Solvent-and Catalyst-Free Reaction of (Aminomethyl)phosphonates with Epoxides: Synthesis of Novel {[(2-Hydroxyethyl) amino] methyl}phosphonates

Uncatalyzed reaction of epoxides with (aminomethyl)phosphonates for the synthesis of novel {[(2-hydroxyethyl)amino]methyl}phosphonates is described. Treatment of (aminomethyl)phosphonates with epoxides without any catalyst and under solvent-free conditions gives novel {[(2hydroxyethyl)amino]methyl}phosphonates. Using this method, a series of {[(2-hydroxyethyl)arnino]methyl}phosphonates was synthesized in good yields. (C) 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:284-289, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20615