Article
Immunology
Liang Cheng, Guangming Li, Caroline Marnata Pellegry, Fumihiko Yasui, Feng Li, Sandra M. Zurawski, Gerard Zurawski, Yves Levy, Jenny P. -Y. Ting, Lishan Su
Summary: TLR9 and CD40-targeting vaccination can induce human B cell maturation and immunoglobulin class-switch in humanized mice in a pDC-dependent manner, leading to the production of IgG antibodies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Leyuan Xu, Jiankan Guo, Dennis G. Moledina, Lloyd G. Cantley
Summary: Incomplete repair after acute kidney injury can lead to the development of chronic kidney disease, and this response is mediated by macrophages promoting a proinflammatory environment and progressive tubule injury.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Xinning Zhang, Yong Xu, Guodong Zhao, Rong Liu, Haisheng Yu
Summary: The study found that sorafenib suppressed the function of plasmacytoid dendritic cells (pDCs) and inhibited the production of interferon alpha (IFN-α) by peripheral blood mononuclear cells (PBMCs) or pDCs from healthy donors in a concentration-dependent manner. This suggests that the immunosuppressive effect of sorafenib on pDCs should be considered during cancer treatment.
Article
Medicine, Research & Experimental
Nan Li, Hong Liu, Yujia Xue, Qiang Zhu, Zhiwen Fan
Summary: This study reveals the crucial role of BRG1 in hepatic ischemia-reperfusion injury (IRI) and suggests that targeting BRG1 with small-molecule inhibitors can be considered as a reasonable therapeutic strategy.
Article
Clinical Neurology
Koteswara Rao Nalamolu, Siva Reddy Challa, Casimir A. Fornal, Natalia A. Grudzien, Laura C. Jorgenson, Mouneeb M. Choudry, Nathan J. Smith, Cassandra J. Palmer, David M. Pinson, Jeffrey D. Klopfenstein, Krishna Kumar Veeravalli
Summary: The induction of TLRs 2 and 4 persists for at least 7 days after reperfusion, contributing to the severity of acute inflammation and hindering neurological recovery. Knockdown of TLR2 and TLR4 attenuates post-ischemic inflammation, preserves motor function, and promotes the recovery of sensory and motor functions. This study in a rodent stroke model has translational significance for pharmacological interventions.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jianing Tian, Ruimin Wang, Xiao Yang, Jie Yang, Yifei Zhang, Xuan Li, Hangfei Liang, Shicheng Fan, Yue Gao, Simin Zhang, Xiangyang Qu, Min Huang, Huichang Bi
Summary: This study aimed to explore the features of spatial changes in hepatocytes during PXR-induced liver enlargement. The results showed that hepatocyte hypertrophy mainly occurred around the central vein, while hepatocyte proliferation mainly occurred around the portal vein. Furthermore, the spatial changes in hepatocyte hypertrophy and proliferation were closely associated with the regional expression of related proteins and the regional distribution of triglycerides.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Immunology
Sofi Damjanovska, Carson Smith, Ismail Sayin, Christopher J. Burant, Stefan Gravenstein, David H. Canaday
Summary: This study aimed to determine if IFN-alpha induction in PBMCs exposed to eight different commercial influenza vaccines is a pDC-dependent process mediated through TLR-7 signaling. Multiple vaccines were found to induce IFN-alpha in a TLR-7-dependent fashion, while some lacked this induction. The significance of these differences between vaccines remains unclear, as all approved vaccine formulations offer some degree of protection.
Article
Gastroenterology & Hepatology
Lin Ding, Jayati Chakrabarti, Sulaiman Sheriff, Qian Li, Hahn Nguyen Thi Hong, Ricky A. Sontz, Zoe E. Mendoza, Amanda Schreibeis, Michael A. Helmrath, Yana Zavros, Juanita L. Merchant
Summary: TLR9 plays an essential role in the production of IFN alpha and polarization of SLFNthorn MDSCs on Helicobacter infection. Subjects carrying the rs5743836 TLR9 minor C allele are predisposed to neoplastic complications if chronically infected.
Review
Virology
Trever T. Greene, Elina Zuniga
Summary: Type I interferons (IFN-I) are potent antiviral cytokines that can drive immunopathology if overproduced, with plasmacytoid dendritic cells (pDCs) being specialized producers of IFN-I. After viral infection, pDCs may undergo exhaustion, producing less IFN-I to prevent excessive immune responses and immunopathology.
Article
Critical Care Medicine
Molly Kobritz, Timothy Borjas, Vihas Patel, Gene Coppa, Monowar Aziz, Ping Wang
Summary: H151, a novel STING inhibitor, shows promise as a potential therapeutic in attenuating the inflammatory response, reducing tissue injury, and improving survival rate in a murine model of intestinal I/R.
