Article
Multidisciplinary Sciences
Ryota Fukaya, Marta Maglione, Stephan J. Sigrist, Takeshi Sakaba
Summary: This study suggests a potential mechanism for the cAMP-dependent increase in neurotransmission at hippocampal mossy fiber-CA3 synapses, involving an accumulation of active zone Ca2+ channels. Experimental results indicate an increase in the local Ca2+ concentration at the release site following potentiation, driven by rapid Ca2+ channel accumulation, rather than changes in intracellular Ca2+ sensitivity. Various microscopy techniques provide insights into the underlying mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Jithin D. Nair, Kevin A. Wilkinson, Jeremy M. Henley, Jack R. Mellor
Summary: This article reviews the roles of kainate receptors in synaptic plasticity, focusing on their impact on postsynaptic signaling and presynaptic auto-receptor functions. It also explores the plasticity of kainate receptors themselves and their contribution to synaptic transmission plasticity.
Review
Neurosciences
Meishar Shahoha, Ronni Cohen, Yoav Ben-Simon, Uri Ashery
Summary: Cyclic adenosine monophosphate (cAMP) is a key second messenger involved in synaptic plasticity. In the hippocampal mossy fiber (MF) synapse, cAMP mediates long-term changes to synaptic efficacy through the activation of the protein kinase A (PKA) cascade. This review summarizes the current knowledge on cAMP catalysts, PKA-dependent molecular cascades, and non-canonical cAMP-dependent but PKA-independent pathways in MF terminals. Understanding the molecular mechanisms underlying MF plasticity could provide insights into the relationship between transcriptional and computational levels in different brain regions.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Daniel B. Dorman, Kim T. Blackwell
Summary: Synaptic plasticity, the experience-induced change in connections between neurons, plays a crucial role in learning and memory. This study investigates how spatiotemporal synaptic input patterns produce plasticity under in vivo-like conditions. The findings reveal the robustness of plasticity to trial-to-trial variability of spike timing and derive general rules describing the control of plasticity by spatiotemporal patterns of synaptic inputs.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Article
Biochemistry & Molecular Biology
Grzegorz Wiera, Katarzyna Lebida, Anna Maria Lech, Patrycja Brzdak, Inge Van Hove, Lies De Groef, Lieve Moons, Enrica Maria Petrini, Andrea Barberis, Jerzy W. Mozrzymas
Summary: This study demonstrates that MMP3 plays a key role in iLTP mechanisms, affecting behaviors that in part depend on GABAergic plasticity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Jonas Cornelius, Stefan Haak, Martin Rothkegel, Martin Korte, Kristin Michaelsen-Preusse
Summary: The study reveals that phosphorylated profilin2a in glutamate uncaging agents regulates actin dynamics and structural plasticity in neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Neurosciences
Margarita Anisimova, Bas van Bommel, Rui Wang, Marina Mikhaylova, Joern Simon Wiegert, Thomas G. Oertner, Christine E. Gee
Summary: The study uses optogenetic stimulation to induce STDP and observes timing-dependent depression and potentiation. This study does not require electrodes and results suggest that synaptic depression after anticausal activation is a transient phenomenon.
