Article
Immunology
Neetu Saini, Sowmya Lakshminarayanan, Priyanka Kundu, Apurva Sarin
Summary: This study reveals that calcium uptake and mitochondrial metabolism play a crucial role in regulating the survival of regulatory T cells (Tregs) and Notch1 activity is a key factor in modulating these processes. By modulating cellular calcium dynamics, Notch1 regulates mitochondrial homeostasis and anti-apoptotic activity, thus impacting the survival of Tregs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Qin Hou, Qiongniu Zhu, Wenwei Lu, Wangang Zhang
Summary: The study found that treatment with nitric oxide significantly increased Bcl-2 expression and mitochondrial membrane potential at 6 h postmortem, while inhibiting cytochrome c release from mitochondria to the cytoplasm and elevating S-nitrosylation levels of caspase-3 and caspase-9, resulting in decreased apoptosis of beef SM.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Rituparna Chaudhuri, Himali Arora, Pankaj Seth
Summary: Calcium channels in brain cells play a crucial role in regulating ATP generation and cell death, also influencing viral infection and dissemination.
Article
Gastroenterology & Hepatology
Yanze Yin, Defu Kong, Kang He, Qiang Xia
Summary: This study investigated the mechanism of AURKA on liver regeneration using a 70% hepatectomy model and human liver organoids. The results showed that AURKA inhibition reduced beta-catenin levels by decreasing GSK-3 beta phosphorylation, leading to impaired liver regeneration. Additionally, AURKA inhibition affected human liver organoid formation, M1 macrophage polarization, and cytokine release, ultimately exacerbating liver injury.
LIVER INTERNATIONAL
(2022)
Article
Reproductive Biology
Zi-Bin Liu, Jia-Bao Zhang, Sheng-Peng Li, Wen-Jie Yu, Na Pei, Hai-Tao Jia, Ze Li, Wen-Fa Lv, Jun Wang, Nam-Hyung Kim, Bao Yuan, Hao Jiang
Summary: This study investigated the effects of inhibiting the expression of ID3 on cumulus cells (CCs) and uncovered the downstream regulatory network of ID3. The results showed that ID3 inhibition disrupted mitochondrial function, progesterone synthesis, and oocyte maturation. GO and KEGG analysis revealed the involvement of cholesterol-related processes and progesterone-mediated oocyte maturation. The study also found that ID3 inhibition led to increased apoptosis, inhibited phosphorylation of ERK1/2, and disrupted mitochondrial dynamics and function, resulting in poor oocyte maturation and quality. These findings contribute to the understanding of the biological roles of ID3 and cumulus cells.
Article
Cell Biology
Jing-lin Wang, Hao-ran Ding, Chen-yan Pan, Xiao-lei Shi, Hao-zhen Ren
Summary: Hepatectomy is effective for liver diseases, but complications like post-hepatectomy liver failure (PHLF) threaten patients' lives. Liver transplantation is limited by donor shortage and high cost, so there is a need for new treatments. Mesenchymal stem cell (MSC) transplantation shows promise due to easy access and low immunogenicity.
CELL DEATH & DISEASE
(2021)
Article
Integrative & Complementary Medicine
Jie Lin, Zhe Qing, Hanfei Huang, Shikun Yang, Zhong Zeng
Summary: The aim of this study was to investigate the mechanism by which Rg1 alleviates hepatic ischemia-reperfusion injury (HIRI) through the mitophagy pathway. The results showed that Rg1 could protect against liver damage by regulating the PINK1/Parkin signaling pathway and mitochondrial autophagy, thus improving the mechanism of HIRI.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Marc A. Fernandez-Yague, Alexandre Trotier, Secil Demir, Sunny Akogwu Abbah, Aitor Larranaga, Arun Thirumaran, Aimee Stapleton, Syed A. M. Tofail, Matteo Palma, Michelle Kilcoyne, Abhay Pandit, Manus J. Biggs
Summary: Tendon disease is an unmet clinical need in orthopaedic surgery, and bioelectronic therapies show promise in treating musculoskeletal diseases by activating tissue regeneration-specific signaling pathways. Piezoelectric materials represent a paradigm shift in biomedicine, with self-powered bioelectronic devices accelerating repair processes through motion-powered stimulation.
