Review
Pharmacology & Pharmacy
Yuki Saito, Takako S. S. Chikenji
Summary: Senescent cells play both beneficial and detrimental roles in tissue regeneration, aging, and disease development. Accumulation of senescent cells may lead to progressive tissue degeneration. Targeting senescent cells for therapy could potentially improve muscle regeneration.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Felipe Cantore Tiburcio, Ana Paula Silveira Leite, Kevin Silva Muller, Carina Guidi Pinto, Erick Valentino, Paula Aiello Tome de Souza Castro, Cintia Yuri Matsumura, Shelly Favorito de Carvalho, Selma Maria Michelin Matheus
Summary: The study aimed to investigate the effects of supraphysiological doses of Nandrolone decanoate (ND) on neuromuscular interactions. The results showed that ND caused muscle degeneration in sedentary rats, but no major morphological changes were found in exercised rats. Therefore, physical exercise partially reversed the alterations caused by ND.
MEDICINA-LITHUANIA
(2023)
Article
Biochemistry & Molecular Biology
Alessandra Sacco, Laura Belloni, Lucia Latella
Summary: Senescence is a cellular state induced by internal or external stimuli, resulting in cell cycle arrest, morphological changes, and dysfunctions in mitochondrial and lysosomal functionality. Recent evidence suggests that senescent cells in vivo are a heterogeneous cell population due to different activated pathways and distinct microenvironmental contexts. Future research will focus on exploring the heterogeneity of senescent cells to map cell progression and study the therapeutic advantages of senolytic drugs.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Health Care Sciences & Services
Ekene Anakor, William John Duddy, Stephanie Duguez
Summary: Amyotrophic lateral sclerosis is a disease that affects the upper and lower motor neurons. It has been found that the disease not only affects motor neurons, but also other tissues and cell types, leading to metabolic dysfunctions, impaired proteostasis, deficits in muscle regeneration and RNA metabolism. Skeletal muscle is considered an important contributor to the occurrence and progression of the disease, acting as a secretory organ and affecting the skeletal muscle secretome, which can have consequences for neuronal function and survival.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ayumi Goto, Yuki Endo, Hitoshi Yamashita
Summary: The study investigates the role of CREG1 in skeletal muscle regeneration and glucose uptake. Results show that CREG1 stimulates glucose uptake in skeletal muscles partially through AMPK activation. This suggests that CREG1 plays an essential role in muscle regeneration by affecting glucose metabolism in skeletal muscles.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Michael J. Stec, Qi Su, Christina Adler, Lance Zhang, David R. Golann, Naveen P. Khan, Lampros Panagis, S. Armando Villalta, Min Ni, Yi Wei, Johnathon R. Walls, Andrew J. Murphy, George D. Yancopoulos, Gurinder S. Atwal, Sandra Kleiner, Gabor Halasz, Mark W. Sleeman
Summary: Using spatial transcriptomics and single-cell RNA sequencing datasets, a high-resolution cellular and molecular spatial atlas of the severely dystrophic D2-mdx mouse model was generated. Clustering analysis revealed the nonuniform distribution of unique cell populations associated with multiple regenerative timepoints, faithfully recapitulating the asynchronous regeneration observed in human DMD muscle. Through spatiotemporal gene expression signatures, it was found that propagation of inflammatory and fibrotic signals from locally damaged areas contributes to widespread pathology and identifying targetable pathways for DMD therapy within discrete microenvironments. Overall, this spatial atlas of dystrophic muscle provides a valuable resource for studying DMD disease biology and therapeutic target discovery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Geriatrics & Gerontology
James G. Tidball, Ivan Flores, Steven S. Welc, Michelle Wehling-Henricks, Eisuke Ochi
Summary: The regeneration of skeletal muscle following acute injury is influenced by interactions with immune cells, particularly myeloid cells and lymphoid cells. Aging leads to a decline in the regenerative capacity of muscle, with age-related changes in the immune system affecting the process. Aging immune cells alter their expression of factors that impact the function of muscle stem cells, contributing to defects in muscle regeneration.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yoonhee Jin, Dena Shahriari, Eun Je Jeon, Seongjun Park, Yi Sun Choi, Jonghyeok Back, Hyungsuk Lee, Polina Anikeeva, Seung-Woo Cho
Summary: The passage highlights the need for interventions to induce functional skeletal muscle restoration, with a focus on tissue-engineered muscle constructs. It mentions the current challenges in reliable cell sources and tissue scaffold engineering for tissue-engineering treatments.
