Article
Biochemistry & Molecular Biology
Sejin Kim, Hyunjae Lee, Hanbyeol Moon, Ran Kim, Minsuk Kim, Seongtae Jeong, Hojin Kim, Sang Hyeon Kim, Soo Seok Hwang, Min Young Lee, Jongmin Kim, Byeong-Wook Song, Woochul Chang
Summary: Cardiac tissue damage following ischemia leads to cardiomyocyte apoptosis and myocardial fibrosis. The active polyphenol flavonoid or catechin epigallocatechin-3-gallate (EGCG) protects ischemic myocardium and is involved in the regulation of endothelial-to-mesenchymal transition (EndMT). In this study, EGCG treatment was shown to regenerate ischemic tissue and induce cardioprotection by regulating proteins associated with the EndMT process, as well as positively regulating cardiomyocyte apoptosis and fibrosis.
Article
Biochemistry & Molecular Biology
Yi-Ping Luo, Xiao-Fang Tang, Yi-Chi Zhang, Su-Mei Chen, Qiong Wu, Wen-Juan Li
Summary: The study demonstrated that epigallocatechin-3-gallate (EGCG), a tea polyphenol, could modulate gut-brain communication in a mouse aging model. EGCG improved aging-associated changes by increasing immune organ and brain indexes, as well as enhancing learning and memory abilities. The protection of the aging brain by EGCG was associated with reduced lipid peroxidation and increased antioxidant activities. Additionally, EGCG attenuated the hypothalamic-pituitary-adrenal axis and enhanced the content of short-chain fatty acids (SCFAs) in aging mice.
Article
Cell Biology
Honghui Zhang, Wei Su, Rusong Zhao, Mei Li, Shigang Zhao, Zi-Jiang Chen, Han Zhao
Summary: This study delves into the precise impact and underlying mechanisms of EGCG on aged oocytes. Both in vitro and in vivo experiments demonstrate EGCG's capacity to enhance the quality of aged oocytes. In vitro application of EGCG yields remarkable improvements, including heightened rates of first polar body extrusion, refined spindle morphology, enhanced mitochondrial function, and reduced oxidative stress. Besides, EGCG may enhance Arf6 expression through direct interaction in aged oocytes, consequently promoting the assembly of spindle-associated F-actin and mitigating the aneuploidy induced by the disruption of spindle F-actin. In addition, these positive outcomes are corroborated by enhanced fertility observed in aged mice, providing a therapeutic intervention to address fertility challenges associated with advanced age.
CELL PROLIFERATION
(2023)
Article
Integrative & Complementary Medicine
Pei-Ying Pai, Wan-Ching Chou, Shih-Hung Chan, Shu-Yih Wu, Hsiu- Chen, Chi-Wen Li, Pei-Ling Hsieh, Pei-Ming Chu, Yu-An Chen, Hsiu-Chung Ou, Kun-Ling Tsai
Summary: The study demonstrated that EGCG can ameliorate homocysteine-induced endothelial cell apoptosis by enhancing the SIRT1/AMPK signaling pathway, providing potential benefits for hyperhomocysteinemia.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jana Adamcakova, Sona Balentova, Romana Barosova, Juliana Hanusrichterova, Pavol Mikolka, Kristian Prso, Juraj Mokry, Zuzana Tatarkova, Dagmar Kalenska, Daniela Mokra
Summary: This study aimed to evaluate the early effects of EGCG on markers of inflammation and lung fibrosis in silicotic rats. The results showed that early treatment with EGCG had the potential to alleviate inflammation and oxidative stress-induced changes, and prevent fibrotic changes in the bronchioles and pulmonary vessels. However, further investigations are needed to elucidate the effects of EGCG in the lung silicosis model and its potential adverse effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Liangwei Mei, Yi Zheng, Teng Ma, Bing Xia, Xue Gao, Yiming Hao, Zhuojing Luo, Jinghui Huang
Summary: The circadian clock is crucial for managing daily physiological and metabolic processes, and disturbances can lead to degenerative diseases. EGCG, a compound with antioxidant properties, has been found to have protective effects on intervertebral disc degeneration by entraining the biological clock. This study provides evidence that EGCG's protective effects on NPCs are related to the circadian clock and depend on the core clock gene Bmal1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shin Koike, Kazuya Toriumi, Sakura Kasahara, Yosuke Kibune, Yo-ichi Ishida, Takashi Dan, Toshio Miyata, Makoto Arai, Yuki Ogasawara
Summary: This study used Glo1-knockout and vitamin B6-deficient mice as a CS-SCZ model, finding significantly increased carbonyl protein levels, particularly MG-H1-modified proteins, in various regions of the brain. Further studies focusing on MG-H1-modified and accumulated proteins in the hippocampus may reveal the onset mechanism of CS-SCZ induced by MGO-induced oxidative damages.