Article
Multidisciplinary Sciences
Malika Sammari, Yanis Inglebert, Norbert Ankri, Michael Russier, Salvatore Incontro, Dominique Debanne
Summary: This study reveals that brain oscillations at specific frequencies can induce both synaptic and intrinsic potentiation in O-LM interneurons, contrary to the typical response seen in glutamatergic neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Amanda M. Perozzo, Jochen Schwenk, Aichurok Kamalova, Terunaga Nakagawa, Bernd Fakler, Derek Bowie
Summary: This study reveals the unique characteristics of GSG1L in terms of its spatiotemporal expression, composition, and functionality. It is expressed late during brain development in a region-specific manner and constitutes about 5% of all AMPAR complexes in adulthood. GSG1L can assemble with TARPs or CNIHs, but it also has the ability to function as the sole auxiliary subunit. Through its interaction with two evolutionarily conserved sites on the agonist-binding domain, GSG1L weakly slows desensitization at the TARP/KGK site and strongly slows recovery from desensitization at a different site. These findings provide insights into the unique signaling role of GSG1L within glutamatergic synapses.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Ye Sun, Michael Smirnov, Naomi Kamasawa, Ryohei Yasuda
Summary: The structural plasticity of dendritic spines plays a crucial role in synaptic plasticity, learning, and memory. Rapid ultrastructural changes in the PSD and surrounding membrane during sLTP induction may contribute to rapid electrophysiological plasticity. PSD area transiently increases while nsASI area shows lasting expansion after sLTP induction.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
J. Fernandez-Felipe, B. Merino, A. B. Sanz-Martos, A. Plaza, A. Contreras, V Naranjo, L. Morales, J. A. Chowen, V Cano, M. Ruiz-Gayo, N. Del Olmo
Summary: Chronic consumption of both SOLF and UOLF impairs spatial short-term memory, modulates hippocampal synaptic plasticity mechanisms and gene expression of NMDA receptor subunits. PPAR gamma gene expression is specifically down-regulated in adolescent SOLF individuals and up-regulated in adult UOLF mice.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Cell Biology
Lorenzo More, Lucia Privitera, Daniel D. Cooper, Marianthi Tsogka, J. Simon C. Arthur, Bruno G. Frenguelli
Summary: Positive experiences, such as social interaction, cognitive training, and physical exercise, can improve cognitive abilities and synaptic plasticity associated with ageing. However, the mechanisms through which the environment influences neuronal response and adaptation to these positive sensory experiences remain unclear.
Review
Neurosciences
Ryota Fukaya, Rinako Miyano, Himawari Hirai, Takeshi Sakaba
Summary: Presynaptic plasticity refers to the activity-dependent changes in neurotransmitter release, playing a crucial role in modulating synaptic strength. Among these changes, presynaptic potentiation mediated by cyclic adenosine monophosphate (cAMP) is widely observed and implicated in learning and memory. Researchers have used hippocampal mossy fiber-CA3 pyramidal cell synapses as a model to investigate presynaptic potentiation, as the mechanisms underlying it can be dissected through direct presynaptic recordings. Recent advancements in super-resolution microscopy and flash-and-freeze electron microscopy have provided insights into the nanoscale localization of release site molecules and synaptic vesicles during potentiation, shedding light on the molecular mechanisms involved. In light of these findings, this study aims to propose plausible mechanisms underlying cAMP-mediated presynaptic potentiation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Magdalena Jatczak-Sliwa, Magdalena Kisiel, Marta Magdalena Czyzewska, Marek Brodzki, Jerzy Wladyslaw Mozrzymas
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Neurosciences
Katarzyna Terejko, Przemyslaw T. Kaczor, Michal A. Michalowski, Agnieszka Dabrowska, Jerzy W. Mozrzymas
Article
Pharmacology & Pharmacy
Marek Brodzki, Michal A. Michalowski, Michalina Gos, Jerzy W. Mozrzymas
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Grzegorz Wiera, Katarzyna Lebida, Anna Maria Lech, Patrycja Brzdak, Inge Van Hove, Lies De Groef, Lieve Moons, Enrica Maria Petrini, Andrea Barberis, Jerzy W. Mozrzymas
Summary: This study demonstrates that MMP3 plays a key role in iLTP mechanisms, affecting behaviors that in part depend on GABAergic plasticity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Katarzyna Terejko, Michal A. Michalowski, Anna Dominik, Anna Andrzejczak, Jerzy W. Mozrzymas
Summary: Recent studies have shown that the activation of pLGICs is associated with coordinated subunit twisting in the membrane plane, indicating a crucial role of intersubunit interactions in receptor activation, especially in preactivation and opening processes. The underlying mechanisms of this intersubunit cross-talk outside the top-down pathway remain largely unknown.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Terejko, Michal A. Michalowski, Ilona Izykowska, Anna Dominik, Aleksandra Brzostowicz, Jerzy W. Mozrzymas
Summary: GABA type A receptors play a crucial role in mediating inhibition in the adult mammalian brain and have a complex gating mechanism involving openings/closings, preactivation, and desensitization. The ligand binding sites affect the receptor's gating mechanism, suggesting shared structural determinants for distinct conformational transitions.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Michal A. Michalowski, Marta M. Czyzewska, Ilona Izykowska, Jerzy W. Mozrzymas
Summary: The pH sensitivity of the GABA-A receptor can be altered by mutating the beta 2E155 residue, affecting its modulation by protons.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soumyendu Sekhar Bandyopadhyay, Anup Kumar Halder, Monika Zareba-Koziol, Anna Bartkowiak-Kaczmarek, Aviinandaan Dutta, Piyali Chatterjee, Mita Nasipuri, Tomasz Wojtowicz, Jakub Wlodarczyk, Subhadip Basu
Summary: The study introduces a consensus strategy for predicting palmitoylated cysteine sites on synaptic proteins, which significantly improves prediction performance in mouse datasets through efficient feature selection and a three-star quality consensus strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Marcin Wyroslak, Katarzyna Lebida, Jerzy W. Mozrzymas
Summary: The study examined the plasticity of tonic inhibition in hippocampal pyramidal neurons under NMDAR-dependent GABAergic inhibitory long-term potentiation (iLTP) induction protocol. It was found that alpha 5-containing GABA(A)Rs played a key role in mediating the plastic change in tonic current during this process.
