in patients with advanced CTCL.
Article
Oncology
Cheng Chi, Lisa Harth, Marina Ramirez Galera, Marina Passos Torrealba, Chella Krishna Vadivel, Carsten Geisler, Charlotte Menne Bonefeld, Pia Rude Nielsen, Michael Bzorek, Juergen C. Becker, Lise Mette Rahbek Gjerdrum, Niels Odum, Anders Woetmann
Summary: In this study, researchers found that FASN is highly expressed in CTCL cells, and inhibition of FASN affects cell viability and proliferation. The upregulation of FASN induced by FASN inhibitors can be partially reversed by SREBP. Therefore, the combination of FASN and SREBP inhibitors may have promising therapeutic effects in CTCL.
Article
Biochemistry & Molecular Biology
Magnus S. Agren, Thomas Litman, Jens Ole Eriksen, Peter Schjerling, Michael Bzorek, Lise Mette Rahbek Gjerdrum
Summary: Using NanoString technology, we measured gene expression during wound healing and identified 22 upregulated and 6 downregulated differentially expressed genes. These findings correlate well with the current understanding of physiological reepithelialization and may provide potential therapeutic targets for patients with impaired healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Khazra Bhatti, Aqsa Nazir, Simon Ostergaard, Lone Schejbel, Peter Norgaard, Lise M. R. Gjordrum, Mahnaz Moghaddas, Torsten H. Nielsen, Lars Munksgaard, Lars M. Pedersen
Summary: This article describes a rare case of bone involvement in a patient with Waldenstrom macroglobulinemia (WM) and presents an analysis based on the Danish Lymphoma Registry (LYFO) to determine the prevalence and rarity of skeletal-related disease in WM patients.
JOURNAL OF HEMATOLOGY
(2022)
Article
Medicine, General & Internal
Pernille Yde Nielsen, Andreas Bartholdy, Lise Mette Rahbek Gjerdrum, Rudi Gerardus Johannes Westendorp, Laust Hvas Mortensen, Samir Bhatt, Majken Karoline Jensen
Summary: The Danish Pathology Life Course (PATHOLIFE) cohort was established to conduct epidemiological research on histological and cytological features in relation to the life course histories of the entire Danish population. The research results can improve the quality of diagnosis, prognosis, and stratification of patients, and may identify new routes of treatment.
Review
Otorhinolaryngology
Ahmed Ehsan Al-Khafaf, Fahd Al-Shahrestani, Yusuf Baysal, Lise Mette Rahbek Gjerdrum, Steffen Heegaard, Lars Moller Pedersen, Preben Homoe
Summary: In this systematic review, the demographics and characteristics of salivary gland lymphomas were presented. The results showed that lymphomas occur in all salivary glands and mainly in elderly female patients, with a close association with Sjogren's syndrome. Depending on the anatomical location, the lymphoma subtypes vary in aggressiveness, stage, and prognosis.
ACTA OTO-LARYNGOLOGICA
(2023)