Article
Radiology, Nuclear Medicine & Medical Imaging
Cailing Pu, Xi Hu, Sangying Lv, Yan Wu, Feidan Yu, Wenchao Zhu, Lingjie Zhang, Jingle Fei, Chengbin He, Xiaoli Ling, Fuyan Wang, Hongjie Hu
Summary: The developed predictive model is able to identify patients with high risk of fibrosis in hypertrophic cardiomyopathy (HCM) through fusion of image and radiomic features, and screen out patients without fibrosis, avoiding unnecessary injection of contrast.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fuyi Xu, Yuanjian Chen, Kaitlin A. Tillman, Yan Cui, Robert W. Williams, Syamal K. Bhattacharya, Lu Lu, Yao Sun
Summary: This study identified modifier genes for cardiac fibrosis in HCM using a murine cohort, with different candidates in males (Nek6 and Nr6a1) and females (Nipsnap3b and Fktn). The findings suggest gender-specific modifier genes play a role in the variability of HCM phenotypes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Health Care Sciences & Services
Aleksandra Karabinowska-Malocha, Ewa Dziewiecka, Pawel Banys, Malgorzata Urbanczyk-Zawadzka, Maciej Krupinski, Malgorzata Mielnik, Jacek Lach, Aleksandra Budkiewicz, Piotr Podolec, Lukasz Zydzik, Sylwia Wisniowska-Smialek, Katarzyna Holcman, Magdalena Kostkiewicz, Pawel Rubis
Summary: This study aimed to evaluate the relationship between interstitial fibrosis on cardiac magnetic resonance (CMR) and non-sustained ventricular tachycardia (nsVT) in hypertrophic cardiomyopathy (HCM). The study found that the presence of late gadolinium enhancement (LGE) alone is not enough to determine the occurrence of nsVT in HCM patients, but rather the actual extent of LGE is important, while the role of interstitial fibrosis remains unclear.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiaqi She, Shihai Zhao, Yinyin Chen, Mengsu Zeng, Hang Jin
Summary: The study aimed to explore non-contrast parameters for evaluating myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM) using cardiac magnetic resonance (CMR), and to identify the best parameter. It was found that segmental circumferential strain (SCS) and maximal wall thickness (MWT) were significant biomarkers for differentiating myocardial segments with or without late gadolinium enhancement (LGE). Combining SCS >-13.9% and MWT >16.4mm achieved the highest specificity for predicting fibrosis.
ACADEMIC RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kristine Andreassen, Chloe Rixon, Marie H. Hansen, Ida Marie Hauge-Iversen, Lili Zhang, Mani Sadredini, Pugazendhi M. Erusappan, Ivar Sjaastad, Geir Christensen, Kristina H. Haugaa, Thor Edvardsen, Ida G. Lunde, Mathis K. Stokke
Summary: The effect of exercise training initiated before phenotype development on cardiac fibrosis, morphology, and function in a mouse model of hypertrophic cardiomyopathy (HCM) was investigated. The results showed that early aerobic exercise training attenuated left atrial dilatation and had no detrimental effects on left ventricular function in HCM mice, but did not have a significant impact on cardiac fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Sophie Urtado, Helene Hergault, Stephen Binsse, Vincent Aidan, Mounir Ouadahi, Catherine Szymanski, Sophie Mallet, Marie Hauguel-Moreau, Robert Yves Carlier, Olivier Dubourg, Nicolas Mansencal
Summary: This study assessed the usefulness of a longitudinal strain adjusted to regional thickness in hypertrophic cardiomyopathy (HCM). The results demonstrated that this adjusted method can provide a better evaluation of myocardial deformation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Andrei Dan Radu, Cosmin Cojocaru, Sebastian Onciul, Alina Scarlatescu, Alexandru Zlibut, Alexandrina Nastasa, Maria Dorobantu
Summary: Hypertrophic cardiomyopathy (HCM) is a genetic myocardial disease with poor prognosis. Cardiac resynchronization therapy (CRT) has emerged as a minimally invasive tool for patients with heart failure (HF) to improve symptoms and increase left ventricle (LV) systolic performance. This review assesses the importance of CRT in HCM patients based on current research from various published studies.
