Article
Biochemistry & Molecular Biology
Tatsuhiro Ayabe, Chika Takahashi, Rena Ohya, Yasuhisa Ano
Summary: Beta-lactolin improves mitochondrial functions and prevents neuronal cell death in Alzheimer's disease-related neuronal cell models, demonstrating its advantage in maintaining neuronal health.
Article
Neurosciences
Alexandre Androuin, Manon Thierry, Susana Boluda, Asha Baskaran, Dominique Langui, Charles Duyckaerts, Marie-Claude Potier, Khalid Hamid El Hachimi, Benoit Delatour, Serge Marty
Summary: This study investigates the subcellular localization of Aβ fibrils in transgenic mouse models and human brain tissue of Alzheimer's disease (AD). Results show the accumulation of Aβ fibrils in intralysosomal lipofuscin granules in mice and undigested material in enlarged lipofuscin granules in human cortical biopsies. However, no intraneuronal accumulations of Aβ fibrils were detected in the examined samples.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Madhura P. Dixit, Shubham N. Rahmatkar, Prachi Raut, Milind J. Umekar, Brijesh G. Taksande, Nandkishor R. Kotagale
Summary: Alzheimer's disease is a progressive neurodegenerative disorder characterized by decline in cognitive functions. The study found that cognitive impairment in Aβ(1-42) injected mice was associated with alterations in agmatine metabolism.
NEUROSCIENCE LETTERS
(2021)
Article
Immunology
Guijuan Zhou, Qing Ye, Yan Xu, Bing He, Lin Wu, Guanghua Zhu, Juan Xie, Lan Yao, Zijian Xiao
Summary: Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid-beta (Aβ) in the cerebrovascular system and is often associated with Alzheimer's disease (AD). Mitochondrial dysfunction is involved in the progression of CAA, leading to cell death, inflammation, and oxidative stress. In this study, the researchers found that MICU3, a regulator of mitochondrial calcium uptake, was reduced in the brains of CAA transgenic mice. Increasing MICU3 expression through gene therapy improved behavioral performance, cerebral blood flow, and reduced Aβ deposition in the mice. Additionally, MICU3 protected against neuronal death, glial activation, and oxidative stress, which were dependent on the interaction between MICU3 and PINK1. These findings indicate that targeting the MICU3-PINK1 axis could be a potential treatment strategy for CAA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Neurosciences
Arturo G. Isla, Hugo Balleza-Tapia, Andre Fisahn
Summary: Despite multiple pharmacological approaches developed over the years for treating Alzheimer's Disease, very few have been approved for clinical use, with no disease-modifying treatment yet available. Efforts may have been lacking in focusing on neuronal processes essential to memory, as brain oscillations like theta and gamma have been strongly correlated to memory performance. Using cognitive-relevant neuronal network oscillations as outcome measures in drug research and development against cognitive impairment in AD is proposed.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Luciana Domett Siqueira, Ana Paula M. Celes, Hellin Dos Santos, Sergio T. Ferreira
Summary: The study showed that the AZ formulation had protective effects against glial cell activation and memory deficits induced by A beta Os in a mouse model of AD, suggesting a promising preventative and non-pharmacological strategy to reduce brain inflammation and attenuate memory impairment in AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Immunology
Liu Yang, Huimin Zhou, Lei Huang, Yong Su, Liangliang Kong, Pengmin Ji, Ran Sun, Chao Wang, Weiping Li, Weizu Li
Summary: Chronic glucocorticoid exposure can accelerate neuronal damage and beta-amyloid production by activating oxidative stress and NLRP1 inflammasome, leading to the deterioration of Alzheimer's disease. Inhibition of NLRP1 inflammasome may be an important strategy in improving chronic glucocorticoid-induced neuronal injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Daiane F. Engel, Licio A. Velloso
Summary: In experimental models, hypothalamic dysfunction is a crucial component in the pathophysiology of diet-induced obesity. Structural and functional changes in neurons, microglia, astrocytes, and tanycytes of the mediobasal hypothalamus, shortly after the introduction of a high-fat diet, impact caloric intake, energy expenditure, and systemic glucose tolerance. Inflammation plays a central role in this response, and there is a temporal sequence of events determining the fate of different cells involved in the central regulation of whole-body energy homeostasis.
