Article
Multidisciplinary Sciences
Shivaprasad H. Sathyanarayana, Jasmine A. Saunders, Jacob Slaughter, Kamran Tariq, Rajarshi Chakrabarti, Madhumala K. Sadanandappa, Bryan W. Luikart, Giovanni Bosco
Summary: This study investigated the interaction between PTEN and FMRP in the development of hippocampal granule neurons. The findings suggest that PTEN protein expression is negatively regulated by FMRP, and disruptions in this regulation may contribute to the pathogenesis of Fmr1-related fragile X neurodevelopmental disorders. The study also showed that heterozygosity of Pten can partially restore cellular phenotypes caused by Fmr1 knockout, while complete deletion of both Pten and Fmr1 results in severe abnormalities in neuron development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Xiumin Chen, Yuko Fukata, Masaki Fukata, Roger A. Nicoll
Summary: This study reveals the essential role of the MAGUK family of synaptic scaffolding proteins in LTP, with PSD-95 requiring binding to ADAM22 for synaptic transmission enhancement. Additionally, an alternative pathway involving SAP102 is proposed, independent of ADAM22.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Ting Feng, Christian Alicea, Vincent Pham, Amanda Kirk, Simon Pieraut
Summary: The study found that using an enriched environment during the preweaning period affects the circuit plasticity of inhibitory cell types in the hippocampus, with CCK+ basket cells showing a significant increase in somatic inhibition and PV+ cells showing no changes. The change in somatic inhibition from CCK+ neurons increases CB1R-mediated inhibition in the circuit.
JOURNAL OF NEUROSCIENCE
(2021)
Correction
Biochemistry & Molecular Biology
Jasper O. Nuninga, Rene C. W. Mandl, Iris E. C. Sommer
Summary: The amended version of the paper has been published and is accessible via a link at the top of the paper.
MOLECULAR PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Katharina Klinger, Miguel del Angel, Gursel Caliskan, Oliver Stork
Summary: This study reveals significant sex differences in NPY levels in mice, with higher concentrations in males and a decrease during aging specifically in males. The reduction of NPY levels in aged males leads to impaired LTP in the MPP-DG synapse, which can be rescued by enhancing cholinergic activation. NPYergic transmission is crucial for maintaining dorsal DG LTP in aging male mice.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Sara Bottes, Baptiste N. Jaeger, Gregor-Alexander Pilz, David J. Jorg, John Darby Cole, Merit Kruse, Lachlan Harris, Vladislav Korobeynyk, Izaskun Mallona, Fritjof Helmchen, Francois Guillemot, Benjamin D. Simons, Sebastian Jessberger
Summary: Researchers identified long-term self-renewing neural stem cells (NSCs) in the adult mouse hippocampus using intravital imaging and single-cell RNA sequencing. They found that Gli1-targeted NSCs exhibit long-term self-renewal, while Ascl1-targeted NSCs have limited proliferative activity before exhaustion. The study revealed the existence of heterogeneous NSC populations with diverse behavioral properties in contributing to neurogenesis in the adult hippocampus.
NATURE NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Karima Habbas, Oktay Cakil, Boglarka Zambo, Ricardos Tabet, Fabrice Riet, Doulaye Dembele, Jean-Louis Mandel, Michael Hocquemiller, Ralph Laufer, Francoise Piguet, Herve Moine
Summary: Fragile X syndrome (FXS) is a common form of familial intellectual disability caused by the lack of RNA-binding protein FMRP. This study demonstrates that DGKk, an mRNA target of FMRP and a regulator of lipid signaling, plays an important role in FXS pathogenesis, and the delivery of modified and FMRP-independent DGKk can correct abnormal lipid signaling and behavioral phenotypes in FXS mice.
EMBO MOLECULAR MEDICINE
(2022)
Article
Behavioral Sciences
Samaneh Safari, Nesa Ahmadi, Reihaneh Mohammadkhani, Reza Ghahremani, Maryam Khajvand-Abedeni, Siamak Shahidi, Alireza Komaki, Iraj Salehi, Seyed Asaad Karimi
Summary: Gender differences in brain functions have significant impacts on spatial learning and memory in rodents, with male rats outperforming female rats in Morris water maze task. Male rats also exhibit larger long-term potentiation at PP-DG synapses compared to female rats, indicating a potential contribution of synaptic plasticity to the observed sex differences in spatial abilities.