Review
Cardiac & Cardiovascular Systems
Fernando Luis Scolari, Lucas Simonetto Faganello, Henrique Iahnke Garbin, Beatriz Piva e Mattos, Andreia Biolo
Summary: Several miRNAs are associated with hypertrophic cardiomyopathy (HCM), with differential expression noted in 87 miRNAs, mostly up-regulated. Mir-21, mir-29a, and mir-133 are the most reported, with mir-29a showing more consistent phenotypic correlation.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sara Ranjbarvaziri, Kristina B. Kooiker, Mathew Ellenberger, Giovanni Fajardo, Mingming Zhao, Alison Schroer Vander Roest, Rahel A. Woldeyes, Tiffany T. Koyano, Robyn Fong, Ning Ma, Lei Tian, Gavin M. Traber, Frandics Chan, John Perrino, Sushma Reddy, Wah Chiu, Joseph C. Wu, Joseph Y. Woo, Kathleen M. Ruppel, James A. Spudich, Michael P. Snyder, Kevin Contrepois, Daniel Bernstein
Summary: The study found that metabolic signaling disruption and mitochondrial dysfunction are common pathogenic mechanisms in patients with HCM, highlighting potential new drug targets for mitigating the disease by improving metabolic function and reducing mitochondrial injury.
Article
Cardiac & Cardiovascular Systems
Hao Cui, Hartzell Schaff, Juliano Lentz Carvalho, Rick A. Nishimura, Jeffrey B. Geske, Joseph A. Dearani, Brian D. Lahr, Alexander T. Lee, J. Martijn Bos, Michael J. Ackerman, Steve R. Ommen, Joseph J. Maleszewski
Summary: This study analyzed the myocardial histopathology of 1,836 patients with obstructive HCM undergoing septal myectomy, finding associations between myocyte hypertrophy, myocyte disarray, and interstitial fibrosis with severity of heart disease. Older age, lower degree of myocyte hypertrophy, and lower degree of endocardial thickening were independently associated with worse post-myectomy survival.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Critical Care Medicine
Bradley A. Maron, David E. Kleiner, Elena Arons, Bradley M. Wertheim, Nirmal S. Sharma, Kathleen J. Haley, Andriy O. Samokhin, Ethan J. Rowin, Martin S. Maron, Douglas R. Rosing, Barry J. Maron
Summary: This study found that in patients with hypertrophic cardiomyopathy (HCM), the interpretation of pulmonary hypertension (PH) pathophysiological features may be confounded by dynamic left ventricular outflow tract obstruction. By comparing multiple HCM patients and control tissue specimens, the study found that HCM patients exhibited pulmonary arterial hypertrophy and fibrosis, which correlated with myocardial thickness and left ventricular outflow tract gradient. These findings have important implications for understanding the PH pathophysiological features in HCM patients.
Article
Biochemistry & Molecular Biology
Byeong-Yun Ahn, Myong-Ho Jeong, Jung-Hoon Pyun, Hyeon-Ju Jeong, Tuan Anh Vuong, Ju-Hyeon Bae, Subin An, Su Woo Kim, Yong Kee Kim, Dongryeol Ryu, Hyun-Ji Kim, Hana Cho, Gyu-Un Bae, Jong-Sun Kang
Summary: PRMT7 plays an important role in cardiac hypertrophy and fibrosis. Overexpression of PRMT7 can alleviate cellular hypertrophic response, while depletion of PRMT7 exacerbates hypertrophic response. Transcriptome analysis reveals altered gene expression profile related to Wnt signaling pathway in PRMT7-deficient hearts.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maja Schlittler, Peter P. Pramstaller, Alessandra Rossini, Marzia De Bortoli
Summary: Hypertrophic cardiomyopathy is the most common inherited heart disease and a leading cause of sudden cardiac death in young people. Mutations in genes that encode structural proteins of the heart can cause hypertrophic cardiomyopathy, leading to myocardial fibrosis and impaired cardiac function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Rosa Lillo, Francesca Graziani, Francesco Franceschi, Giulia Iannaccone, Massimo Massetti, Iacopo Olivotto, Filippo Crea, Giovanna Liuzzo
Summary: The hypertrophic cardiomyopathy phenotype is a group of genetic and acquired diseases characterized by left ventricular hypertrophy without abnormal cardiac loading conditions. Inflammation plays a critical role in cardiovascular conditions, including cardiomyopathies, and can contribute to cardiomyocyte hypertrophy and dysfunction. Systemic inflammation may be involved in the pathogenesis of cardiac disease progression and affect the severity and outcome of the phenotype. This review summarizes the current knowledge on the prevalence, clinical significance, and therapeutic implications of inflammation in hypertrophic cardiomyopathy and its phenocopies.
