期刊
HETEROCYCLES
卷 81, 期 4, 页码 935-942出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-09-11890
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资金
- Grants-in-Aid for Scientific Research [22550087] Funding Source: KAKEN
A highly effective one-pot synthesis of poly-substituted quinolines from 2-alkynylnitrobenzenes using inexpensive reagents has been developed. Reaction of 2-alkynylnitrobenzenes with Sn/HCl in EtOH resulted in the formation of 2-aminophenyl ketones and subsequently condensed in situ with ketones to form tri-substituted quinolines in 80-97% yields.
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