Article
Medicine, General & Internal
Jun Li, Zhao Wu, Gui-Qiang Wang, Hong Zhao
Summary: The study revealed correlations between HBcrAg and antiviral efficacy, virological, and histological variables in chronic hepatitis B patients, with a decreased HBcrAg predicting HBeAg loss after antiviral therapy.
CHINESE MEDICAL JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Hye-Lin Kim, Gi-Ae Kim, Jae-A Park, Hye-Rim Kang, Eui-Kyung Lee, Young-Suk Lim
Summary: This study found that starting antiviral therapy in the immune-tolerant phase is more cost-effective compared with delaying treatment until the active hepatitis phase in CHB patients, especially with increasing hepatocellular carcinoma risk, decreasing drug costs, and consideration of productivity loss.
Article
Infectious Diseases
Bingqin Tan, Mei Liu, Liming Wang, Jinhuan Wang, Fang Xiong, Xuli Bao, Yao Gao, Lele Yu, Jun Lu
Summary: The study suggests that the dynamic fluctuations of serum microRNAs could predict the efficacy of antiviral therapy for CHB. There were differences in the expression levels of microRNAs between responder and non-responder groups at baseline and after therapy, with some microRNAs correlated with hepatitis B virus DNA titer and e antigen.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Menglin Liang, Meiqi Wu, Chenhao Jia, Ruijie Guo, Ruixue Cui
Summary: An 18-year-old man presented with progressive exercise intolerance and muscle weakness for 1 year with recent acute exacerbation. Laboratory test demonstrated lactic acidosis. F-18-FDG PET/CT was performed to exclude malignancy and showed generalized muscular hypermetabolism. Muscle biopsy combined with patient's history suggested mitochondrial myopathy. This report illustrates that mitochondrial myopathy may present as generalized muscular hypermetabolism on F-18-FDG PET/CT and thus should be added to the differential diagnoses.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Microbiology
Xin Yu, Ying Chen, Lele Cui, Kaming Yang, Xumeng Wang, Linyuan Lei, Yanping Zhang, Xinyi Kong, Wanwen Lao, Zhenlin Li, Yang Liu, Yuetong Li, Changlong Bi, Chao Wu, Aixia Zhai
Summary: This study found that CXCL8, CXCL9, CXCL10, and CXCL11 can be used as serum biomarkers to forecast liver injury caused by HBV infection, using a combination of bioinformatics, cell experiments, and clinical correlation analysis.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Li-Chiu Wang, Huey-Pin Tsai, Shun-Hua Chen, Shih-Min Wang
Summary: Neonatal infection with nonpolio enteroviruses (EVs) can cause severe diseases such as hepatitis and multiorgan failure. Recent studies have proposed treatment options, such as intravenous immunoglobulin and antiviral therapy. However, further research is needed to determine the full potential and safety of these treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jia-Horng Kao, Wen-Juei Jeng, Qin Ning, Tung-Hung Su, Tai-Chung Tseng, Yoshiyuki Ueno, Man-Fung Yuen
Summary: Chronic HBV infection is currently incurable and long-term treatment with NAs can reduce complications, but stopping treatment may lead to virological relapse and adverse outcomes. Close monitoring and personalized follow-up strategies are essential for a safe cessation of NA therapy.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Health Care Sciences & Services
Min Li, Lianhui Zhao, Jialing Zhou, Yameng Sun, Xiaoning Wu, Xiaojuan Ou, Hong You, Yuanyuan Kong, Jidong Jia