Review
Cell Biology
Grzegorz Wiera, Jerzy W. Mozrzymas
Summary: Long-term synaptic plasticity is regulated by the controlled reorganization of the synaptic proteome, including the crucial role of extracellular matrix metalloproteinases (MMPs) such as MMP9 and MMP3 in excitatory synapses. These enzymes are also implicated in memory, learning deficits, and psychiatric disorders. Research into the role of extracellular proteolysis in inhibitory synapses is just beginning.
Article
Pharmacology & Pharmacy
Karol Klopotowski, Marta M. Czyzewska, Jerzy W. Mozrzymas
Summary: Recent studies have shown that phenylalanine 64 (alpha 1F64) located at loop D of GABA(A) receptors plays a crucial role in the conformational transitions of the receptor, with mutations of alpha 1F64 dramatically altering gating properties.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Izabela Figiel, Ewa Baczynska, Tomasz Wojtowicz, Marta Magnowska, Anna Buszka, Monika Bijata, Jakub Wlodarczyk
Summary: This study reveals that the deletion of DG in rat hippocampal cell cultures leads to significant changes in the density and morphology of dendritic spines, accompanied by a decrease in laminin and aquaporin 4. However, silencing of DG does not affect synaptic transmission or Psd-95 protein expression, suggesting the existence of unknown mechanisms to maintain proper synaptic signaling despite impaired structure of dendritic spines. Presumably, astrocytes are involved in these processes.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Przemyslaw T. Kaczor, Michal A. Michalowski, Jerzy W. Mozrzymas
Summary: Cys-loop receptors are important in mammalian CNS signaling. Little is known about the GABAA receptor's activation mechanisms. Recent studies have provided structural insights into the GABAA receptor, enabling further molecular functional studies. The interface region between the transmembrane and extracellular domains plays a crucial role in transmitting conformational changes. A highly conserved proline residue within this interface is involved in regulating receptor gating.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Marek Brodzki, Jerzy W. Mozrzymas
Summary: This study investigated the role of the beta(2)P273 residue in the gating transitions of GABA(A) receptors. The results showed that mutations of this residue impaired macroscopic desensitization and accelerated current deactivation. Furthermore, the mutations also affected the intraburst open probability of the receptors. The findings suggest that beta(2)P273 is a crucial element in regulating the receptor's ability to undergo late gating transitions and could be a potential target for pharmacological tools affecting GABA(A)R-mediated inhibition.
Review
Cell Biology
Anna Buszka, Agata Pytys, Domnic Colvin, Jakub Wlodarczyk, Tomasz Wojtowicz
Summary: Protein lipidation, specifically S-palmitoylation, is a common post-translational modification that regulates protein trafficking in membranes and has essential roles in human physiology and brain function. Recent experimental studies have shed light on the discrete molecular switch function of protein S-palmitoylation within minutes to hours, expanding protein functions and subcellular localization. This review focuses on the impact of protein palmitoylation on functional changes in synapses associated with neuronal activity and plasticity, highlighting its crucial role in learning, memory, and cognitive functions.