Article
Gastroenterology & Hepatology
Chenglin Xie, Xu Ye, Li Zeng, Xi Zeng, Deliang Cao
Summary: This study aimed to evaluate the prognostic value of serum AKR1B10 in hepatocellular carcinoma (HCC). The results showed that serum AKR1B10 level was associated with tumor stage, size, primary tumor number, and Child-Pugh classification. High levels of serum AKR1B10 were correlated with shorter survival. Univariate and multivariate COX regression analyses demonstrated that serum AKR1B10 level was an independent unfavorable prognostic marker of HCC.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Genetics & Heredity
Yibin Che, Ge Wang, Qiang Xia
Summary: CDK2AP1 expression in HCC is associated with clinical stage, prognosis, and immune infiltration levels. KEGG enrichment analysis revealed pathways affected by CDK2AP1 including phagocytosis, T cell differentiation, and cell cycle. CDK2AP1 is a potential target for HCC therapy.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Elton Yang, Wei Chua, Weng Ng, Tara Laurine Roberts
Summary: Gastric cancer is uniquely associated with chronic gastritis caused by H. pylori infection, leading to the activation of inflammatory pathways and transcription factors which upregulate cytokine production. The diverse cytokine patterns in gastric cancer, including pro-tumour and anti-tumour effects, may play a role in patient outcomes, with higher interleukin-6 levels linked to poorer prognosis. Further studies linking peripheral cytokine levels to patient prognosis may uncover important pathological mechanisms impacting survival in gastric cancer.
Article
Gastroenterology & Hepatology
Dong Zhao, Lei Xia, Wei Geng, Dongwei Xu, Chengpeng Zhong, Jianjun Zhang, Qiang Xia
Summary: The study shows that metformin inhibits HCC progression by activating the Hippo signaling pathway and regulating IL-22, thereby reducing the incidence and tumor burden of hepatocellular carcinoma.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tadashi Kegasawa, Ryotaro Sakamori, Kazuki Maesaka, Ryoko Yamada, Yuki Tahata, Ayako Urabe, Takahiro Kodama, Hayato Hikita, Kazuho Imanaka, Kazuyoshi Ohkawa, Naoki Hiramatsu, Masahide Oshita, Yukinori Yamada, Masami Inada, Takayuki Yakushijin, Yasuharu Imai, Tomohide Tatsumi, Tetsuo Takehara
Summary: In patients with hepatocellular carcinoma, serum sodium levels are associated with the efficacy of sorafenib, with low sodium levels, high alpha-fetoprotein levels, and low AFP levels being independent prognostic factors for TTP.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Clinical Neurology
Qingyuan Liu, Peng Liu, Yisen Zhang, Mahmud Mossa-Basha, David M. Hasan, Jiangan Li, Chengcheng Zhu, Shuo Wang
Summary: This study aimed to investigate whether serum interleukin-1 (IL-1) could discriminate unstable intracranial aneurysms (RIAs and UIAs) from stable, asymptomatic UIAs. The IL-1 ratio showed excellent diagnostic accuracy for RIAs. Serum IL-1 levels correlate with aneurysm tissue IL-1 levels and could serve as a potential biomarker for IA instability.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Julia M. Lewis, Patrick F. Monico, Fatima N. Mirza, Suzanne Xu, Sara Yumeen, Jack L. Turban, Anjela Galan, Michael Girardi
Summary: Chronic UV exposure leads to a shift in the immune response towards ROR gamma t+ IL-22/IL-17A-producing cells, which are associated with mutant KC growth, and targeting these immune components may represent potential strategies for skin cancer prevention.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Qing-hua Chang, Ting Mao, Yan Tao, Tao Dong, Xuan-xuan Tang, Guo-hong Ge, Zi-jun Xu
Summary: The study comprehensively analyzed the expression patterns and clinical significance of ITIHs in various cancers, showing primarily down-regulated expression. ITIH1 was found to be significantly decreased in liver hepatocellular carcinoma (LIHC) and its down-regulation adversely impacted patient outcome, possibly involving cellular metabolic processes. The findings established ITIH1 as a potential diagnostic and prognostic biomarker for LIHC.
