Article
Chemistry, Inorganic & Nuclear
Filip Horky, Jiri Schulz, Martin Zabransky, Petr Stepnicka
Summary: The strategy of modifying phosphane ligands through substituent variation has been widely used in coordination chemistry and catalysis. This study synthesized unsymmetric ferrocene diphosphanes with electronically distinct phosphane moieties and converted them to corresponding selenides and Pd(0) complexes. The compounds were characterized by various techniques and their structures were determined. The redox behavior of the compounds was studied and compared with DFT calculations. The prepared Pd(0) complexes were applied in Pd-catalyzed C-H arylation reaction and compared with characterization data.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Polymer Science
Robson Pereira, Kenia S. Freitas, Polyanna M. Pereira, Tiago Venancio, Samir L. Mathias, Aparecido J. de Menezes
Summary: The polysaccharide chitosan was modified with ethoxymethylenemalononitrile (ChMM) through a nucleophilic vinylic substitution reaction. The ChMM showed successful modifications as confirmed by spectroscopic and analytical techniques. The modified chitosan exhibited good dye removal capacity in both acidic and alkaline conditions.
POLYMER INTERNATIONAL
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Brad Gilbertson, Kanta Subbarao
Summary: An influenza vaccine is created by attenuating the live virus through targeted proteolysis.
NATURE BIOTECHNOLOGY
(2022)
Article
Chemistry, Organic
Qitao Shen, Xiangyun Zheng, Lianghao Li, Tianshuo Zhong, Chuanliu Yin, Chuanming Yu
Summary: Diverse difluoroamidosulfonylated dihydrobenzofurans were synthesized in moderate to good yields through a visible-light-induced three-component radical cascade bicyclization. This protocol eliminates the need for photocatalysts, avoiding potential toxicity and tedious removal procedures, and it features mild reaction conditions and good functional group tolerance.
Article
Physics, Applied
Yannan Lu, Weili Li, Zhengyi Sun, Xizu Wang, Xiao-Chun Hang, David James Young
Summary: The study demonstrated that control of film thickness and annealing temperature under high relative humidity can lead to improved thermoelectric properties of PEDOT:PSS films, enhancing electrical conductivity and Seebeck coefficient.
APPLIED PHYSICS LETTERS
(2021)
Article
Pharmacology & Pharmacy
Karolina Dziemidowicz, Steve Brocchini, Gareth R. Williams
Summary: This study explores the feasibility of functionalizing PCL scaffolds with PFPA-NHS, successfully attaching proteins and enzyme catalase to the scaffold surface while maintaining their activity. The prolonged presentation and sustained release of proteins through PFPA-NHS conjugation could be advantageous for protein-based therapies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Energy & Fuels
Wissem Zayani, Samir Azizi, Karam S. El-Nasser, Ibraheem Othman Ali, Michel Moliere, Nouredine Fenineche, Hamadi Mathlouthi, Jilani Lamloumi
Summary: Zinc ferrite spinel alloy synthesized using sol-gel technique was studied for its hydrogen storage properties and applied as an anode in Ni-MH accumulators. Various electromechanical methods were used to examine the hydrogen storage properties, showing good cycling stability. The electrolyte/ZnFe2O4 anode interface was studied using electrochemical impedance spectroscopy before and after activation.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Lachlan O. Smith, Deborah L. Crittenden
Summary: In this study, novel redox-active protic ionic liquids (RAPILs) are introduced and electrochemically characterized. These RAPILs are formed by acid-base neutralization from inexpensive starting materials. A new RAIL-in-IL solvent system is also demonstrated for efficient and cost-effective determination of redox potentials and screening for electrochemical reversibility. The results show that among the tested redox-active ionic liquids, only propylammonium 4-nitrophenylacetate exhibits completely reversible electrochemistry and preservation of ionic character under acidic or neutral conditions. Propylammonium 2,5-dihydroxyphenyl-carboxylate also demonstrates two reversible redox processes, but is unstable to oxidation, likely forming an uncharged benzoquinone species at 0.27 V vs Ag (-0.14 V vs Fc). Based on these findings, design criteria are proposed for future experimental and computational work.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Kaitlin R. Albanese, Parker T. Morris, Javier Read de Alaniz, Christopher M. Bates, Craig J. Hawker
Summary: This study presents the synthesis and characterization of statistical and block copolymers containing alpha-lipoic acid (LA) using reversible addition-fragmentation chain-transfer (RAFT) polymerization. The controlled copolymerization of LA and vinyl monomers allows for the synthesis of copolymers with predictable molecular weights and low molar-mass dispersities. The presence of lipoic acid diads in the resulting copolymers, which include disulfide bonds, enables efficient degradation when exposed to mild reducing agents.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yang Chen, Yuichi Terazono, Michael Fefer, Jun Liu, Cody B. Gale, Michael A. Brook
Summary: The efficient synthesis of Ce6 dianhydride using acetic anhydride as both dehydrating agent and reagent is reported. The reaction of the dianhydride produces mixtures of mono- and di-amide derivatives, which are difficult to separate but offer advantages over traditional methods. This method avoids the challenge of removing unreacted Ce6 and unwanted by-products arising from carbodiimides.