ADVANCED MATERIALS
(2021)
Article
Cell Biology
Xiaoping Zhang, Yong Zhong, Lin Liu, Chengyou Jia, Haidong Cai, Jianshe Yang, Bo Wu, Zhongwei Lv
Summary: The study found that fasting can inhibit glycolysis and mitochondrial function in papillary thyroid carcinoma (PTC). Fasting significantly increases the expression of lncRNA PRKCQ-AS1 in PTC cells, which leads to suppression of glycolysis and reduced mitochondrial function. PRKCQ-AS1 interacts with IGF2BPs and enhances the expression of PRMT7 mRNA, thereby regulating glycolysis and mitochondrial function in PTC and inhibiting tumor growth.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Jingjing Pan, Yanfeng Wei, Linlin Ni, Xiaoyang Li, Yu Deng, Bin Xu, Tianyao Yang, Jingyi Sun, Wei Liu
Summary: This study investigates the role of calcium ion (Ca2+) homeostasis in MeHg-induced neurotoxicity. The results suggest that MeHg causes cell damage and increases Ca2+ release from the ER as well as free Ca2+ levels in the cytoplasm and mitochondria. Ca2+ channel inhibitors and Ca2+ chelator can partially inhibit MeHg-induced mitochondrial damage and apoptosis.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yalin Guan, Xia Zhao, Nuan Song, Yuan Cui, Ying Chang
Summary: The study found that albicanol can inhibit Cd-induced apoptosis by regulating the NO/iNOS-mediated mitochondrial pathway.
Article
Cardiac & Cardiovascular Systems
Jufang Wang, Dhadendra Tomar, Thomas G. Martin, Shubham Dubey, Praveen K. Dubey, Jianliang Song, Gavin Landesberg, Michael G. Mccormick, Valerie D. Myers, Salim Merali, Carmen Merali, Bonnie Lemster, Charles F. Mctiernan, Kamel Khalili, Muniswamy Madesh, Joseph Y. Cheung, Jonathan A. Kirk, Arhtur M. Feldman
Summary: Bag3 is widely expressed in various animal species, with higher levels observed in the heart, skeletal muscle, central nervous system, and many cancers. Studies show that hearts carrying alleles with one knockout of BAGS exhibit significant changes in multiple cellular pathways, such as apoptosis, autophagy, mitochondrial homeostasis, and the inflammasome, even before clinical signs of dilatation and heart failure occur.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Hon-Kan Yip, Navneet Kumar Dubey, Kun-Chen Lin, Pei-Hsun Sung, John Y. Chiang, Yi-Ching Chu, Chi-Ruei Huang, Yi-Ling Chen, Yue-Hua Deng, Hsin-Chung Cheng, Win-Ping Deng
Summary: The study found that melatonin can promote neuroregeneration under ischemic conditions by increasing mitochondrial transfer, antioxidants, and inhibiting apoptosis, leading to reduced brain infarct area and improved neurological function.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell & Tissue Engineering
Nicole Baker, Steven Wade, Matthew Triolo, John Girgis, Damian Chwastek, Sarah Larrigan, Peter Feige, Ryo Fujita, Colin Crist, Michael A. Rudnicki, Yan Burelle, Mireille Khacho
Summary: Physiological changes in mitochondrial shape play a crucial role in regulating the quiescent state and activation potential of adult stem cells. Mitochondrial fragmentation promotes the exit from deep quiescence, while loss of the mitochondrial fusion protein OPA1 leads to premature activation and depletion of stem cells.
Article
Pharmacology & Pharmacy
Pingping Xue, Qian Chen, Xiuhua Ren, Dong Liu, Xiaofan Yang
Summary: The study confirmed the pro-apoptotic effect of RY10-4 on breast cancer cells, revealing that it induces apoptosis by increasing mitochondrial calcium levels through MCU, disrupting mitochondrial function, and ultimately activating the mitochondrial apoptosis pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Cell Biology
Sara Santos Bernardes, Mauro Cunha Xavier Pinto, Jaime Henrique Amorim, Vasco Ariston de Carvalho Azevedo, Rodrigo Ribeiro Resende, Akiva Mintz, Alexander Birbrair
Summary: This article introduces a research finding that periostin expressed by pericytes in the glioma microenvironment is crucial for glioma angiogenesis. This new discovery will contribute to the development of therapies for gliomas.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Joana O. P. A. Coutinho, Monica F. Quintanilha, Marina R. A. Campos, Enio Ferreira, Graciele C. A. de Menezes, Luiz H. Rosa, Carlos A. Rosa, Katia D. Vital, Simone O. A. Fernandes, Valbert N. Cardoso, Jacques R. Nicoli, Fabiana C. P. Tiago, Flaviano S. Martins
Summary: Mucositis, a severe side effect of chemotherapy drugs in cancer treatment, has no effective treatment currently. This study showed that oral administration of the Antarctic strain of Rhodotorula mucilaginosa UFMGCB 18,377 could effectively reduce mucositis induced by 5-FU.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Multidisciplinary Sciences
Leonardo da Silva Neto, Angelica Faleiros da Silva Maia, Adriana Martins Godin, Paulo Sergio de Almeida Augusto, Raissa Lima Goncalves Pereira, Sordaini Maria Caligiorne, Rosemeire Brondi Alves, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Gisele Assis Castro Goulart, Felipe Terra Martins, Maila de Castro Lourenco das Neves, Frederico Duarte Garcia, Angelo de Fatima
Summary: The study introduces two novel calix[n]arene-based anti-cocaine immunogens (V4N2 and V8N2) and evaluates their preclinical efficacy. The immunogens induce high titers of cocaine antibodies and modify the biodistribution of a cocaine analogue, reducing cocaine-induced behavior. These findings demonstrate the potential of V4N2 and V8N2 as immunogens for the treatment of cocaine use disorder.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Danielle C. Teles-Ferreira, Cristian Manzoni, Lara Martinez-Fernandez, Giulio Cerullo, Ana Maria de Paula, Rocio Borrego-Varillas
Summary: Understanding the primary steps following UV photoexcitation in sulphur-substituted DNA bases is crucial for developing new phototherapeutic drugs. This study successfully tracks the ultrafast decay mechanisms in 6-thioguanine and provides experimental evidence of fast internal conversion and electron trapping in the triplet manifold.
