Article
Biochemistry & Molecular Biology
Guillermo Santos-Sanchez, Ivan Cruz-Chamorro, Carlotta Bollati, Martina Bartolomei, Justo Pedroche, Francisco Millan, Maria del Carmen Millan-Linares, Anna Laura Capriotti, Andrea Cerrato, Aldo Lagana, Anna Arnoldi, Antonio Carrillo-Vico, Carmen Lammi
Summary: This study elucidated the molecular mechanism underlying the hypocholesterolemic effects of Lupin protein hydrolysates (LPHs) in an in vivo model. The results showed that LPH treatment reduced de novo cholesterol synthesis through the regulation of HMGCoAR and LDLR protein levels. LPHs also controlled the PSCK9 signal pathway, leading to decreased cholesterol absorption. These findings highlight LPHs as a potential ingredient for developing new functional foods.
Review
Pharmacology & Pharmacy
David M. Dolivo, Charlotte R. Reed, Kristine A. Gargiulo, Adrian E. Rodrigues, Robert D. Galiano, Thomas A. Mustoe, Seok Jong Hong
Summary: Fibrosis is a common pathological repair process in organs, but there is a lack of effective therapeutic methods. Repurposing existing drugs, such as statins, can be a complementary strategy to treat tissue fibrosis. Statins have been found to have anti-fibrotic effects through various mechanisms, and a better understanding of these effects can aid in the development of novel therapeutic agents.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Dongbo Yu, James K. Liao
Summary: This review discusses the development of statins, their non-lipid-lowering benefits, and proposes future research directions in this field.
CARDIOVASCULAR RESEARCH
(2022)
Article
Clinical Neurology
Bradley S. Guidry, Katherine A. Kelly, Aaron M. Yengo-Kahn, Matthews Lan, Alan R. Tang, Silky Chotai, Peter Morone, Patrick D. Kelly
Summary: This study found that concurrent use of statin drugs after surgical treatment for cSDH can help reduce the size of hematoma, potentially serving as a low-cost, low-risk supplement to surgical management for cSDH patients.
WORLD NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Man K. S. Lee, Olivia D. Cooney, Xuzhu Lin, Shaktypreya Nadarajah, Dragana Dragoljevic, Kevin Huynh, Danise-Ann Onda, Sandra Galic, Peter J. Meikle, Thomas Edlund, Morgan D. Fullerton, Bruce E. Kemp, Andrew J. Murphy, Kim Loh
Summary: The study revealed that the AMPK/HMGCR axis plays a crucial role in the development of atherosclerosis. Defects in AMPK regulation of HMGCR lead to increased aortic lesions, plaque-associated macrophages, lipid accumulation, and atherogenic monocytes.
MOLECULAR METABOLISM
(2022)
Article
Surgery
Jane J. He, Joshua J. Horns, Larry W. Kraiss, Brigitte K. Smith, Claire L. Grif, Randall R. DeMartino, Mark R. Sarfati, Benjamin S. Brooke
Summary: This study aimed to evaluate the impact of high-intensity statin therapy on the risk of amputation and reintervention in patients with chronic limb-threatening ischemia (CLTI) undergoing lower extremity bypass (LEB) surgery. The study found that patients maintained on high-intensity statins had a lower risk of requiring reintervention and amputation compared to patients on limited statin therapy. Therefore, these findings suggest that patients with CLTI should be up-titrated and/or maintained on high-intensity statins following revascularization whenever possible.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Chemistry, Medicinal
Xing-Zi Li, Shi-You Jiang, Guo-Qiang Li, Qian-Ru Jiang, Jue-Wan Li, Chen-Chen Li, Yu-Qin Han, Bao-Liang Song, Xin-Ran Ma, Wei Qi, Wen-Wei Qiu
Summary: A series of novel HMG499 analogs were synthesized and one of the compounds, 29 (QH536), showed potent activity in promoting HMGCR degradation without inducing cholesterol accumulation in cells. Compound 29 also exhibited effects on lowering cholesterol levels and suppressing various related genes, making it a potential candidate for the treatment of CVD and NASH.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Chung-Yu Chen, Wen-Ting Wu, Ya-Ling Wang, Kuang-Ming Liao
Summary: The study found that statins benefit patients with COPD and PH by reducing mortality related to PH.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Je-Wen Liou, Hemalatha Mani, Jui-Hung Yen
Summary: Hepatitis is an inflammatory disease of the liver caused by viral infections, most commonly hepatitis B and hepatitis C. Host lipid metabolism, particularly cholesterol metabolism, is crucial for hepatitis viral infection and life cycle. Manipulating host cholesterol metabolism-related genes and proteins, such as using cholesterol-lowering drugs, has shown promising results in the treatment of viral hepatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jia-Li Feng, Suzanne C. Dixon-Suen, Susan J. Jordan, Penelope M. Webb
Summary: The use of statins may provide a survival benefit for women with ovarian cancer, particularly for those with endometrioid cancers. However, bias in observational studies poses challenges in conclusively establishing this association.