Article
Neurosciences
Erica S. Brady, Jessica Griffiths, Lilya Andrianova, Monika H. Bielska, Takashi Saito, Takaomi C. Saido, Andrew D. Randall, Francesco Tamagnini, Jonathan Witton, Michael T. Craig
Summary: In the early stages of Alzheimer's disease, the accumulation of the peptide amyloid-beta damages synapses and disrupts neuronal activity, leading to the disruption of neuronal oscillations associated with cognition. Research in this field has largely been conducted in mouse models and an in-depth characterization is currently lacking. Using the AppNL-G-F/NL-G-F mouse model, this study found changes in the power of mPFC spindles and hippocampal sharp-wave ripples during NREM sleep, accompanied by alterations in PV-expressing interneuron activity and density.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Tobey J. Betthauser, Murat Bilgel, Rebecca L. Koscik, Bruno M. Jedynak, Yang An, Kristina A. Kellett, Abhay Moghekar, Erin M. Jonaitis, Charles K. Stone, Corinne D. Engelman, Sanjay Asthana, Bradley T. Christian, Dean F. Wong, Marilyn Albert, Susan M. Resnick, Sterling C. Johnson
Summary: Alzheimer's disease biomarkers are crucial for understanding disease progression and predicting symptoms. This study develops and evaluates methods for modeling amyloid accumulation and investigates factors influencing the timing of amyloid onset and impairment onset. The findings suggest that APOE genotype, rather than sex, is associated with amyloid onset age, and that higher APOEe4 dosage, being female, and older amyloid onset age shorten the time from amyloid onset to dementia.
Article
Clinical Neurology
Noah Schweitzer, Jinghang Li, Rebecca C. Thurston, Brian Lopresti, William E. Klunk, Beth Snitz, Dana Tudorascu, Ann Cohen, M. Ilyas Kamboh, Edythe Halligan-Eddy, Bistra Iordanova, Victor L. Villemagne, Howard Aizenstein, Minjie Wu
Summary: Males showed increased hippocampal-prefrontal connectivity over 2 years, associated with higher Aβ burden. Females had increased bilateral hippocampal functional connectivity, associated with higher white matter hyperintensity volume.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Carmen Nanclares, Andres Mateo Baraibar, Alfonso Araque, Paulo Kofuji
Summary: Recent studies investigate the role of astrocytes in Alzheimer's disease, suggesting that their active involvement at synapses could lead to synaptic and neuronal network dysfunction, as well as cognitive impairment in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Zoology
Thomas A. Kim, Michelle D. Syty, Kaitlyn Wu, Shaoyu Ge
Summary: Adult neurogenesis is the creation of new neurons in the adult brain, which play a crucial role in brain functions such as learning and memory. However, diseases like Alzheimer's can impair hippocampal neurogenesis, leading to cognitive decline and memory loss.
ZOOLOGICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Nisarath Veschsanit, Jenq-Lin Yang, Sukonthar Ngampramuan, Kittikun Viwatpinyo, Jitrapa Pinyomahakul, Thit Lwin, Pongrung Chancharoen, Saowalak Rungruang, Piyarat Govitrapong, Sujira Mukda
Summary: The study revealed that melatonin treatment significantly ameliorated METH-induced cognitive and neuronal impairments in mice, likely through modulation of various neurotransmitter systems and downstream signaling molecules.
