Article
Biology
Peter R. Strege, Luke M. Cowan, Constanza Alcaino, Amelia Mazzone, Christopher A. Ahern, Lorin S. Milescu, Gianrico Farrugia, Arthur Beyder
Summary: Shear stress and patch suction can reversibly alter the kinetic properties and maximum current of NaChBac, suggesting it is mechanosensitive. Structural analysis reveals a large displacement of the intracellular gate, supporting the proposed mechanosensitive mechanism.
Article
Chemistry, Medicinal
Juan Antonio Contreras Vite, Carlos Vega Valle, Happi Biekeu Mbem, Sarah-Maude Boivin, Robert Dumaine
Summary: Lamotrigine is commonly used for treating bipolar disorder and epilepsy. The US FDA has recently issued a warning regarding the drug's potential to cause conduction anomalies and Brugada syndrome in epileptic patients. In this study, researchers used patch clamp technique on rat cardiomyocytes to investigate the effect of Lamotrigine on cardiac sodium current (I-Na). The results showed that Lamotrigine inhibited I-Na peak amplitude, reduced cardiac excitability, and prolonged the action potential refractory period in epileptic rats.
Article
Developmental Biology
Carla Arganaraz, Tamara S. Adjimann, Paula P. Perissinotti, Mariano Soiza-Reilly
Summary: Serotonin neurons are involved in anxiety and depression. This study investigated the developmental trajectory of synaptic inputs to these neurons and found that cortical glutamate and subcortical GABA inputs undergo refinement during postnatal development, while subcortical glutamate inputs do not. This refinement process is accompanied by the presence of inhibitory mechanisms. These findings contribute to our understanding of neurodevelopmental vulnerability to psychiatric disorders.
Article
Biochemistry & Molecular Biology
Deepika Singh, Priya Singh, Pooja Srivastava, Dipti Kakkar, Mallika Pathak, Anjani Kumar Tiwari
Summary: Serotonin is an important neurotransmitter and hormone that affects mood, anxiety, depression, and sleep. It is one of the most desirable targets for medical chemists and pharmaceutical firms. The 5-HT1A and 5-HT7 receptors are related to psychological conditions such as anxiety, depression, and movement disorders, with the 5-HT7 receptor potentially being a beneficial target for depression treatment.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Karl Josef Foehr, Michael Rapp, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, David Alexander Christian Messerer
Summary: Aripiprazole has been identified as a potent blocker of the dominant voltage-gated sodium channel of heart muscle. Its interactions with the channel differ depending on the state, with weaker affinity for the resting state and stronger affinity for the inactivated state.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Edward Ofori, Edem K. Onyameh, Uma M. Gonela, Chandrashekhar Voshavar, Barbara Bricker, Tracy L. Swanson, Amy J. Eshleman, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: We have conducted a study to explore the potential of dual 5-HT1AR and 5-HT7R ligands, resulting in the identification of a new compound with high affinity for these receptors. This compound, designated as 21, shows promising functional characteristics as a potential antidepressant agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Damian C. Bell, Luigi Leanza, Saverio Gentile, Daniel R. Sauter
Summary: Ion channels play key roles in various physiological processes, and their dysfunction can lead to channelopathies, including cancer. The field of ion channel and cancer research has rapidly grown in the past two decades, allowing us to gain deeper insights into the mechanisms of ion channels in cancer and develop therapeutic interventions.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Anesthesiology
Tyler J. Browne, Kelly M. Smith, Mark A. Gradwell, Jacqueline A. Iredale, Christopher V. Dayas, Robert J. Callister, David I. Hughes, Brett A. Graham
Summary: Projection neurons in the spinal dorsal horn play a crucial role in relaying sensory information to higher brain centres, receiving inputs from the periphery, brain, and local circuits. Recent studies in transgenic mice have provided insights into dorsal horn circuitry, while information on projection neurons is mainly based on previous studies in monkey, cat, and rat. The study on mouse spinoparabrachial projection neurons identified distinct subpopulations in lamina I based on electrophysiological properties, suggesting different sensory signalling features. Additionally, the research revealed novel information on deeper lamina SPBNs, showing different sensory codes destined for the PBN and their contribution to excitatory input in dorsal horn circuits.