Article
Anatomy & Morphology
Amir Raoofi, Melody Omraninava, Roghayeh Javan, Davood Maghsodi, Auob Rustamzadeh, Davood Nasiry, Alireza Ghaemi
Summary: Chronic scrotal hyperthermia (SHT) can lead to serious male reproductive system disorders, mainly due to oxidative stress. Epigallocatechin gallate (EGCG) as a potent antioxidant can alleviate cellular and tissue damage caused by SHT. EGCG improves sperm parameters, testosterone levels, and reduces cellular apoptosis and oxidative stress.
Article
Medicine, Research & Experimental
Hong Wei, Jun Qin, Quanxin Huang, Zhiqiang Jin, Li Zheng, Jinmin Zhao, Zainen Qin
Summary: Metal-polyphenol nanoformulations (Cu-EGCG nanosheets) were synthesized and found to possess antioxidant and anti-inflammatory effects. The nanosheets effectively reduced pro-inflammatory cytokine expression and shifted macrophages to M2 phenotypes. The secreted factor from the treated macrophages showed anti-inflammatory potential in chondrocytes. This study suggests a novel strategy for osteoarthritis therapy targeting macrophages.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Yumin Wang, Shuang Wu, Qiang Li, Weihong Lang, Wenjing Li, Xiaodong Jiang, Zhirong Wan, Jichao Chen, Hongquan Wang
Summary: This review summarizes the recent updates and knowledge of the molecular mechanisms underlying the neuroprotective effects of epigallocatechin 3-gallate (EGCG) derived from green tea extract in Parkinson's disease (PD). The review highlights the pleiotropic effects of EGCG, including anti-apoptotic, anti-oxidative stress, anti-inflammatory, modulation of dopamine production, and inhibition of alpha-synuclein aggregation, which make it a promising neuroprotective compound for the treatment of PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Ling Lin, Li Zeng, An Liu, Dongyin Yuan, Yingqi Peng, Sheng Zhang, Yinhua Li, Jinhua Chen, Wenjun Xiao, Zhihua Gong
Summary: The study found that EGCG can regulate nutrient metabolism in rats by activating the AMPK and insulin pathways, while LTA cooperates with EGCG to promote glycogen metabolism and suppress the effects of EGCG on fatty acid and protein synthesis.
Review
Biochemistry & Molecular Biology
Iwona Zwolak
Summary: This review focuses on the effects of epigallocatechin gallate (EGCG) on toxicities induced by heavy metals (HMs), highlighting both the protective mechanisms and potential adverse impacts of EGCG. Challenges related to EGCG's low bioavailability and proper dosing in HM intoxication therapy are also discussed, offering insights into the design of new therapeutics for HM poisoning.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Sangmin Lee, Jinkyu Lee, Hayeon Byun, Se-jeong Kim, Jinmyoung Joo, Hee Ho Park, Heungsoo Shin
Summary: The study demonstrated that coating biomaterial surfaces with antioxidant epigallocatechin gallate (EGCG) and metal ions enhances anti-oxidative and ROS scavenging properties. EGCG-coating increases hydrophilicity and anti-oxidative properties, improving cell attachment, viability, and anti-oxidative activities. The use of EGCG coating on biomaterials shows promise for various tissue engineering applications.
