期刊
HIPPOCAMPUS
卷 18, 期 11, 页码 1099-1102出版社
WILEY-LISS
DOI: 10.1002/hipo.20486
关键词
protein kinase C; GAP-43; spatial memory; contextual fear; extinction
资金
- National Institutes of Health [MH65436]
- MRH [NIA AG20506]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH065436] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [T32AG020506] Funding Source: NIH RePORTER
Protein kinase C (PKC) is known to regulate phosphorylation of substrates such as MARCKS, GAP-43, and the NMDA receptor, all of which have been linked to synaptic plasticity underlying information storage processes. Here we report on three transgenic mice isoforms differentiated both by mutation of the PKC site on GAP-43 as well as by their performance in three learning situations: (1) a radial arm maze task, which evaluates spatial memory and its retention, (2) fear conditioning which assesses contextual memory, and (3) the water maze which also evaluates spatial memory and its retention. The present results show, for the first time to our knowledge, that the phosphorylation state of a single site on an identified brain growth- and plasticity-associated protein differentially regulates performance of three different memory-associated tasks. (C) 2008 Wiley-Liss, Inc.
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