The cyclophilin inhibitor alisporivir prevents hepatitis C virus-mediated mitochondrial dysfunction

Structural Basis for the Non-Immunosuppressive Character of the Cyclosporin A Analogue Debio 025

(2010) Isabelle Landrieu et al.   BIOCHEMISTRY

Cellular Lipid Droplets and Hepatitis C Virus Life Cycle

(2010) Masayoshi Fukasawa   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Signal transduction to the permeability transition pore

(2010) Andrea Rasola et al.   FEBS LETTERS

DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

(2010) Lotte Coelmont et al.   PLoS One

Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics

(2010) Deborah L. Diamond et al.   PLoS Pathogens

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cyclophilin D in mitochondrial pathophysiology

(2009) Valentina Giorgio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Caspase Inhibitors for the Treatment of Hepatitis C

(2009) Howard C. Masuoka et al.   Clinics in Liver Disease

Cyclophilin Inhibitors

(2009) Philippe A. Gallay   Clinics in Liver Disease

An evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C

(2009) Raf Crabbé et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Hepatitis C Virus Proteins Induce Lipogenesis and Defective Triglyceride Secretion in Transgenic Mice

(2009) Hervé Lerat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex

(2009) Valentina Giorgio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C virus NS5A and core proteins induce oxidative stress-mediated calcium signalling alterations in hepatocytes

(2009) Natalia Dionisio et al.   JOURNAL OF HEPATOLOGY

95 EFFICACY AND SAFETY OF THE CYCLOPHILIN INHIBITOR DEBIO 025 IN COMBINATION WITH PEGYLATED INTERFERON ALPHA-2A AND RIBAVIRIN IN PREVIOUSLY NULL-RESPONDER GENOTYPE 1 HCV PATIENTS

(2009) D.R. Nelson et al.   JOURNAL OF HEPATOLOGY

Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex

(2009) Z. Liu et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1 -Mediated Glycolytic Adaptation

(2009) M. Ripoli et al.   JOURNAL OF VIROLOGY

Access of viral proteins to mitochondria via mitochondria-associated membranes

(2009) Chad D. Williamson et al.   REVIEWS IN MEDICAL VIROLOGY

Multiple cyclophilins involved in different cellular pathways mediate HCV replication

(2009) L. Alex Gaither et al.   VIROLOGY

Debio 025, a Cyclophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) Inhibitors

(2008) L. Coelmont et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The versatility of mitochondrial calcium signals: From stimulation of cell metabolism to induction of cell death

(2008) Alessandro Rimessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

HCV infection induces mitochondrial bioenergetic unbalance: Causes and effects

(2008) C. Piccoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Superoxide Flashes in Single Mitochondria

(2008) Wang Wang et al.   CELL

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

(2008) Douglas P Millay et al.   NATURE MEDICINE

Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies

(2008) Luciano Merlini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral Control of Mitochondrial Apoptosis

(2008) Lorenzo Galluzzi et al.   PLoS Pathogens