Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Gastroenterology & Hepatology
Elodie Beaumont, Vincent Larochette, Laurence Preisser, Charline Miot, Pascale Pignon, Simon Blanchard, Bjorn-Thore Hansen, Jonathan Dauve, Caroline Poli, Minna M. Poranen, Patricia Lamourette, Marc Plaisance, Alain Morel, Helmut Fickenscher, Pascale Jeannin, Philippe Roingeard, Yves Delneste
Summary: IL-26 plays a crucial role in protecting against HCV infection in the liver of patients with chronic hepatitis C, exerting direct antiviral activity by inhibiting viral replication and interfering with RNA polymerase activity.
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lisa Crozier, Reece Foy, Brandon L. Mouery, Robert H. Whitaker, Andrea Corno, Christos Spanos, Tony Ly, Jeanette Gowen Cook, Adrian T. Saurin
Summary: CDK4/6 inhibitors can induce a prolonged G1 arrest, downregulate replisome components, impair origin licencing, and lead to long-lasting effects on tumor growth. This unexpected ability to induce DNA damage provides a rationale for predicting responsive tumor types and effective combination therapies.
Editorial Material
Chemistry, Medicinal
Mark Klein
Summary: Cyclin-dependent kinases (CDKs) have important roles in normal cells and can be targeted for cancer therapy. CDK4 inhibitors have been approved for advanced breast cancer treatment. However, the development of selective inhibitors for individual CDKs is challenging due to the highly conserved ATP-binding site.
Article
Microbiology
Juri Kim, Eun-Ah Park, Mee Young Shin, Soon-Jung Park
Summary: This study investigated the functional roles of Giardia lamblia CDKs (GlCDKs) and their cognate cyclins. Using morpholino-mediated knockdown and coimmunoprecipitation, the functions of GlCDK1 and GlCDK2 were distinguished. GlCDK1 with Glcyclin 3977 plays a crucial role in flagellum formation and cell cycle control of G. lamblia, while GlCDK2 with Glcyclin 22394/6584 is involved in cell cycle control.
MICROBIOLOGY SPECTRUM
(2023)
Review
Biochemistry & Molecular Biology
Pawel Lukasik, Michal Zaluski, Izabela Gutowska
Summary: Cyclin-dependent kinases are crucial in various cellular processes and their dysregulation can lead to diseases, making them potential drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Andrew Dolson, Safia Mahabub Sauty, Kholoud Shaban, Krassimir Yankulov
Summary: Dbf4-Dependent Kinase (DDK) plays an essential role in DNA replication and repair, although some of its activities are not essential for viability. Recent studies have shown that DDK also plays a key role in regulating genome-wide origin firing and replication-coupled chromatin assembly.
Article
Virology
Lefang Jiang, Yang Yu, Zhuogang Li, Yarou Gao, Haonan Zhang, Mingxin Zhang, Weihua Cao, Qun Peng, Xulin Chen
Summary: CDK inhibitors, such as BMS-265246, have shown potential as effective antiviral agents against HSV-1 infection by inhibiting viral replication at multiple stages.
Article
Biochemistry & Molecular Biology
M. Herranz-Iturbide, J. Lopez-Luque, E. Gonzalez-Sanchez, D. Caballero-Diaz, E. Crosas-Molist, B. Martin-Mur, M. Gut, A. Esteve-Codina, V Jaquet, J. X. Jiang, N. J. Torok, I Fabregat
Summary: NOX4 plays a role in promoting hepatocyte proliferation and repair during liver regeneration, with its deletion leading to accelerated liver recovery. NOX4-deleted mice show faster cell proliferation and better liver weight restoration, suggesting the potential of NOX4 as a therapeutic target for improving liver regeneration.