Article
Biology
Guilherme M. J. Costa, Samyra M. S. N. Lacerda, Andre F. A. Figueiredo, Natalia T. Wnuk, Marcos R. G. Brener, Lidia M. Andrade, Gabriel H. Campolina-Silva, Andrea Kauffmann-Zeh, Lucila G. G. Pacifico, Alice F. Versiani, Maisa M. Antunes, Fernanda R. Souza, Geovanni D. Cassali, Andre L. Caldeira-Brant, Helio Chiarini-Garcia, Fernanda G. de Souza, Vivian V. Costa, Flavio G. da Fonseca, Mauricio L. Nogueira, Guilherme R. F. Campos, Lucas M. Kangussu, Estefania M. N. Martins, Loudiana M. Antonio, Cintia Bittar, Paula Rahal, Renato S. Aguiar, Barbara P. Mendes, Marcela S. Procopio, Thiago P. Furtado, Yuri L. Guimaraes, Gustavo B. Menezes, Ana Martinez-Marchal, Kyle E. Orwig, Miguel Brieno-Enriquez, Marcelo H. Furtado
Summary: The SARS-CoV-2 virus has a higher affinity for the testes and can maintain its replicative and infective abilities for a prolonged period. Testicular alterations observed include angiogenesis, inflammation, and fibrosis. These findings suggest that critically ill patients may experience severe testicular pathogenesis with active viral presence.
Article
Microbiology
Denny M. Ceccon, Paulo Henrique R. Amaral, Lidia M. Andrade, Maria I. N. da Silva, Luis A. F. Andrade, Thais F. S. Moraes, Flavia F. Bagno, Raissa P. Rocha, Daisymara Priscila de Almeida Marques, Geovane Marques Ferreira, Alice Aparecida Lourenco, Agata Lopes Ribeiro, Jordana G. A. Coelho-dos-Reis, Flavio G. da Fonseca, J. C. Gonzalez
Summary: Fast, precise, and low-cost diagnostic testing is crucial for controlling the global COVID-19 pandemic caused by SARS-CoV-2. The current gold standard method, RT-qPCR test, is not universally available and is time-consuming. Machine learning can be used to classify spectroscopic data from samples, enabling the identification of infection regardless of symptoms or other tests. This study presents a new methodology combining spectroscopic data acquisition and artificial intelligence algorithms for rapid and precise label-free diagnosing of SARS-CoV-2 infection. The results show high accuracy in detecting the virus in different types of samples and suggest this methodology as a promising tool for future biomedical diagnosis.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Biochemical Research Methods
Egleidson F. A. Gomes, Eduardo Paulino Junior, Mario F. R. de Lima, Luana A. Reis, Giovanna Paranhos, Marcelo Mamede, Francis G. J. Longford, Jeremy G. Frey, Ana Maria de Paula
Summary: Prostate carcinoma, the second most common cancer among men worldwide, is often slow-growing and indolent. Prognosis relies heavily on the Gleason system, but new treatment and monitoring strategies require a more precise diagnosis. This study used multiphoton imaging to analyze prostate tumor samples from 120 patients, resulting in quantitative parameters that can indicate specific tumor aggressiveness signatures. The automated image analysis distinguished between non-neoplastic tissue and carcinoma areas with an accuracy of 89% +/- 3%, but only achieved 46% +/- 6% accuracy in differentiating between Gleason groups. However, the inclusion of stromal parameters improved the accuracy to 65% +/- 5%, highlighting the importance of considering these parameters for a more accurate diagnosis.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Optics
Christiano J. S. De Matos, Enrique G. Rosa, Juan D. Zapata, David Steinberg, Melissa Maldonado, E. A. Thoroh De Souza, Ana M. De Paula, Leandro M. Malard, Anderson S. L. Gomes
Summary: This paper reviews the work carried out in the field of nonlinear optics in two-dimensional and ultrathin lamellar materials, with a special focus on contributions authored and co-authored by researchers affiliated with Latin American institutions. It is shown that important and impactful contributions have emerged from Latin America, which has a consolidated and active optics community. Nonlinear optical refraction, nonlinear optical absorption, and nonlinear frequency conversion in materials such as graphene, transition metal dichalcogenides, and black phosphorus are among the reviewed themes.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
(2023)
Review
Oncology
Lidia M. Andrade, Guilherme M. J. Costa
Summary: The application of nanotechnology in medicine, especially gold nanoparticles, has shown potential in the diagnosis and treatment of head and neck cancer. Research has revealed the positive impact of gold nanoparticles in oncology, improving patients' quality of life and potentially changing paradigms in this field. A state-of-the-art review can help clinicians, students, researchers, and readers stay updated with the use of gold nanoparticles in managing upper aerodigestive tract tumors.
