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Medicine, Research & Experimental
Meng-Lu Chen, Chun-Gu Hong, Tao Yue, Hong-Ming Li, Ran Duan, Wen-Bao Hu, Jia Cao, Zhen-Xing Wang, Chun-Yuan Chen, Xiong-Ke Hu, Ben Wu, Hao-Ming Liu, Yi-Juan Tan, Jiang-Hua Liu, Zhong-Wei Luo, Yan Zhang, Shan-Shan Rao, Ming-Jie Luo, Hao Yin, Yi-Yi Wang, Kun Xia, Si-Yuan Tang, Hui Xie, Zheng-Zhao Liu
Summary: The study found biphasic changes of miR-331-3p and miR-9-5p in AD progression, inhibiting these two microRNAs can promote autophagic clearance of A beta and prevent AD development. This was demonstrated in experiments and offers a potential new therapeutic strategy for AD patients.
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Biochemistry & Molecular Biology
Aline Freville, Benedicte Gnangnon, Annie Z. Tremp, Caroline De Witte, Katia Cailliau, Alain Martoriati, El Moukthar Aliouat, Priyanka Fernandes, Cerina Chhuon, Olivier Silvie, Sabrina Marion, Ida Chiara Guerrera, Johannes T. Dessens, Christine Pierrot, Jamal Khalife
Summary: This study reveals the regulation mechanism of key enzyme PP1 in Plasmodium development, including the formation of PbLRR1 complex and its inhibition on PP1 phosphatase activity. Depletion of PbLRR1 negatively affects oocyst development and controls the phosphorylation status of multiple proteins through interaction with new partners.
Review
Biochemistry & Molecular Biology
Sharad Khare, Tripti Khare, Raghu Ramanathan, Jamal A. Ibdah
Summary: This review discusses the role and involvement of microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma, with a special emphasis on their potential as diagnostic and prognostic tools in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
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Geriatrics & Gerontology
Qingling Liu, Chengbin Lei
Summary: The study found that the expression of miR-331-3p was significantly downregulated in AD patients and Aβ(1-40) treated SH-SY5Y cells. Serum miR-331-3p showed diagnostic potential and was correlated with MMSE scores and serum proinflammatory cytokine levels in AD patients. Overexpression of miR-331-3p in Aβ(1-40) treated SH-SY5Y cells enhanced cell viability and inhibited inflammatory responses, indicating a potential neuroprotective role of miR-331-3p.
EXPERIMENTAL GERONTOLOGY
(2021)
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Oncology
Qian Zeng, Fangfang Jin, Husun Qian, Hongling Chen, Yange Wang, Dian Zhang, Yu Wei, Tingmei Chen, Bianqin Guo, Chengsen Chai
Summary: This study found that miR-345-3p gene is upregulated in breast cancer tissues and cells, and its overexpression enhances the proliferation and invasion of breast cancer cells. The study also discovered that miR-345-3p promotes AKT phosphorylation by inhibiting protein phosphatase 2 catalytic subunit alpha (PPP2CA), and regulates the PI3K-AKT signaling pathway. Furthermore, inhibiting miR-345-3p can suppress tumor growth and invasiveness in mice.
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Oncology
Yu-Yun Shao, Pai-Sheng Chen, Liang-In Lin, Bin-Shyun Lee, Andrew Ling, Ann-Lii Cheng, Chiun Hsu, Da-Liang Ou
Summary: This study identified miR-10b-3p as a potential biomarker for predicting sorafenib efficacy in advanced HCC patients and confirmed its mechanism of action.
BRITISH JOURNAL OF CANCER
(2022)
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Oncology
Jiaxin Luo, Lingxi Jiang, Changyu He, Minmin Shi, Zhong-Yin Yang, Min Shi, Sheng Lu, Chen Li, Jun Zhang, Min Yan, Zheng-Gang Zhu, Chao Yan
Summary: This study found that the expression levels of microRNAs in peritoneal lavage samples of gastric cancer patients are associated with peritoneal metastasis. Specifically, hsa-let-7g-3p and hsa-miR-10395-3p have been identified as biomarkers predicting peritoneal metastasis and the efficacy of intraperitoneal chemotherapy.
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Engineering, Multidisciplinary
Tao Rui, Xueyou Zhang, Shi Feng, Haitao Huang, Shaowei Zhan, Haiyang Xie, Lin Zhou, Shusen Zheng, Qi Ling
Summary: The study found that miR-516a-3p is highly expressed in HCC and is associated with tumor progression and poor prognosis. They demonstrated that miR-516a-3p promotes malignant behaviors in HCC cells by regulating cellular metabolism and affecting neighboring cells via the exosome delivery system.
Article
Biotechnology & Applied Microbiology
Chanchan Gao, Yazhou Wen, Feng Jiang, Xuyu Gu, Xinhua Zhu
Summary: This study found that circ_0008274 is highly expressed in HCC, promoting proliferation, migration, and invasion of HCC cells. Depleting circ_0008274 inhibits malignant behaviors, with the mechanism involving upregulation of GRN to expedite HCC progression.
Article
Medicine, Research & Experimental
Yanlin Jin, Yi Zhang, Xiaoming Luo
Summary: The study found that circRNA_PTPRA may regulate HCC cell proliferation, invasion, apoptosis and migration by sponging miR-582-3p, suggesting that the circRNA_PTPRA/miR-582-3p axis could be a potential target for HCC diagnosis and treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
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Endocrinology & Metabolism
Shaojian Lin, Yue Zhu, Chengcheng Ji, Weiming Yu, Cheng Zhang, Langping Tan, Miaoyun Long, Dingyuan Luo, Xinzhi Peng
Summary: This study suggests that the overexpression of METTL3 is associated with malignant behaviors in thyroid carcinoma (TC), and it promotes tumor development and metastasis by regulating the expression levels of miR-222-3p and STK4.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
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Cell Biology
Hu Chen, Lequn Bao, Jianhua Hu, Dongde Wu, Xianli Tong
Summary: The study revealed that in hepatocellular carcinoma, miR-1-3p targets ORC6 to inhibit cell proliferation, migration, invasion, and promote apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yijie Zhang, Qi Pan, Zigong Shao
Summary: This study identified a novel miR-202-3p/KDM3A/HOXA1/MEIS3 pathway in HCC, where miR-202-3p negatively regulated KDM3A, leading to increased expression of HOXA1 and MEIS3, and reduced viability, migration, and invasion of HCC cells. Upregulation of miR-202-3p also inhibited the growth of human HCC cells in vivo, suggesting a potential therapeutic target for HCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Dan Zu, Qi Dong, Sunfang Chen, Yongde Chen, Jun Yao, Yubin Zou, Jiawei Lin, Bin Fang, Bing Wu
Summary: miR-331-3p reduces the expression of SOCS1, activates the JAK2/STAT3 signaling pathway, and inhibits the proliferation, metastasis, and invasion of osteosarcoma. This provides a new theoretical basis for the treatment of osteosarcoma.
JOURNAL OF ONCOLOGY
(2022)
Article
Cell Biology
Min Shi, Zhao-Yun Li, Li-Ming Zhang, Xiao-Yu Wu, Shi-Hao Xiang, Yu-Gang Wang, Ya-Qiong Zhang
Summary: The research identified hsa_circ_0007456 as a promising biomarker for HCC, with its downregulation affecting the susceptibility of HCC cells to NK cells. Through modulation of the miR-6852-3p/ICAM-1 axis, hsa_circ_0007456 plays a crucial role in NK cell cytotoxicity towards HCC cells.
CELL DEATH & DISEASE
(2021)