Article
Multidisciplinary Sciences
Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki, Yuta Kubota, Hiroshi Tsumura
Summary: The reduced expression of miR-152 leads to the overexpression of CDK5R1 in Ewing's sarcoma cells, which in turn promotes cell proliferation through the activation of CDK5 and the phosphorylation of retinoblastoma protein.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Zhaoxin Wang, Chenchen Ren, Li Yang, Xiaoan Zhang, Jiaxi Liu, Yuanhang Zhu, Dongyuan Jiang
Summary: The study revealed that circ_0000326 is highly expressed in cervical cancer and acts as a sponge for microRNA-338-3p to upregulate Cyclin-dependent kinase 4, promoting cancer cell proliferation and migration. Inhibition of circ_0000326 showed promising effects in suppressing tumor growth and decreasing Cyclin-dependent kinase 4 expression.
Review
Biochemistry & Molecular Biology
Jorrit M. Enserink, Pierre Chymkowitch
Summary: Cdk1 is a master regulator of the cell cycle, controlling progression through different phases. It also directly regulates RNA polymerase activity, which is important for protein synthesis and meeting cellular demands. This regulation promotes cell cycle entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pierluigi Ramadori, Marius Maximilian Woitok, Olga Estevez-Vazquez, Raquel Benede-Ubieto, Hector Leal-Lassalle, Arantza Lamas-Paz, Feifei Guo, Jeanne Fabre, Julia Otto, Anna Verwaayen, Johanna Reissing, Tony Bruns, Stephanie Erschfeld, Ute Haas, Daniela Paffen, Leonard J. Nelson, Javier Vaquero, Rafael Banares, Christian Trautwein, Francisco Javier Cubero, Christian Liedtke, Yulia A. Nevzorova
Summary: Cyclin E1 plays a crucial role in liver fibrosis and hepatocarcinogenesis. The study investigated its role in alcohol-associated liver disease (ALD). The results showed that the lack of Cyclin E1 in hepatocytes worsens liver damage and leads to body weight loss.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Tao Wang, Lu-Yu Zhou, Xin-Min Li, Fang Liu, Lin Liang, Xin-Zhe Chen, Jie Ju, Murugavel Ponnusamy, Kai Wang, Cui-Yun Liu, Kao-Wen Yan, Kun Wang
Summary: The role of ABRO1 in cardiomyocyte proliferation and myocardial regeneration is explored in this study. It is found that ABRO1 regulates cardiomyocyte proliferation by targeting METTL3-mediated m6A methylation of Psph mRNA. ABRO1 deletion increases cardiomyocyte proliferation and restores heart function, while ABRO1 overexpression inhibits neonatal cardiomyocyte proliferation and cardiac regeneration. The mechanism involves METTL3-mediated Psph mRNA methylation and CDK2 phosphorylation.
Article
Oncology
Satu Pallasaho, Aishwarya Gondane, Anni Kuivalainen, Samuel Girmay, Siver Moestue, Massimo Loda, Harri M. Itkonen
Summary: The study reveals that CDK7 and CDK9 are highly active in castration-resistant prostate cancer (CRPC) cells, and inhibiting these kinases can effectively suppress the proliferation of CRPC cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Tanzeela Awan, Aaron Babendreyer, Abid Mahmood Alvi, Stefan Duesterhoeft, Daniela Lambertz, Joerg W. Bartsch, Christian Liedtke, Andreas Ludwig
Summary: The ADAM8 protein is highly expressed in hepatocellular carcinoma, promoting proliferation, migration, and invasion of liver cancer cells while inhibiting apoptosis. ADAM8 expression levels are positively correlated with activation of various signaling pathways in hepatoma cells, contributing significantly to HCC growth and metastasis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Correction
Mathematics
Christian Liedtke
INVENTIONES MATHEMATICAE
(2021)
Article
Cell Biology
Tanzeela Awan, Aaron Babendreyer, Justyna Wozniak, Abid Mahmood Alvi, Viktor Sterzer, Lena Cook, Jorg W. Bartsch, Christian Liedtke, Daniela Yildiz, Andreas Ludwig
Summary: In both acute and chronic liver inflammation, upregulation of ADAM8 enhances expression and release of inflammatory mediators, promoting the inflammatory process.
