Article
Multidisciplinary Sciences
Satoru Joshita, Masao Ota, Hiroyuki Kobayashi, Shun-ichi Wakabayashi, Yuki Yamashita, Ayumi Sugiura, Tomoo Yamazaki, Eiji Tanaka, Takeji Umemura
Summary: This study revealed significant associations of KIR/HLA with HCC development (KIR2DS3) and freedom from NUC therapy (KIR3DL1/HLA-Bw4) in HBV patients, although larger case studies are needed for statistical purposes.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Xiaohui Zhang, Yingying Jiang, Shaobin Li, Dandan Bian, Mei Liu, Ming Kong, Yu Chen, Zhongping Duan, Sujun Zheng
Summary: After DAA treatment, NK cell cytotoxicity initially recovers in the early stage of treatment, but then continuously decreases to below normal levels. Changes in NK cell subsets and phenotypes are closely related to NK function.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Xiaohui Zhang, Yingying Jiang, Shaobin Li, Dandan Bian, Mei Liu, Ming Kong, Yu Chen, Zhongping Duan, Sujun Zheng
Summary: This study investigated the dynamic changes of natural killer (NK) cells during and after direct-acting antiviral (DAA) treatment in chronic hepatitis C patients. The study found that the cytotoxicity of NK cells showed a transient recovery in the early stage of treatment but continuously decreased below normal levels afterwards, and did not fully revert to pre-treatment levels. Additionally, alterations in NK subsets, phenotypes, and the microenvironment may be involved in these changes.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yingzhi Zhang, Shiwen Tong, Shiying Li, Xuefu Wang, Hong Ren, Wenwei Yin
Summary: NK cell activity is impaired in chronic hepatitis B (CHB) patients due to increased expression of inhibitory receptor ILT2. The level of ILT2 expression is positively correlated with viral load, and antiviral therapy can decrease ILT2 expression and restore NK cell function.
ANTIVIRAL RESEARCH
(2022)
Article
Immunology
Jaiprasath Sachithanandham, Ashwin Balagopal, Julia Leep-Lazar, Jeffrey Quinn, Kenneth Bowden, Kathleen Ward, Ruy M. Ribeiro, Mark S. Sulkowski
Summary: Using single-cell methods, the proportion of HCV-infected hepatocytes significantly decreased after initiating direct-acting antivirals (DAAs), proving that the second-phase viral dynamics derive from the loss of infected cells.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Yanqin Du, Olympia E. Anastasiou, Benedikt Strunz, Janina Scheuten, Birgit Bremer, Anke Kraft, Karolina Kleinsimglinhaus, Daniel Todt, Ruth Broering, Matthias Hardtke-Wolenski, Jun Wu, Dongliang Yang, Ulf Dittmer, Mengji Lu, Markus Cornberg, Niklas K. Bjorkstrom, Tanvi Khera, Heiner Wedemeyer
Summary: The study assessed the effects of HBsAg quantities on NK cell functionality in CHB patients, finding a reshaping of the NK cell pool towards more CD56(bright) NK cells during infection. Patients with low HBsAg levels displayed an activated NK cell phenotype with defective functional responses.
LIVER INTERNATIONAL
(2021)
Article
Oncology
Elena Panisova, Anna Lunemann, Simone Buergler, Monika Kotur, Julien Lazarovici, Alina Danu, Meike Kaulfuss, Juliane Mietz, Obinna Chijioke, Christian Muenz, Pierre Busson, Christoph Berger, David Ghez, Tarik Azzi
Summary: Research has shown that there are quantitative and qualitative differences in NK cells in EBV+ cHL patients, resulting in a reduced anti-tumor ability. By identifying these differences, it may help in designing more effective treatment approaches.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Emily C. Goins, Lauren E. Wein, Virginia Y. Watkins, Alexa I. K. Campbell, R. Phillips Heine, Brenna L. Hughes, Sarah K. Dotters-Katz, Jerome Jeffrey Federspiel
Summary: Hepatitis C virus and intrahepatic cholestasis of pregnancy (ICP) are independent risk factors for adverse outcomes in pregnancy. Having both Hepatitis C and ICP increases the risk of adverse maternal and obstetric outcomes compared to having either Hepatitis C or ICP alone.