ACTA BIOMATERIALIA
(2021)
Article
Cell Biology
Dongjie Zhou, Ming -Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song -Hee Lee, Geun Heo, Ying- Jie Niu, Sun A. Ock, Xiang -Shun Cui
Summary: This study found that EGCG can delay porcine oocyte aging by inhibiting oxidative stress and promoting mitochondrial biogenesis. An optimal concentration of EGCG can maintain oocyte morphology and developmental competence, and prevent aging-induced oxidative stress, apoptosis, and autophagy.
Review
Biochemistry & Molecular Biology
Ashley Payne, Samuel Nahashon, Equar Taka, Getinet M. Adinew, Karam F. A. Soliman
Summary: Alzheimer's and Parkinson's diseases are common neurodegenerative diseases with complex etiology involving environmental, molecular, and genetic factors. This review focuses on the neuroinflammatory and neuroprotective role of EGCG, a medicinal component of green tea, which has antioxidant, anti-inflammatory, and anti-aging abilities. It shows promise in modulating AD progression and offers innovative approaches for prevention of AD and other neurodegenerative disorders.
Article
Chemistry, Applied
Carolina Rojas-Garbanzo, Julia Winter, Maria Laura Montero, Benno F. Zimmermann, Andreas Schieber
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2019)
Article
Biochemistry & Molecular Biology
Beatrice Paola Festa, Marine Berquez, Alkaly Gassama, Irmgard Amrein, Hesham M. Ismail, Marijana Samardzija, Leopoldo Staiano, Alessandro Luciani, Christian Grimm, Robert L. Nussbaum, Maria Antonietta De Matteis, Olivier M. Dorchies, Leonardo Scapozza, David Paul Wolfer, Olivier Devuyst
HUMAN MOLECULAR GENETICS
(2019)
Article
Nutrition & Dietetics
Janina Rynarzewski, Lisa Dicks, Benno F. Zimmermann, Birgit Stoffel-Wagner, Norbert Ludwig, Hans-Peter Helfrich, Sabine Ellinger
Article
Plant Sciences
Oliver S. Doerr, Benno F. Zimmermann, Stine Koegler, Heiko Mibus
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2019)
Article
Clinical Neurology
Johannes Levin, Sylvia Maass, Madeleine Schuberth, Armin Giese, Wolfgang H. Oertel, Werner Poewe, Claudia Trenkwalder, Gregor K. Wenning, Ulrich Mansmann, Martin Suedmeyer, Karla Eggert, Brit Mollenhauer, Axel Lipp, Matthias Loehle, Joseph Classen, Alexander Muenchau, Jan Kassubek, Florin Gandor, Daniela Berg, Silvia Egert-Schwender, Cornelia Eberhardt, Friedemann Paul, Kai Boetzel, Birgit Ertl-Wagner, Hans-Juergen Huppertz, Ingrid Ricard, Gunter U. Hoeglinger, Elisabeth Andre, Christiane Blankenstein, Monica Canelo, Marco Duering, Jens Ebentheuer, Christopher Fricke, Alexander Gerbes, Stefan Groiss, Doreen Gruber, Christian Hartmann, Thomas Kirchner, Daniel Kroneberg, Martin Kunz, Stefan Lorenzl, Alexia Moldovan, Anna Noda, Heidi Pape, Gesine Respondek, Eva Schaeffer, Alfons Schnitzler, Walter Schulz-Schaeffer, Johannes Schwarz, Cornelia Skowronek, Alexander Storch, Vera Tadic, David Vadasz, Benno Zimmermann, Martina Schneider
Meeting Abstract
Clinical Neurology
O. Dorchies, L. Neff, E. Gayi, C. Baulet, S. Fabien, R. de Mestral, P. Hafner, D. Fischer, T. Dor, L. Scapozza
NEUROMUSCULAR DISORDERS
(2019)
Article
Nutrition & Dietetics
Sabine Ellinger, Andreas Reusch, Lisa Henckes, Christina Ritter, Benno F. Zimmermann, Joerg Ellinger, Rudolf Galensa, Peter Stehle, Hans-Peter Helfrich
Editorial Material
Nutrition & Dietetics