BEHAVIORAL AND BRAIN FUNCTIONS
(2021)
Article
Multidisciplinary Sciences
Jinhu Kim, Dongseok Park, Na-Young Seo, Taek-Han Yoon, Gyu Hyun Kim, Sang-Hoon Lee, Jinsoo Seo, Ji Won Um, Kea Joo Lee, Jaewon Ko
Summary: Synaptic cell-adhesion molecules (CAMs) play a crucial role in organizing the structure and properties of neural circuits. This study found that Leucine-rich repeat transmembrane protein 3 (LRRTM3) is important for the development of excitatory synapses in hippocampal dentate gyrus (DG) granule neurons. The deletion of LRRTM3 leads to reduced synapse density and synaptic strength in specific projections involving the medial entorhinal cortex (MEC) and DG granule neurons. Additionally, LRRTM3 loss affects neurotransmitter release, excitability of granule neurons, and long-term potentiation of mossy fiber synapses in DG neurons. Silencing the MEC-DG circuits protects against the negative effects of LRRTM3 deficiency on excitatory synapse inputs, granule neuron excitability, and mossy fiber long-term potentiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Megane Missaire, Nicolas Fraize, Jean-Christophe Comte, Bruno Truchet, Regis Parmentier, Paul-Antoine Salin, Gael Malleret
Summary: Long-term storage of information in memory relies on long-term synaptic plasticity processes. Studies have shown synaptic changes after training in long-term/reference memory and working memory tasks. Consolidation of long-term information leads to delayed synaptic potentiation, while optimal information processing into working memory triggers synaptic depression.
Article
Pharmacology & Pharmacy
Yeonggwang Hwang, Hyoung-Chun Kim, Eun-Joo Shin
Summary: In this study, it was found that repeated BKM120 treatment induced anxiety- and depression-like behaviors in mice and these behaviors were positively correlated with the extent of DCX-positive cell migration. The treatment also affected the activity of Akt, JNK, DCX, and RhoA.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Seyoung Oh, Ojun Kwon, Hyun Young Seo, Do Hyeong Kim, Soo-Hong Jeong, Hyeon Ki Park, Woojin Park, Byungjin Cho
Summary: Photon-based neuromorphic systems have numerous advantages and are ideal for ultrafast neuromorphic systems due to their low crosstalk, high bandwidth, and low power consumption. This study demonstrates the significant enhancement of longterm potentiation (LTP) behavior in an InGaZnO (IGZO) photonic synapse through HfO2 passivation. The improvement in LTP characteristics is attributed to the higher activation energy required for neutralization of ionized oxygen vacancies in the HfO2/IGZO synapse. The LTP behavior can be dynamically modulated by external light pulse conditions. Furthermore, HfO2/IGZO synapses exhibit different learning capacities depending on the external stimuli configuration.
APPLIED MATERIALS TODAY
(2023)
Article
Neurosciences
Natalia A. Simonova, Maxim A. Volgushev, Alexey Y. Malyshev
Summary: The dentate gyrus is a site of neurogenesis in the adult brain where integration of new-generated granule cells into the hippocampal circuitry is crucial for normal function. It has been found that GABA-ergic inputs play a significant role in synaptic plasticity, and non-associative plasticity changes with maturation of newly generated granule cells.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Alessandra Borsini, Juliette Giacobbe, Gargi Mandal, Maura Boldrini
Summary: Adolescence is a critical period for brain and behavioral health, with increased vulnerability to mood, psychotic, and anxiety disorders. Stress-related changes in hippocampal neurogenesis during adolescence may play a role in the onset of psychiatric symptoms. This systematic review identified studies showing reduced hippocampal cell proliferation, neuroplasticity, cognitive impairments, and depressive-like behaviors in adolescent rodents exposed to stress. Treating adolescent mice with antidepressants and other interventions prevented or reversed these changes, highlighting potential therapeutic strategies.