Article
Immunology
Ratna S. Wijaya, Scott A. Read, Sakthi P. Selvamani, Stephen Schibeci, Mahmoud K. Azardaryany, Adrian Ong, David van der Poorten, Rita Lin, Mark W. Douglas, Jacob George, Golo Ahlenstiel
Summary: Direct acting antiviral therapies clear chronic hepatitis C virus (HCV) infection rapidly and restore natural killer (NK) cell function. Following HCV clearance, NK-cell memory formation involving KLRG1(+) NK cells is observed, which indicates their role in HCV clearance and potential for vaccine design.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Keyla Santos Guedes de Sa, Ednelza da Silva Graca Amoras, Simone Regina Souza da Silva Conde, Maria Alice Freitas Queiroz, Izaura Maria Vieira Cayres-Vallinoto, Ricardo Ishak, Antonio Carlos Rosario Vallinoto
Summary: Inefficient immune response and viral evasion mechanisms contribute to the chronicity of hepatitis C virus infection. The gene expressions of TLR3 and IFN-lambda 3 in liver tissue were investigated as potential biomarkers of HCV infection. The study found that TLR3 expression was higher and IFNL3 expression was lower in chronic HCV carriers, with different levels of expression in early and advanced stages of liver fibrosis and inflammation, showing no correlation with serum viral load.
Article
Medicine, General & Internal
Man-Fung Yuen, Seng-Gee Lim, Robert Plesniak, Keiji Tsuji, Harry L. A. Janssen, Cristina Pojoga, Adrian Gadano, Corneliu P. Popescu, Tatyana Stepanova, Tarik Asselah, Gheorghe Diaconescu, Hyung Joon Yim, Jeong Heo, Ewa Janczewska, Alexander Wong, Nevin Idriz, Michio Imamura, Giuliano Rizzardini, Koichi Takaguchi, Pietro Andreone, Manuela Arbune, Jinlin Hou, Sung Jae Park, Andrei Vata, Jennifer Cremer, Robert Elston, Tamara Lukic, Geoff Quinn, Lauren Maynard, Stuart Kendrick, Helene Plein, Fiona Campbell, Melanie Paff, Dickens Theodore, B-Clear Study Grp
Summary: Bepirovirsen treatment for 24 weeks at a dose of 300 mg per week resulted in sustained loss of hepatitis B surface antigen (HBsAg) and HBV DNA in 9%-10% of patients with chronic HBV infection. Larger and longer trials are needed to assess the efficacy and safety of bepirovirsen.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Takeji Umemura, Satoru Joshita, Hiromi Saito, Shun-ichi Wakabayashi, Hiroyuki Kobayashi, Yuki Yamashita, Ayumi Sugiura, Tomoo Yamazaki, Masao Ota
Summary: Natural killer cells, mediated through KIR-HLA interactions, play a role in hepatocellular carcinoma (HCC) development. In patients with hepatitis C virus-associated cirrhosis, the presence of HLA-Bw4 and the KIR3DL1 + HLA-Bw4 pair was significantly associated with HCC onset, suggesting a potential risk factor for HCC development in HCV cirrhosis.
Article
Gastroenterology & Hepatology
Robert J. Wong, Carol L. Brosgart, Sue Welch, Tim Block, Mark Chen, Chari Cohen, W. Ray Kim, Kris Kowdley, Anna S. Lok, Naoky Tsai, John Ward, Steven S. Wong, Robert G. Gish
Summary: The study estimated the number of foreign-born persons with chronic hepatitis B (CHB) in the USA by country of origin, updating a previous study from 2011. Systematic searches were conducted for articles published between 2009-2019 to calculate pooled prevalence estimates for 99 countries using meta-analyses. The total number of foreign-born persons with CHB in the USA in 2018 was estimated to be 1.47 million, substantially higher than previously reported, with a weighted average CHB prevalence of 3.07%.