BRITISH JOURNAL OF CANCER
(2021)
Review
Chemistry, Medicinal
Tyler Bahr, Gavin Butler, Christian Rock, Kyle Welburn, Kathryn Allred, Damian Rodriguez
Summary: Mono- and sesquiterpenoids are the main chemical constituents of essential oils, which have lipid-lowering properties. Many essential oil compounds have similar effects on cholesterol metabolism, likely through direct agonism of peroxisome-proliferator-activated receptors and direct interaction with sterol-sensing domains. Terpene derivatives in essential oils may have cholesterol-lowering activity and could potentially synergize with statins, but further high-quality studies are needed to establish their clinical efficacy.
PHYTOTHERAPY RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Janaina S. da Silva, Alessandra F. Rosa, Cristina T. Moncau, Barbara Silva-Vignato, Silvana Marina P. Pugine, Mariza P. de Melo, Joao Marcelo D. Sanchez, Marcus Antonio Zanetti
Summary: The effects of different sources and concentrations of selenium on glutathione forms and cholesterol metabolism in beef cattle were investigated in this study. Selenium supplementation can impact cholesterol metabolism by affecting GSH/GSSG ratio, GSH-Px, and HMGCR. The interaction between selenium source and concentration can influence glutathione forms.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Shubhi Singh, Smriti Gaur
Summary: Hypercholesterolemia is a major health concern and research has shown that bioactive compounds from edible seeds have strong binding interactions with HMG-CoA reductase, a key protein in cholesterol metabolism. These compounds have favorable drug likeliness and ADME properties, with good absorption in the human intestine. Molecular dynamics simulation studies provide insights into the stability of these compounds under simulated conditions.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Maria Giovanna Lupo, Silvia Marchiano, Maria Pia Adorni, Francesca Zimetti, Massimiliano Ruscica, Maria Francesca Greco, Alberto Corsini, Nicola Ferri
Summary: Overexpression of PCSK9 in rat SMCs led to downregulation of LDL receptor and marker of contractile phenotype. This resulted in increased cell proliferation rate and partial resistance to simvastatin, indicating a potential role of PCSK9 in atherosclerotic plaque development and pharmacological response to statins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Verena Korte, Guenther Gademann, Ahmed Gawish, Hans-Joachim Ochel
Summary: This study investigated the antiproliferative effects of simvastatin in combination with ionizing radiation on prostate cancer cells, and found that radiation had a stronger inhibitory effect compared to simvastatin alone. However, the combined application of both modalities had a synergistic effect. Simvastatin exerted its antiproliferative effects by inducing the elevation of HMG-CoA reductase levels.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Food Science & Technology
M. Mamani, M. E. LOpez, J. Correa, G. Ravest, P. Hinrichsen
Summary: This study identified key genes associated with sweetness and acidity in grapes, providing a basis for developing selection tools for grape breeding. Genomic regions hosting these genes were identified through a genetic map, showing significant quantitative trait loci for sugar and acidity traits. Additionally, an association between candidate gene expression changes and sugar/acidity concentration was observed.
AUSTRALIAN JOURNAL OF GRAPE AND WINE RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Nelson Naveas, Miguel Manso-Silvan, Erico Carmona, Karla Garrido, Jacobo Hernandez-Montelongo, Gonzalo Recio-Sanchez
Summary: In this study, nanostructured porous silicon thin films were used as a substrate for the deposition of green synthesized silver nanoparticles. The hybrid layers nPSi/AgNPs showed high catalytic activity in the reduction of organic dyes in water, and they demonstrated reusability after multiple cycles, making them promising for wastewater management.
GREEN CHEMISTRY LETTERS AND REVIEWS
(2022)
Article
Engineering, Environmental
Ruth Pulido, Nelson Naveas, J. Martin-Palma Raul, Teoftlo Graber, Ivan Brito, Jacobo Hernandez-Montelongo, Miguel Manso Silvan
Summary: The demand for portable electronic devices and batteries has led to increased interest in Li compounds. In this study, the lithium desorption behavior of different LiCoO2 nanocomposites in acidic media was investigated through experiments and theoretical calculations.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Ruth Pulido, Nelson Naveas, Raul J. Martin-Palma, Fernando Agullo-Rueda, Victor R. Ferro, Jacobo Hernandez-Montelongo, Gonzalo Recio-Sanchez, Ivan Brito, Miguel Manso-Silvan
Summary: In this study, the crystal structure and vibrational properties of layered monoclinic Li2MnO3 were investigated using first-principles calculations. The results were compared with experimental data, revealing the structural and vibrational characteristics of Li2MnO3 and providing a basis for further physicochemical characterization research.