Benno F. Zimmermann, Sabine Ellinger
Article
Biochemistry & Molecular Biology
Mario Lorenz, Stephanie Lehmann, Ilija Djordjevic, Thomas Duesterhoeft, Benno F. Zimmermann, Karl Stangl, Verena Stangl
Article
Biotechnology & Applied Microbiology
Sarah Djeddi, David Reiss, Alexia Menuet, Sebastien Freismuth, Juliana de Carvalho Neves, Sarah Djerroud, Xenia Massana-Munoz, Anne-Sophie Sosson, Christine Kretz, Wolfgang Raffelsberger, Celine Keime, Olivier M. Dorchies, Julie Thompson, Jocelyn Laporte
Summary: This study utilized multiple Omics approaches to analyze CNMs, identifying common disease features and therapeutic targets, validating the potential application of multi-Omics methods in different disease forms and treatment strategies.
Article
Chemistry, Multidisciplinary
Teresa Leszczynska, Barbara Pieklo, Aneta Kopec, Benno F. Zimmermann
Summary: This study compares the basic nutrients, steviol glycosides, antioxidants, and antioxidant activity in dried leaves of Stevia rebaudiana Bertoni from Poland, Paraguay, and Brazil. The findings show that leaves from Poland have higher dietary fiber content, while those from Brazil and Paraguay have lower steviol glycoside contents. Furthermore, dried leaves from Poland have higher vitamin C content but lower antioxidant activity compared to the other two countries.
APPLIED SCIENCES-BASEL
(2021)
Article
Clinical Neurology
Judith Bellmann-Strobl, Friedemann Paul, Jens Wuerfel, Jan Doerr, Carmen Infante-Duarte, Elmira Heidrich, Benedict Koertgen, Alexander Brandt, Caspar Pfuller, Helena Radbruch, Rebekka Rust, Volker Siffrin, Orhan Aktas, Christoph Heesen, Juergen Faiss, Frank Hoffmann, Mario Lorenz, Benno Zimmermann, Sergiu Groppa, Klaus-Dieter Wernecke, Frauke Zipp
Summary: In patients with RRMS, adding oral EGCG to GA did not show superiority over placebo in affecting MRI and clinical disease activity. Despite indications of EGCG bioavailability, it did not influence immune parameters. However, treatment with up to 800 mg of EGCG daily was safe and well tolerated.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Chemistry, Applied
Flora M. Rezaeian, Benno F. Zimmermann
Summary: A simplified extraction method using ethanol + water for ultrasonication was found to be the quickest and simplest way to analyze flavanols in matcha tea. The method was successfully applied to various traditional matcha teas and green tea powders, demonstrating its time-saving and accurate capabilities in analyzing tea components.
Article
Nutrition & Dietetics
Elisabeth Khaikin, Sigrun Chrubasik-Hausmann, Sebahat Kaya, Benno F. Zimmermann
Summary: This study analyzed the TQ content of commercial black seed oils and black seed oil-containing capsules and found variations in TQ content. The highest TQ content was found in a bottled oil, which may be suitable for clinical studies without causing harm to health. It is recommended to regulate the TQ content of black seed products for consumers to purchase supplements with known ingredients.
Article
Food Science & Technology
Tania Paquignon, Mathias Scholz, Benno F. Zimmermann
Summary: Research has shown the positive health effects of EGCg3Me in Benifuuki tea, with the ISO 14502-2 method being suitable for its analysis. According to the study, brewing Benifuuki tea at recommended temperatures can provide effective doses of EGCg3Me.