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2022)
Article
Chemistry, Multidisciplinary
Mohd Nazish, Mujahuddin M. Siddiqui, Samir Kumar Sarkar, Annika Munch, Christina M. Legendre, Regine Herbst-Irmer, Dietmar Stalke, Herbert W. Roesky
Summary: This work describes the synthesis and coordination behavior of a new mixed-donor ligand PhC(NtBu)(2)SiC6H4PPh2, which can induce the formation of various metal complexes and has been extensively characterized by mass spectrometry, elemental analysis, NMR spectroscopy, and single-crystal X-ray diffraction studies.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Chang Qiao, Wangyu Shi, Arianna Brandolese, Jordi Benet-Buchholz, Eduardo C. Escudero-Adan, Arjan W. Kleij
Summary: A new catalytic route has been developed for the coupling of epoxides and CO2 to produce polymerizable six-membered bicyclic carbonates. By utilizing cyclic epoxides with a beta-positioned OH group, structurally diverse bicyclic cyclic carbonates can be obtained with good yields and high selectivity. The difference in reactivity between syn- and anti-configured epoxy alcohols is the key to achieve chemo-selectivity, with the anti-isomer leading to the formation of six-membered ring carbonates in the presence of a binary Al-III aminotriphenolate complex/DIPEA catalyst.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Applied
Jiajun Wu, Satawat Tongdee, Yuvaraj Ammaiyappan, Christophe Darcel
Summary: By starting from nitroarenes and using hydrosilylation conditions with a well-defined N-heterocyclic carbene iron(0) catalyst, aniline derivatives were successfully produced in moderate to high yields. Furthermore, a selective synthesis of cyclic amines such as pyrrolidines, piperidines, and azepanes was achieved from levulinic acid, 1,5- and 1,6-keto acids, respectively, with isolated yields up to 69% under visible light irradiation and thermal conditions.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Polymer Science
Weipei Li, Liqing Xu, Xiangqin Wang, Ruitian Zhu, Yurong Yan
Summary: A novel thermoplastic polyurethane (TPU) PCFs with high loaded ratio and high elasticity were prepared by vacuum absorption and coating. The PCFs have excellent thermal cycle stability, elastic recovery, and temperature sensitivity.
Article
Materials Science, Multidisciplinary
Lawal Lanre Adebayo, Hassan Soleimani, Beh Hoe Guan, Noorhana Yahya, Andreas Oechsner, Maziyar Sabet, Jemilat Yetunde Yusuf, Hassan Ali
Summary: In this study, Fe3O4@C microspheres with a high BET surface area and excellent EM wave absorption performance were prepared. The Fe3O4@C microspheres exhibited a minimum reflection loss value at 16.89 GHz, showing promising application prospects.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Biochemistry & Molecular Biology
Michele Di Foggia, Carla Boga, Gabriele Micheletti, Benedetta Nocentini, Paola Taddei
Summary: Many restoring formulations for damaged hair keratin have been developed, claiming repair occurs through the reconstruction of disulfide bridges of keratin. Experimental results showed that shikimic acid and maleate-based restoring agents interacted with hair fibers, modifying the hair structure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Giorgia Simonetti, Carla Boga, Joseph Durante, Gabriele Micheletti, Dario Telese, Paolo Caruana, Andrea Ghelli Luserna di Rora, Fabio Mantellini, Samantha Bruno, Giovanni Martinelli, Natalia Calonghi
Summary: Novel tryptamine derivatives with azelayl chain or 1,1,1-trichloroethyl group showed potential anti-cancer activity. Compound 9 exhibited high activity in hematological cancer cell lines, while compound 13 had selective effects on HT29 cells among solid tumor models.