Article
Pharmacology & Pharmacy
M. Y. Dron, A. S. Zhigulin, D. B. Tikhonov, O. I. Barygin
Summary: Phenytoin inhibits CI-AMPARs and CP-AMPARs with similar potency, resembling the characteristics of the CI-AMPARs pore blocker pentobarbital. This action suggests a common binding site and mechanism of inhibition, different from classical competitive inhibitors, negative allosteric inhibitors, and CP-AMPARs selective channel blockers.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Ingrid Nogueira, Thiago Z. Lima, Thawann Malfatti, Katarina E. Leao
Summary: This study compares the effects of noise exposure on membrane properties of neurons in the auditory cortex of mice. The results show that different types of neurons exhibit distinct changes after noise exposure, which may affect the activity levels of the auditory system.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Walter Francesconi, Fulvia Berton, Valentina Olivera-Pasilio, Joanna Dabrowska
Summary: The study reveals that oxytocin has distinct effects on different types of neurons in the dorsolateral bed nucleus of the stria terminalis. It selectively excites some neurons while inhibiting others, potentially facilitating conditioned fear by suppressing inter-neuronal interactions.
Article
Biochemical Research Methods
Christopher Miranda, Madeleine R. Howell, Joel F. Lusk, Ethan Marschall, Jarrett Eshima, Trent Anderson, Barbara S. Smith
Summary: This study demonstrates a method of guiding glass micropipette electrodes to neurons by collecting fluorescence at the aperture using an intra-electrode tapered optical fiber. The use of a tapered fiber for excitation and collection of fluorescence at the micropipette tip allows for targeted robotic approach to labeled neurons independent of microscopy.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Neurosciences
Marcela Lipovsek, Cedric Bardy, Cathryn R. Cadwell, Kristen Hadley, Dmitry Kobak, Shreejoy J. Tripathy
Summary: Patch-seq is a revolutionary technique in neuroscience that integrates morphology, physiology, and gene expression data to study neuronal biology comprehensively. It enables targeted study of specific neuronal populations, compilation of multimodal cell type atlases, and investigation of the molecular basis of morphologic and functional diversity. This technique has the potential for further technical development and implementation in various research areas to directly link gene expression to brain function.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Shirin Ahmadi, Melisa Benard-Valle, Kim Boddum, Fernanda C. Cardoso, Glenn F. King, Andreas Hougaard Laustsen, Anne Ljungars
Summary: Ion channels are crucial for various physiological processes. Venomous creatures exploit ion channels by producing toxins that target them, leading to dysregulation which can cause severe complications in humans. However, the discovery of selective venom toxins has contributed to the development of drugs for envenoming and ion channel-related diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mark L. Dallas, Damian Bell
Summary: It is clear that APC technology has significantly advanced drug discovery programs, particularly in the fields of neuroscience and cardiovascular research. The challenge for the future lies in keeping up with fundamental research and improving the translation of the large datasets obtained.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Article
Neurosciences
Thomas Maurin, Francesca Melancia, Marielle Jarjat, Liliana Castro, Lara Costa, Sebastien Delhaye, Anouar Khayachi, Sara Castagnola, Elia Mota, Audrey Di Giorgio, Michela Servadio, Malgorzata Drozd, Gwenola Poupon, Sara Schiavi, Lara Sardone, Stephane Azoulay, Lucia Ciranna, Stephane Martin, Pierre Vincent, Viviana Trezza, Barbara Bardoni
Article
Biochemistry & Molecular Biology
Elena Cellini, Annalisa Vetro, Valerio Conti, Carla Marini, Viola Doccini, Claudia Clementella, Elena Parrini, Sabrina Giglio, Matteo Della Monica, Marco Fichera, Sebastiano Antonino Musumeci, Renzo Guerrini
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Letter
Clinical Neurology
Antonio Gennaro Nicotera, Francesco Cali, Mirella Vinci, Sebastiano Antonino Musumeci
