Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

The Role of IL-15 in Activating STAT5 and Fine-Tuning IL-17A Production in CD4 T Lymphocytes

(2012) Pushpa Pandiyan et al.   JOURNAL OF IMMUNOLOGY

Negative regulators take center stage

(2012) Silvia Monticelli et al.   NATURE IMMUNOLOGY

The endocannabinoid system as a key mediator during liver diseases: new insights and therapeutic openings

(2011) A Mallat et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatoprotective effects of IL-22 on fulminant hepatic failure induced by d-galactosamine and lipopolysaccharide in mice

(2011) Wei-wei Xing et al.   CYTOKINE

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

(2011) Alexandre Louvet et al.   HEPATOLOGY

Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

(2011) Guoliang Cui et al.   JOURNAL OF CLINICAL INVESTIGATION

The liver X receptor in hepatic stellate cells: A novel antifibrogenic target?

(2011) Ariane Mallat et al.   JOURNAL OF HEPATOLOGY

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27

(2011) Caroline Pot et al.   SEMINARS IN IMMUNOLOGY

Th17 cells and their associated cytokines in liver diseases

(2010) Fouad Lafdil et al.   Cellular & Molecular Immunology

Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration

(2010) Fatima Teixeira-Clerc et al.   HEPATOLOGY

Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

(2010) Mark S. Wilson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

γδ T cells protect against lung fibrosis via IL-22

(2010) Philip L. Simonian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Matrix Metalloproteinase 12-Deficiency Augments Extracellular Matrix Degrading Metalloproteinases and Attenuates IL-13-Dependent Fibrosis

(2010) S. K. Madala et al.   JOURNAL OF IMMUNOLOGY

Anandamide Suppresses Proliferation and Cytokine Release from Primary Human T-Lymphocytes Mainly via CB2 Receptors

(2010) Maria Teresa Cencioni et al.   PLoS One

Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor

(2010) M. S. Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice

(2009) Jeon-OK Moon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure

(2009) Weiwei Feng et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Myeloid STAT3 Inhibits T Cell-Mediated Hepatitis by Regulating T Helper 1 Cytokine and Interleukin-17 Production

(2009) Fouad Lafdil et al.   GASTROENTEROLOGY

Interleukin-17-producing CD4+ T cells increase with severity of liver damage in patients with chronic hepatitis B

(2009) Ji-Yuan Zhang et al.   HEPATOLOGY

The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

(2009) Luisa Klotz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune Interactions in Hepatic Fibrosis

(2008) Andrew P. Holt et al.   Clinics in Liver Disease

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

The interleukin-17 pathway is involved in human alcoholic liver disease

(2008) Arnaud Lemmers et al.   HEPATOLOGY

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells

(2008) V. L. Hegde et al.   MOLECULAR PHARMACOLOGY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abrogation of the Antifibrotic Effects of Natural Killer Cells/Interferon-γ Contributes to Alcohol Acceleration of Liver Fibrosis

(2007) Won–Il Jeong et al.   GASTROENTEROLOGY