Article
Chemistry, Multidisciplinary
Silvia Bordoni, Stefano Cerini, Riccardo Tarroni, Magda Monari, Gabriele Micheletti, Carla Boga
Summary: Ruthenium complexes have antineoplastic activity by interacting with DNA, and studies on the binding modes of ruthenium with thymine acetate have been conducted to understand the structure-activity relationship. The reaction between dihydride ruthenium and thymine acetic acid resulted in different coordinating species, with metal coordination stabilizing minor tautomers that may influence the anticancer activity.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Elena Chugunova, Gabriele Micheletti, Dario Telese, Carla Boga, Daut Islamov, Konstantin Usachev, Alexander Burilov, Alena Tulesinova, Alexandra Voloshina, Anna Lyubina, Syumbelya Amerhanova, Tatiana Gerasimova, Aisylu Gilfanova, Victor Syakaev
Summary: A series of novel hybrid compounds containing benzofuroxan and 2-aminothiazole moieties were synthesized and found to exhibit potential as anticancer agents, with higher activity and lower toxicity compared to starting materials. The mechanism of action may involve apoptosis induction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Elena Chugunova, Nurgali Akylbekov, Alexey Dobrynin, Alexander Burilov, Carla Boga, Gabriele Micheletti, Vincenzo Frenna, Edoardo Jun Mattioli, Matteo Calvaresi, Domenico Spinelli
Summary: The research focuses on the X-ray structure and DFT calculations of 4,6-dichloro-5-nitrobenzofuroxan and its amino derivatives, revealing different polymorphic structures and nitro group torsional angles dependent on the steric hindrance of the substituent. DFT calculations confirm the influence of the furoxan ring and chlorine atoms on the nucleophilic substitution reaction with amines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Natalia Calonghi, Carla Boga, Patrizia Nitti, Dario Telese, Silvia Bordoni, Giovanna Farruggia, Fioretta Asaro, Martina Grandi, Chiara Zalambani, Gabriele Micheletti
Summary: Among a series of hydroxystearic acid regioisomers, those with hydroxyl groups at positions 5, 7, and 9 showed growth inhibitory activity against various human tumor cell lines. 5-HSA not only reduced cell proliferation but also induced changes in cell displacement, directionality, and speed in HeLa, HT29, MCF7, and NLF cell lines.
Article
Biochemistry & Molecular Biology
Gabriele Micheletti, Carla Boga, Chiara Zalambani, Giovanna Farruggia, Erika Esposito, Jessica Fiori, Nicola Rizzardi, Paola Taddei, Michele Di Foggia, Natalia Calonghi
Summary: A series of naphthoquinone derivatives were synthesized through the reaction with N-acetyl-L-cysteine. Compounds 8, 9, and 12 exhibited cytotoxicity against malignant cell lines, while compound 11 showed biological activity at higher IC50 values. Compounds 8 and 11 induced increases in ROS generation.
Article
Chemistry, Organic
Gabriele Micheletti, Natalia Calonghi, Carla Boga
Summary: Methyl 9-(2-iminothiazol-3(2H)-yl)-9-oxononanoate was synthesized via the Schotten-Baumann reaction between 2-aminothiazole and methyl 9-chloro-9-oxononanoate. The structure of the newly synthesized compound was confirmed using H-1-NMR, C-13-NMR, DEPT, NOE, ESI-MS, FT-IR, and UV-Vis spectroscopy.
Article
Chemistry, Organic
Gabriele Micheletti, Carla Boga
Summary: Methyl 9-(1-methyl-1H-indol-3-yl)-9-oxononanoate was synthesized using Friedel-Crafts acylation between N-methyl indole and methyl 9-chloro-9-oxononanoate. The structure of the newly synthesized compound was elucidated using H-1-NMR, C-13-NMR, NOESY-1D, ESI-MS, FT-IR, and UV-Vis spectroscopy.
Article
Biochemistry & Molecular Biology
Silvia Bordoni, Riccardo Tarroni, Magda Monari, Stefano Cerini, Fabio Battaglia, Gabriele Micheletti, Carla Boga, Giacomo Drius
Summary: The reaction between Ru complex 1 and thymine acetic acid (THAcH) unexpectedly gives rise to macrocyclic dimer 4 and doubly coordinated species 5. By considering the energetics calculated by DFT, two possible reaction paths were proposed. The stable symmetric 14-membered binuclear macrocycle 4 is formed through self-aggregation, whereas species 2 achieves additional stabilization through k(2)(N,O) thymine heteroleptic side-chelation.
Article
Biochemistry & Molecular Biology
Giacomo Drius, Silvia Bordoni, Carla Boga, Magda Monari, Jessica Fiori, Erika Esposito, Chiara Zalambani, Luca Pincigher, Giovanna Farruggia, Natalia Calonghi, Gabriele Micheletti
Summary: In this study, three Ru(II) complexes containing hydroxy stearic acids (HSAs) were successfully synthesized and evaluated for their synergistic effects between the known antitumor activity of HSA bio-ligands and the metal center. The results showed that Ru-7-HSA and Ru-9-HSA complexes exhibited biological activity, with Ru-9-HSA showing increased antitumor activity on colon cancer cells, HT29.
