4.3 Article

The single place fields of CA3 cells: A two-stage transformation from grid cells

期刊

HIPPOCAMPUS
卷 22, 期 2, 页码 200-208

出版社

WILEY
DOI: 10.1002/hipo.20882

关键词

hippocampus; dentate gyrus; medial entorhinal cortex; place cells

资金

  1. NIH/NIMH [P50 MH060450]
  2. NIH/NIDA CRCNS [R01DA027807]
  3. European Commission [217148]
  4. Brazilian agency CNPq
  5. Brazilian agency CAPES

向作者/读者索取更多资源

Granule cells of the dentate gyrus (DG) generally have multiple place fields, whereas CA3 cells, which are second order, have only a single place field. Here, we explore the mechanisms by which the high selectivity of CA3 cells is achieved. Previous work showed that the multiple place fields of DG neurons could be quantitatively accounted for by a model based on the number and strength of grid cell inputs and a competitive network interaction in the DG that is mediated by gamma frequency feedback inhibition. We have now built a model of CA3 based on similar principles. CA3 cells receive input from an average of one active DG cell and from 1,400 cortical grid cells. Based on experimental findings, we have assumed a linear interaction of the two pathways. The results show that simulated CA3 cells generally have a single place field, as observed experimentally. Thus, a two-step process based on simple rules (and that can occur without learning) is able to explain how grid cell inputs to the hippocampus give rise to cells having ultimate spatial selectivity. The CA3 processes that produce a single place depend critically on the competitive network processes and do not require the direct cortical inputs to CA3, which are therefore likely to perform some other unknown function. (C) 2010 Wiley Periodicals, Inc.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据