期刊
HIPPOCAMPUS
卷 20, 期 10, 页码 1105-1108出版社
WILEY-BLACKWELL
DOI: 10.1002/hipo.20736
关键词
NMDA receptors; hippocampus; MMP-9; current responses; patchclamp
资金
- Polish Ministry for Science and Higher Education [P-N/030/2006]
Matrix Metalloproteinase 9 (MMP-9) has been demonstrated to play a crucial role in maintenance of NMDA receptor-dependent LTP and in lateral mobility of these receptors. However, the effect of MMP-9 on NMDA receptor (NMDAR) functional properties is unknown. For this purpose we have investigated the impact of recombinant MMP-9 on the whole-cell NMDAR-mediated current responses in cultured hippocampal neurons. Treatment with MMP-9 induced a reversible acceleration of desensitization and deactivation kinetics but had no effect on current amplitude. Interestingly, phorbol ester, a PKC activator known to enhance NMDAR lateral mobility, induced kinetic changes of currents similar to those produced by MMP-9. In conclusion, our results show that MMP-9 reversibly modulates the NMDAR kinetics and raise a possibility that this modulation could be related to the lateral mobility of these receptors. (C) 2009 Wiley-Liss, Inc.
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