Summary: The study using the BMCIE database in Beijing, China showed a significant increase in the rates of CHB patients in care, receiving HBV tests, and on antiviral therapy from 2010 to 2018. However, more efforts are still needed to increase the uptake of HBV tests and treatment in order to achieve the goal of HBV elimination by 2030.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Article
Immunology
Do Seon Song, Jeong Won Jang, Sun Hong Yoo, Jung Hyun Kwon, Soon Woo Nam, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon
Summary: This study identified end-of-therapy HBsAg levels, consolidation duration, and cirrhosis as key determinants of off-therapy relapse. Extended consolidation therapy for >= 2 years, in combination with low HBsAg levels, is recommended for HBeAg-positive patients, while the risk of relapse in HBeAg-negative patients is mainly associated with HBsAg levels.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Gastroenterology & Hepatology
Sheikh Mohammad Fazle Akbar, Osamu Yoshida, Yoichi Hiasa
Summary: Patients with chronic hepatitis B (CHB) are a long-term reservoir of hepatitis B virus (HBV). If not properly treated, these CHB patients may develop serious complications. Current antiviral drugs for CHB treatment cannot eradicate all forms of HBV and cannot stop the progression of complications for most patients. Therefore, there is an urgent need for the development of new therapies for CHB. Immune dysregulation may be responsible for HBV persistence and liver damage in CHB. Despite 30 years of immune therapies for CHB, an effective regimen of immune therapy is yet to be realized. This review discusses the pros and cons of different immune therapies for CHB patients in the past 30 years to provide insights for the development of an evidence-based, effective, and patient-friendly immune therapy regimen for CHB treatment.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ramisha Khan, Amjad Ali, Sadia Bibi, Shazia Rafique, Muhammad Idrees, Sobia Ahsan Halim, Muhammad Waqas, Haji Bahadar, Jalal Uddin, Ajmal Khan, Ahmed Al-Harrasi
Summary: This study evaluated the expression of three TRIM family genes in patients with chronic hepatitis C and found that TRIM25 and TRIM14 had the highest expression levels in the group with good treatment response. The expression levels of TRIM genes were also linearly correlated with the viral load of hepatitis C virus.
Article
Immunology
Ning Li, Kangkang Yu, Minhui Dong, Jinyu Wang, Feifei Yang, Haoxiang Zhu, Jie Yu, Jingshu Yang, Wentao Xie, Bidisha Mitra, Richeng Mao, Feizhen Wu, Haitao Guo, Jiming Zhang
Summary: This study investigates the gene expression profiles in CHB patients treated with PegIFN alpha and finds that the treatment induces significant antiviral responses. Responders who achieved HBV DNA loss and seroconversion showed higher expression of interferon-stimulated genes (ISGs). Non-responders had higher baseline HBeAg levels than responders in HBeAg+ patients. PegIFN alpha treatment increased monocyte and mast cell infiltration, but decreased CD8+ T cell and M1 macrophage infiltration. B cell infiltration was increased only in responders.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Gastroenterology & Hepatology
Samuel Anthony Lachlan Hall, Sara Vogrin, Olivia Wawryk, Gareth S. Burns, Kumar Visvanathan, Vijaya Sundararajan, Alexander Thompson
Summary: A meta-analysis was conducted on clinical outcomes after nucleot(s)ide analogue (NA) discontinuation for HBeAg-negative CHB patients, revealing that virological relapse is common but clinical relapse occurs in only one-third of patients at 12 months post-NA discontinuation. Discontinuation of NA therapy can lead to HBsAg clearance, with higher rates observed with longer follow-up periods.
