Review
Physiology
Pierre Lemieux, Olivier Birot
Summary: Hypoxia, defined as reduced oxygen availability, triggers complex angio-adaptive responses in skeletal muscle tissue, resulting in the growth, stabilization, or regression of muscle capillaries, known as angio-adaptation. Angio-adaptive molecules released in the circulation act on distant tissues. The combined potency of ambient hypoxia and exercise in generating a cellular hypoxic stress in skeletal muscle is discussed, highlighting the molecular complexity and identifying gaps in knowledge in this field.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Catherine M. Avitabile, Michael G. McBride, Xuemei Zhang, Steve Ampah, Bryan H. Goldstein, Tarek Alsaied, Samuel G. Wittekind, Kevin K. Whitehead, Babette S. Zemel, Stephen M. Paridon
Summary: Peak work rate and anaerobic activity increased with lower extremity-focused training in adolescents with Fontan circulation. However, leg lean mass did not improve. Additionally, training had no impact on physical activity questionnaire, quality of life scores, exercise cardiac magnetic resonance performance, and peripheral vascular function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Macsue Jacques, Shanie Landen, Javier Alvarez Romero, Danielle Hiam, Ralf B. Schittenhelm, Iresha Hanchapola, Anup D. Shah, Sarah Voisin, Nir Eynon
Summary: Exercise has significant effects on both the epigenome and proteome in human muscle. A 12-week high-intensity interval training intervention was conducted on 16 healthy moderately trained males, and muscle biopsies were collected at baseline and after 4, 8, and 12 weeks. The study found significant changes in proteins and DNA methylation levels, with some proteins consistently changed across individuals and the discovery of two novel exercise-related proteins. These findings contribute to a better understanding of the impact of exercise on the human body.
Article
Biology
Shiyi He, Lu Yan, Rongxin Zhu, Hao Wei, Jianxiong Wang, Lan Zheng, Ying Zhang
Summary: This study demonstrates that overexpression of Chrono in skeletal muscle leads to impaired glucose metabolism and decreased exercise capacity in mice.
Article
Biochemistry & Molecular Biology
Miaomiao Xu, Xiaoguang Liu, Peng Bao, Yanjie Wang, Xiaoyan Zhu, Yujian Liu, Xin Ni, Jianqiang Lu
Summary: Cystathionine-gamma-lyase (CSE) plays a critical role in skeletal muscle by regulating multiple signaling pathways involved in insulin sensitivity and glucose metabolism.
Article
Biochemistry & Molecular Biology
Pia Apablaza, Juan Carlos Borquez, Rodrigo Mendoza, Monica Silva, Gladys Tapia, Alejandra Espinosa, Rodrigo Troncoso, Luis A. Videla, Nevenka Juretic, Andrea del Campo
Summary: Increase in body fat leads to changes in skeletal muscle and accelerates sarcopenia, known as sarco-obesity or sarcopenic obesity. Obesity affects the skeletal muscle's ability to oxidize glucose and causes mitochondrial dysfunction. Exercise improves mitochondrial dysfunction, but the effects on the mitochondrial unfolded protein response (UPRmt) in the skeletal muscle are not well understood. This study aimed to investigate the UPRmt response to exercise in obese mice and its association with skeletal muscle function improvement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Mina Nakayama, Masaaki Konishi, Teruyasu Sugano, Masatsugu Okamura, Masaomi Gohbara, Kiwamu Iwata, Naoki Nakayama, Eiichi Akiyama, Naohiro Komura, Manabu Nitta, Noriyuki Kawaura, Tomoaki Ishigami, Kiyoshi Hibi, Toshiyuki Ishikawa, Takeshi Nakamura, Kouichi Tamura, Kazuo Kimura
Summary: This retrospective study analyzed the exercise capacity and skeletal muscle measures of 107 patients with pulmonary hypertension. The study found that sarcopenia and its components were associated with reduced exercise capacity in these patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Joshua C. Drake, Rebecca J. Wilson, Rhianna C. Laker, Yuntian Guan, Hannah R. Spaulding, Anna S. Nichenko, Wenqing Shen, Huayu Shang, Maya Dorn, Kian Huang, Mei Zhang, Aloka B. Bandara, Matthew H. Brisendine, Jennifer A. Kashatus, Poonam R. Sharma, Alexander Young, Jitendra Gautam, Ruofan Cao, Horst Wallrabe, Paul A. Chang, Michael Wong, Eric M. Desjardins, Simon A. Hawley, George J. Christ, David F. Kashatus, Clint L. Miller, Matthew J. Wolf, Ammasi Periasamy, Gregory R. Steinberg, D. Grahame Hardie, Zhen Yan
Summary: Mitochondria form a complex, interconnected reticulum maintained through coordination among biogenesis, dynamic fission, fusion and mitophagy in response to various cues. Specific isoforms of AMP-activated protein kinase are localized on the outer mitochondrial membrane and vary in activation across the reticulum in response to energetic stress. The discovery highlights the complexity of sensing cellular energetics in vivo and its implications for targeting mitochondrial energetics in disease treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agriculture, Dairy & Animal Science
Nicolas Busse, Madison L. Gonzalez, Mackenzie L. Krason, Sally E. Johnson