Article
Gastroenterology & Hepatology
Calvin Q. Pan, Bao-Shen Zhu, Jian-Ping Xu, Jian-Xia Li, Li-Juan Sun, Hong-Xia Tian, Xi-Hong Zhang, Su-Wen Li, Er-Hei Dai
Summary: This study compared pregnancy and fetal outcomes between HCV-infected mothers and healthy mothers, and found that HCV-infected mothers are more likely to experience pregnancy complications such as anemia, requiring caesarian sections, and nuchal cords.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Juan Wang, Hongyan Hou, Lie Mao, Feng Wang, Jing Yu, Ying Luo, Qun Lin, Ziyong Sun
Summary: The TIGIT signaling pathway plays a role in regulating NK cell functions and may serve as a potential therapeutic target for protecting patients with chronic HBV infection from severe liver injury.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Uberto Fumagalli Romario, Filippo Ascari, Stefano De Pascale
Summary: Although ERAS programs have been widely adopted for colorectal surgery, their implementation for upper gastrointestinal surgery is challenging in Italy. A survey showed that Italian centers dedicated to gastric cancer do not fully follow evidence-based practices and guidelines of ERAS for gastric surgery. This may be due to surgeons' hesitation to introduce radical changes to traditional postoperative management after gastrectomy.
UPDATES IN SURGERY
(2023)
Article
Surgery
Eider Talavera-Urquijo, Paolo Parise, Agnese Carresi, Andrea Cossu, Lavinia Barbieri, Francesco Puccetti, Ugo Elmore, Riccardo Rosati
Summary: This study describes TBEF cases after esophagectomy and compares them with other cases. Surgical treatment as the first approach achieved good results, but treatment guidelines need to be developed.
UPDATES IN SURGERY
(2023)
Review
Surgery
Francesco Puccetti, Ugo Elmore, Riccardo Rosati
Summary: Management and treatment of esophagogastric diseases are constantly evolving, focusing on multimodal approach and quality of care. The introduction of standardized perioperative protocols has offered a chance to enhance patients' recovery after surgery worldwide. This review provides a comprehensive overview of the scientific basis, current evidence, and potential limitations of these protocols.
UPDATES IN SURGERY
(2023)
Article
Gastroenterology & Hepatology
Andrea Balla, Federica Saraceno, Marika Rullo, Salvador Morales-Conde, Eduardo M. Targarona Soler, Salomone Di Saverio, Mario Guerrieri, Pasquale Lepiane, Nicola Di Lorenzo, Michel Adamina, Isaias Alarcon, Alberto Arezzo, Jesus Bollo Rodriguez, Luigi Boni, Sebastiano Biondo, Francesco Maria Carrano, Manish Chand, John T. Jenkins, Justin Davies, Salvadora Delgado Rivilla, Paolo Delrio, Ugo Elmore, Eloy Espin-Basany, Alessandro Fichera, Blas Flor Lorente, Nader Francis, Marcos Gomez Ruiz, Dieter Hahnloser, Eugenio Licardie, Carmen Martinez, Monica Ortenzi, Yves Panis, Carlos Pastor Idoate, Alessandro M. Paganini, Miguel Pera, Roberto Perinotti, Daniel A. Popowich, Timothy Rockall, Riccardo Rosati, Alberto Sartori, Daniele Scoglio, Mostafa Shalaby, Vicente Simo Fernandez, Neil J. Smart, Antonino Spinelli, Patricia Sylla, Pieter J. Tanis, Javier Valdes-Hernandez, Steven D. Wexner, Pierpaolo Sileri
Summary: This qualitative study investigated the decision-making process of surgeons regarding protective ileostomy creation after rectal cancer surgery. The results showed that 76% of surgeons supported the creation of ileostomy. When making the decision, 88% of surgeons considered risk factors. Emotions influenced the decision-making process in 22% of cases, and personal experiences influenced it in 49% of cases. The most frequently considered risk factors were the distance between the anus and the tumor (96%), neoadjuvant chemoradiotherapy (88%), positive intraoperative leak test (65%), blood loss (37%), and immunosuppression therapy (35%).