Article
Biochemistry & Molecular Biology
David Schumacher, Elisa A. Liehn, Anjana Singh, Adelina Curaj, Erwin Wijnands, Sergio A. Lira, Frank Tacke, Joachim Jankowski, Erik A. L. Biessen, Emiel P. C. van der Vorst
Summary: The study found that CCR6 plays an important role in ischemia-reperfusion injury after acute myocardial infarction, exerting protective effects on the heart through bone marrow cells. Increasing CCR6-dependent immune mechanisms may represent an interesting therapeutic target for cardiac damage and inflammation.
Article
Hematology
Kathryn N. Phoenix, Zhichao Yue, Lixia Yue, Chunxia G. Cronin, Bruce T. Liang, Luke H. Hoeppner, Kevin P. Claffey
Summary: This study identifies PLC beta 2 as a key regulator of vascular permeability induced by VEGF, functioning through regulation of calcium flux and phosphatidylinositol 4,5-bisphosphate levels. Targeting PLC beta 2 could provide a novel approach to regulate vascular permeability in patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Genetics & Heredity
Muhammad Farooq, Melanie Simoes Eugenio, Claire Piquet-Pellorce, Sarah Dion, Celine Raguenes-Nicol, Kathleen Santamaria, Ghania Hounana Kara-Ali, Thibaut Larcher, Marie-Therese Dimanche-Boitrel, Michel Samson, Jacques Le Seyec
Summary: This study investigates the role of RIPK1 in NASH and finds that RIPK1 in hepatocytes limits the progression of liver fibrosis during NASH.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Medicine, Research & Experimental
Kunsheng Li, Pengyu Zhou, Jie Li, Yongqing Cheng, Shiliang Li, Yumeng Wang, Weipeng Jiang, Yang Bai, Hailong Cao, Dongjin Wang
Summary: The expression and function of P2Y14 receptor in neutrophils after myocardial infarction/reperfusion (MIR) injury were investigated. The results showed that P2Y14 receptor is involved in the regulation of inflammation in the infarct area after MIR, and it establishes a novel signaling pathway concerning the interplay between cardiomyocytes and neutrophils in the heart tissue.
Article
Biochemistry & Molecular Biology
Sheng Han, Xiangdong Li, Nan Xia, Yu Zhang, Wenjie Yu, Jie Li, Chenyu Jiao, Ziyi Wang, Liyong Pu
Summary: Trem2 plays a complex and heterogeneous role in liver inflammation, with its function changing at different stages. In the early stage of inflammation induction after hepatic ischemia-reperfusion (IR), myeloid Trem2 deletion inhibits the induction of inflammatory markers and reduces neutrophil accumulation and mitochondrial damage. However, as pro-inflammatory macrophages transition into resolution macrophages, Trem2 promotes phagocytosis of apoptotic cells, contributing to the resolution of inflammation. Overexpression of myeloid Trem2 accelerates the transition of monocytes to a resolution phenotype, while knockdown of Trem2 delays upregulation of certain markers. Overall, Trem2 is involved in the cascade of IR inflammation in a two-sided capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Patrick Bou-Samra, Paul Scott, Hannah Cheng, Cramer Kallem, Ritambhara Pathak, David A. Geller, Wallis Marsh, Yisi Wang, Michael Antoni, Frank Penedo, Allan Tsung, Jennifer L. Steel
Summary: The study found that older age and lower perceived social support were significantly associated with poorer survival in gastrointestinal cancer patients.
