Article
Medicine, Research & Experimental
Ann-Kathrin Rahm, Teresa Wieder, Dominik Gramlich, Mara Elena Muller, Maximilian N. Wunsch, Fadwa A. El Tahry, Tanja Heimberger, Tanja Weis, Patrick Most, Hugo A. Katus, Dierk Thomas, Patrick Lugenbiel
Summary: The study revealed that the expression of atrial KCNN2 and KCNN3 is reduced in AF complicated by HF, with a suppression of HDAC2 expression. High atrial rates trigger epigenetic remodeling mechanisms, and knock-down of HDAC2 decreases KCNN3 expression.
Article
Cardiac & Cardiovascular Systems
Patrick Lugenbiel, Katharina Govorov, Pascal Syren, Ann-Kathrin Rahm, Teresa Wieder, Maximilian Wunsch, Nadine Weiberg, Emili Manolova, Dominik Gramlich, Rasmus Rivinius, Daniel Finke, Lorenz H. Lehmann, Patrick A. Schweizer, Derk Frank, Fadwa A. El Tahry, Claus Bruehl, Tanja Heimberger, Steffi Sandke, Tanja Weis, Patrick Most, Bastian Schmack, Arjang Ruhparwar, Matthias Karck, Norbert Frey, Hugo A. Katus, Dierk Thomas
Summary: Atrial fibrillation is associated with electrical remodeling, which may be influenced by HDAC2 and NRSF, impacting action potential duration in atrial myocytes through direct regulation of K+ channel expression.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Valentina Dzreyan, Svetlana Sharifulina
Summary: Cerebral ischemia is the second leading cause of death worldwide, requiring multimodal stroke therapy. Histone deacetylase inhibitors have shown to be effective in protecting the brain from ischemic damage by inducing neurogenesis and angiogenesis in damaged brain areas, promoting functional recovery after stroke.
Review
Obstetrics & Gynecology
Marina Ilicic, Tamas Zakar, Amy Gregson, Waleed M. Hussein, Roger Smith, Jonathan W. Paul
Summary: The article summarizes the crucial role of myometrial phenotypic transformation during pregnancy to facilitate childbirth, and the involvement of protein acetylation in this process. Studies show that histone deacetylase inhibitors have significant relaxation effects on pregnant human myometrium.
REPRODUCTIVE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Meran Keshawa Ediriweera
Summary: Histone acetylation is a crucial epigenetic event and continues to be an area of great interest in biochemical research. The balance between histone acetyltransferases (HATs) and histone deacetylases (HDACs) is disrupted in various human cancers. Histone deacetylase inhibitors (HDACi) have shown promising results in restoring dysregulated histone acetylation profiles and are considered as potential anti-cancer therapeutics. Recent studies have identified odd-chain fatty acids as novel HDACi, further expanding the understanding of fatty acids in cancer therapy.
DRUG DISCOVERY TODAY
(2023)
Review
Oncology
Fengyi Guo, Hongjing Wang
Summary: This review summarizes the classification and mechanisms of action of histone deacetylase and the clinical application of their inhibitors in ovarian cancer. Histone deacetylase inhibitors show promising potential as anti-cancer drugs, and combination therapy with other anticancer drugs for synergistic effects can improve efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Yu Liu, Xinyi Shen, Mingchang Pang, Zhen Sun, Yongjiang Qian, Wenxin Xue, Zhongqun Wang, Lihua Li
Summary: Atherosclerosis (AS) is the leading cause of death in cardiovascular diseases, and Sirt3, an important histone deacetylase, plays a crucial role in the development and regression of AS by deacetylating mitochondrial proteins in blood vessels and participating in various metabolic activities. Medical research targeting Sirt3 is also actively underway, aiming to provide new insights and intervention strategies for AS.