MOLECULAR PSYCHIATRY
(2023)
Review
Neurosciences
Yosef Avchalumov, Chitra D. Mandyam
Summary: Synaptic plasticity in the hippocampus is crucial for the consolidation and storage of long-lasting memories, while addiction is a chronic disorder characterized by loss of control over drug taking and drug seeking. The review highlights the impact of drug-induced alterations in hippocampal plasticity on relapse behaviors associated with addiction.
Review
Critical Care Medicine
Taylor Snowden, Hannah Reid, Samantha Kennedy, Rebecca Kenny, Amanda McQuarrie, Lynneth Stuart-Hill, Mauricio A. Garcia-Barrera, Jodie Gawryluk, Brian R. Christie
Summary: This systematic review examined the effects of heading on youth and young adult soccer players, finding that due to lack of standardization, no conclusive methods could be identified to assess the impact of heading on players.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
Itziar Bonilla-Del Rio, Nagore Puente, Amaia Mimenza, Almudena Ramos, Maitane Serrano, Leire Lekunberri, Inmaculada Gerrikagoitia, Brian R. Christie, Patrick C. Nahirney, Pedro Grandes
Summary: The study found that acute THC exposure during early adulthood can significantly affect the expression of CB1 receptors and alter the ultrastructure of CA1. These changes may contribute to the behavioral alterations experienced by young individuals shortly after cannabis intoxication.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Biochemical Research Methods
Jonathan S. Thacker, Delaney Andersen, Stanley Liang, Natalia Zieniewicz, Juan S. Trivino-Paredes, Patrick C. Nahirney, Brian R. Christie
Summary: A series of antigen-retrieval steps have been developed to make fixed brain lysates suitable for Western blot analysis, successfully revealing a variety of proteins. This protocol has significant utility for future studies using fixed tissue samples in different neuropathological conditions.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Biochemistry & Molecular Biology
Thomas H. Lee, Brian R. Christie, Henriette van Praag, Kangguang Lin, Parco Ming-Fai Siu, Aimin Xu, Kwok-Fai So, Suk-yu Yau
Summary: This study found that low-dose AdipoRon treatment promoted hippocampal cell proliferation in mice, while high-dose AdipoRon treatment had detrimental effects on hippocampal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Hannah M. O. Reid, Nathan Chen-Mack, Taylor Snowden, Brian R. Christie
Summary: This systematic review focused on the relationship between Alzheimer's disease and hippocampal interneurons, highlighting the early impact on PV interneurons and later effects on NPY and CCK interneurons. Future studies should aim to clarify the role of PV interneurons in Alzheimer's disease and conduct further investigations on NPY and CCK interneurons.
BRAIN CONNECTIVITY
(2021)
Article
Substance Abuse
Hannah M. O. Reid, Taylor M. Snowden, Irene Shkolnikov, Kristen R. Breit, Cristina Rodriguez, Jennifer D. Thomas, Brian R. Christie
Summary: Prenatal exposure to alcohol and THC has distinct effects on parvalbumin-positive interneuron numbers in the hippocampus, suggesting that individual and combined exposures can influence the balance of excitation and inhibition in a structure crucial for learning and memory processes.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Neurosciences
Erin L. Grafe, Christine J. Fontaine, Jennifer D. Thomas, Brian R. Christie
Summary: Choline directly impacts synaptic communication in the brain, inducing a long-term depression of synaptic efficacy in both male and female animals. It involves M1 receptors in control animals, but uniquely involves NMDA receptors in a model of FASD.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Thomas H. Lee, Ahadullah, Brian R. Christie, Kangguang Lin, Parco Ming-fai Siu, Li Zhang, Ti-fei Yuan, Pragya Komal, Aimin Xu, Kwok-fai So, Suk-yu Yau
Summary: Administration of exercise mimetic drugs, such as AdipoRon, can improve hippocampal-dependent spatial recognition memory in diabetic mice. AdipoRon treatment increases progenitor cell proliferation and neuronal differentiation in the hippocampus, and also enhances dendritic complexity and spine density. Furthermore, AdipoRon activates AMPK/PGC-1 alpha signalling to mimic the benefits of physical exercise for learning and memory in the diabetic brain.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Erin L. Grafe, Mira M. M. Wade, Claire E. Hodson, Jennifer D. Thomas, Brian R. Christie
Summary: This study found that choline supplementation can restore hippocampal synaptic plasticity impaired by prenatal alcohol exposure. The results showed that choline supplementation improves excitability in female offspring affected by PNEE, and rescues decreased long-term potentiation in male offspring with PNEE.