JOURNAL OF GASTROINTESTINAL CANCER
(2022)
Article
Gastroenterology & Hepatology
Mikhail Efanov, Diana Salimgereeva, Ruslan Alikhanov, Andrew G. R. Wu, David Geller, Federica Cipriani, Davit L. Aghayan, Asmund Avdem Fretland, Jasper Sijberden, Andrea Belli, Marco V. Marino, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Prieto, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Constantino Fondevila, Fernando Rotellar, Gi-Hong Choi, Ricardo Robless Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Eric Lai, Charing C. Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, Paulo Herman, Fabrizio Di Benedetto, T. Peter Kingham, Rong Liu, Tran Cong Duy Long, Alessandro Ferrero, Giovanni Battista Levi Sandri, Daniel Cherqui, Olivier Scatton, Go Wakabayashi, Roberto I. Troisi, Tan-To Cheung, Atsushi Sugioka, Ho-Seong Han, Mohammad Abu Hilal, Olivier Soubrane, David Fuks, Luca Aldrighetti, Bjorn Edwin, Brian K. P. Goh
Summary: This study compares the outcomes of laparoscopic liver resection of segments 7 and 8 and finds that atypical resection of segment 7 is more difficult than segment 8, while segmentectomy 8 is more difficult than segmentectomy 7.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Yun-Le Linn, Andrew G. Wu, Ho-Seong Han, Rong Liu, Kuo-Hsin Chen, David Fuks, Olivier Soubrane, Daniel Cherqui, David Geller, Tan-To Cheung, Bjorn Edwin, Luca Aldrighetti, Mohammad Abu Hilal, Roberto Troisi, Go Wakabayashi, Brian K. P. Goh
Summary: This study reviewed the literature on difficulty scoring systems (DSS) for minimally invasive liver resection (MILR) and found that existing DSS are effective in predicting the difficulty of the surgery.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Surgery
Epameinondas Dogeas, David A. A. Geller, Samer Tohme, Jennifer Steel, Winifred Lo, Brittany Morocco, Amit Tevar, Michele Molinari, Christopher Hughes, Abhinav Humar
Summary: This study compared textbook outcomes (TO) of open live donor right hepatectomy (RH) versus open right hepatic lobectomy for cancer in a single Western center and identified clinical factors associated with failure to achieve a TO. The results showed that the TO rate after RH for live donor purposes was 92.2% and for RH for cancer cases was 53.7%.
Article
Oncology
Qiang Du, Silvia Liu, Kun Dong, Xiao Cui, Jing Luo, David A. Geller
Summary: Metastasis is the main cause of death in patients with colorectal cancer. The study found that iNOS downregulation induces the EMT program and promotes metastasis in colorectal cancer. The reduced expression of iNOS may serve as a potential therapeutic target for patients with colorectal cancer.
MOLECULAR CANCER RESEARCH
(2023)
Article
Oncology
Ning-Ning Zhang, Jian Zheng, Ying Wu, Jia-Yu Lv, Shu-Wen Zhang, Ya-Min Zhang, Wen-Tao Jiang, Tian-Qiang Song, Victoria Kim, Samer Tohme, Tian Liu, Wei Zhang, Jie Gu, Ze-Yu Wang, Yu-Hong Suo, Shuai Wang, Wang Li, Li Zhang, Yan Xie, Yong-He Zhou, Jian-Yong Liu, Yi-Bo Qiu, Zhong-Yang Shen, Ji-Hui Hao, David Geller, Wei Lu
Summary: This study aimed to develop a prognostic calculator to compare the long-term outcomes of liver transplantation (LT), resection (LR), and ablation (LA) as treatment options for early hepatocellular carcinoma (HCC) patients. The study found that LT resulted in significantly higher recurrence-free survival (RFS) and HCC-specific survival (HSS) rates compared to LR and LA, and LR had significantly better outcomes than LA. For multinodular HCC with a diameter ≤3 cm, LR and LA showed similar effectiveness. A prognostic calculator was developed based on preoperative clinical factors to evaluate RFS, recurrence within the Milan criteria (RWM), and HSS at different time intervals for all three treatment options.
Article
Gastroenterology & Hepatology
Giada Aizza, Nadia Russolillo, Alessandro Ferrero, Nicholas L. Syn, Federica Cipriani, Davit Aghayan, Marco Marino, Riccardo Memeo, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Marco Vivarelli, Fabrizio Di Benedetto, Sung-Hoon Choi, Jae Hoon Lee, James O. Park, Mikel Gastaca, Constantino Fondevila, Mikhail Efanov, Fernando Rotellar, Gi-Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Chung Ngai Tang, Charing C. Chong, Mathieu D'Hondt, Chee Chien Yong, Andrea Ruzzenente, Paolo Herman, T. Peter Kingham, Olivier Scatton, Rong Liu, Giovanni Battista Levi Sandri, Olivier Soubrane, Alejandro Mejia, Santiago Lopez-Ben, Kazateru Monden, Go Wakabayashi, Daniel Cherqui, Roberto Troisi, Mengqiu Yin, Felice Giuliante, David Geller, Atsushi Sugioka, Bjorn Edwin, Tan-To Cheung, Tran Cong Duy Long, Mohammad Abu Hilal, David Fuks, Kuo-Hsin Chen, Luca Aldrighetti, Ho-Seong Han, Brian K. P. Goh
