Article
Chemistry, Physical
Lin Yang, Xueying An, Wang Gong, Wenshu Wu, Bin Liu, Xiaoyan Shao, Yansi Xian, Rui Peng, Baosheng Guo, Qing Jiang
Summary: This study investigates the potential of alpha-cyperone (alpha-CYP) as a therapeutic agent for osteoporosis and develops a liposome-based nano-drug delivery system that specifically targets bone resorption. The results demonstrate that alpha-CYP inhibits osteoclast differentiation and the progression of osteoporosis by silencing the PI3K/Akt pathway. The liposome targeting delivery system loaded with alpha-CYP shows enhanced efficacy in inhibiting osteoclasts and may provide a novel strategy for treating osteoporosis.
Article
Multidisciplinary Sciences
Samim Ali Mondal, Shivani N. Mann, Carl van der Linden, Roshini Sathiaseelan, Maria Kamal, Snehasis Das, Matthew P. Bubak, Sreemathi Logan, Benjamin F. Miller, Michael B. Stout
Summary: A recent study found that 17α-estradiol (17α-E2) treatment improves metabolic parameters and slows aging in male mice but is partially blocked in female mice. The study also revealed that the inhibitory effect of 17α-E2 on liver fibrosis is mediated by estrogen receptor β. These findings suggest that 17α-E2 has gender and disease-specific effects on metabolism, and could be a potential therapeutic approach for metabolic disorders.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Nicholas G. Martinez, David F. Thieker, Leiah M. Carey, Juhi A. Rasquinha, Samantha K. Kistler, Brian A. Kuhlman, Sharon L. Campbell
Summary: Phosphatidylinositol-3-kinases (PI3Ks) play a crucial role in controlling cellular growth, differentiation, and survival through activation by RAS proteins. Differences in the binding modes of RAS to PI3K alpha and PI3K gamma have been identified, which could aid in the development of anti-cancer agents targeting this interaction.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Cell Biology
Shaobin Yang, Yaqin Du, Xiaoqian Zhao, Chendong Wu, Peng Yu
Summary: The study provides an overview of the neuropathology of Alzheimer's disease (AD) and the role of the PDK1/Akt signaling pathway in its pathophysiology. It discusses the modulation of AD by the PDK1/Akt/TACE signaling axis and its potential for therapeutic targeting.
Article
Multidisciplinary Sciences
Qian Wang, Chenqi Tao, Abdul Hannan, Sungtae Yoon, Xuanyu Min, John Peregrin, Xiuxia Qu, Hongge Li, Honglian Yu, Jean Zhao, Xin Zhang
Summary: The patterning of epithelial buds in lacrimal gland development is determined by the interplay between PI3K, Ras, and ERK signaling pathways. PI3K is activated by both IGF and FGF signaling, and also promotes ERK signaling through direct interaction with Ras. Inhibition of EGF signaling is essential for induction of lacrimal gland buds, and the cross-talk among FGF, IGF, and EGF signaling is mediated by PI3K, MAPK, and mTOR.
Article
Pharmacology & Pharmacy
Mohamed A. Fouda, Peter C. Ruben
Summary: Inflammation or high glucose conditions alter the biophysical properties of the cardiac voltage-gated sodium channel, leading to prolonged action potentials and potentially causing arrhythmia. Protein kinases A and C mediate these effects, while CBD and E-2 have cardioprotective effects that mitigate the detrimental effects induced by high glucose/inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fang Zhu, Jujia Zheng, Fang Xu, Yiyuan Xi, Jun Chen, Xiangwei Xu
Summary: The study found that RSV can alleviate UC symptoms by mediating intestinal microflora homeostasis, suppressing the activation of the PI3K/Akt pathway, and reducing the expression of the VEGFA gene.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Florentina Negoita, Alex B. Addinsall, Kristina Hellberg, Conchita Fraguas Bringas, Paul S. Hafen, Tyler J. Sermersheim, Marianne Agerholm, Christopher T. A. Lewis, Danial Ahwazi, Naomi X. Y. Ling, Jeppe K. Larsen, Atul S. Deshmukh, Mohammad A. Hossain, Jonathan S. Oakhill, Julien Ochala, Jeffrey J. Brault, Uma Sankar, David H. Drewry, John W. Scott, Carol A. Witczak, Kei Sakamoto
Summary: This study aimed to investigate the role of CaMKK2 in the activation of AMPK and glucose uptake in skeletal muscle following contractions. The results showed that the inhibition or genetic loss of CaMKK2 does not affect AMPK activation and glucose uptake.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Alexandra M. Simond, Tung Bui, Dongmei Zuo, Virginie Sanguin-Gendreau, Trisha Rao, Wayne A. Phillips, Robert D. Cardiff, William J. Muller
Summary: This study found that the p110 alpha(HR) mutation attenuates metastatic behavior and is associated with the formation of ductal carcinoma in situ (DCIS) in ErbB2-driven breast cancer.