COLORECTAL DISEASE
(2023)
Letter
Gastroenterology & Hepatology
Francesco V. Mandarino, Alberto Barchi, Lorella Fanti, Francesco Azzolini, Riccardo Rosati, Silvio Danese
Editorial Material
Surgery
Giovanni de Manzoni, Riccardo Rosati
UPDATES IN SURGERY
(2023)
Article
Medicine, General & Internal
Byorn W. L. Tan, Bryce W. Q. Tan, Amelia L. M. Tan, Emily R. Schriver, Alba Gutierrez-Sacristan, Priyam Das, William Yuan, Meghan R. Hutch, Noelia Garcia Barrio, Miguel Pedrera Jimenez, Noor Abu-el-rub, Michele Morris, Bertrand Moal, Guillaume Verdy, Kelly Cho, Yuk-Lam Ho, Lav P. Patel, Arianna Dagliati, Antoine Neuraz, Jeffrey G. Klann, Andrew M. South, Shyam Visweswaran, David A. Hanauer, Sarah E. Maidlow, Mei Liu, Danielle L. Mowery, Ashley Batugo, Adeline Makoudjou, Patric Tippmann, Daniela Zoeller, Gabriel A. Brat, Yuan Luo, Paul Avillach, Riccardo Bellazzi, Luca Chiovato, Alberto Malovini, Valentina Tibollo, Malarkodi Jebathilagam Samayamuthu, Pablo Serrano Balazote, Zongqi Xia, Ne Hooi Will Loh, Lorenzo Chiudinelli, Clara-Lea Bonzel, Chuan Hong, Harrison G. Zhang, Griffin M. Weber, Isaac S. Kohane, Tianxi Cai, Gilbert S. Omenn, John H. Holmes, Kee Yuan Ngiam
Summary: This retrospective observational study analyzed data from 12,891 COVID-19 patients and found that age, severe COVID-19, severe acute kidney injury (AKI), and ischemic heart disease were associated with worse mortality outcomes. The severity of AKI was associated with poorer kidney function recovery, while the use of remdesivir was associated with better recovery. In patients without chronic kidney disease, age, male sex, severe AKI, and hypertension were associated with post-AKI kidney function impairment. COVID-19-associated AKI was also linked to higher mortality and worse long-term kidney function recovery.
Review
Biochemistry & Molecular Biology
Stefania Mantovani, Barbara Oliviero, Stefania Varchetta, Alessandra Renieri, Mario U. Mondelli
Summary: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a devastating pandemic since March 2020. Toll-like receptors (TLRs) have been shown to be involved in the dysregulated immune response observed in patients with severe COVID-19. TLR2, TLR3, TLR4, and TLR7 have been associated with COVID-19 severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Gastroenterology & Hepatology
Luisa Siciliani, Alessandro Vanoli, Francesca Berton, Mario U. Mondelli
Summary: This case highlights the importance of initiating empiric treatment for NTM even without microbiological confirmation. It also emphasizes the association between disseminated mycobacteriosis and occult aggressive neoplasms.
LIVER INTERNATIONAL
(2023)
Letter
Biochemistry & Molecular Biology
Harrison G. Zhang, Jacqueline P. Honerlaw, Monika Maripuri, Malarkodi Jebathilagam Samayamuthu, Brendin R. Beaulieu-Jones, Huma S. Baig, Sehi L'Yi, Yuk-Lam Ho, Michele Morris, Vidul Ayakulangara Panickan, Xuan Wang, Griffin M. Weber, Katherine P. Liao, Shyam Visweswaran, Bryce W. Q. Tan, William Yuan, Nils Gehlenborg, Sumitra Muralidhar, Rachel B. Ramoni, Isaac S. Kohane, Zongqi Xia, Kelly Cho, Tianxi Cai, Gabriel A. Brat, James R. Aaron, Giuseppe Agapito, Adem Albayrak, Giuseppe Albi, Mario Alessiani, Anna Alloni, Danilo F. Amendola, Francois Angoulvant, Li L. L. J. Anthony, Bruce J. Aronow, Fatima