Article
Pharmacology & Pharmacy
Na Li, Qihang Pang, Yanhong Zhang, Jianan Lin, Hui Li, Zhen Li, Yaxin Liu, Xingyu Fang, Yu An, Haonan Bai, Dianyu Li, Zhanhong Cao, Jian Liu, Qing Yang, Shaodan Hu
Summary: The study found that Ginsenoside Compound K (CK) can bind to A beta, reduce its aggregation, and inhibit its accumulation in the extracellular space. CK also improves cognitive impairment and protects neurons by reducing oxidative damage and enhancing synaptic function through modulation of the Nrf2/Keap1 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Carlos Pomilio, Patricio Pavia, Roxana Mayra Gorojod, Angeles Vinuesa, Agustina Alaimo, Veronica Galvan, Monica Lidia Kotler, Juan Beauquis, Flavia Saravia
Article
Endocrinology & Metabolism
Angeles Vinuesa, Carlos Pomilio, Martin Menafra, Maria Marta Bonaventura, Laura Garay, Maria Florencia Mercogliano, Roxana Schillaci, Victoria Lux Lantos, Fernando Brites, Juan Beauquis, Flavia Saravia
PSYCHONEUROENDOCRINOLOGY
(2016)
Article
Neurosciences
Angeles Vinuesa, Melisa Bentivegna, Gaston Calfa, Fabia Filipello, Carlos Pomilio, Maria Marta Bonaventura, Victoria Lux-Lantos, Maria Eugenia Matzkin, Amal Gregosa, Jessica Presa, Michela Matteoli, Juan Beauquis, Flavia Saravia
MOLECULAR NEUROBIOLOGY
(2019)
Article
Neurosciences
Aural Gregosa, Angeles Vinuesa, Maria Florencia Todero, Carlos Pomilio, Soledad P. Rossi, Melisa Bentivegna, Jessica Presa, Shirley Wenker, Flavia Saravia, Juan Beauquis
NEUROBIOLOGY OF DISEASE
(2019)
Article
Geriatrics & Gerontology
Carlos Pomilio, Roxana M. Gorojod, Miguel Riudavets, Angeles Vinuesa, Jessica Presa, Amal Gregosa, Melisa Bentivegna, Agustina Alaimo, Soledad Porte Alcon, Gustavo Sevlever, Monica L. Kotler, Juan Beauquis, Flavin Saravia
Article
Developmental Biology
Natalia Pascuali, Leopoldina Scotti, Gonzalo Oubina, Ignacio de Zuniga, Mariana Gomez Pena, Carlos Pomilio, Flavia Saravia, Marta Tesone, Dalhia Abramovich, Fernanda Parborell
MOLECULAR HUMAN REPRODUCTION
(2020)
Review
Physiology
Jessica L. Presa, Flavia Saravia, Zsolt Bagi, Jessica A. Filosa
FRONTIERS IN PHYSIOLOGY
(2020)
Review
Neurosciences
Angeles Vinuesa, Carlos Pomilio, Amal Gregosa, Melisa Bentivegna, Jessica Presa, Melina Bellotto, Flavia Saravia, Juan Beauquis
Summary: Overnutrition and diets high in saturated fat contribute to inflammation and metabolic disturbances, leading to an increased risk for conditions like Alzheimer's disease. Understanding the interplay between inflammation and insulin resistance may offer potential therapeutic targets to prevent neurodegeneration and cognitive impairment.
FRONTIERS IN NEUROSCIENCE
(2021)
Editorial Material
Pharmacology & Pharmacy
Mariela Fernanda Perez, Flavia Saravia, Maria Graciela Castro, Claudia Bregonzio
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juan Turati, Julieta Rudi, Juan Beauquis, Lila Carniglia, Federico Lopez Couselo, Julieta Saba, Carla Caruso, Flavia Saravia, Mercedes Lasaga, Daniela Durand
Summary: The altered expression of mGlu3 Delta 4 in Alzheimer's disease (AD) is associated with the onset of the disease, and it has a detrimental effect on astrocytes. The expression levels of mGlu3 Delta 4 increase with age, and they are prematurely overexpressed in the hippocampus of PDAPP-J20 mice. Moreover, heterologous expression of mGlu3 Delta 4 leads to cell death in astrocytes.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Geriatrics & Gerontology
Carlos Pomilio, Nicolas Gonzalez Perez, Ismael Calandri, Lucia Crivelli, Ricardo Allegri, Gustavo Sevlever, Flavia Saravia
Summary: We evaluated the effect of the antidiabetic drug metformin on patients with mild cognitive impairment due to Alzheimer's disease. The study found that metformin treatment improved cognitive performance, CSF biomarkers profile, and neuroanatomical measures in these patients.
Article
Toxicology
R. M. Gorojod, A. Alaimo, S. Porte Alcon, F. Saravia, M. L. Kotler
ARCHIVES OF TOXICOLOGY
(2017)