Article
Biochemistry & Molecular Biology
Elena Tortosa, Arundhati Sengupta Ghosh, Qingling Li, Weng Ruh Wong, Trent Hinkle, Wendy Sandoval, Christopher M. Rose, Casper C. Hoogenraad
Summary: The phosphorylation and membrane localization of DLK, a component of MAPK, is crucial for its activation during neuronal stress responses. The recruitment of DLK to specific vesicles upon stress induces kinase activation, which is essential for neuronal survival and degeneration.
Article
Endocrinology & Metabolism
Xi-juan Zhao, Kui Wang, Rong Li, Yang Lu, Pan Lu, Pei Fan, Yu-ying Lv, Xin-lin Chen, Hao-zheng Yuan
Summary: This study aimed to investigate the action of simvastatin on cortical neurons exposed to isoflurane and establish the mechanism of this action. It was found that simvastatin pretreatment protected neurons from isoflurane-induced neurotoxicity in vitro, and the phosphoinositide 3-kinase (PI3K)/Akt pathway mediated this effect.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Ophthalmology
Hao Huang, Xielan Kuang, Yuxiu Zou, Jingshu Zeng, Han Du, Han Tang, Chongde Long, Yan Mao, Xinyue Yu, Chaojuan Wen, Jianhua Yan, Huangxuan Shen
Summary: The loss of MAP4K4 gene leads to neural developmental disorder and impairment of photoreceptor development. MAP4K4 promotes neuronal development and plays a vital role in vision formation.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dong Han, Wei Wang, Julie Heejin Jeon, Tao Shen, Xiangsheng Huang, Ping Yi, Bingning Dong, Feng Yang
Summary: Phosphoinositide-dependent kinase-1 (PDK1) is a master kinase that regulates cancer cell proliferation, survival, and metabolism. It phosphorylates/activates AKT and other AGC kinases, including MAPK4, promoting tumor growth. MAPK4 can independently promote AKT activation and tumor growth, and also enhance PDK1 protein synthesis, leading to the activation of PDK1 substrates beyond AKT. Co-targeting AKT and PDK1 effectively represses MAPK4-induced cancer cell growth, providing a potential therapeutic strategy for MAPK4-high cancers.
Review
Pharmacology & Pharmacy
Carolina I. Ghanem, Jose E. Manautou
Summary: The severity of drug-induced liver injury (DILI) can vary from mild and asymptomatic to irreversible damage, sometimes requiring liver transplantation. DILI is traditionally classified as intrinsic DILI, dose-dependent DILI, or idiosyncratic DILI. Recent research has identified a third type called indirect hepatotoxicity. This review highlights the role of hepatic ATP-binding cassette transporters in DILI and their impact on the development and severity of liver injury.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Multidisciplinary Sciences
Masashi Kuriyama, Hisaaki Hirose, Toshihiro Masuda, Masachika Shudou, Jan Vincent Arafiles, Miki Imanishi, Masashi Maekawa, Yuji Hara, Shiroh Futaki
Summary: This study discovers that inhibition of macropinocytosis can be achieved through regulating the activity of mechanosensitive channels, offering a new strategy for cancer therapy.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Gisel S. Miszczuk, Ismael R. Barosso, Maria Cecilia Larocca, Julieta Marrone, Raul A. Marinelli, Andrea C. Boaglio, Enrique J. Sanchez Pozzi, Marcelo G. Roma, Fernando A. Crocenzi
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Biochemistry & Molecular Biology
Emy Basso, Giulia Rigotto, Andres E. Zucchetti, Tullio Pozzan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Gisel S. Miszczuk, Jesus M. Banales, Andres E. Zucchetti, Gerardo B. Pisani, Andrea C. Boaglio, Elena Saez, Juan F. Medina, Marcelo G. Roma, Fernando A. Crocenzi
Review
Biochemistry & Molecular Biology