ADVANCED MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Ziyu Chen, HaiQiang Lan, ZhaoHong Liao, JingWen Huang, XiaoTing Jian, Jijie Hu, Hua Liao
Summary: This review summarizes the role and functioning process of Treg cells in the treatment of skeletal muscle diseases, emphasizing their importance in skeletal muscle repair and providing new research perspectives.
CELL AND BIOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Vasileios Papalazarou, Oliver D. K. Maddocks
Summary: Nutrient supply and demand play a crucial role in shaping cell behavior in health and disease, with mammalian cells employing various strategies to obtain necessary nutrients for metabolic needs. Disruption of homeostasis, as seen in conditions like cancer, can lead to increased proliferation rates in energetically challenging environments where nutrient sources are limited.
Article
Chemistry, Medicinal
Min Yang, Luchuanyang Sun, Yasunosuke Kawabata, Fumihito Murayama, Takahiro Maegawa, Takeshi Nikawa, Katsuya Hirasaka
Summary: This study found that supplementation of balenine promotes muscle regeneration and increases macrophage phagocytic activity. In addition, a balenine-enriched extract diet enhances the expression of regeneration-related genes as well as pro-inflammatory and anti-inflammatory cytokines.
Article
Chemistry, Multidisciplinary
Mauro Sousa De Almeida, Patricia Taladriz-Blanco, Barbara Drasler, Sandor Balog, Phattadon Yajan, Alke Petri-Fink, Barbara Rothen-Rutishauser
Summary: The uptake of nanoparticles by cells can trigger gene expression regulation, specifically related to inflammation, chemotaxis, and cell adhesion. Understanding these cellular processes is important for the approval of new nanomedicines.
Article
Cell Biology
Paulina Roux-Biejat, Marco Coazzoli, Pasquale Marrazzo, Silvia Zecchini, Ilaria Di Renzo, Cecilia Prata, Alessandra Napoli, Claudia Moscheni, Matteo Giovarelli, Maria Cristina Barbalace, Elisabetta Catalani, Maria Teresa Bassi, Clara De Palma, Davide Cervia, Marco Malaguti, Silvana Hrelia, Emilio Clementi, Cristiana Perrotta
Summary: The acid sphingomyelinase (ASMase) plays a crucial role in skeletal muscle regeneration by regulating the balance between M1 and M2 macrophages in the injured muscles, reducing inflammation and accelerating the early phases of muscle regeneration. This study reveals a novel function of ASMase in modulating the immune response during muscle repair and suggests ASMase as a potential therapeutic target to improve muscle recovery in conditions with excessive inflammation.
Article
Medicine, Research & Experimental
Ana Claudia Lima, Rui L. Reis, Helena Ferreira, Nuno M. Neves
Summary: This study aimed to assess the internalization rates of different NPs under normal and proinflammatory states in three types of cells, revealing the importance of surface charge and chemistry in determining NP internalization levels. The study also identified different cellular uptake and internalization pathways, providing guidance for designing functional NPs for therapeutic purposes.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biology
Tooba Abbassi-Daloii, Salma el Abdellaoui, Lenard M. Voortman, Thom T. J. Veeger, Davy Cats, Hailiang Mei, Duncan E. Meuffels, Ewoud van Arkel, Peter Bram 't Hoen, Hermien Kan, Vered Raz
Summary: We constructed a large atlas of RNA-seq profiles from leg muscles, identifying differential expression patterns and cellular composition across different tissues. The muscle samples were clustered into three groups based on anatomical location, which were associated with oxidative metabolism and fast- or slow-twitch myofibers. Expression profiles of Homeobox transcription factors differed between the three groups. Our study provides a novel resource to study muscle-specific molecular features and their potential links to physiological processes.