NEUROLOGICAL SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
G. M. Leggio, S. A. Torrisi, R. Mastrogiacomo, D. Mauro, M. Chisari, C. Devroye, D. Scheggia, M. Nigro, F. Geraci, N. Pintori, G. Giurdanella, L. Costa, C. Bucolo, V. Ferretti, M. A. Sortino, L. Ciranna, M. A. De Luca, M. Mereu, F. Manago, S. Salomone, F. Drago, F. Papaleo
Summary: The dopamine D2 and D3 receptors are associated with schizophrenia and its treatment; a genetic interaction between D3 and Dys suggests that reducing D3 and Dys functionality can improve cognitive abilities; Dys interference with the D3 receptor subtype mechanism needs further investigation.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Simona D'Antoni, Lidia de Bari, Daniela Valenti, Marina Borro, Carmela Maria Bonaccorso, Maurizio Simmaco, Rosa Anna Vacca, Maria Vincenza Catania
BIOLOGICAL CHEMISTRY
(2020)
Article
Genetics & Heredity
Maria Cristina Costanzo, Antonio Gennaro Nicotera, Mirella Vinci, Aurelio Vitello, Agata Fiumara, Francesco Cali, Sebastiano Antonino Musumeci
JOURNAL OF GENETICS
(2020)
Article
Chemistry, Medicinal
Enza Lacivita, Mauro Niso, Madia Letizia Stama, Anna Arzuaga, Concetta Altamura, Lara Costa, Jean-Francois Desaphy, Michael E. Ragozzino, Lucia Ciranna, Marcello Leopoldo
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Neurosciences
Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Ciranna
Summary: The study demonstrates that Cdk5 modulates hippocampal synaptic plasticity, with 5-HT7 receptors requiring Cdk5 to regulate synaptic plasticity and rescue abnormal plasticity in Fmr1 KO neurons. This suggests that Cdk5 could be a novel target in Fragile X Syndrome.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
B. Di Marco, P. Dell'Albani, S. D'Antoni, M. Spatuzza, C. M. Bonaccorso, S. A. Musumeci, F. Drago, B. Bardoni, M. V. Catania
Summary: The study found a novel modulatory role of mGlu5 receptor in SGs formation, providing new perspectives for understanding cellular response to stress in FXS pathophysiology.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Neurosciences
Giulia Leonardi, Rosella Ciurleo, Francesca Cucinotta, Bartolo Fonti, Daniele Borzelli, Lara Costa, Adriana Tisano, Simona Portaro, Angelo Alito
Summary: This review examined randomized controlled trials on brain oscillations in stroke patients and explored the role of brain oscillations in modulating cortical excitability. Neuromodulation approaches are considered effective tools for improving stroke rehabilitation outcomes, but further high-quality research is needed to determine their specific effects.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2022)
Article
Neurosciences
Luisa Di Menna, Rosamaria Orlando, Giovanna 'Errico, Roxana Paula Ginerete, Agata Machaczka, Carmela Maria Bonaccorso, Andrea Arena, Michela Spatuzza, Roberta Celli, Marika Alborghetti, Eleonora Ciocca, Anna Rita Zuena, Mariarosaria Scioli, Valeria Bruno, Giuseppe Battaglia, Ferdinando Nicoletti, Maria Vincenza Catania
Summary: The involvement of mGlu5 receptors in monogenic autism has been supported by various studies, but there is a lack of research on the canonical signal transduction pathway activated by these receptors in mouse models of autism. In this study, we developed a method to assess PI hydrolysis in vivo and found that mGlu5 receptor-mediated PI hydrolysis was impaired in different brain regions of mice modeling Angelman syndrome and fragile-X syndrome. These findings provide the first evidence that the canonical transduction pathway of mGlu5 receptors is downregulated in mouse models of monogenic autism.
Article
Neurosciences
Girolamo A. Vitello, Francesco Cali, Mirella Vinci, Carmela Scuderi, Francesca L'Episcopo, Antonino Musumeci, Sebastiano A. Musumeci, Antonio G. Nicotera
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
(2020)
Article
Psychology, Developmental
Antonio Gennaro Nicotera, Randi Jenssen Hagerman, Maria Vincenza Catania, Serafino Buono, Santo Di Nuovo, Elisa Maria Liprino, Emanuela Stracuzzi, Stefania Giusto, Giuseppina Di Vita, Sebastiano Antonino Musumeci
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2019)