Analysis of hepatitis C virus resistance to silibininin vitroandin vivopoints to a novel mechanism involving nonstructural protein 4B

Failure of Intravenous Silibinin Monotherapy to Prevent Hepatitis C Genotype 2A Liver Graft Reinfection

(2012) Alessio Aghemo et al.   Hepatitis Monthly

Antiviral strategies in hepatitis C virus infection

(2012) Christoph Sarrazin et al.   JOURNAL OF HEPATOLOGY

Intravenous silibinin as ‘rescue treatment’ for on-treatment non-responders to pegylated interferon/ribavirin combination therapy

(2011) Karoline Rutter et al.   ANTIVIRAL THERAPY

Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment

(2011) Simon Reiss et al.   Cell Host & Microbe

High-dose silibinin rescue treatment for HCV-infected patients showing suboptimal virologic response to standard combination therapy

(2011) M. Biermer et al.   JOURNAL OF VIRAL HEPATITIS

NS4B Self-Interaction through Conserved C-Terminal Elements Is Required for the Establishment of Functional Hepatitis C Virus Replication Complexes

(2011) D. Paul et al.   JOURNAL OF VIROLOGY

Differential In Vitro Effects of Intravenous versus Oral Formulations of Silibinin on the HCV Life Cycle and Inflammation

(2011) Jessica Wagoner et al.   PLoS One

Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV–HCV coinfected patient

(2010) B.A. Payer et al.   JOURNAL OF CLINICAL VIROLOGY

Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapy

(2010) U.P. Neumann et al.   JOURNAL OF HEPATOLOGY

Silibinin monotherapy prevents graft infection after orthotopic liver transplantation in a patient with chronic hepatitis C

(2010) Sandra Beinhardt et al.   JOURNAL OF HEPATOLOGY

Amphipathic  -Helix AH2 Is a Major Determinant for the Oligomerization of Hepatitis C Virus Nonstructural Protein 4B

(2010) J. Gouttenoire et al.   JOURNAL OF VIROLOGY

Identification of hepatoprotective flavonolignans from silymarin

(2010) S. J. Polyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory

(2010) Jérôme Gouttenoire et al.   REVIEWS IN MEDICAL VIROLOGY

The Future of HCV Therapy: NS4B as an Antiviral Target

(2010) Hadas Dvory-Sobol et al.   Viruses-Basel

Rapid Suppression of Hepatitis C Viremia Induced by Intravenous Silibinin Plus Ribavirin

(2009) Michael Biermer et al.   GASTROENTEROLOGY

Silibinin and Related Compounds Are Direct Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

(2009) Abdelhakim Ahmed–Belkacem et al.   GASTROENTEROLOGY

Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C

(2009) Roy L. Hawke et al.   JOURNAL OF CLINICAL PHARMACOLOGY

An Amphipathic  -Helix at the C Terminus of Hepatitis C Virus Nonstructural Protein 4B Mediates Membrane Association

(2009) J. Gouttenoire et al.   JOURNAL OF VIROLOGY

Silibinin Is a Potent Antiviral Agent in Patients With Chronic Hepatitis C Not Responding to Pegylated Interferon/Ribavirin Therapy

(2008) Peter Ferenci et al.   GASTROENTEROLOGY

A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication

(2008) A. M. Paredes et al.   JOURNAL OF VIROLOGY