Article
Medicine, Research & Experimental
Yu Zhu, Lingjing Zhou, Wei Xing, Wen Wang
Summary: The analysis of plasma IL-12 and IL-16 can improve the diagnostic sensitivity and specificity of PHC, with IL-12 and IL-16 combined analysis being more effective than separate analysis.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Qunying Han, Huan Deng, Xiude Fan, Xiaoyun Wang, Xiaoge Zhang, Kun Zhang, Na Li, Yi Lv, Zhengwen Liu
Summary: High serum PTX3 levels are associated with shorter overall survival time in HBV-related HCC patients, suggesting PTX3 as an independent risk factor for overall survival in HCC patients.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Biochemistry & Molecular Biology
Shuxian Zhang, Hanjuan Gong, Hailun Xie, Zhimin Huangfu, Yi Tang, Ming Xiao, Ming Li, Qingshu Li, Yalan Wang
Summary: In this study, the expression and clinical significance of DNM1L in hepatocellular carcinoma (HCC) were investigated. It was found that DNM1L expression was significantly higher in HCC tissues compared to adjacent/normal liver tissues. High DNM1L expression was associated with poorer overall survival and disease-free survival in HCC patients. Furthermore, DNM1L was found to be involved in key metabolic pathways and the resistance to sorafenib therapy, as well as the infiltration of immune cells in the tumor microenvironment.
MOLECULAR CARCINOGENESIS
(2023)
Article
Cell Biology
Lixu Zhu, Wenzhi Guo
Summary: This study identified the methylation characteristics of PD-1-negative HCC samples and proposed a prognostic model based on DMEGs. The tumor samples showed significantly lower ESTIMATE scores compared to normal samples, and 31 DMEGs were identified as able to distinguish PD-1-negative samples from normal samples. Functional enrichment analysis revealed the involvement of these genes in tumor-related and immune-related pathways, and potential therapeutic drugs were identified through DrugBank screening. The prognostic model based on three DMEGs demonstrated good predictive power for HCC prognosis and was validated in an independent cohort.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medical Laboratory Technology
Lunjun Zhang, Tao Xu, Yuanyuan Li, Qing Pang, Xiaolin Ding
Summary: The study found that hsa_circ_0000615 is significantly upregulated in hepatocellular carcinoma patients with chemoresistance, and its upregulation is positively correlated with disease stage. High levels of hsa_circ_0000615 expression are associated with shorter overall survival among chemoresistant patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Endocrinology & Metabolism
Hyunju Park, So Young Park, Jun Park, Jun Ho Choe, Man Ki Chung, Sook-Young Woo, Joon Young Choi, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim
Summary: Preoperative serum calcitonin levels are useful in predicting disease recurrence and determining optimal postoperative follow-up strategies for patients with MTC. It is also the best predictive factor for disease-free survival.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Chihao Zhang, Jiayun Lin, Xiaochun Ni, Hongjie Li, Lei Zheng, Zhifeng Zhao, Xiaoliang Qi, Haizhong Huo, Xiaolou Lou, Qiang Fan, Meng Luo
Summary: The study found a negative association between high OPG levels and survival rates in HCC patients, indicating OPG as a potential prognostic predictor for those undergoing radical resection. This association was further confirmed in specific subgroups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Malte Bachmann, Josef Pfeilschifter, Heiko Muehl
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2018)
Article
Pathology
Patrick Scheiermann, Malte Bachmann, Hamar Goren, Bernhard Zwissler, Josef Pfeilschifter, Heiko Muehl
AMERICAN JOURNAL OF PATHOLOGY
(2013)
Article
Medicine, General & Internal
Bernd Kronenberger, Ina Rudloff, Malte Bachmann, Friederike Brunner, Lisa Kapper, Natalie Filmann, Oliver Waidmann, Eva Herrmann, Josef Pfeilschifter, Stefan Zeuzem, Albrecht Piiper, Heiko Muehl
Article
Biochemistry & Molecular Biology
Malte Bachmann, Patrick Scheiermann, Lorena Haerdle, Josef Pfeilschifter, Heiko Muehl
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Christian D. Sadik, Malte Bachmann, Josef Pfeilschifter, Heiko Muehl
NUCLEIC ACIDS RESEARCH
(2009)
Article
Microbiology
Malte Bachmann, Katharina Horn, Ina Rudloff, Itamar Goren, Martin Holdener, Urs Christen, Nicole Darsow, Klaus-Peter Hunfeld, Ulrike Koehl, Peter Kind, Josef Pfeilschifter, Peter Kraiczy, Heiko Muehl
Article
Immunology
J Paulukat, M Bosmann, M Nold, S Garkisch, H Kämpfer, S Frank, J Raedle, S Zeuzem, J Pfeilschifter, H Mühl
JOURNAL OF IMMUNOLOGY
(2001)
Article
Biochemistry & Molecular Biology
Elisabeth Ziesche, Malte Bachmann, Hartmut Kleinert, Josef Pfeilschifter, Heiko Muehl
JOURNAL OF BIOLOGICAL CHEMISTRY
(2007)