Article
Multidisciplinary Sciences
Kosuke Saito, Tetsuro Tamaki, Maki Hirata, Hiroyuki Hashimoto, Kenei Nakazato, Nobuyuki Nakajima, Akihito Kazuno, Akihiro Sakai, Masahiro Iida, Kenji Okami
Article
Physiology
Tetsuro Tamaki, Yoshiyasu Uchiyama, Maki Hirata, Hiroyuki Hashimoto, Nobuyuki Nakajima, Kosuke Saito, Toshiro Terachi, Joji Mochida
FRONTIERS IN PHYSIOLOGY
(2015)
Article
Multidisciplinary Sciences
Tetsuro Tamaki, Maki Hirata, Nobuyuki Nakajima, Kosuke Saito, Hiroyuki Hashimoto, Shuichi Soeda, Yoshiyasu Uchiyama, Masahiko Watanabe
Article
Multidisciplinary Sciences
Hiroyuki Hashimoto, Tetsuro Tamaki, Maki Hirata, Yoshiyasu Uchiyama, Masato Sato, Joji Mochida
Editorial Material
Cell Biology
Tetsuro Tamaki
NEURAL REGENERATION RESEARCH
(2017)
Article
Immunology
Nobuyuki Nakajima, Tetsuro Tamaki, Maki Hirata, Shuichi Soeda, Masahiro Nitta, Akio Hoshi, Toshiro Terachi
Article
Medicine, General & Internal
Hiroya Seta, Daisuke Maki, Akihito Kazuno, Ippei Yamato, Nobuyuki Nakajima, Shuichi Soeda, Yoshiyasu Uchiyama, Tetsuro Tamaki
JOURNAL OF CLINICAL MEDICINE
(2018)
Article
Cell Biology
Tetsuro Tamaki, Kayoko Tono, Yoshiyasu Uchiyama, Yoshinori Okada, Maki Masuda, Shuichi Soeda, Masahiro Nitta, Akira Akatsuka
CELL AND TISSUE RESEARCH
(2011)
Review
Pharmacology & Pharmacy
Tetsuro Tamaki, Yoshiyasu Uchiyama, Akira Akatsuka
CURRENT PHARMACEUTICAL DESIGN
(2010)
Review
Cell Biology
Tetsuro Tamaki
NEURAL REGENERATION RESEARCH
(2014)
Article
Multidisciplinary Sciences
Tetsuro Tamaki, Maki Hirata, Shuichi Soeda, Nobuyuki Nakajima, Kosuke Saito, Kenei Nakazato, Yoshinori Okada, Hiroyuki Hashimoto, Yoshiyasu Uchiyama, Joji Mochida
Article
Cell & Tissue Engineering
Tetsuro Tamaki
REGENERATIVE MEDICINE
(2013)
Article
Geriatrics & Gerontology
Tetsuro Tamaki, Maki Hirata, Yoshiyasu Uchiyama
FRONTIERS IN AGING NEUROSCIENCE
(2014)
Article
Medicine, General & Internal
Akihito Kazuno, Daisuke Maki, Ippei Yamato, Nobuyuki Nakajima, Hiroya Seta, Shuichi Soeda, Soji Ozawa, Yoshiyasu Uchiyama, Tetsuro Tamaki
JOURNAL OF CLINICAL MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Tetsuro Tamaki, Toshiharu Natsume, Akira Katoh, Nobuyuki Nakajima, Kosuke Saito, Tsuyoshi Fukuzawa, Masayoshi Otake, Satoko Enya, Akihisa Kangawa, Takeshi Imai, Miyu Tamaki, Yoshiyasu Uchiyama
Summary: This study investigates the differentiation potential of pig skeletal muscle-derived stem cells (Sk-MSCs) for nerve muscle regenerative therapy. The results show that these cells have a high capacity to differentiate into skeletal muscle, peripheral nerve, and vascular cell lineages, making them a valuable intermediate model between mice and humans. This research contributes to preclinical studies of regenerative stem cell transplantation therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)