MEDIATORS OF INFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Olga Estevez-Vazquez, Raquel Benede-Ubieto, Feifei Guo, Beatriz Gomez-Santos, Patricia Aspichueta, Johanna Reissing, Tony Bruns, Carlos Sanz-Garcia, Svenja Sydor, Lars P. Bechmann, Eva Maranillo, Jose Ramon Sanudo, Maria Teresa Vazquez, Arantza Lamas-Paz, Laura Moran, Marina S. Mazariegos, Andreea Ciudin, Juan M. Pericas, Maria Isabel Peligros, Javier Vaquero, Eduardo Martinez-Naves, Christian Liedtke, Jose R. Regueiro, Christian Trautwein, Rafael Banares, Francisco Javier Cubero, Yulia A. Nevzorova
Summary: This study found that diets high in Palmitic Acid (PA), mainly sourced from palm oil, may lead to obesity, high cholesterol, more severe liver injury, and fibrosis, while diets high in trans-fat may result in glucose intolerance and elevated liver enzymes. Temporary withdrawal of these unhealthy diets can reverse symptoms of Metabolic Syndrome and Fatty Liver Disease, but mild hepatic inflammation remains detectable in the high PA diet groups.
Article
Oncology
Roland Sonntag, Christian Penners, Marlene Kohlhepp, Ute Haas, Daniela Lambertz, Andreas Kroh, Thorsten Cramer, Fabio Ticconi, Ivan G. Costa, Frank Tacke, Nikolaus Gassler, Christian Trautwein, Christian Liedtke
Summary: Cyclin E1 plays a crucial role in liver cancer progression, with its over-expression affecting multiple biological processes and its intervention significantly reducing tumor burden, while Cyclin-dependent kinase 2 is not essential in this process.
Article
Oncology
Feifei Guo, Olga Estevez-Vazquez, Raquel Benede-Ubieto, Douglas Maya-Miles, Kang Zheng, Rocio Gallego-Duran, Angela Rojas, Javier Ampuero, Manuel Romero-Gomez, Kaye Philip, Isioma U. Egbuniwe, Chaobo Chen, Jorge Simon, Teresa C. Delgado, Maria Luz Martinez-Chantar, Jie Sun, Johanna Reissing, Tony Bruns, Arantza Lamas-Paz, Manuel Gomez del Moral, Marius Maximilian Woitok, Javier Vaquero, Jose R. Regueiro, Christian Liedtke, Christian Trautwein, Rafael Banares, Francisco Javier Cubero, Yulia A. Nevzorova
Summary: This study suggests that the oncogene c-MYC plays a crucial role in the progression from MAFLD to HCC, making it a potential target for preventative strategies and individualized therapy. The study also found that metformin can significantly alleviate the MAFLD phenotype.
Review
Medicine, General & Internal
Christian Liedtke, Yulia A. Nevzorova, Tom Luedde, Henning Zimmermann, Daniela Kroy, Pavel Strnad, Marie-Luise Berres, Juergen Bernhagen, Frank Tacke, Jacob Nattermann, Ulrich Spengler, Tilman Sauerbruch, Alexander Wree, Zeinab Abdullah, Rene H. Tolba, Jonel Trebicka, Twan Lammers, Christian Trautwein, Ralf Weiskirchen
Summary: The Transregional Collaborative Research Center on Organ Fibrosis conducted a 13-year study to gain detailed knowledge on the mechanisms, immunological factors, and therapeutic approaches of organ fibrosis. This review summarizes the key findings in liver fibrogenesis, including cell death and cell cycle pathways, nutritional and iron-related mechanisms, and immune cell compartments. Potential signaling pathways and pharmacological targets are also highlighted for improved therapy and diagnosis of liver fibrosis.
FRONTIERS IN MEDICINE
(2022)
Article
Mathematics
Xi Chen, Frank Gounelas, Christian Liedtke
Summary: This paper completes the proof of the conjecture predicting the existence of infinitely many rational curves on K3 surfaces, proving almost all cases and improving the proofs of previously known cases. Two new techniques, regeneration and the marked point trick, are introduced in the deformation theory of curves on K3 surfaces for this purpose.