Review
Immunology
Shuling Wu, Wei Yi, Yuanjiao Gao, Wen Deng, Xiaoyue Bi, Yanjie Lin, Liu Yang, Yao Lu, Ruyu Liu, Min Chang, Ge Shen, Leiping Hu, Lu Zhang, Minghui Li, Yao Xie
Summary: Functional cure is considered achieved when chronic hepatitis B patients achieve HBsAg seroclearance after treatment. Clearing the virus is challenging due to the difficulty in clearing both cccDNA and integrated dslDNA. High levels of HBsAg in the serum lead to immune system failure, making it unable to produce an effective antiviral response. Only less than 1% of chronic hepatitis B patients are cured annually with antiviral treatment. Coinfection with other viruses such as HIV, HCV, and HDV makes it even more difficult to cure. However, it has been found that patients with coinfection have a higher probability of achieving HBsAg seroclearance, especially those with HBV/HIV coinfection with up to 36% 5-year seroclerance rate. This interesting phenomenon is related to the functional reconstruction of the immune system after antiretroviral therapy (ART).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jordan J. Feld, Anna S. Lok, Fabien Zoulim
Summary: Current therapy for chronic hepatitis B rarely achieves a functional cure, but novel treatments are being developed. Understanding the mechanisms of hepatitis B virus persistence has helped identify new treatment targets and evaluate novel agents in clinical trials. Combining different agents appears to be a promising strategy to reduce viral replication, invigorate immune responses, and induce specific adaptive immune responses.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Joon Seop Lee, Seong Woo Jeon, Hyun Seok Lee, Yong Hwan Kwon, Su Youn Nam, Han Ik Bae, An Na Seo
Summary: The study demonstrated that administration of rebamipide improved atrophic gastritis and intestinal metaplasia in the antrum, especially in patients with Helicobacter pylori non-infection.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Su Youn Nam, Sang Won Lee, Seong Woo Jeon, Yong Hwan Kwon
Summary: The study found that sodium alginate can relieve epigastric pain/soreness after EGD with biopsy. The treatment group showed decreased scores for acid regurgitation and epigastric soreness, while there were no significant improvements in the control group.
Article
Gastroenterology & Hepatology
Sun Young Moon, Jun Heo, Min Kyu Jung, Chang Min Cho
Summary: This study compared the efficacy of temporary self-expanding metallic stent (SEMS) and angioembolization for refractory immediate ERCP-related bleeding. The results showed that temporary SEMS and angioembolization had similar success rates in hemostasis, but the angioembolization group required more blood transfusions.
CLINICAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Sun Young Moon, Min Kyu Jung, Jun Heo
Summary: Percutaneous endoscopic gastrostomy (PEG) is a common method for long-term enteral nutrition. The over-the-scope clip system is a new device used for hemostasis and fistula closure. In this case, the over-the-scope clip device was used to achieve hemostasis and fistula closure for persistent bleeding around the PEG tube.
CLINICAL ENDOSCOPY
(2022)
Article
Medicine, General & Internal
Young-Gon Kim, Kyungsang Kim, Dufan Wu, Hui Ren, Won Young Tak, Soo Young Park, Yu Rim Lee, Min Kyu Kang, Jung Gil Park, Byung Seok Kim, Woo Jin Chung, Mannudeep K. Kalra, Quanzheng Li
Summary: Imaging plays an important role in assessing the severity of COVID-19 pneumonia. This paper proposes a fully automated framework that utilizes deep learning models to assist in quantifying the regional pulmonary opacities of COVID-19 pneumonia. The results show a correlation between the proposed method and the radiographic assessment conducted by physicians.
Article
Gastroenterology & Hepatology
Jong Yop Pae, Eun Soo Kim, Sung Kook Kim, Min Kyu Jung, Jun Heo, Jang Hoon Lee, Min Ae Park
Summary: This study compared the risk of gastrointestinal bleeding (GIB) for non-vitamin K antagonist oral anticoagulants (NOACs) and warfarin. The results showed that NOACs patients had a lower risk of overall GIB than warfarin patients, but a higher risk of post-polypectomy GIB. Among NOACs, apixaban had the lowest risk of GIB.
INTESTINAL RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Sang Hyub Lee, Jung Wan Choe, Young Koog Cheon, Miyoung Choi, Min Kyu Jung, Dong Kee Jang, Jung Hyun Jo, Jae Min Lee, Eui Joo Kim, Sung Yong Han, Young Hoon Choi, Hyung-Il Seo, Dong Ho Lee, Hong Sik Lee
Summary: Acute pancreatitis can vary in severity and have life-threatening complications. In order to improve the management of acute pancreatitis and contribute to healthcare improvements, the Korean Pancreatobiliary Association developed guidelines in 2013. However, challenging issues and new evidence have led to an extensive revision of the guidelines.