Article
Chemistry, Multidisciplinary
Ana Luisa Almeida Lage, Juliana Martins Ribeiro, Tairine Fernanda da Silva Magalhaes, Elaine Maria de Souza-Fagundes, Mateus Fernandes Venancio, Michelle Fernanda Brugnera, Dayse Carvalho da Silva Martins
Summary: This paper presents an approach to degrade atrazine, an environmentally harmful herbicide. Different types of porphyrins were studied and their effects on degradation were evaluated. The formed products were found to be equally or more toxic than the original atrazine, highlighting the importance of verifying the products and determining their toxicities.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Materials Science, Multidisciplinary
Andrea Schirato, Mychel G. Silva, Danielle C. Teles-Ferreira, Cristian Manzoni, Ana Maria de Paula, Giulio Cerullo, Giuseppe Della Valle, Marcel Di Vece
Summary: The photoexcitation of plasmonic nanostructures with ultrashort laser pulses allows for understanding the ultrafast nonlinear optical response and fundamental processes triggered by light absorption. The effects of photoexcitation on plasmonic nanostructures are studied using broadband transient absorption spectroscopy and semiclassical nonlinear simulations. The results provide a comprehensive understanding of the thermo-modulational nonlinearities of plasmonic nanostructures exhibiting resonances close to the interband transition threshold.
ADVANCED PHOTONICS RESEARCH
(2023)
Article
Chemistry, Physical
Danielle Cristina Teles-Ferreira, Ivo Hm van Stokkum, Irene Conti, Lucia Ganzer, Cristian Manzoni, Marco Garavelli, Giulio Cerullo, Artur Nenov, Rocio Borrego-Varillas, Ana Maria de Paula
Summary: This study investigates the mechanism of thionated nucleobases' ultrafast transition from singlet states to triplet states using transient absorption spectroscopy. Experimental results combined with theoretical simulations suggest that the relaxation to the triplet state is mediated by conical intersections promoted by vibrational coherences through the population of an intermediate singlet state.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Cell & Tissue Engineering
Raphaela A. Chiareli, Bruno L. Marques, Gustavo A. de Carvalho, Raysa T. de Souza, Pedro H. G. Santana, Helton C. Santiago, Mauro C. X. Pinto, Alexander Birbrair, Ricardo C. Parreira, Henning Ulrich, Rodrigo R. Resende
Summary: Neurogenesis is the process of forming new neurons from stem cells. While it was previously believed that neurons only multiplied during development, it has been discovered that neural stem cells can generate new neurons and glial cells in the mature brain. Certain regions, such as the subgranular and subventricular zones, retain the ability to undergo neurogenesis. This has important implications for the treatment of brain damage and neurodegenerative diseases.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Cell & Tissue Engineering
Anderson K. Santos, Katia N. Gomes, Ricardo C. Parreira, Sergio Scalzo, Mauro C. X. Pinto, Helton C. Santiago, Alexander Birbrair, Ulrich Sack, Henning Ulrich, Rodrigo R. Resende
Summary: Research has shown that adult neural stem cells have the potential for neural repair, with new neural differentiation methods successfully producing neurons, astrocytes, and oligodendrocytes. This provides novel strategies for central nervous system regeneration therapy.
STEM CELL REVIEWS AND REPORTS
(2022)