Article
Multidisciplinary Sciences
Brian R. Christie, Allyson Gross, Annika Willoughby, Erin Grafe, Justin Brand, Emily Bosdachin, Hannah M. O. Reid, Crystal Acosta, Eric Eyolfson
Summary: Mild traumatic brain injuries (mTBIs) are a common health issue in North America, and there is a growing need for ecologically valid models to study their effects. The awake closed-headed injury (ACHI) model is a suitable method, as it induces clinically relevant behavioral deficits without major physical damage. This model is particularly useful for studying repetitive mTBI (r-mTBI), which can lead to long-term consequences in the younger population. The ACHI model allows researchers to study changes in synaptic plasticity following mTBI and r-mTBI.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Review
Endocrinology & Metabolism
E. L. Grafe, H. M. O. Reid, I. Shkolnikov, K. Conway, A. Kit, C. Acostaa, B. R. Christie
Summary: The use of cannabis has increased significantly due to global decriminalization and interest in potential therapeutic benefits. However, there is a lack of specific data on how cannabis affects women. This scoping review aims to discuss the prevalence of cannabis use and Cannabis Use Disorder (CUD) in women, as well as provide a balanced perspective on the positive and negative consequences of cannabis use. It emphasizes the need for further research beyond sex differences.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Jenessa N. Johnston, Josh Allen, Irene Shkolnikov, Carla L. Sanchez-Lafuente, Brady S. Reive, Kaylene Scheil, Stanley Liang, Brian R. Christie, Lisa E. Kalynchuk, Hector J. Caruncho
Summary: In a rat model of chronic stress, researchers found that both reelin and ketamine can alleviate depressive symptoms caused by chronic stress and improve brain electrophysiological activity. The findings suggest that reelin may be a potential rapid-acting antidepressant.
Correction
Endocrinology & Metabolism
Mohammad R. Islam, Sophia Valaris, Michael F. Young, Erin B. Haley, Renhao Luo, Sabrina F. Bond, Sofia Mazuera, Robert R. Kitchen, Barbara J. Caldarone, Luis E. B. Bettio, Brian R. Christie, Angela B. Schmider, Roy J. Soberman, Antoine Besnard, Mark P. Jedrychowski, Hyeonwoo Kim, Hua Tu, Eunhee Kim, Se Hoon Choi, Rudolph E. Tanzi, Bruce M. Spiegelman, Christiane D. Wrann
Article
Endocrinology & Metabolism
Mohammad R. Islam, Sophia Valaris, Michael F. Young, Erin B. Haley, Renhao Luo, Sabrina F. Bond, Sofia Mazuera, Robert R. Kitchen, Barbara J. Caldarone, Luis E. B. Bettio, Brian R. Christie, Angela B. Schmider, Roy J. Soberman, Antoine Besnard, Mark P. Jedrychowski, Hyeonwoo Kim, Hua Tu, Eunhee Kim, Se Hoon Choi, Rudolph E. Tanzi, Bruce M. Spiegelman, Christiane D. Wrann
Summary: Irisin, a cleaved and circulating form of the exercise-induced membrane protein FNDC5, has been shown to mediate the beneficial effects of exercise on cognitive function, and improve cognitive function in mouse models of Alzheimer's disease. Irisin plays a crucial role in regulating cognitive benefits of exercise and may be a potential therapeutic agent for treating cognitive disorders, including Alzheimer's disease.
Meeting Abstract
Substance Abuse
H. M. O. Reid, T. M. Snowden, I. Shkolnikov, K. R. Breit, C. Rodriguez, J. D. Thomas, B. R. Christie
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)