DUKE MATHEMATICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Pierluigi Ramadori, Marius Maximilian Woitok, Olga Estevez-Vazquez, Raquel Benede-Ubieto, Hector Leal-Lassalle, Arantza Lamas-Paz, Feifei Guo, Jeanne Fabre, Julia Otto, Anna Verwaayen, Johanna Reissing, Tony Bruns, Stephanie Erschfeld, Ute Haas, Daniela Paffen, Leonard J. Nelson, Javier Vaquero, Rafael Banares, Christian Trautwein, Francisco Javier Cubero, Christian Liedtke, Yulia A. Nevzorova
Summary: Cyclin E1 plays a crucial role in liver fibrosis and hepatocarcinogenesis. The study investigated its role in alcohol-associated liver disease (ALD). The results showed that the lack of Cyclin E1 in hepatocytes worsens liver damage and leads to body weight loss.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Immunology
Sandro Capellmann, Roland Sonntag, Herdit Schueler, Steffen K. Meurer, Lin Gan, Marlies Kauffmann, Katharina Horn, Hiltrud Koenigs-Werner, Ralf Weiskirchen, Christian Liedtke, Michael Huber
Summary: Mast cells (MCs) are heterogeneous immune cells with different protease repertoires and receptor expressions. A new cell line, PMC-306, derived from primary peritoneal MCs, can be used to study PMC function and tumorigenic processes associated with MC leukemia.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Julia Otto, Anna Verwaayen, Christian Penners, Jana Hundertmark, Cheng Lin, Carina Kallen, Daniela Paffen, Tobias Otto, Hilmar Berger, Frank Tacke, Ralf Weiskirchen, Yulia A. Nevzorova, Matthias Bartneck, Christian Trautwein, Roland Sonntag, Christian Liedtke
Summary: Hepatocellular carcinoma (HCC) is a severe malignancy with limited treatment options. The development of HCC involves chronic liver inflammation and liver fibrosis. This study reveals the role of Cyclin E1 (CCNE1) and Cdk2 genes in Hepatic Stellate Cells (HSCs) in liver fibrogenesis and hepatocarcinogenesis.
CELL DEATH & DISEASE
(2023)
Article
Mathematics
Bruno Chiarellotto, Christopher Lazda, Christian Liedtke
Summary: We demonstrate that for smooth and proper varieties over local fields without non-trivial vector fields, good reduction can be obtained through purely inseparable extensions. We utilize this to extend the Néron-Ogg-Shafarevich criterion for K3 surfaces from [5] to the equicharacteristic p > 0 case.
ANNALI DELLA SCUOLA NORMALE SUPERIORE DI PISA-CLASSE DI SCIENZE
(2022)
Article
Gastroenterology & Hepatology
Raquel Benede-Ubieto, Olga Estevez-Vazquez, Feifei Guo, Chaobo Chen, Youvika Singh, Helder Nakaya, Manuel Gomez del Moral, Arantza Lamas-Paz, Laura Moran, Nuria Lopez-Alcantara, Johanna Reissing, Tony Bruns, Matias A. Avila, Eva Santamaria, Marina S. Mazariegos, Marius Maximilian Woitok, Ute Haas, Kang Zheng, Ignacio Juarez, Jose Manuel Martin-Villa, Iris Asensio, Javier Vaquero, Maria Isabel Peligros, Josepmaria Argemi, Ramon Bataller, Javier Ampuero, Manuel Romero-Gomez, Christian Trautwein, Christian Liedtke, Rafael Banares, Francisco Javier Cubero, Yulia A. Nevzorova
Summary: This study successfully developed a preclinical DUAL model in mice that showed symptoms of fatty liver diseases associated with both alcohol consumption and metabolic risk. The model exhibited obesity, glucose intolerance, liver damage, steatohepatitis, fibrosis, inflammation in white adipose tissue, and dysregulated molecular pathways similar to human steatohepatitis, making it a valuable tool for developing therapeutic targets.
HEPATOLOGY COMMUNICATIONS
(2021)