Ashraf, Andrew Atz, Paul Avillach, Paula S. Azevedo, James Balshi, Brett K. Beaulieu-Jones, Douglas S. Bell, Antonio Bellasi, Riccardo Bellazzi, Vincent Benoit, Michele Beraghi, Jose Luis Bernal-Sobrino, Melodie Bernaux, Romain Bey, Surbhi Bhatnagar, Alvar Blanco-Martinez, Clara-Lea Bonzel, John Booth, Silvano Bosari, Florence T. Bourgeois, Robert L. Bradford, Gabriel A. Brat, Stephane Breant, Nicholas W. Brown, Raffaele Bruno, William A. Bryant, Mauro Bucalo, Emily Bucholz, Anita Burgun, Tianxi Cai, Mario Cannataro, Aldo Carmona, Charlotte Caucheteux, Julien Champ, Jin Chen, Krista Y. Chen, Luca Chiovato, Lorenzo Chiudinelli, Kelly Cho, James J. Cimino, Tiago K. Colicchio, Sylvie Cormont, Sebastien Cossin, Jean B. Craig, Juan Luis Cruz-Bermudez, Jaime Cruz-Rojo, Arianna Dagliati, Mohamad Daniar, Christel Daniel, Priyam Das, Batsal Devkota, Audrey Dionne, Rui Duan, Julien Dubiel, Scott L. DuVall, Loic Esteve, Hossein Estiri, Shirley Fan, Robert W. Follett, Thomas Ganslandt, Noelia Garcia-Barrio, Lana X. Garmire, Nils Gehlenborg, Emily J. Getzen, Alon Geva, Tobias Gradinger, Alexandre Gramfort, Romain Griffier, Nicolas Griffon, Olivier Grisel, Alba Gutierrez-Sacristan, Larry Han, David A. Hanauer, Christian Haverkamp, Derek Y. Hazard, Bing He, Darren W. Henderson, Martin Hilka, Yuk-Lam Ho, John H. Holmes, Chuan Hong, Kenneth M. Huling, Meghan R. Hutch, Richard W. Issitt, Anne Sophie Jannot, Vianney Jouhet, Ramakanth Kavuluru, Mark S. Keller, Chris J. Kennedy, Daniel A. Key, Katie Kirchoff, Jeffrey G. Klann, Isaac S. Kohane, Ian D. Krantz, Detlef Kraska, Ashok K. Krishnamurthy, Sehi L'Yi, Trang T. Le, Judith Leblanc, Guillaume Lemaitre, Leslie Lenert, Damien Leprovost, Molei Liu, Ne Hooi Will Loh, Qi Long, Sara Lozano-Zahonero, Yuan Luo, Kristine E. Lynch, Sadiqa Mahmood, Sarah E. Maidlow, Adeline Makoudjou, Alberto Malovini, Kenneth D. Mandl, Chengsheng Mao, Anupama Maram, Patricia Martel, Marcelo R. Martins, Jayson S. Marwaha, Aaron J. Masino, Maria Mazzitelli, Arthur Mensch, Marianna Milano, Marcos F. Minicucci, Bertrand Moal, Taha Mohseni Ahooyi, Jason H. Moore, Cinta Moraleda, Jeffrey S. Morris, Michele Morris, Karyn L. Moshal, Sajad Mousavi, Danielle L. Mowery, Douglas A. Murad, Shawn N. Murphy, Thomas P. Naughton, Carlos Tadeu Breda Neto, Antoine Neuraz, Jane Newburger, Kee Yuan Ngiam, Wanjiku F. M. Njoroge, James B. Norman, Jihad Obeid, Marina P. Okoshi, Karen L. Olson, Gilbert S. Omenn, Nina Orlova, Brian D. Ostasiewski, Nathan P. Palmer, Nicolas Paris, Lav P. Patel, Miguel Pedrera-Jimenez, Emily R. Pfaff, Ashley C. Pfaff, Danielle Pillion, Sara Pizzimenti, Hans U. Prokosch, Robson A. Prudente, Andrea Prunotto, Victor Quiros-Gonzalez, Rachel B. Ramoni, Maryna Raskin, Siegbert Rieg, Gustavo Roig-Dominguez, Pablo Rojo, Paula Rubio-Mayo, Paolo Sacchi, Carlos Saez, Elisa Salamanca, Malarkodi Jebathilagam Samayamuthu, L. Nelson Sanchez-Pinto, Arnaud Sandrin, Nandhini Santhanam, Janaina C. C. Santos, Fernando J. Sanz Vidorreta, Maria Savino, Emily R. Schriver, Petra Schubert, Juergen Schuettler, Luigia Scudeller, Neil J. Sebire, Pablo Serrano-Balazote, Patricia Serre, Arnaud Serret-Larmande, Mohsin Shah, Zahra Shakeri Hossein Abad, Domenick Silvio, Piotr Sliz, Jiyeon Son, Charles Sonday, Andrew M. South, Anastasia Spiridou, Zachary