Marcelo G. Roma, Ismael R. Barosso, Gisel S. Miszczuk, Fernando A. Crocenzi, Enrique J. Sanchez Pozzi
CURRENT MEDICINAL CHEMISTRY
(2019)
Article
Toxicology
Romina Belen Andermatten, Nadia Ciriaci, Virginia Soledad Schuck, Nicolas Di Siervi, Maria Valeria Razori, Gisel Sabrina Miszczuk, Anabela Carolina Medeot, Carlos Alberto Davio, Fernando Ariel Crocenzi, Marcelo Gabriel Roma, Ismael Ricardo Barosso, Enrique Juan Sanchez Pozzi
ARCHIVES OF TOXICOLOGY
(2019)
Article
Pharmacology & Pharmacy
Nadia Ciriaci, Romina Belen Andermatten, Maria Valeria Razori, Virginia Soledad Schuck, Gisel Sabrina Miszczuk, Anabela Carolina Medeot, Fernando Ariel Crocenzi, Marcelo Gabriel Roma, Ismael Ricardo Barosso, Maria Laura Ruiz, Enrique Juan Sanchez Pozzi
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Multidisciplinary Sciences
Andres Ernesto Zucchetti, Laurence Bataille, Jean-Marie Carpier, Stephanie Dogniaux, Mabel San Roman-Jouve, Mathieu Maurin, Michael W. Stuck, Rosa M. Rios, Cosima T. Baldari, Gregory J. Pazour, Claire Hivroz
NATURE COMMUNICATIONS
(2019)
Review
Immunology
Loredana Saveanu, Andres E. Zucchetti, Irini Evnouchidou, Laurence Ardouin, Claire Hivroz
IMMUNOLOGICAL REVIEWS
(2019)
Article
Multidisciplinary Sciences
Irini Evnouchidou, Pascal Chappert, Samira Benadda, Andres Zucchetti, Mirjana Weimershaus, Marcelle Bens, Vivien Caillens, Despoina Koumantou, Sophie Lotersztajn, Peter van Endert, Jean Davoust, Pierre Guermonprez, Claire Hivroz, David A. Gross, Loredana Saveanu
NATURE COMMUNICATIONS
(2020)
Article
Biology
Eliot Morrison, Tatjana Wegner, Andres Ernesto Zucchetti, Miguel Alvaro-Benito, Ashley Zheng, Stefanie Kliche, Eberhard Krause, Britta Bruegger, Claire Hivroz, Christian Freund
COMMUNICATIONS BIOLOGY
(2020)
Article
Cell Biology
Andres Ernesto Zucchetti, Noemie Paillon, Olga Markova, Stephanie Dogniaux, Claire Hivroz, Julien Husson
Summary: The research showed that external forces influence the dynamic of actin protrusions generated by T cells, with compressive forces slightly decreasing the length and growth speed, while pulling forces increase these parameters. The study also demonstrated that the dynamic of the protrusion is controlled by the Arp2/3 complex, and its inhibition affects the length, growth speed, and delay in growth of the protrusion.
BIOLOGY OF THE CELL
(2021)
Article
Cell Biology
Juan Jose Saez, Stephanie Dogniaux, Massiullah Shafaq-Zadah, Ludger Johannes, Claire Hivroz, Andres Ernesto Zucchetti
Summary: The paragraph discusses the important role of LAT in the signaling cascade induced by TCR activation, and its distribution and trafficking pathways in T cells upon activation. It shows that different proteins play specific roles in regulating the retrograde and anterograde transport of LAT during T cell activation.
Review
Biochemistry & Molecular Biology
Cecilia L. Basiglio, Fernando A. Crocenzi, Enrique J. Sanchez Pozzi, Marcelo G. Roma
Summary: Most hepatopathies involve cholestatic characteristics and oxidative stress, which impairs bile generation machinery. Despite recent advances in understanding oxidative stress-induced hepatocellular transporter internalization, the cholestatic implications have been overlooked. Future research should focus on understanding the pro-oxidant triggering factors and signaling pathways to develop personalized therapeutic strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Toxicology
Ismael R. Barosso, Gisel S. Miszczuk, Nadia Ciriaci, Romina B. Andermatten, Paula M. Maidagan, Valeria Razori, Diego R. Taborda, Marcelo G. Roma, Fernando A. Crocenzi, Enrique J. Sanchez Pozzi
ARCHIVES OF TOXICOLOGY
(2018)