Summary: Consumption of HMB increased the percentage of type IIA and IIA/X muscle fibers in the GM, but did not improve athletic performance in horses. Additionally, HMB supplementation did not have measurable effects on the biomechanical properties of the muscles in horses.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Geriatrics & Gerontology
Jan Spaas, Richie P. Goulding, Charly Keytsman, Lena Fonteyn, Jack van Horssen, Richard T. Jaspers, Bert O. Eijnde, Rob C. I. Wust
Summary: Patients with multiple sclerosis (MS) have lower exercise tolerance due to reduced skeletal muscle oxidative phenotype. However, skeletal muscle mitochondria seem resistant to the effects of exercise training, suggesting that other physiological systems may be driving the improvements in exercise capacity following exercise training in MS.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Multidisciplinary Sciences
Fabio Leandro Breda, Fulvia Barros Manchado-Gobatto, Filipe Antonio de Barros Sousa, Wladimir Rafael Beck, Allan Pinto, Marcelo Papoti, Pedro Paulo Menezes Scariot, Claudio Alexandre Gobatto
Summary: This study investigated the effects of a 30-day altitude training on Paralympic athletes. The results showed that aerobic performance initially decreased but significantly improved after a certain period of training. Anaerobic parameters decreased initially but returned to their initial levels after further training. Hematological analysis revealed increased levels of hemoglobin after the training, which gradually returned to pre-training levels. Complex network analysis highlighted the importance of hemoglobin and hematocrit in improving endurance performance.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Maria Apostolopoulou, Lucia Mastrototaro, Sonja Hartwig, Dominik Pesta, Klaus Strassburger, Elisabetta de Filippo, Tomas Jelenik, Yanislava Karusheva, Sofiya Gancheva, Daniel Markgraf, Christian Herder, K. Sreekumaran Nair, Andreas S. Reichert, Stefan Lehr, Karsten Mussig, Hadi Al-Hasani, Julia Szendroedi, Michael Roden
Summary: The study found that 12 weeks of high-intensity interval training can improve insulin sensitivity in males, but individuals with insulin resistance showed different alterations in metabolism and inflammatory signals. Changes in the proteome of SEVs might influence the metabolic response to exercise training in humans.
Article
Sport Sciences
M. O. S. T. A. F. A. M. ALI, R. Y. A. N. P. MCMILLAN, D. A. N. E. W. FAUSNACHT, J. O. H. N. W. KAVANAUGH, M. O. R. D. E. C. A. I. M. HARVEY, J. O. S. E. P. H. R. STEVENS, Y. A. R. U. WU, R. A. N. D. A. L. L. L. MYNATT, M. A. T. T. H. E. W. W. HULVER
Summary: This study established a novel muscle-specific TLR4 knockout mouse model and identified mTLR4 as an immunomodulatory effector of exercise-induced metabolic adaptations in skeletal muscle.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Biochemistry & Molecular Biology
Amy D. Mackay, Erik D. Marchant, Makensie Louw, David M. Thomson, Chad R. Hancock
Summary: This study assessed muscle function in mice following DOX administration and found that exercise may be an effective strategy for preventing muscle fatigue caused by DOX treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tzortzis Nomikos, Spyridon Methenitis, Demosthenes B. Panagiotakos
Summary: This article discusses the impact of skeletal muscle fiber composition on lipid metabolism and potential benefits of certain exercise modalities in improving metabolic dyslipidemia by affecting skeletal muscle mass, fiber composition, and functionality. It highlights the mediating role of nutrition and proposes directions for future experimental research in this field.
LIPIDS IN HEALTH AND DISEASE
(2022)
Letter
Sport Sciences
S. Perrey
Review
Anatomy & Morphology
Qian Yu, Fabian Herold, Benjamin Becker, Ben Klugah-Brown, Yanjie Zhang, Stephane Perrey, Nicola Veronese, Notger G. Mueller, Arthur F. Kramer, Liye Zou
Summary: The study found that physical exercise interventions lead to changes in functional activation patterns primarily located in the precuneus and associated with frontoparietall, dorsal attention, and default mode networks.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Meyi Duleme, Stephane Perrey, Gerard Dray
Summary: This study examines the frequency band modulations underlying working memory load and the role of executive control using scalp EEG data. The results show that decoding accuracy is higher for combined frequency bands compared to isolated frequency bands, and that there are transient changes in frequency band clusters during specific time windows.
COGNITIVE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Frank Imbach, Stephane Perrey, Romain Chailan, Thibaut Meline, Robin Candau
Summary: This study aims to provide a transferable methodology in the context of sport performance modelling, with a special focus on the generalization of models. Data from seven elite short track speed skaters were collected over a three-month training period. Different models were compared, including the variable dose-response model, elastic net, principal component regression, and random forest models. The results showed that the ENET model achieved greater generalization and predictive accuracy performances.