Article
Chemistry, Multidisciplinary
Andres Perez-San Martin, Karina Uribe, Jacobo Hernandez-Montelongo, Nelson Naveas, Miguel Manso-Silvan, Patricio Oyarzun, Victor Diaz-Garcia, Braulio Contreras, Gonzalo Recio-Sanchez
Summary: This study investigated the antibacterial activity of Laureliopsis philippiana essential oil and its release performance on different surface-functionalized nanostructured porous silicon (nPSi). The results showed that the essential oil had a high inhibitory effect on Staphylococcus aureus and Klebsiella pneumoniae. The essential oil was successfully loaded onto various functionalized nPSi, and the release was controlled using a quasi-Fickian diffusion mechanism. Functionalized nPSi-APTS and nPSi-UAc structures demonstrated a more controlled release of the essential oil compared to other functionalizations, increasing its availability and exposure to the environment.
APPLIED SCIENCES-BASEL
(2022)
Review
Pharmacology & Pharmacy
Karen Escobar, Karla A. Garrido-Miranda, Ruth Pulido, Nelson Naveas, Miguel Manso-Silvan, Jacobo Hernandez-Montelongo
Summary: This review comprehensively covers the chemical properties and synthesis routes of CD/CTR cross-linking, as well as their applications as drug-delivery systems on different substrates. The study found that the CD/CTR biopolymers were nontoxic, environmentally friendly, and inexpensive, making them widely used in coating implants and biomedical materials. The importance of pretreatment methods on substrates and the analysis of release mechanisms, including the Korsmeyer-Peppas mathematical model, were also discussed. The flexibility of CD/CTR in hosting a wide variety of drugs, integrating with diverse implantable materials, and controllable release kinetics provide a range of advantages for future uses.
Article
Multidisciplinary Sciences
Nelson Naveas, Ruth Pulido, Carlo Marini, Jacobo Hernandez-Montelongo, Miguel Manso Silvan
Summary: Due to limitations in Fe-3d orbitals and self-interaction error of exchange-correlation functionals, approximate DFT fails to accurately describe the electronic structure and magnetic properties of iron oxides. Hybrid DFT or DFT + U can solve these problems, but are expensive or only consider on-site interactions. In this study, we used DFT + U + V, an extension that includes intersite interactions, to simulate the properties of alpha-Fe2O3. We found that DFT + U + V improves the description of structural, magnetic, and electronic properties compared to approximate DFT, with the accuracy depending on the type of atomic orbital projectors used.
Article
Biochemistry & Molecular Biology
Nelson Naveas, Ruth Pulido, Vicente Torres-Costa, Fernando Agullo-Rueda, Mauricio Santibanez, Francisco Malano, Gonzalo Recio-Sanchez, Karla A. Garrido-Miranda, Miguel Manso-Silvan, Jacobo Hernandez-Montelongo
Summary: This study proposes the formation of antibacterial films with silver nanoparticles embedded in carboxymethylcellulose/chitosan multilayers by the layer-by-layer method. The films exhibited high antibacterial activity against both Escherichia coli and Staphylococcus aureus, indicating their potential for biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Karen Escobar, Ignacio Carrera, Nelson Naveas, Ruth Pulido, Miguel Manso, Joao Paulo de Oliveira Guarnieri, Marcelo Lancellotti, Monica A. Cotta, Yendry Regina Corrales-Urena, Klaus Rischka, Jacobo Hernandez-Montelongo
Summary: This study aimed to functionalize commercially available silicone breast implants for controlled drug delivery. The results showed that the proposed pre-treatment significantly increased the polymerization yield, and the functionalized samples demonstrated superior properties compared to unprotected implants.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Nelson Naveas, Ruth Pulido, Carlo Marini, Pierluigi Gargiani, Jacobo Hernandez-Montelongo, Ivan Brito, Miguel Manso-Silvan
Summary: In this report, the DFT + U + V approach was used to simulate the properties of Fe3O4 and compare them with experimental data. The study showed that DFT + U + V can improve the structural, magnetic, and electronic properties of Fe3O4 compared to approximate DFT and DFT + U. Furthermore, the observations highlighted the significance of intersite interactions in the theoretical analysis of Fe3O4.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)