HEART FAILURE REVIEWS
(2023)
Article
Cell Biology
Bianca C. Bernardo, Gunes S. Yildiz, Helen Kiriazis, Claudia A. Harmawan, Celeste M. K. Tai, Rebecca H. Ritchie, Julie R. McMullen
Summary: Inhibition of miR-34a only provided limited protection in a mouse model of established type 1 diabetes-induced cardiomyopathy, failing to improve diastolic function. Therefore, strategies targeting multiple miRNAs and/or earlier intervention may be required for systemic disorders like diabetes where numerous miRNAs are dysregulated in the heart and other organs.
Editorial Material
Hematology
Fong W. Lam, Rolando E. Rumbaut
Letter
Hematology
Fong W. Lam, Miguel A. Cruz, Kathan Parikh, Rolando E. Rumbaut
Letter
Hematology
Fong W. Lam, Miguel A. Cruz, Kathan Parikh, Rolando E. Rumbaut
Article
Surgery
Abbas Rana, Michael Kueht, Moreshwar Desai, Fong Lam, Tamir Miloh, Jennifer Moffett, N. Thao N. Galvan, Ronald Cotton, Christine O'Mahony, John Goss
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2017)
Article
Immunology
Fong W. Lam, Qi Da, Bobby Guillory, Miguel A. Cruz
JOURNAL OF IMMUNOLOGY
(2018)
Article
Oncology
Jade Wulff, Judith Margolin, Nana E. Coleman, Gail Demmler-Harrison, Fong Lam, Mona D. Shah
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2018)
Article
Hematology
Qi Da, Paul J. Derry, Fong W. Lam, Rolando E. Rumbaut
Article
Gastroenterology & Hepatology
Noelle M. Gorgis, Curtis Kennedy, Fong Lam, Kathleen Thompson, Jorge Coss-Bu, Ayse Akcan Arikan, Trung Nguyen, Kathleen Hosek, Tamir Miloh, Saul J. Karpen, Daniel J. Penny, John Goss, Moreshwar S. Desai
Article
Multidisciplinary Sciences
Fong W. Lam, Jenny Phillips, Paul Landry, Sri Magadi, C. Wayne Smith, Rolando E. Rumbaut, Alan R. Burns
Article
Hematology
Fong W. Lam, Miguel A. Cruz, Hon-Chiu E. Leung, Kathan S. Parikh, C. Wayne Smith, Rolando E. Rumbaut
THROMBOSIS RESEARCH
(2013)
Article
Multidisciplinary Sciences
Fong Wilson Lam, Cameron August Brown, Christian Valladolid, Dabel Cynthia Emebo, Timothy Gerald Palzkill, Miguel Angel Cruz
Editorial Material
Hematology
Asher A. Mendelson, Fong Lam, Shayn M. Peirce, Walter L. Murfee
Article
Biochemistry & Molecular Biology
Angie de la Cruz, Aubrey Hargrave, Sri Magadi, Justin A. Courson, Paul T. Landry, Wanyu Zhang, Fong W. Lam, Monica A. Bray, C. Wayne Smith, Alan R. Burns, Rolando E. Rumbaut
Summary: Platelet extravasation during inflammation is influenced by CD18, PMNs, and mast cell degranulation. Injured corneas with deficiencies in CD18 or mast cells show reduced platelet and RBC extravasation, highlighting the importance of these factors in the process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Monica Bray, Melda A. Guzel, Fong Lam, Andrew Yee, Miguel A. Cruz, Rolando E. Rumbaut
Summary: COVID-19 is associated with changes in the activity and quality of VWF, but these changes are not specific to COVID-19. Similar changes in VWF activity and quality are observed in hospitalized patients with or without COVID-19. Further research is needed to understand the mechanisms responsible for qualitative changes in VWF in COVID-19 and other critical illnesses.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Physiology
Fong W. Lam, K. Vinod Vijayan, Rolando E. Rumbaut
COMPREHENSIVE PHYSIOLOGY
(2015)