Article
Chemistry, Multidisciplinary
Hirokazu Mishima, Yukihiro Itoh, Takashi Kurohara, Takayoshi Suzuki, Naoya Asada, Ken-ichi Kusakabe, Yuko Okamoto
Summary: A newly synthesized small molecule, KTT-1, shows selective inhibition of histone deacetylase 2 (HDAC2) over HDAC1. The residence time of KTT-1 in HDAC2 is longer, suggesting its stable binding. The difference between the enzymes is a single un-conserved residue, Ala268 in HDAC2 and Ser263 in HDAC1, which affects the binding stability.
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yunjian Dai, Taofeng Wei, Yuwen Huang, Yun Bei, Haoran Lin, Zexu Shen, Lingyan Yu, Mingdong Yang, Huimin Xu, Wei He, Zheng Lin, Haibin Dai
Summary: Inhibition of HDAC9 may be a novel approach for treating depression, as it is highly expressed in the hippocampus of a mouse model of chronic restraint stress-induced depression and is associated with depression-like behavior. Furthermore, the study also found that HDAC9 interacts with Annexin A2, resulting in the development of depressive symptoms.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Harald Frankowski, Fred Yeboah, Bonnie J. Berry, Chizuru Kinoshita, Michelle Lee, Kira Evitts, Joshua Davis, Yoshito Kinoshita, Richard S. Morrison, Jessica E. Young
Summary: This study reveals that levels of HDAC2 decrease while neuron-specific isoforms of Endophilin-B1 increase during hiPSC differentiation, potentially related to mitochondrial dynamics and neuronal development. Manipulation of HDAC2 and Endophilin-B1 in hiPSC-Ns affects mitochondrial morphology, cytotoxic stress response, and gene expression related to mitochondrial dynamics and synaptogenesis, highlighting the role of HDAC2 in regulating key neuronal and mitochondrial pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Henry F. Duncan, Yoshifumi Kobayashi, Yukako Yamauchi, Angela Quispe-Salcedo, Zhi Chao Feng, Jia Huang, Nicola C. Partridge, Teruyo Nakatani, Jeanine D'Armiento, Emi Shimizu
Summary: Matrix-metalloproteinase-13 (MMP13) plays an important role in tooth development and mineralization processes. Knockout of MMP13 in mice resulted in altered dentin phenotype, reduced dentin volume, and decreased calcium deposition. The study also revealed an interaction between MMP13 and the Wnt-signaling pathway. These findings highlight the critical role of MMP13 in tooth development and mineralization.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Decai Chen, Yan Du, Shouwan Ye, Jinsong Yu
Summary: In this study, the researchers found that ASV exerted a protective effect on cell damage related to atherosclerosis by regulating the HDAC9/NF-kappa B axis.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sonali Bahl, Edward Seto
Summary: Histone deacetylases (HDACs) are enzymes that regulate cellular processes by removing acetyl groups from proteins. HDAC activities are regulated by various mechanisms, including posttranslational modifications like reversible phosphorylation. Dysregulation of HDACs can contribute to disease development, making it important to understand how reversible phosphorylation affects their functions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hyein Jo, Kyeonghee Shim, Han-Ul Kim, Hyun Suk Jung, Dooil Jeoung
Summary: Histone deacetylases (HDACs) can deacetylate histones H3 and H4, and an imbalance in histone acetylation and deacetylation can contribute to various diseases. HDAC2, located in the nucleus, plays a critical role in modifying chromatin structures and regulating gene expression as a transcriptional regulator. This review discusses the roles of HDAC2 in tumorigenesis and anti-cancer drug resistance, and highlights its potential as a prognostic marker for various cancers. It also explores the involvement of microRNAs in directly regulating the expression of HDAC2 during tumorigenesis, and emphasizes HDAC2 as a valuable target for developing anti-cancer drugs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Agronomy
Seung Hee Eom, Tae Kyung Hyun
Summary: In this study, 20 HDAC genes were identified in the Brassica rapa genome, with segmental duplicated paralogs and tandem duplicated paralogs present in the BraHDAC family. The expression patterns of paralogous gene pairs suggest functional divergence, and BraHDA3 is suggested to encode a functional HDAC enzyme that can be inhibited by SAHA.