SCIENTIFIC REPORTS
(2022)
Correction
Biochemical Research Methods
Yashika Arora, Pushpinder Walia, Mitsuhiro Hayashibe, Makii Muthalib, Shubhajit Roy Chowdhury, Stephane Perrey, Anirban Dutta
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Psychology, Biological
I Hoang, L. Paire-Ficout, R. Derollepot, S. Perrey, H. Devos, M. Ranchet
Summary: Executive functions are crucial for successful walking tasks, especially when performing dual tasks. Previous studies have focused on the prefrontal cortex activity in older adults under different walking conditions, but little is known about the changes in dorsolateral prefrontal cortex (DLPFC) activity during the early stages of aging. This study aimed to compare the changes in DLPFC activity during simple and dual task walking across three age groups. The results revealed that older adults exhibited increased DLPFC activity in the right hemisphere during simple task walking, but they seemed to have enough cognitive resources to maintain performance during dual task walking. These findings suggest the presence of compensation mechanisms in early aging, which may have implications for fall risk assessment.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Quentin Chenot, Caroline Hamery, Evelyne Lepron, Pierre Besson, Xavier De Boissezon, Stephane Perrey, Sebastien Scannella
Summary: This study investigated the effects of tRNS on performance in a complex task and found that high-definition tRNS was more effective than simple-definition tRNS in enhancing long-term performance, with faster learning rate and better performance retention.
SCIENTIFIC REPORTS
(2022)
Article
Sport Sciences
Frank Imbach, Nicolas Sutton-Charani, Jacky Montmain, Robin Candau, Stephane Perrey
Summary: The emergence of Fitness-Fatigue impulse response models (FFMs) has allowed for the investigation of training effects on athletic performance. However, their effectiveness in describing and predicting performance is limited due to simplified physiological processes and a univariate consideration of factors. Therefore, machine-learning methods can enhance performance prediction by incorporating physiological representations and multivariate algorithms.
SPORTS MEDICINE-OPEN
(2022)
Review
Sport Sciences
Stephane Perrey
Summary: This article emphasizes the importance of cognitive demand in training monitoring and proposes methods for better applying cognitive demand indicators in various sports settings. While the assessment of cognitive demand is still in its early stages, it may yield fruitful results if rigorous protocols and deep understanding of neurobehavioral and cognitive aspects are employed.
Article
Multidisciplinary Sciences
Frank Imbach, Waleed Ragheb, Valentin Leveau, Romain Chailan, Robin Candau, Stephane Perrey
Summary: This study aims to predict individual A-V profiles using GNSS measurements in real-world situations. The study found that GNSS features have limited relevance for predicting individual A-V profiles, but new signal processing features have potential in modeling athletic performance or injury occurrence.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Alexandre P. Gutknecht, Martin Gonzalez-Figueres, Thomas Brioche, Olivier Maurelli, Stephane Perrey, Francois B. Favier
Summary: The purpose of this study was to determine the optimal altitude for hypoxic training and investigate the relationship between pulse oxygen saturation and training-induced performance improvement. The results showed that hypoxic training at an altitude of 1,500 meters significantly improved anaerobic performance, while the correlation between pulse oxygen saturation and performance improvement during training was weak.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Stephane Perrey
Summary: While physical abilities are known to be important for elite sport performance, recent focus has shifted towards the role of cognitive processes. Noninvasive transcranial electrical stimulation (tES) has been found to modulate brain functioning and improve cognitive functions related to sports performance. However, more research is needed to fully understand its effectiveness and benefits, particularly in elite athletes. Modulating inhibitory control through tES over the frontal cortex may significantly enhance mental performance. Further studies are required to assess the long-term effects of tES as an ergogenic aid in conjunction with other cognitive training methods.
Article
Neurosciences
Ludovic Molle, Alexandre Coste, Charles-Etienne Benoit, Gerard Derosiere, Stefan Janaqi, Stephane Perrey, Arnaud Dupeyron
Summary: The emergence of consciousness is a biological mystery, and little is known about the physiological mechanisms underlying subjective experience. Recent research suggests that the breathing phase can modulate attention, with inhalation improving perceptual awareness and decision-making speed. This study tested this hypothesis and found that inhalation enhances perceptual awareness and speeds up objective decision-making.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Sport Sciences
Lenaic Borot, Benjamin Pageaux, Davy Laroche, Gregoire Vergotte, Romuald Lepers, Stephane Perrey
Summary: Compared to concentric exercise, eccentric exercise has a higher mental demand and activates the frontoparietal network, especially when the exercise intensity is fixed by torque.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Clinical Neurology
Zaineb Ajra, Binbin Xu, Gerard Dray, Jacky Montmain, Stephane Perrey
Summary: The study proposes the use of shallow neural networks to analyze EEG signals in order to diagnose dementia at an early stage. The results show that the CNN-based models outperformed conventional methods and achieved an accuracy of 94.54% in the test dataset.
FRONTIERS IN NEUROLOGY
(2023)