Article
Gastroenterology & Hepatology
Myeongseok Koh, Jong Yoon Lee, Song-Hee Han, Seong Woo Jeon, Su Jin Kim, Joo Young Cho, Seong Hwan Kim, Jae Young Jang, Gwang Ho Baik, Jin Seok Jang
Summary: This study aimed to compare the efficacy of I-SCAN-optical enhancement (I-SCAN-OE) versus chromoendoscopy in evaluating the horizontal margins of gastric epithelial neoplasms, and the results showed no significant difference in delineation scores between the two methods.
Article
Gastroenterology & Hepatology
Hyo-Joon Yang, Young-Il Kim, Ji Yong Ahn, Kee Don Choi, Sang Gyun Kim, Seong Woo Jeon, Jie-Hyun Kim, Sung Kwan Shin, Hyuk Lee, Wan Sik Lee, Gwang Ha Kim, Jae Myung Park, Woon Geon Shin, Il Ju Choi
Summary: This study validated the effectiveness of the eCura system in undifferentiated-type early gastric cancer, and found that close follow-up without additional treatment can be considered for low-risk patients, while additional surgery is recommended for intermediate- and high-risk patients.
Article
Gastroenterology & Hepatology
Eunae Cho, Seong-Hun Kim, Seong Ji Choi, Min Kyu Jung, Byeong Jun Song, Jin Myung Park, Jingu Kang, Won Suk Park, Joo Kyung Park, Sang Myung Woo, Hyo Jung Kim
Summary: This study investigates the current practice of diagnosing and treating perihilar cholangiocarcinoma (CCA) in Korea. It suggests the need for a new coding system for classifying CCAs and the development of guidelines based on the clinical situation in Korea.
Article
Oncology
Thanaporn Viriyasaranon, Jung Won Chun, Young Hwan Koh, Jae Hee Cho, Min Kyu Jung, Seong-Hun Kim, Hyo Jung Kim, Woo Jin Lee, Jang-Hwan Choi, Sang Myung Woo
Summary: Researchers have developed an innovative self-supervised learning algorithm that improves the differentiation of malignant and benign lesions, leading to increased accuracy in computer-assisted pancreatic cancer diagnosis. By utilizing a pseudo-lesion segmentation self-supervised learning model, the performance of convolutional neural network-based and transformer-based deep learning models was significantly enhanced. The study also found that self-supervised learning can improve the performance and robustness of the model on unseen and small datasets.
Article
Medicine, General & Internal
O. Seong Kweon, Jun Heo, Min Kyu Jung
Summary: This study aimed to evaluate the recurrence rate of choledocholithiasis and identify risk factors for recurrent choledocholithiasis in patients following gastrectomy. The study found that the recurrence rate of choledocholithiasis was 14.5%, and the stone removal modality, no use of balloon sphincteroplasty, and the presence of periampullary diverticulum were significant risk factors for recurrent choledocholithiasis. Therefore, the study recommends using ERCP with active use of balloon sphincteroplasty to decrease recurrent CBD stones following gastrectomy.
Article
Infectious Diseases
Su Youn Nam, Seong Woo Jeon, Deuk Kju Jung, Sung-Jae Heo
Summary: This study aimed to determine factors affecting serum levels of anti-SARS-CoV-2 antibodies in young and middle aged healthy adults 2 months after COVID-19 vaccination. The study found an inverse correlation between antibody levels and weight and BMI.
INFECTION AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Min Kyu Jung, Sanghee Yeo, Won Kee Lee
Summary: Empathy is crucial for healthcare professionals, as it can improve patient adherence, satisfaction, and treatment outcomes. Female students scored higher in empathy compared to male students, and students aspiring to be attending faculty showed better empathy scores. Additionally, students with empathy towards patients performed better in clinical comprehensive assessments.
Article
Medicine, General & Internal
Min Su Jung, Man-Hoon Han, Tae In Park, Min Kyu Jung
Summary: This study investigated the relationship among ICC number, gallbladder contractibility, and gallstones in patients undergoing cholecystectomy. Results showed that male participants had a higher number of ICC in the mucosal layer compared to females, and larger gallbladder size was associated with decreased ICC in the muscular layer. The number of ICC in the muscular layer decreased with an increase in gallbladder stone number, but there was no significant correlation with other factors.
