Treatment response in the PIVENS trial is associated with decreased hedgehog pathway activity

The improvement of cognitive functions is associated with a decrease of plasma Osteopontin levels in Natalizumab treated relapsing multiple sclerosis

(2013) Pietro Iaffaldano et al.   BRAIN BEHAVIOR AND IMMUNITY

Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists

(2013) James Kim et al.   CANCER CELL

Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity

(2013) Albert Herms et al.   CURRENT BIOLOGY

Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease

(2013) Cynthia A. Moylan et al.   HEPATOLOGY

Hedgehog pathway and pediatric nonalcoholic fatty liver disease

(2013) Marzena Swiderska-Syn et al.   HEPATOLOGY

Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH

(2013) Salvatore Sutti et al.   HEPATOLOGY

Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice

(2013) Xiaodong Ge et al.   HEPATOLOGY

Non-alcoholic steatohepatitis: Pathogenesis and novel therapeutic approaches

(2013) Detlef Schuppan et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

(2013) Utpal B Pajvani et al.   NATURE MEDICINE

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vismodegib Suppresses TRAIL-mediated Liver Injury in a Mouse Model of Nonalcoholic Steatohepatitis

(2013) Petra Hirsova et al.   PLoS One

Targeting hedgehog signaling in cancer: research and clinical developments

(2013) Jingwu Xie et al.   OncoTargets and Therapy

Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling

(2012) Jiangbo Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma

(2012) I. S. Chan et al.   CANCER RESEARCH

Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

(2012) Raffaele Teperino et al.   CELL

Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism

(2012) Yuping Chen et al.   GASTROENTEROLOGY

A hedgehog survival pathway in ‘undead’ lipotoxic hepatocytes

(2012) Keisuke Kakisaka et al.   JOURNAL OF HEPATOLOGY

Mitogenic signaling from apoptotic cells in Drosophila

(2011) Ginés Morata et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish

(2011) Prakash C. Thakur et al.   HEPATOLOGY

Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease

(2011) Cynthia D. Guy et al.   HEPATOLOGY

Increased production of sonic hedgehog by ballooned hepatocytes

(2011) Fatima Rangwala et al.   JOURNAL OF PATHOLOGY

Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate

(2010) J. Andrew Pospisilik et al.   CELL

Signals from dying hepatocytes trigger growth of liver progenitors

(2010) Y. Jung et al.   GUT

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

(2010) Wing-Kin Syn et al.   HEPATOLOGY

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

The role of Hedgehog signaling in fibrogenic liver repair

(2010) Steve S. Choi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hepatocellular ballooning in NASH

(2010) Stephen Caldwell et al.   JOURNAL OF HEPATOLOGY

Hedgehog signaling in the liver

(2010) Alessia Omenetti et al.   JOURNAL OF HEPATOLOGY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apoptosis in Drosophila: compensatory proliferation and undead cells

(2009) Francisco A. Martin et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

(2009) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

The Adventures of Sonic Hedgehog in Development and Repair. II. Sonic hedgehog and liver development, inflammation, and cancer

(2008) Alessia Omenetti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Liver fibrosis

(2008) Karen Wallace et al.   BIOCHEMICAL JOURNAL

Distinct Mechanisms of Apoptosis-Induced Compensatory Proliferation in Proliferating and Differentiating Tissues in the Drosophila Eye

(2008) Yun Fan et al.   DEVELOPMENTAL CELL

Liver Cell–Derived Microparticles Activate Hedgehog Signaling and Alter Gene Expression in Hepatic Endothelial Cells

(2008) Rafal P. Witek et al.   GASTROENTEROLOGY

Ballooned hepatocytes in steatohepatitis: The value of keratin immunohistochemistry for diagnosis

(2008) Carolin Lackner et al.   JOURNAL OF HEPATOLOGY