H. Strasser, Amelia L. M. Tan, Bryce W. Q. Tan, Byorn W. L. Tan, Suzana E. Tanni, Deanne M. Taylor, Ana I. Terriza-Torres, Valentina Tibollo, Patric Tippmann, Emma M. S. Toh, Carlo Torti, Enrico M. Trecarichi, Yi-Ju Tseng, Andrew K. Vallejos, Gael Varoquaux, Margaret E. Vella, Guillaume Verdy, Jill-Jenn Vie, Shyam Visweswaran, Michele Vitacca, Kavishwar B. Wagholikar, Lemuel R. Waitman, Xuan Wang, Demian Wassermann, Griffin M. Weber, Martin Wolkewitz, Scott Wong, Zongqi Xia, Xin Xiong, Ye Ye, Nadir Yehya, William Yuan, Alberto Zambelli, Harrison G. Zhang, Daniela Zoller, Valentina Zuccaro, Chiara Zucco
Correction
Emergency Medicine
Lorenzo Cobianchi, Daniele Piccolo, Francesca Dal Mas, Vanni Agnoletti, Luca Ansaloni, Jeremy Balch, Walter Biffl, Giovanni Butturini, Fausto Catena, Federico Coccolini, Stefano Denicolai, Belinda De Simone, Isabella Frigerio, Paola Fugazzola, Gianluigi Marseglia, Giuseppe Roberto Marseglia, Jacopo Martellucci, Mirko Modenese, Pietro Previtali, Federico Ruta, Alessandro Venturi, Haytham M. Kaafarani, Tyler J. Loftus
WORLD JOURNAL OF EMERGENCY SURGERY
(2023)
Article
Emergency Medicine
Lorenzo Cobianchi, Francesca Dal Mas, Vanni Agnoletti, Luca Ansaloni, Walter Biffl, Giovanni Butturini, Stefano Campostrini, Fausto Catena, Stefano Denicolai, Paola Fugazzola, Jacopo Martellucci, Maurizio Massaro, Pietro Previtali, Federico Ruta, Alessandro Venturi, Sarah Woltz, Haytham M. Kaafarani, Tyler J. Loftus, Team Dynamics Study Grp
Summary: This study explores the understanding, barriers, and facilitators of shared decision-making (SDM) in trauma and emergency surgery. Findings show that less than half of the surgeons understand SDM and 30% still see value in exclusively engaging multidisciplinary provider teams without involving the patient. The inclusion of SDM practices in clinical guidelines is recommended.
WORLD JOURNAL OF EMERGENCY SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Jose Camilla Sammartino, Marta Colaneri, Cecilia Bassoli, Mariaelena Ceresini, Antonio Piralla, Alessandro Ferrari, Elena Percivalle, Fausto Baldanti, Raffaele Bruno, Mario U. Mondelli
Summary: This study aimed to verify the presence of viable virus on different surfaces exposed to droplets released by coughing in SARS-CoV-2 RNA positive patients. The results showed that droplets on common inanimate surfaces did not contain viable virus, while laboratory-propagated viruses could survive and grow on the same surfaces.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Oncology
Arianna Orsini, Luca Mastracci, Isotta Bozzarelli, Anna Ferrari, Federica Isidori, Roberto Fiocca, Marialuisa Lugaresi, Antonietta D'Errico, Deborah Malvi, Erica Cataldi-Stagetti, Paola Spaggiari, Anna Tomezzoli, Luca Albarello, Ari Ristimaki, Luca Bottiglieri, Kausilia K. Krishnadath, Riccardo Rosati, Uberto Fumagalli Romario, Giovanni De Manzoni, Jari Rasanen, Giovanni Martinelli, Sandro Mattioli, Elena Bonora
Summary: Esophageal adenocarcinoma (EAC) is a severe malignancy with increasing incidence, poorly understood pathogenesis, and low survival rates. TP53 gene alterations, especially missense mutations, negatively affect cancer-specific survival in EAC. HNF1alpha gene disruption is associated with other gene alterations and is identified as a new EAC-mutated gene.