Summary: This study aimed to investigate the relationship between tumor size and the difficulty of laparoscopic left lateral sectionectomy (L-LLS). Three optimal tumor size cutoffs (40-, 70-, and 100-mm) were identified. As tumor size increased, there was a stepwise increase in the rates of open conversion, operative time, blood loss, intraoperative blood transfusion, Pringle maneuver use, major morbidity, and 30-day readmission.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Surgery
Victor Lopez-Lopez, Jaime Arthur Pirola Krurger, Christopher Kuemmerli, Samer Tohme, Concepcion Gomez-Gavara, Maria Iniesta, Asuncion Lopez-Conesa, Epameinondas Dogeas, Mar Dalmau, Roberto Brusadin, Ignacio Sanchez-Esquer, David A. Geller, Paulo Herman, Ricardo Robles-Campos
Summary: This study compared the short-term and long-term outcomes of hand-assisted laparoscopic (HALS)/Hybrid and pure laparoscopic (PLS) resection for colorectal cancer liver metastasis. The results showed no differences in long-term oncologic outcomes between the two techniques. However, the PLS group had longer operative time, higher rates of intraoperative ablation, positive resection margins, and longer time to control bleeding. HALS/Hybrid may have a shorter learning curve and better hemorrhage control.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Guido P. Fiorentini, Yasmin Essaji, David A. Geller, David A. Iannitti, Erin H. Baker, Susanne G. Warner, Iswanto Sucandy, Pablo E. Serrano, Edwin Onkendi, William S. Helton, Adnan Alseidi, Sean P. Cleary
Summary: The aim of this study was to determine the benchmark performance of MILLS throughout the AMILES database. Results showed that among 1665 minimally invasive liver resections, 49% of MILLS cases met all textbook outcomes. Benchmark performance metrics for MILLS included conversion rate, blood loss, OR time, transfusion rate, complication rate, and length of stay.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Winifred M. M. Lo, Samer T. T. Tohme, David A. A. Geller
Summary: Minimally invasive surgery, including laparoscopic and robotic approaches, is a safe and effective option for treating liver metastases from colorectal cancer. Laparoscopic liver resection (LLR) is associated with shorter hospital stays and similar post-operative complications compared to open techniques. LLR allows for early initiation of chemotherapy and simultaneous resection of colorectal and liver tumors can be safe in selected patients. Robotic liver resection (RLR) has comparable safety and may improve resection rates. It is important to carefully select patients and ensure surgeon experience when considering minimally invasive liver surgery for colorectal liver metastases.
Review
Gastroenterology & Hepatology
Ioannis A. Ziogas, Christos D. Kakos, Dimitrios P. Moris, Christof Kaltenmeier, Georgios Tsoulfas, Martin I. Montenovo, Sophoclis P. Alexopoulos, David A. Geller, Elizabeth A. Pomfret
Summary: The value of minimally invasive approaches for living donor hepatectomy remains unclear. This study compared donor outcomes after different surgical approaches and found that pure laparoscopic and robotic living donor hepatectomy were associated with decreased blood loss and length of stay compared to open hepatectomy, but had longer operative time. Robotic living donor hepatectomy was also associated with decreased length of stay compared to laparoscopy-assisted hepatectomy.
LIVER TRANSPLANTATION
(2023)
Review
Oncology
Jurgis Alvikas, Winifred Lo, Samer Tohme, David A. Geller
Summary: Surgically removing part of the liver is an essential method of treating liver cancers, particularly hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM). Laparoscopic liver resection (LLR) has been developed as a minimally invasive technique, offering better short-term outcomes compared to open liver resection (OLR). LLR patients have fewer complications, reduced blood loss, and shorter hospital stays, while maintaining similar long-term survival as OLR. The article also discusses patient selection for LLR and the emerging robotic-assisted liver resection technique.
Article
Oncology
Xicai Li, Jingquan Huang, Qiulin Wu, Qiang Du, Yingyu Wang, Yubin Huang, Xiaoyong Cai, David A. Geller, Yihe Yan
Summary: This study reveals the relationship between CHK1 expression and the tumor microenvironment in hepatocellular carcinoma (HCC). High CHK1 expression is associated with advanced tumor stage and poor prognosis. CHK1 inhibition and cisplatin induce DNA damage and apoptosis in HCC cells. CHK1 directly interacts with IRF1 to regulate MICA expression, which is correlated with NK cell and CD8+T cell infiltration in HCC.
Meeting Abstract
Surgery
H. O. Yazdani, C. Kaltenmeier, R. Nakano, R. L. Simmons, D. A. Geller, S. Tohme
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Surgery
H. Liu, W. Zhang, M. Di, H. Lee, R. Cruz, X. Wang, C. Kaltenmeier, A. Thompson, D. Reddy, E. Ashwat, M. D'Alesio, S. Lebowitz, S. Tohme, D. Geller, A. Tevar, C. Hughes, A. Humar, J. Behari, R. Bataller, S. Hariharan, M. Molinari
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)